Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0508 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0025 | 0.0278 | 0.5 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0025 | 0.0278 | 0.0278 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0073 | 0.1244 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0508 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.006 | 0.006 |
Trypanosoma brucei | trypanothione reductase | 0.0073 | 0.1244 | 0.0994 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0455 | 0.0455 |
Leishmania major | trypanothione reductase | 0.0073 | 0.1244 | 0.0994 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0085 | 0.0085 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0019 | 0.0142 | 0.0142 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0013 | 0.0021 | 0.0021 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0508 | 1 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0085 | 0.0085 |
Brugia malayi | Thioredoxin reductase | 0.0073 | 0.1244 | 0.1244 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0073 | 0.1244 | 0.1244 |
Echinococcus granulosus | twitchin | 0.0019 | 0.0153 | 0.0153 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0085 | 0.0085 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0025 | 0.0278 | 0.0278 |
Treponema pallidum | NADH oxidase | 0.0025 | 0.0278 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0508 | 1 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0073 | 0.1244 | 0.0994 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0508 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0774 | 0.0774 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0508 | 1 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0073 | 0.1244 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0085 | 0.0085 |
Echinococcus multilocularis | basic fibroblast growth factor receptor 1 A | 0.01 | 0.1776 | 0.1776 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0774 | 0.0774 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0085 | 0.0085 |
Schistosoma mansoni | nephrin | 0.0015 | 0.006 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0774 | 0.0774 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0085 | 0.0085 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0085 | 0.0085 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0085 | 0.0085 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0508 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0508 | 1 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0085 | 0.0085 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0085 | 0.0085 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0025 | 0.0278 | 0.0278 |
Plasmodium vivax | glutathione reductase, putative | 0.0073 | 0.1244 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0025 | 0.0278 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0085 | 0.0085 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0508 | 1 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0508 | 1 | 1 |
Echinococcus granulosus | neuroglian | 0.0015 | 0.006 | 0.006 |
Loa Loa (eye worm) | TK protein kinase | 0.0103 | 0.1836 | 0.1836 |
Plasmodium falciparum | glutathione reductase | 0.0073 | 0.1244 | 1 |
Brugia malayi | glutathione reductase | 0.0073 | 0.1244 | 0.1244 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0774 | 0.0774 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0025 | 0.0278 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0025 | 0.0278 | 0.5 |
Echinococcus granulosus | roundabout 2 | 0.0015 | 0.006 | 0.006 |
Echinococcus multilocularis | neuroglian | 0.0015 | 0.006 | 0.006 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0019 | 0.0142 | 0.0142 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.006 | 0.006 |
Echinococcus granulosus | basic fibroblast growth factor receptor 1 A | 0.01 | 0.1776 | 0.1776 |
Echinococcus multilocularis | fibroblast growth factor receptor 4 | 0.01 | 0.1776 | 0.1776 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0073 | 0.1244 | 0.1244 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0073 | 0.1244 | 0.0994 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0508 | 1 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0508 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0073 | 0.1244 | 0.1244 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0508 | 1 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.0015 | 0.006 | 0.006 |
Plasmodium falciparum | thioredoxin reductase | 0.0073 | 0.1244 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0508 | 1 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0508 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0085 | 0.0085 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0455 | 0.0455 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0085 | 0.0085 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0455 | 0.0455 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0013 | 0.0021 | 0.0021 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0508 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0025 | 0.0278 | 0.5 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0025 | 0.0278 | 0.0278 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0025 | 0.0278 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0508 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0508 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0508 | 1 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0085 | 0.0085 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0103 | 0.1836 | 0.1836 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0508 | 1 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0073 | 0.1244 | 0.1244 |
Echinococcus granulosus | fibroblast growth factor receptor 4 | 0.01 | 0.1776 | 0.1776 |
Schistosoma mansoni | tyrosine kinase | 0.01 | 0.1776 | 0.1776 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0025 | 0.0278 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.05 uM | Cytotoxic activity against mouse lymphocytic leukemia cells (L1210) | ChEMBL. | 10780917 |
EC50 (functional) | = 0.43 uM | Cytotoxic activity of the compound against human epidermoid carcinoma cells (KB) | ChEMBL. | 10780917 |
EC50 (functional) | = 0.87 uM | Cytotoxic activity against african green monkey (C. aethiops) kidney epithelial cells (VERO) | ChEMBL. | 10780917 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.