Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | elastase, neutrophil expressed | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | transmembrane protease serine 3 | elastase, neutrophil expressed | 267 aa | 236 aa | 27.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0108 | 0.0585 | 0.0421 |
Trypanosoma brucei | adenosine kinase, putative | 0.0084 | 0.0171 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0585 | 0.0421 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0084 | 0.0171 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0108 | 0.0585 | 0.5 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0108 | 0.0585 | 0.0421 |
Echinococcus multilocularis | acetylcholinesterase | 0.0638 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0108 | 0.0585 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0585 | 0.0421 |
Trypanosoma brucei | adenosine kinase, putative | 0.0084 | 0.0171 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0108 | 0.0585 | 0.0421 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0108 | 0.0585 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0108 | 0.0585 | 0.0421 |
Loa Loa (eye worm) | hypothetical protein | 0.0638 | 1 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0108 | 0.0585 | 0.0421 |
Onchocerca volvulus | 0.0108 | 0.0585 | 1 | |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0108 | 0.0585 | 0.0421 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0585 | 0.0421 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0638 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0108 | 0.0585 | 0.0421 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0108 | 0.0585 | 0.5 |
Onchocerca volvulus | 0.0108 | 0.0585 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0108 | 0.0585 | 0.0421 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0108 | 0.0585 | 0.0421 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0108 | 0.0585 | 0.5 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0108 | 0.0585 | 0.0421 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0638 | 1 | 1 |
Echinococcus multilocularis | neuroligin | 0.0108 | 0.0585 | 0.0421 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0108 | 0.0585 | 0.0421 |
Onchocerca volvulus | 0.0108 | 0.0585 | 1 | |
Onchocerca volvulus | 0.0108 | 0.0585 | 1 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0638 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0638 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0638 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0585 | 0.0421 |
Brugia malayi | Carboxylesterase family protein | 0.0638 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0585 | 0.0421 |
Leishmania major | adenosine kinase, putative | 0.0084 | 0.0171 | 0.5 |
Onchocerca volvulus | 0.0108 | 0.0585 | 1 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0638 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0108 | 0.0585 | 0.0421 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0108 | 0.0585 | 0.0421 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0084 | 0.0171 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0638 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0585 | 0.0421 |
Loa Loa (eye worm) | carboxylesterase | 0.0108 | 0.0585 | 0.0421 |
Schistosoma mansoni | gliotactin | 0.0108 | 0.0585 | 0.0421 |
Echinococcus granulosus | acetylcholinesterase | 0.0638 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0108 | 0.0585 | 0.0421 |
Brugia malayi | Carboxylesterase family protein | 0.0108 | 0.0585 | 0.0421 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0585 | 0.0421 |
Loa Loa (eye worm) | carboxylesterase | 0.0108 | 0.0585 | 0.0421 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0108 | 0.0585 | 0.5 |
Toxoplasma gondii | kinase, pfkB family protein | 0.0084 | 0.0171 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0638 | 1 | 1 |
Echinococcus granulosus | neuroligin | 0.0108 | 0.0585 | 0.0421 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0108 | 0.0585 | 0.0421 |
Brugia malayi | Carboxylesterase family protein | 0.0108 | 0.0585 | 0.0421 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 46 nM | Inhibitory concentration against Human Leukocyte Elastase from human sputum | ChEMBL. | 9191969 |
IC50 (binding) | = 46 nM | Inhibitory concentration against Human Leukocyte Elastase from human sputum | ChEMBL. | 9191969 |
IC50 (functional) | 0 uM | Inhibitory concentration of the compound against ferric ascorbate-induced lipid peroxidation from rat liver microsomal preparation; Inactive | ChEMBL. | 9191969 |
Inhibition (functional) | = 0 % | Percentage inhibition of HLE induced hemorrhage in the hamster lung at 3 hours | ChEMBL. | 9191969 |
Inhibition (functional) | = 0 % | Percentage inhibition of HLE induced hemorrhage in the hamster lung at 3 hours | ChEMBL. | 9191969 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.