Detailed information for compound 378064

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1010.26 | Formula: C55H83N3O14
  • H donors: 3 H acceptors: 7 LogP: 5.65 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: CO[C@@H]1CC(CC[C@H]1OCC(=O)Nc1ccc(cc1)N1CCOCC1)/C=C(/[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@H]([C@H](C[C@H](C/C(=C/[C@H](C(=O)C[C@@H]([C@H]1C)O)CC)/C)C)OC)[C@H](C[C@H]2C)OC)\C
  • InChi: 1S/C55H83N3O14/c1-10-39-26-33(2)25-34(3)27-47(67-8)51-48(68-9)29-36(5)55(65,72-51)52(62)53(63)58-20-12-11-13-42(58)54(64)71-50(37(6)43(59)31-44(39)60)35(4)28-38-14-19-45(46(30-38)66-7)70-32-49(61)56-40-15-17-41(18-16-40)57-21-23-69-24-22-57/h15-18,26,28,34,36-39,42-43,45-48,50-51,59,65H,10-14,19-25,27,29-32H2,1-9H3,(H,56,61)/b33-26+,35-28+/t34-,36+,37+,38?,39+,42-,43-,45+,46+,47-,48-,50+,51+,55+/m0/s1
  • InChiKey: IBVUPCRUPJCEEY-SYLPMWGPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens FK506 binding protein 1A, 12kDa Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative Get druggable targets OG5_126727 All targets in OG5_126727
Plasmodium yoelii FK506-binding protein Get druggable targets OG5_126727 All targets in OG5_126727
Candida albicans one of two identical potential FKBP-type peptidyl-prolyl cis-trans isomerase genes Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma japonicum FK506-binding protein 1A, putative Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania mexicana fk506-binding protein 1-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A Get druggable targets OG5_126727 All targets in OG5_126727
Plasmodium berghei peptidyl-prolyl cis-trans isomerase FKBP35, putative Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania donovani peptidylprolyl isomerase-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Trichomonas vaginalis peptidylprolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma brucei gambiense peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania donovani fk506-binding protein 1-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma mansoni immunophilin Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania major fk506-binding protein 1-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Plasmodium knowlesi peptidyl-prolyl cis-trans isomerase FKBP35, putative Get druggable targets OG5_126727 All targets in OG5_126727
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) Get druggable targets OG5_126727 All targets in OG5_126727
Theileria parva peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma mansoni immunophilin Get druggable targets OG5_126727 All targets in OG5_126727
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 Get druggable targets OG5_126727 All targets in OG5_126727
Trichomonas vaginalis fk506-binding protein, putative Get druggable targets OG5_126727 All targets in OG5_126727
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Trichomonas vaginalis peptidylprolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Neospora caninum Peptidylprolyl isomerase D (Cyclophilin D), related Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma japonicum ko:K09568 FK506-binding protein 1, putative Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Candida albicans hypothetical protein Get druggable targets OG5_126727 All targets in OG5_126727
Trichomonas vaginalis immunophilin, putative Get druggable targets OG5_126727 All targets in OG5_126727
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 Get druggable targets OG5_126727 All targets in OG5_126727
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 Get druggable targets OG5_126727 All targets in OG5_126727
Echinococcus multilocularis fk506 binding protein Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania braziliensis fk506-binding protein 1-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania major peptidylprolyl isomerase-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Loa Loa (eye worm) FKBP5 protein Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania infantum fk506-binding protein 1-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Candida albicans one of two identical potential FKBP-type peptidyl-prolyl cis-trans isomerase genes Get druggable targets OG5_126727 All targets in OG5_126727
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 Get druggable targets OG5_126727 All targets in OG5_126727
Candida albicans one of two identical potential FKBP-type peptidyl-prolyl cis-trans isomerase genes Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania mexicana peptidylprolyl isomerase-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma mansoni immunophilin Get druggable targets OG5_126727 All targets in OG5_126727
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 Get druggable targets OG5_126727 All targets in OG5_126727
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma congolense peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_126727 All targets in OG5_126727
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania braziliensis peptidylprolyl isomerase-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Leishmania infantum peptidylprolyl isomerase-like protein Get druggable targets OG5_126727 All targets in OG5_126727
Schistosoma japonicum ko:K09571 FK506-binding protein 4/5, putative Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma congolense FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative Get druggable targets OG5_126727 All targets in OG5_126727
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 Get druggable targets OG5_126727 All targets in OG5_126727
Trypanosoma brucei gambiense peptidylprolyl isomerase-like protein, putative Get druggable targets OG5_126727 All targets in OG5_126727
Candida albicans one of two identical potential FKBP-type peptidyl-prolyl cis-trans isomerase genes Get druggable targets OG5_126727 All targets in OG5_126727
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 Get druggable targets OG5_126727 All targets in OG5_126727
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei macrophage infectivity potentiator, precursor, putative FK506 binding protein 1A, 12kDa 108 aa 107 aa 48.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0267 1 1
Loa Loa (eye worm) hypothetical protein 0.0141 0.3758 0.3758
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0065 0 0.5
Brugia malayi nuclear hormone receptor 0.0126 0.3009 0.3009
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0267 1 1
Schistosoma mansoni retinoic acid receptor RXR 0.0267 1 1
Leishmania major fk506-binding protein 1-like protein 0.0065 0 0.5
Trichomonas vaginalis fk506-binding protein, putative 0.0065 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0267 1 1
Loa Loa (eye worm) hypothetical protein 0.0126 0.3009 0.3009
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0267 1 1
Echinococcus granulosus ecdysone induced protein 78C 0.0267 1 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0126 0.3009 0.3009
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0065 0 0.5
Schistosoma mansoni nuclear hormone receptor 0.0267 1 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0267 1 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0267 1 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0126 0.3009 0.3009
Brugia malayi nuclear receptor NHR-88 0.0126 0.3009 0.3009
Brugia malayi nuclear hormone receptor 0.0267 1 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0126 0.3009 0.3009
Schistosoma mansoni coup transcription factor 0.0267 1 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0126 0.3009 0.3009
Schistosoma mansoni zinc finger protein 0.0126 0.3009 0.3009
Brugia malayi nuclear hormone receptor family member odr-7 0.0126 0.3009 0.3009
Onchocerca volvulus Protein ultraspiracle homolog 0.0267 1 1
Loa Loa (eye worm) hypothetical protein 0.0267 1 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0126 0.3009 0.3009
Onchocerca volvulus Bile acid receptor homolog 0.0267 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0267 1 1
Brugia malayi conserved hypotetical protein 0.0126 0.3009 0.3009
Loa Loa (eye worm) hypothetical protein 0.0267 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0267 1 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0126 0.3009 0.3009
Loa Loa (eye worm) hypothetical protein 0.0267 1 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0267 1 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0126 0.3009 0.3009
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0267 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0267 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0267 1 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0267 1 1
Brugia malayi nuclear receptor NHR-88 0.0267 1 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0267 1 1
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0065 0 0.5
Brugia malayi hypothetical protein 0.0141 0.3758 0.3758
Brugia malayi Nuclear hormone receptor-like 1 0.0141 0.3758 0.3758
Brugia malayi nuclear receptor RXR 0.0141 0.3758 0.3758
Loa Loa (eye worm) hypothetical protein 0.0126 0.3009 0.3009
Schistosoma mansoni nuclear receptor 0.0126 0.3009 0.3009
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0141 0.3758 0.3758
Schistosoma mansoni thyroid hormone receptor 0.0267 1 1
Schistosoma mansoni thyroid hormone receptor 0.0267 1 1
Leishmania major peptidylprolyl isomerase-like protein 0.0065 0 0.5
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0126 0.3009 0.3009
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0267 1 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0126 0.3009 0.3009
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0267 1 1
Schistosoma mansoni RAR-like nuclear receptor 0.0267 1 1
Brugia malayi tailless protein 0.0126 0.3009 0.3009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0267 1 1
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0065 0 0.5
Brugia malayi orphan nuclear receptor NR2E1 0.0126 0.3009 0.3009
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0141 0.3758 0.3758
Brugia malayi Steroid receptor seven-up type 2 0.0267 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0267 1 1
Loa Loa (eye worm) hypothetical protein 0.0126 0.3009 0.3009
Schistosoma mansoni nuclear receptor nhr-48 0.0126 0.3009 0.3009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0267 1 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0267 1 1
Loa Loa (eye worm) hypothetical protein 0.0126 0.3009 0.3009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0267 1 1
Brugia malayi Nuclear hormone receptor E75 0.0126 0.3009 0.3009
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0126 0.3009 0.3009
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0267 1 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0267 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0267 1 1
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0065 0 0.5
Trichomonas vaginalis immunophilin, putative 0.0065 0 0.5
Echinococcus granulosus FTZ F1 alpha 0.0267 1 1
Loa Loa (eye worm) hypothetical protein 0.0267 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0267 1 1
Loa Loa (eye worm) hypothetical protein 0.0267 1 1
Loa Loa (eye worm) hypothetical protein 0.0126 0.3009 0.3009
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0267 1 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0267 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0267 1 1
Brugia malayi nuclear receptor RXR 0.0126 0.3009 0.3009
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0267 1 1
Loa Loa (eye worm) DR-78 0.0126 0.3009 0.3009
Loa Loa (eye worm) hypothetical protein 0.0141 0.3758 0.3758
Brugia malayi photoreceptor-specific nuclear receptor 0.0267 1 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0267 1 1
Brugia malayi hypothetical protein 0.0141 0.3758 0.3758
Brugia malayi Nuclear hormone receptor-like 1 0.0267 1 1
Loa Loa (eye worm) hypothetical protein 0.0141 0.3758 0.3758
Loa Loa (eye worm) hypothetical protein 0.0126 0.3009 0.3009
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0141 0.3758 0.3758
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0267 1 1
Schistosoma mansoni nuclear hormone receptor 0.0126 0.3009 0.3009
Brugia malayi ecdysone receptor 0.0126 0.3009 0.3009
Brugia malayi nuclear hormone receptor family member nhr-6 0.0126 0.3009 0.3009
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0267 1 1
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0065 0 0.5
Brugia malayi nuclear receptor NHR-67 0.0126 0.3009 0.3009
Loa Loa (eye worm) steroid hormone receptor 0.0267 1 1
Loa Loa (eye worm) hypothetical protein 0.0126 0.3009 0.3009
Brugia malayi Nuclear hormone receptor-like 1 0.0141 0.3758 0.3758
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0267 1 1
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0065 0 0.5
Loa Loa (eye worm) nuclear receptor NHR-67 0.0126 0.3009 0.3009
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0065 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0141 0.3758 0.3758
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0267 1 1
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0065 0 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0267 1 1
Schistosoma mansoni nuclear receptor 0.0126 0.3009 0.3009
Brugia malayi steroid hormone receptor 0.0267 1 1
Loa Loa (eye worm) nuclear hormone receptor 0.0126 0.3009 0.3009
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0126 0.3009 0.3009
Loa Loa (eye worm) hypothetical protein 0.0267 1 1
Echinococcus multilocularis FTZ F1 alpha 0.0267 1 1
Loa Loa (eye worm) hypothetical protein 0.0126 0.3009 0.3009
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0065 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0126 0.3009 0.3009
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0065 0 0.5
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0267 1 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0065 0 0.5
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0267 1 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0065 0 0.5
Schistosoma mansoni nuclear hormone receptor 0.0126 0.3009 0.3009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0126 0.3009 0.3009
Echinococcus multilocularis thyroid hormone receptor alpha 0.0267 1 1
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0065 0 0.5
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0141 0.3758 0.3758
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0065 0 0.5
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0267 1 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0267 1 1
Loa Loa (eye worm) hypothetical protein 0.0126 0.3009 0.3009
Loa Loa (eye worm) hypothetical protein 0.0141 0.3758 0.3758
Loa Loa (eye worm) hypothetical protein 0.0126 0.3009 0.3009
Onchocerca volvulus 0.0267 1 1
Echinococcus granulosus nuclear receptor nhr 48 0.0126 0.3009 0.3009
Echinococcus multilocularis nuclear receptor nhr 48 0.0126 0.3009 0.3009
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0065 0 0.5
Brugia malayi Nuclear hormone receptor E75 0.0126 0.3009 0.3009
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0126 0.3009 0.3009
Brugia malayi hypothetical protein 0.0126 0.3009 0.3009
Loa Loa (eye worm) hypothetical protein 0.0126 0.3009 0.3009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0267 1 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0267 1 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0267 1 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0141 0.3758 0.3758
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0267 1 1
Loa Loa (eye worm) hypothetical protein 0.0126 0.3009 0.3009
Brugia malayi hypothetical protein 0.0126 0.3009 0.3009
Loa Loa (eye worm) hypothetical protein 0.0267 1 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0126 0.3009 0.3009

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.58 nM Inhibition of human mixed lymphocyte response (MLR) ChEMBL. 9599228
IC50 (functional) = 0.58 nM Inhibition of human mixed lymphocyte response (MLR) ChEMBL. 9599228
IC50 (binding) = 19 nM Inhibitory binding activity against human Immunophilin-FK506 binding protein 12 ChEMBL. 9599228
IC50 (binding) = 19 nM Inhibitory binding activity against human Immunophilin-FK506 binding protein 12 ChEMBL. 9599228
Selectivity (functional) = 33 Inhibitory selectivity for human FK506 binding protein 12 and human mixed lymphocyte response(MLR) ChEMBL. 9599228
Selectivity (functional) = 33 Inhibitory selectivity for human FK506 binding protein 12 and human mixed lymphocyte response(MLR) ChEMBL. 9599228

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 9599228

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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