Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0018 | 0.0298 | 0.292 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.0018 | 0.0298 | 0.9876 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0298 | 0.0298 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0018 | 0.0298 | 0.012 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0018 | 0.0298 | 0.292 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0018 | 0.0298 | 0.9876 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0298 | 0.0298 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0298 | 0.0298 |
Echinococcus multilocularis | serine protein kinase ATM | 0.0025 | 0.0598 | 0.0679 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.003 | 0.082 | 0.3033 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0018 | 0.0298 | 0.4987 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0298 | 0.0298 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0195 | 0.0099 |
Trichomonas vaginalis | set domain proteins, putative | 0.024 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0298 | 0.0298 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.1707 | 0.1956 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0298 | 0.0298 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.1707 | 0.1772 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0025 | 0.0598 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0443 | 0.0508 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0018 | 0.0298 | 0.012 |
Leishmania major | phosphatidylinositol 3-kinase, putative | 0.0018 | 0.0298 | 0.9876 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0298 | 0.0298 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1007 | 0.1154 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0298 | 0.0298 |
Trypanosoma cruzi | phosphatidylinositol 3-related kinase, putative | 0.0018 | 0.0298 | 0.292 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0021 | 0.0411 | 0.0471 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0195 | 0.0099 |
Brugia malayi | Muscleblind-like protein | 0.0152 | 0.612 | 0.6946 |
Echinococcus granulosus | phosphatidylinositol 3 and 4 kinase | 0.0018 | 0.0298 | 0.0173 |
Plasmodium vivax | SET domain protein, putative | 0.003 | 0.082 | 0.5 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0048 | 0.1576 | 0.233 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0195 | 0.0099 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1007 | 0.3914 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.003 | 0.082 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0023 | 0.0496 | 0.0507 |
Giardia lamblia | GTOR | 0.0018 | 0.0298 | 0.5 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.0018 | 0.0298 | 0.4987 |
Schistosoma mansoni | zinc finger protein | 0.002 | 0.0364 | 0.0891 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1707 | 0.1956 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0017 | 0.0252 | 0.0096 |
Leishmania major | phosphatidylinositol kinase related protein, putative | 0.0018 | 0.03 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1302 | 0.1493 |
Echinococcus granulosus | zinc finger protein | 0.002 | 0.0364 | 0.0285 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.082 | 0.3033 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0023 | 0.0496 | 0.0507 |
Echinococcus granulosus | serine protein kinase ATM | 0.0025 | 0.0598 | 0.0679 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0298 | 0.0298 |
Toxoplasma gondii | FATC domain-containing protein | 0.0025 | 0.0598 | 0.7289 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0018 | 0.0298 | 0.0581 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1198 | 0.1373 |
Trypanosoma cruzi | phosphatidylinositol 3-related kinase, putative | 0.0018 | 0.0298 | 0.292 |
Echinococcus multilocularis | phosphatidylinositol 3 and 4 kinase | 0.0018 | 0.0298 | 0.0173 |
Leishmania major | phosphatidylinositol 3-related kinase, putative | 0.0018 | 0.0298 | 0.9876 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0211 | 0.8725 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0298 | 0.0298 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0025 | 0.0598 | 0.0471 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0298 | 0.0298 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0195 | 0.0099 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0298 | 0.0298 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0298 | 0.0298 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0018 | 0.0298 | 0.4987 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0298 | 0.0298 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0298 | 0.0298 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.1007 | 0.0952 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1387 | 0.159 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0298 | 0.0298 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0017 | 0.0252 | 0.0366 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0048 | 0.1576 | 0.233 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0029 | 0.0771 | 0.0972 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0017 | 0.0252 | 0.0366 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0298 | 0.0298 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0298 | 0.0298 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0048 | 0.1576 | 0.6587 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.2632 | 0.3017 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0298 | 0.0298 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0298 | 0.0298 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0018 | 0.0279 | 0.032 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0018 | 0.0298 | 0.0342 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0298 | 0.0298 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0018 | 0.03 | 0.2957 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0152 | 0.612 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.612 | 0.7014 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.612 | 0.7014 |
Echinococcus multilocularis | muscleblind protein | 0.0152 | 0.612 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0195 | 0.0224 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1576 | 0.1806 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0298 | 0.0298 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0018 | 0.0298 | 0.9876 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0298 | 0.0298 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0298 | 0.0298 |
Brugia malayi | PHD-finger family protein | 0.0025 | 0.0601 | 0.0475 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0061 | 0.2143 | 0.3288 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0018 | 0.0298 | 0.0342 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm) | 0.0025 | 0.0598 | 0.1989 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.0018 | 0.0298 | 0.292 |
Brugia malayi | Bromodomain containing protein | 0.0039 | 0.1194 | 0.1171 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0025 | 0.0598 | 0.0598 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0018 | 0.0298 | 0.0173 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0298 | 0.0298 |
Trypanosoma brucei | phosphatidylinositol kinase related protein, putative | 0.0025 | 0.0598 | 1 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0018 | 0.0298 | 0.3635 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0298 | 0.0298 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.1089 | 0.1509 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0048 | 0.1576 | 0.6587 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0298 | 0.0298 |
Schistosoma mansoni | phosphatidylinositol 3-and 4-kinase | 0.0018 | 0.0298 | 0.0581 |
Echinococcus multilocularis | zinc finger protein | 0.002 | 0.0364 | 0.0285 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0018 | 0.0298 | 0.4987 |
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.082 | 0.0732 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0298 | 0.0298 |
Brugia malayi | Bromodomain containing protein | 0.0076 | 0.2822 | 0.3079 |
Brugia malayi | Pre-SET motif family protein | 0.0211 | 0.8725 | 1 |
Trypanosoma brucei | phosphatidylinositol 3-related kinase, putative | 0.0018 | 0.0298 | 0.4987 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.1089 | 0.1509 |
Schistosoma mansoni | bromodomain containing protein | 0.0064 | 0.2302 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0061 | 0.2143 | 0.3288 |
Trypanosoma brucei | ISWI complex protein | 0.0016 | 0.0174 | 0.2919 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0018 | 0.0298 | 0.0173 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0195 | 0.0224 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0018 | 0.0298 | 0.0298 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.1707 | 0.1772 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0022 | 0.0443 | 0.6353 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.003 | 0.082 | 0.1054 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0411 | 0.1112 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0017 | 0.0252 | 0.0096 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.0496 | 0.151 |
Entamoeba histolytica | hypothetical protein | 0.0025 | 0.0598 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0152 | 0.612 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.1 uM | In vitro reversal activity versus ~90% block by rocuronium in isolated mouse hemidiaphragm,expressed as effective conc. | ChEMBL. | 11960492 |
ED50 (functional) | = 0.09 uM kg-1 | In vivo reversal activity versus ~90% block by rocuronium in guinea pig | ChEMBL. | 11960492 |
Max reversal (functional) | = 88.3 % | In vitro reversal activity versus ~90% block by rocuronium in isolated mouse hemidiaphragm,expressed as % of maximum reversal at 5.4 uM conc. | ChEMBL. | 11960492 |
Max reversal (functional) | = 94.5 % | In vivo reversal activity versus ~90% block by rocuronium in guinea pig, expressed as % of maximum reversal at 0.5 umol/kg conc. | ChEMBL. | 11960492 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.