Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | PAN domain-containing protein | 0.025 | 0.0349 | 0.0347 |
Onchocerca volvulus | 0.025 | 0.0349 | 0.0322 | |
Brugia malayi | Trypsin-like protease protein 5 | 0.0123 | 0.0154 | 0.0151 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.653 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0029 | 0.0027 |
Brugia malayi | PAN domain containing protein | 0.025 | 0.0349 | 0.0347 |
Brugia malayi | PAN domain containing protein | 0.025 | 0.0349 | 0.0347 |
Loa Loa (eye worm) | hypothetical protein | 0.025 | 0.0349 | 0.0347 |
Brugia malayi | Trypsin family protein | 0.0123 | 0.0154 | 0.0151 |
Schistosoma mansoni | hypothetical protein | 0.0123 | 0.0154 | 0.0151 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1844 | 0.2799 | 0.2797 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1844 | 0.2799 | 1 |
Trichomonas vaginalis | cyclin A, putative | 0.0042 | 0.0029 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.1844 | 0.2799 | 0.2797 |
Onchocerca volvulus | 0.025 | 0.0349 | 0.0322 | |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0123 | 0.0154 | 0.0151 |
Onchocerca volvulus | 0.025 | 0.0349 | 0.0322 | |
Toxoplasma gondii | hypothetical protein | 0.025 | 0.0349 | 0.0584 |
Echinococcus multilocularis | enteropeptidase | 0.0123 | 0.0154 | 0.0151 |
Toxoplasma gondii | microneme protein MIC17A | 0.025 | 0.0349 | 0.0584 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0123 | 0.0154 | 0.0151 |
Leishmania major | cyclin | 0.0042 | 0.0029 | 0.0249 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.653 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1844 | 0.2799 | 0.5 |
Brugia malayi | PAN domain containing protein | 0.025 | 0.0349 | 0.0347 |
Onchocerca volvulus | 0.0123 | 0.0154 | 0.0126 | |
Onchocerca volvulus | 0.025 | 0.0349 | 0.0322 | |
Toxoplasma gondii | subtilisin SUB12 | 0.025 | 0.0349 | 0.0584 |
Brugia malayi | Trypsin family protein | 0.0123 | 0.0154 | 0.0151 |
Brugia malayi | PAN domain containing protein | 0.025 | 0.0349 | 0.0347 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1844 | 0.2799 | 0.5 |
Onchocerca volvulus | 0.0123 | 0.0154 | 0.0126 | |
Toxoplasma gondii | microneme protein MIC17C | 0.025 | 0.0349 | 0.0584 |
Loa Loa (eye worm) | hypothetical protein | 0.025 | 0.0349 | 0.0347 |
Toxoplasma gondii | PAN domain-containing protein | 0.025 | 0.0349 | 0.0584 |
Trypanosoma brucei | mitotic cyclin 6 | 0.0042 | 0.0029 | 0.0274 |
Toxoplasma gondii | microneme protein, putative | 0.025 | 0.0349 | 0.0584 |
Brugia malayi | dihydrofolate reductase family protein | 0.1844 | 0.2799 | 0.2797 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.0042 | 0.0029 | 0.0249 |
Trichomonas vaginalis | cyclins, putative | 0.0042 | 0.0029 | 1 |
Onchocerca volvulus | 0.0123 | 0.0154 | 0.0126 | |
Trichomonas vaginalis | cyclins, putative | 0.0042 | 0.0029 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.025 | 0.0349 | 0.0347 |
Schistosoma mansoni | cyclin B | 0.0042 | 0.0029 | 0.0026 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0044 | 0.0032 | 0.0034 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0154 | 0.0152 |
Brugia malayi | PAN domain containing protein | 0.025 | 0.0349 | 0.0347 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0041 | 0.0028 | 0.9639 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0705 | 0.1048 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0123 | 0.0154 | 0.0151 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0123 | 0.0154 | 0.0151 |
Toxoplasma gondii | kringle domain-containing protein | 0.0044 | 0.0032 | 0.005 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0154 | 0.0152 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0123 | 0.0154 | 0.0151 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0123 | 0.0154 | 0.0151 |
Toxoplasma gondii | PAN domain-containing protein | 0.3889 | 0.5941 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.653 | 1 | 1 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.653 | 1 | 1 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.653 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0154 | 0.0152 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0029 | 0.0027 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0123 | 0.0154 | 0.0151 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0042 | 0.0029 | 0.0026 |
Onchocerca volvulus | 0.025 | 0.0349 | 0.0322 | |
Brugia malayi | Dihydrofolate reductase | 0.1844 | 0.2799 | 0.2797 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0154 | 0.0152 |
Brugia malayi | PAN domain containing protein | 0.025 | 0.0349 | 0.0347 |
Echinococcus granulosus | Mastin | 0.0123 | 0.0154 | 0.0151 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0123 | 0.0154 | 0.0151 |
Toxoplasma gondii | hypothetical protein | 0.025 | 0.0349 | 0.0584 |
Trichomonas vaginalis | cyclin B, putative | 0.0042 | 0.0029 | 1 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0044 | 0.0032 | 0.003 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0705 | 0.1048 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0705 | 0.1048 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.025 | 0.0349 | 0.0347 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0123 | 0.0154 | 0.0151 |
Brugia malayi | hypothetical protein | 0.0123 | 0.0154 | 0.0151 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0705 | 0.1048 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.0032 | 0.003 |
Trichomonas vaginalis | cyclins, putative | 0.0042 | 0.0029 | 1 |
Toxoplasma gondii | 1,3(4)-beta-glucanase | 0.025 | 0.0349 | 0.0584 |
Brugia malayi | PAN domain containing protein | 0.025 | 0.0349 | 0.0347 |
Entamoeba histolytica | cyclin, putative | 0.0042 | 0.0029 | 0.5 |
Echinococcus granulosus | cyclin B | 0.0042 | 0.0029 | 0.0026 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0123 | 0.0154 | 0.0151 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0123 | 0.0154 | 0.0151 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0123 | 0.0154 | 0.0151 |
Echinococcus multilocularis | Mastin | 0.0123 | 0.0154 | 0.0151 |
Toxoplasma gondii | PAN domain-containing protein | 0.025 | 0.0349 | 0.0584 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0123 | 0.0154 | 0.0151 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0103 | 0.0123 | 0.0121 |
Onchocerca volvulus | 0.025 | 0.0349 | 0.0322 | |
Loa Loa (eye worm) | hypothetical protein | 0.025 | 0.0349 | 0.0347 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.653 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0123 | 0.0154 | 0.0151 |
Leishmania major | hypothetical protein, conserved | 0.0044 | 0.0032 | 0.0282 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0154 | 0.0152 |
Toxoplasma gondii | microneme protein MIC4 | 0.025 | 0.0349 | 0.0584 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0154 | 0.0152 |
Loa Loa (eye worm) | hypothetical protein | 0.025 | 0.0349 | 0.0347 |
Schistosoma mansoni | hypothetical protein | 0.0123 | 0.0154 | 0.0151 |
Loa Loa (eye worm) | hypothetical protein | 0.025 | 0.0349 | 0.0347 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0123 | 0.0154 | 0.0151 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0123 | 0.0154 | 0.0151 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0705 | 0.1048 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0123 | 0.0154 | 0.0151 |
Brugia malayi | PAN domain containing protein | 0.025 | 0.0349 | 0.0347 |
Onchocerca volvulus | 0.025 | 0.0349 | 0.0322 | |
Brugia malayi | PAN domain containing protein | 0.025 | 0.0349 | 0.0347 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0044 | 0.0032 | 0.003 |
Onchocerca volvulus | 0.025 | 0.0349 | 0.0322 | |
Brugia malayi | Kringle domain containing protein | 0.0044 | 0.0032 | 0.003 |
Onchocerca volvulus | 0.0123 | 0.0154 | 0.0126 | |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0044 | 0.0032 | 0.003 |
Trichomonas vaginalis | cyclin B, putative | 0.0042 | 0.0029 | 1 |
Brugia malayi | Trypsin family protein | 0.0123 | 0.0154 | 0.0151 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1844 | 0.2799 | 0.2797 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0044 | 0.0032 | 0.003 |
Loa Loa (eye worm) | PAN domain-containing protein | 0.025 | 0.0349 | 0.0347 |
Toxoplasma gondii | microneme protein MIC17B | 0.025 | 0.0349 | 0.0584 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0044 | 0.0032 | 0.0282 |
Brugia malayi | PAN domain containing protein | 0.025 | 0.0349 | 0.0347 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0041 | 0.0028 | 0.9639 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0705 | 0.1048 | 0.1761 |
Onchocerca volvulus | 0.0044 | 0.0032 | 0.0004 | |
Echinococcus granulosus | enteropeptidase | 0.0123 | 0.0154 | 0.0151 |
Trichomonas vaginalis | cyclin B, putative | 0.0042 | 0.0029 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0042 | 0.0029 | 1 |
Loa Loa (eye worm) | PAN domain-containing protein | 0.025 | 0.0349 | 0.0347 |
Onchocerca volvulus | 0.025 | 0.0349 | 0.0322 | |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0024 | 0.0021 |
Toxoplasma gondii | PAN domain-containing protein | 0.3889 | 0.5941 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0123 | 0.0154 | 0.0151 |
Trichomonas vaginalis | cyclin B, putative | 0.0042 | 0.0029 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0048 | 0.0039 | 0.0036 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0044 | 0.0032 | 0.003 |
Onchocerca volvulus | 0.0123 | 0.0154 | 0.0126 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0123 | 0.0154 | 0.0151 |
Loa Loa (eye worm) | PAN domain-containing protein | 0.025 | 0.0349 | 0.0347 |
Loa Loa (eye worm) | AGC/PKG protein kinase | 0.0025 | 0.0003 | 0.0001 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0123 | 0.0154 | 0.0151 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0044 | 0.0032 | 0.003 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0044 | 0.0032 | 0.003 |
Toxoplasma gondii | PAN domain-containing protein | 0.025 | 0.0349 | 0.0584 |
Onchocerca volvulus | 0.025 | 0.0349 | 0.0322 | |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0123 | 0.0154 | 0.0151 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0123 | 0.0154 | 0.0151 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1844 | 0.2799 | 0.5 |
Onchocerca volvulus | 0.025 | 0.0349 | 0.0322 | |
Echinococcus multilocularis | cyclin B | 0.0042 | 0.0029 | 0.0026 |
Echinococcus granulosus | dihydrofolate reductase | 0.1844 | 0.2799 | 0.2797 |
Toxoplasma gondii | PAN/Apple domain-containing protein | 0.025 | 0.0349 | 0.0584 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0042 | 0.0029 | 0.5 |
Loa Loa (eye worm) | PAN domain-containing protein | 0.025 | 0.0349 | 0.0347 |
Toxoplasma gondii | PAN domain-containing protein | 0.025 | 0.0349 | 0.0584 |
Brugia malayi | Protein kinase domain containing protein | 0.0044 | 0.0032 | 0.003 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.653 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0048 | 0.0039 | 0.0036 |
Onchocerca volvulus | 0.0123 | 0.0154 | 0.0126 | |
Loa Loa (eye worm) | trypsin family protein | 0.0123 | 0.0154 | 0.0152 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0032 | 0.003 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0123 | 0.0154 | 0.0151 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0042 | 0.0029 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0154 | 0.0152 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0123 | 0.0154 | 0.0151 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0123 | 0.0154 | 0.0151 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0123 | 0.0154 | 0.0151 |
Brugia malayi | Trypsin family protein | 0.0123 | 0.0154 | 0.0151 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0123 | 0.0154 | 0.0151 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0123 | 0.0154 | 0.0151 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 71 nM | Antagonism of in vitro SRIF inhibition of GH release in rat in vitro pituitary cell assay | ChEMBL. | 10354394 |
Ki (binding) | = 56 nM | The compound was tested for binding affinity against human Somatostatin receptor type 2 | ChEMBL. | 10354394 |
Ki (binding) | = 153 nM | The compound was tested for binding affinity against human Somatostatin receptor type 5 | ChEMBL. | 10354394 |
Ki (binding) | > 1000 nM | The compound was tested for binding affinity against human Somatostatin receptor type 1 | ChEMBL. | 10354394 |
Ki (binding) | = 1190 nM | The compound was tested for binding affinity against human Somatostatin receptor type 3 | ChEMBL. | 10354394 |
Ki (binding) | = 2880 nM | The compound was tested for binding affinity against human Somatostatin receptor type 4 | ChEMBL. | 10354394 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.