Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Trypanosoma cruzi | nucleoside phosphatase, putative | Curated by TDR Targets | No references |
Trypanosoma cruzi | nucleoside phosphatase, putative | Curated by TDR Targets | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | nucleoside phosphatase, putative | nucleoside phosphatase, putative | 246 aa | 241 aa | 56.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.2232 | 1 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.029 | 0 | 0.5 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.2232 | 1 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.029 | 0 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.2232 | 1 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.029 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.2232 | 1 | 0.5 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.2232 | 1 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.029 | 0 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.2232 | 1 | 0.5 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.2232 | 1 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.029 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ID50 (binding) | = 0.0000007 M | Concentration required to inhibit binding of envelope protein to immobilized heparin in the competition plate assay by 50% | ChEMBL. | 11405655 |
ID50 (binding) | = 0.000007 M | Concentration required to inhibit binding of envelope protein to immobilized heparin in the competition plate assay by 100% | ChEMBL. | 11405655 |
Inhibition (functional) | = 31.6 % | Percent inhibition of agonist-induced calcium mobilization at P2Y purinoceptor 2 recombinantly expressed in human HEK293 cells at 100 uM dose | ChEMBL. | 16250663 |
Inhibition (functional) | = 59.3 % | Percent inhibition of agonist-induced calcium mobilization at P2Y purinoceptor 1 recombinantly expressed in human HEK293 cells at 100 uM dose | ChEMBL. | 16250663 |
Inhibition (functional) | = 89.5 % | Percent inhibition of agonist-induced calcium mobilization at P2Y purinoceptor 11 recombinantly expressed in human HEK293 cells at 100 uM dose | ChEMBL. | 16250663 |
Log Ki (binding) | = 6.95 | Inhibitiory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3 | ChEMBL. | 16250663 |
potency (functional) | = 40 | Relative potency was measured against P2Y purinoceptor 11 | ChEMBL. | 16250663 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Targets |
---|---|---|---|---|---|---|
catalytic activity (GO:0003824) | decreased (PATO:0000468) | trypomastigote (BTO:0001398) | inferred from animal model system (ECO:0000179) | Trypanosoma cruzi | 34434 | |
Annotator: | millerja@u.washington.edu | Comment: | Note: GeneBank ID is AY540630.1; included 3 hits (98% or better homology in BLAST search) to Tc genes in column A. Note: drugs also appear to reduce infectivity. Note: unable to find ARL 67156 in TDR Targets. | References: | 19255624 | |
catalytic activity (GO:0003824) | decreased (PATO:0000468) | trypomastigote (BTO:0001398) | inferred from animal model system (ECO:0000179) | Trypanosoma cruzi | 46102 | |
Annotator: | millerja@u.washington.edu | Comment: | Note: GeneBank ID is AY540630.1; included 3 hits (98% or better homology in BLAST search) to Tc genes in column A. Note: drugs also appear to reduce infectivity. Note: unable to find ARL 67156 in TDR Targets. | References: | 19255624 |
2 literature references were collected for this gene.