Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | hexokinase type 2 | 0.0494 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.031 | 0.6034 | 0.6034 |
Loa Loa (eye worm) | hypothetical protein | 0.0337 | 0.6616 | 0.6616 |
Loa Loa (eye worm) | hexokinase | 0.0494 | 1 | 1 |
Onchocerca volvulus | 0.0494 | 1 | 1 | |
Echinococcus multilocularis | hexokinase | 0.0494 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0494 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.2741 | 0.2741 |
Echinococcus multilocularis | hexokinase | 0.0494 | 1 | 1 |
Onchocerca volvulus | 0.0494 | 1 | 1 | |
Entamoeba histolytica | hexokinase 2 | 0.0494 | 1 | 1 |
Giardia lamblia | Beta tubulin | 0.003 | 0 | 0.5 |
Giardia lamblia | Beta tubulin | 0.003 | 0 | 0.5 |
Plasmodium falciparum | hexokinase | 0.0494 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.0494 | 1 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.003 | 0 | 0.5 |
Schistosoma mansoni | hexokinase | 0.0494 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0494 | 1 | 1 |
Plasmodium vivax | hexokinase, putative | 0.0494 | 1 | 1 |
Leishmania major | hexokinase, putative | 0.0494 | 1 | 1 |
Trypanosoma brucei | hexokinase, putative | 0.0494 | 1 | 1 |
Trichomonas vaginalis | tubulin, putative | 0.003 | 0 | 0.5 |
Onchocerca volvulus | 0.0494 | 1 | 1 | |
Loa Loa (eye worm) | hexokinase | 0.0153 | 0.265 | 0.265 |
Treponema pallidum | hexokinase (hxk) | 0.0494 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase type II | 0.0494 | 1 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.0494 | 1 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.003 | 0 | 0.5 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.003 | 0 | 0.5 |
Leishmania major | hexokinase, putative | 0.0494 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0494 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.2741 | 0.2741 |
Echinococcus multilocularis | hexokinase | 0.0494 | 1 | 1 |
Giardia lamblia | Beta tubulin | 0.003 | 0 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0494 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.031 | 0.6034 | 0.6034 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.003 | 0 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0153 | 0.265 | 0.265 |
Entamoeba histolytica | hexokinase 1 | 0.0494 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.0494 | 1 | 1 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.003 | 0 | 0.5 |
Brugia malayi | hexokinase type II | 0.0157 | 0.2741 | 0.2741 |
Echinococcus multilocularis | hexokinase type 2 | 0.0494 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.0494 | 1 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.0494 | 1 | 1 |
Toxoplasma gondii | hexokinase | 0.0494 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2.77 nM | Tested for the inhibition of L1210 cell proliferation. | ChEMBL. | 2066973 |
IC50 (functional) | = 0.3 uM | The compound tested for the inhibition of tubulin polymerization. | ChEMBL. | 2066973 |
LTS (functional) | = 0 | Long-term survivors (LTS) for 60 days at optimal dose of 3.0 mg/kg for antitumor activity against P388 leukemia cells in 6 mice. | ChEMBL. | 2066973 |
T/C (functional) | = 122 % | Compound was tested for T/C range at optimal dose of 3.0 mg/kg for antitumor activity against P388 leukemia cells in mice. | ChEMBL. | 2066973 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.