Detailed information for compound 378959

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1049.22 | Formula: C49H64N10O12S2
  • H donors: 14 H acceptors: 12 LogP: -1.43 Rotable bonds: 19
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@@H]1NC(=O)[C@H](NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@@H](NC(=O)[C@H](NC1=O)[C@H](O)C)C(=O)N[C@H](C(=O)O)[C@H](O)C)NC(=O)[C@@H](Cc1ccccc1)N)Cc1c[nH]c2c1cccc2
  • InChi: 1S/C49H64N10O12S2/c1-26(60)40-48(69)57-39(47(68)59-41(27(2)61)49(70)71)25-73-72-24-38(56-42(63)33(51)20-28-10-4-3-5-11-28)46(67)54-36(21-29-15-17-31(62)18-16-29)44(65)55-37(22-30-23-52-34-13-7-6-12-32(30)34)45(66)53-35(43(64)58-40)14-8-9-19-50/h3-7,10-13,15-18,23,26-27,33,35-41,52,60-62H,8-9,14,19-22,24-25,50-51H2,1-2H3,(H,53,66)(H,54,67)(H,55,65)(H,56,63)(H,57,69)(H,58,64)(H,59,68)(H,70,71)/t26-,27-,33-,35+,36+,37-,38+,39-,40-,41+/m1/s1
  • InChiKey: QGZGIBMEBJNHKH-QHOIYZQSSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Somatostatin receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus allatostatin A receptor Somatostatin receptor   363 aa 301 aa 31.6 %
Onchocerca volvulus Somatostatin receptor   363 aa 316 aa 21.5 %
Schistosoma mansoni neuropeptide F-like receptor Somatostatin receptor   363 aa 295 aa 24.1 %
Onchocerca volvulus Somatostatin receptor   363 aa 313 aa 24.0 %
Echinococcus multilocularis allatostatin A receptor Somatostatin receptor   363 aa 306 aa 31.7 %
Onchocerca volvulus Somatostatin receptor   363 aa 325 aa 23.4 %
Echinococcus granulosus thyrotropin releasing hormone receptor Somatostatin receptor   363 aa 330 aa 27.0 %
Echinococcus multilocularis neuropeptide receptor Somatostatin receptor   363 aa 344 aa 28.8 %
Schistosoma mansoni adenoreceptor Somatostatin receptor   363 aa 306 aa 26.5 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Somatostatin receptor   363 aa 314 aa 23.9 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Somatostatin receptor   363 aa 292 aa 27.4 %
Onchocerca volvulus Somatostatin receptor   363 aa 331 aa 25.1 %
Echinococcus multilocularis g protein coupled receptor Somatostatin receptor   363 aa 387 aa 21.2 %
Brugia malayi GnHR receptor homolog Somatostatin receptor   363 aa 352 aa 21.3 %
Onchocerca volvulus E3 ubiquitin-protein ligase rpm-1 homolog Somatostatin receptor   363 aa 347 aa 22.5 %
Onchocerca volvulus Somatostatin receptor   363 aa 318 aa 25.2 %
Loa Loa (eye worm) neuropeptide F receptor Somatostatin receptor   363 aa 300 aa 26.7 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Somatostatin receptor   363 aa 330 aa 27.3 %
Schistosoma mansoni peptide (allatostatin)-like receptor Somatostatin receptor   363 aa 297 aa 27.9 %
Loa Loa (eye worm) hypothetical protein Somatostatin receptor   363 aa 291 aa 25.4 %
Onchocerca volvulus Phospholipase d-related homolog Somatostatin receptor   363 aa 295 aa 21.0 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi Immunoglobulin I-set domain containing protein 0.0029 0.0001 0.0001
Echinococcus granulosus epidermal growth factor receptor 0.2124 0.8352 0.9691
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0164 0.054 0.0626
Echinococcus granulosus tar DNA binding protein 0.0064 0.0139 0.0162
Echinococcus granulosus somatostatin receptor 0.003 0.0006 0.0007
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0139 0.0166
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0252 0.0252
Echinococcus multilocularis neuroglian 0.0051 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Schistosoma mansoni biogenic amine (5HT) receptor 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0072 0.0172 0.0206
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0006 0.0006
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0027 0.0019
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.2132 0.8385 1
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0006 0.0007
Brugia malayi Cytochrome P450 family protein 0.0032 0.0011 0.0013
Echinococcus granulosus neuropeptide s receptor 0.0518 0.1952 0.2265
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Echinococcus multilocularis Immunoglobulin 0.0088 0.0237 0.0237
Echinococcus granulosus lachesin 0.0051 0.009 0.0104
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.0127 0.0127
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0051 0.009 0.0107
Brugia malayi acetyltransferase, GNAT family protein 0.0157 0.0512 0.061
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.003 0.0006 0.0007
Echinococcus granulosus neuroglian 0.0111 0.0327 0.0379
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0051 0.009 0.0107
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0219 0.0757 0.0903
Brugia malayi hypothetical protein 0.003 0.0006 0.0007
Brugia malayi Tachykinin-like peptides receptor 99D 0.003 0.0006 0.0007
Echinococcus multilocularis serotonin receptor 0.003 0.0006 0.0006
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.0787 0.3024 0.3607
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0139 0.0166
Echinococcus granulosus allatostatin A receptor 0.003 0.0006 0.0007
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0011 0.0013
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0118 0.0357 0.0426
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0123 0.0134
Echinococcus multilocularis tyrosine protein kinase otk 0.0051 0.009 0.009
Echinococcus granulosus 7TM GPCR rhodopsin 0.003 0.0006 0.0007
Echinococcus multilocularis 0.0032 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Brugia malayi PAS domain containing protein 0.0048 0.0076 0.0091
Brugia malayi ORL1-like opioid receptor 0.003 0.0006 0.0007
Echinococcus granulosus hemicentin 1 0.0051 0.009 0.0104
Echinococcus granulosus neuropeptide Y receptor 0.003 0.0006 0.0007
Brugia malayi neuropeptide F receptor 0.003 0.0006 0.0007
Brugia malayi Serotonin/octopamine receptor family protein 7 0.003 0.0006 0.0007
Schistosoma mansoni cytochrome P450 0.0032 0.0011 0.0013
Echinococcus multilocularis fmrfamide receptor 0.003 0.0006 0.0006
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0034 0.002 0.0023
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0052 0.0093 0.0108
Echinococcus granulosus tachykinin peptides receptor 99D 0.003 0.0006 0.0007
Echinococcus multilocularis neuropeptide receptor 0.003 0.0006 0.0006
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0219 0.0757 0.0903
Echinococcus multilocularis g-protein coupled receptor 0.003 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0252 0.0293
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Echinococcus multilocularis fmrfamide receptor 0.003 0.0006 0.0006
Loa Loa (eye worm) acetyltransferase 0.0157 0.0512 0.061
Brugia malayi G protein-coupled receptor F59B2.13 0.003 0.0006 0.0007
Schistosoma mansoni tyrosine kinase 0.1125 0.437 0.507
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.0032
Echinococcus granulosus sex peptide receptor 0.003 0.0006 0.0007
Brugia malayi Cytochrome P450 family protein 0.0032 0.0011 0.0013
Schistosoma mansoni hypothetical protein 0.0033 0.0018 0.0021
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0123 0.0134
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0018 0.0021
Schistosoma mansoni hypothetical protein 0.0033 0.0018 0.0021
Loa Loa (eye worm) hypothetical protein 0.0051 0.009 0.0107
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0139 0.0162
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.2132 0.8385 1
Leishmania major solanesyl-diphosphate synthase, putative 0.1054 0.4087 0.4868
Mycobacterium ulcerans lipase LipD 0.0035 0.0027 0.0019
Echinococcus granulosus metabotropic glutamate receptor 5 0.0056 0.011 0.0127
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Brugia malayi G-protein coupled receptor 0.003 0.0006 0.0007
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0118 0.014
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0118 0.0357 0.0426
Loa Loa (eye worm) polyprenyl synthetase 0.1054 0.4087 0.4874
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.2132 0.8385 1
Echinococcus granulosus tyrosine protein kinase otk 0.0051 0.009 0.0104
Brugia malayi Immunoglobulin I-set domain containing protein 0.0051 0.009 0.0107
Schistosoma mansoni cell adhesion molecule 0.0117 0.0352 0.0408
Schistosoma mansoni hypothetical protein 0.0033 0.0018 0.0021
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0006 0.0007
Schistosoma mansoni neuropeptide receptor 0.003 0.0006 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0006 0.0007
Brugia malayi Serotonin receptor 0.003 0.0006 0.0007
Echinococcus multilocularis peroxidasin 0.0051 0.009 0.009
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0034 0.002 0.0024
Schistosoma mansoni microtubule-associated protein tau 0.2191 0.8619 1
Echinococcus granulosus biogenic amine 5HT receptor 0.003 0.0006 0.0007
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.1054 0.4087 0.4868
Giardia lamblia Farnesyl diphosphate synthase 0.2132 0.8385 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Mycobacterium tuberculosis Conserved protein 0.0035 0.0027 0.0019
Loa Loa (eye worm) hypothetical protein 0.0051 0.009 0.0108
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.007 0.0051
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0157 0.0512 0.0594
Loa Loa (eye worm) hypothetical protein 0.0126 0.0388 0.0463
Echinococcus multilocularis geminin 0.0347 0.1267 0.1267
Brugia malayi Cache domain containing protein 0.015 0.0485 0.0578
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0139 0.0139
Schistosoma mansoni opsin-like receptor 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0158 0.0517 0.0617
Brugia malayi hypothetical protein 0.003 0.0006 0.0007
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0123 0.0134
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0118 0.0137
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.0305 0.0364
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.0006 0.0007
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0018 0.0022
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.003 0.0006 0.0007
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0054 0.0044
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0034 0.002 0.0023
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.0693 0.2649 0.315
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0252 0.0293
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0051 0.009 0.009
Loa Loa (eye worm) follicle stimulating hormone receptor 0.003 0.0006 0.0007
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.2132 0.8385 0.8385
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Brugia malayi cytochrome P450 0.0032 0.0011 0.0013
Trypanosoma cruzi polyprenyl synthase, putative 0.0787 0.3024 0.3599
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.007 0.007
Schistosoma mansoni neuropeptide F-like receptor 0.003 0.0006 0.0007
Echinococcus multilocularis alpha 1A adrenergic receptor 0.003 0.0006 0.0006
Schistosoma mansoni biogenic amine (5HT) receptor 0.003 0.0006 0.0007
Echinococcus granulosus neuropeptide FF receptor 2 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0051 0.009 0.0107
Schistosoma mansoni alpha-1 adrenergic receptor 0.003 0.0006 0.0007
Echinococcus granulosus carbonic anhydrase 0.0118 0.0357 0.0415
Echinococcus granulosus g-protein coupled receptor 0.003 0.0006 0.0007
Schistosoma mansoni neuropeptide receptor 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0051 0.009 0.0107
Echinococcus granulosus roundabout 2 0.0051 0.009 0.0104
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.0127 0.0139
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0006 0.0007
Loa Loa (eye worm) TK/KIN16 protein kinase 0.1446 0.5649 0.6738
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.003 0.0006 0.0007
Leishmania major polyprenyl synthase, putative 0.0787 0.3024 0.3599
Loa Loa (eye worm) hypothetical protein 0.0126 0.0388 0.0463
Onchocerca volvulus 0.0035 0.0027 0.0039
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0018 0.0022
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0006 0.0006
Brugia malayi hypothetical protein 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Brugia malayi G-protein coupled receptor 0.003 0.0006 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0036 0.0012
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0018 0.0018
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0219 0.0757 0.0903
Echinococcus granulosus serotonin receptor 0.003 0.0006 0.0007
Echinococcus multilocularis neuropeptide Y receptor 0.003 0.0006 0.0006
Echinococcus granulosus carbonic anhydrase 0.0118 0.0357 0.0415
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.1054 0.4087 0.4868
Schistosoma mansoni hypothetical protein 0.003 0.0006 0.0007
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0027 0.0027
Echinococcus multilocularis serotonin receptor 0.003 0.0006 0.0006
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.007 0.0051
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.003 0.0006 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.0618 0.0708
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.0032
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0006 0.0006
Echinococcus multilocularis carbonic anhydrase II 0.0219 0.0757 0.0757
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0219 0.0757 0.0878
Echinococcus granulosus roundabout 2 0.014 0.0442 0.0512
Schistosoma mansoni histamine h1 receptor 0.003 0.0006 0.0007
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.003 0.0006 0.0006
Schistosoma mansoni tyrosine kinase 0.1145 0.4449 0.5162
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.003 0.0006 0.0007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0252 0.0293
Echinococcus multilocularis hemicentin 1 0.0051 0.009 0.009
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0051 0.009 0.009
Leishmania major hypothetical protein, conserved 0.0035 0.0027 0.0019
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.0945 0.1099
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0006 0.0007
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.0006 0.0006
Echinococcus granulosus neuropeptide receptor 0.003 0.0006 0.0007
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0051 0.009 0.0104
Brugia malayi RE15519p 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.1054 0.4087 0.4087
Echinococcus granulosus contactin 0.0051 0.009 0.0104
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0581 0.0663
Schistosoma mansoni tyrosine kinase 0.1125 0.437 0.507
Echinococcus granulosus geminin 0.0347 0.1267 0.147
Echinococcus granulosus alpha 1A adrenergic receptor 0.003 0.0006 0.0007
Brugia malayi neuropeptide F receptor 0.003 0.0006 0.0007
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0118 0.0137
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0219 0.0757 0.0878
Brugia malayi Immunoglobulin I-set domain containing protein 0.0051 0.009 0.0107
Onchocerca volvulus 0.0035 0.0027 0.0039
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.0788 0.0927
Brugia malayi Dopamine receptor protein 2 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Echinococcus multilocularis muscleblind protein 0.0158 0.0517 0.0517
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0219 0.0757 0.0891
Schistosoma mansoni single-minded 0.0048 0.0076 0.0088
Schistosoma mansoni carbonic anhydrase 0.0118 0.0357 0.0415
Echinococcus multilocularis hemicentin 1 0.0051 0.009 0.009
Echinococcus granulosus roundabout 2 0.0051 0.009 0.0104
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Echinococcus multilocularis neuropeptide FF receptor 2 0.003 0.0006 0.0006
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0123 0.0134
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0123 0.0134
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.0305 0.0364
Echinococcus multilocularis roundabout 2 0.014 0.0442 0.0442
Echinococcus multilocularis allatostatin A receptor 0.003 0.0006 0.0006
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0219 0.0757 0.0891
Schistosoma mansoni farnesyl pyrophosphate synthase 0.2132 0.8385 0.9728
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Echinococcus granulosus peroxidasin 0.0051 0.009 0.0105
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0006 0.0007
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0252 0.0293
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0006 0.0007
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.003 0.0006 0.0007
Brugia malayi Muscleblind-like protein 0.0158 0.0517 0.0617
Schistosoma mansoni hypothetical protein 0.0033 0.0018 0.0021
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0027 0.0032
Loa Loa (eye worm) cytochrome P450 0.0032 0.0011 0.0013
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0118 0.0118
Brugia malayi Prion-like- 0.0051 0.009 0.0107
Schistosoma mansoni neuropeptide f receptor 76f 0.003 0.0006 0.0007
Echinococcus granulosus microtubule associated protein 2 0.2191 0.8619 1
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.0945 0.1099
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Echinococcus multilocularis epidermal growth factor receptor 0.2124 0.8352 0.8352
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.1054 0.4087 0.4868
Echinococcus granulosus lysine specific demethylase 5A 0.0058 0.0118 0.0137
Echinococcus multilocularis GPCR, family 2 0.0033 0.0018 0.0018
Echinococcus multilocularis neuroglian 0.0111 0.0327 0.0327
Schistosoma mansoni metabotropic glutamate receptor 0.0038 0.0038 0.0044
Schistosoma mansoni carbonic anhydrase-related 0.0118 0.0357 0.0415
Schistosoma mansoni neuropeptide receptor 0.003 0.0006 0.0007
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.003 0.0006 0.0006
Schistosoma mansoni nephrin 0.0111 0.0327 0.0379
Schistosoma mansoni carbonic anhydrase-related 0.0118 0.0357 0.0415
Schistosoma mansoni lipoxygenase 0.0057 0.0112 0.013
Trypanosoma brucei carbonic anhydrase-like protein 0.0219 0.0757 0.0891
Echinococcus granulosus orexin receptor type 2 0.003 0.0006 0.0007
Brugia malayi hypoxia-induced factor 1 0.0148 0.0476 0.0568
Loa Loa (eye worm) beta-lactamase 0.0035 0.0027 0.0032
Echinococcus multilocularis sex peptide receptor 0.003 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0158 0.0517 0.0617
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0027 0.0032
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Schistosoma mansoni glutathione synthetase 0.0693 0.2649 0.3073
Schistosoma mansoni cell adhesion molecule 0.0051 0.009 0.0104
Loa Loa (eye worm) hypothetical protein 0.0088 0.0237 0.0283
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0088 0.0237 0.0275
Echinococcus granulosus Immunoglobulin 0.0088 0.0237 0.0275
Loa Loa (eye worm) CYP4Cod1 0.0032 0.0011 0.0013
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0051 0.009 0.0104
Schistosoma mansoni amine GPCR 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0112 0.013
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0036 0.003
Echinococcus multilocularis roundabout 2 0.0051 0.009 0.009
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0006 0.0007
Loa Loa (eye worm) G-protein coupled receptor 0.003 0.0006 0.0007
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0139 0.0166
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0027 0.0019
Plasmodium vivax basic transcription factor 3b, putative 0.0038 0.0036 0.0012
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.003 0.0006 0.0007
Schistosoma mansoni neuropeptide receptor 0.003 0.0006 0.0007
Echinococcus granulosus carbonic anhydrase II 0.0219 0.0757 0.0878
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0027 0.0019
Brugia malayi hypothetical protein 0.0088 0.0237 0.0283
Schistosoma mansoni hypothetical protein 0.0118 0.0357 0.0415
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0018 0.0021
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0684 0.2613 0.2613
Echinococcus granulosus transcription factor btf3 0.0038 0.0036 0.0042
Brugia malayi jmjC domain containing protein 0.0058 0.0118 0.014
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Echinococcus granulosus GPCR family 2 0.0033 0.0018 0.0021
Brugia malayi Immunoglobulin I-set domain containing protein 0.0051 0.009 0.0107
Loa Loa (eye worm) hypothetical protein 0.0118 0.0357 0.0426
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.003 0.0006 0.0007
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0027 0.0019
Brugia malayi G protein-coupled receptor 0.003 0.0006 0.0007
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.003 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.015 0.0485 0.0578
Echinococcus multilocularis g protein coupled receptor 0.003 0.0006 0.0006
Schistosoma mansoni tyrosine kinase 0.0684 0.2613 0.3031
Schistosoma mansoni septate junction protein 0.0051 0.009 0.0104
Schistosoma mansoni peptide (allatostatin)-like receptor 0.003 0.0006 0.0007
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.0945 0.1099
Brugia malayi hypothetical protein 0.0161 0.0525 0.0627
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.0693 0.2649 0.315
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.0127 0.0139
Toxoplasma gondii ABC1 family protein 0.0035 0.0027 0.0019
Brugia malayi beta-lactamase family protein 0.0035 0.0027 0.0032
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0011 0.0013
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0123 0.0134
Brugia malayi gonadotropin-releasing hormone receptor 2 0.003 0.0006 0.0007
Loa Loa (eye worm) carbonic anhydrase 3 0.0219 0.0757 0.0903
Brugia malayi hypothetical protein 0.003 0.0006 0.0007
Echinococcus multilocularis carbonic anhydrase 0.0118 0.0357 0.0357
Echinococcus granulosus 7tm_1 domain containing protein 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0088 0.0237 0.0283
Echinococcus granulosus carbonic anhydrase 0.0118 0.0357 0.0415
Echinococcus multilocularis 0.0655 0.2496 0.2496
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0018 0.0022
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0036 0.003
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.003 0.0006 0.0007
Schistosoma mansoni amine GPCR 0.003 0.0006 0.0007
Brugia malayi putative neuropeptide receptor NPR1 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Onchocerca volvulus 0.0035 0.0027 0.0039
Echinococcus granulosus dro:myosuppressin receptor 0.003 0.0006 0.0007
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.003 0.0006 0.0006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0006 0.0007
Schistosoma mansoni vesicular amine transporter 0.0088 0.0237 0.0275
Echinococcus granulosus neuropeptides capa receptor 0.003 0.0006 0.0007
Brugia malayi Immunoglobulin I-set domain containing protein 0.1446 0.5649 0.6738
Schistosoma mansoni neuroglian 0.0051 0.009 0.0104
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0097 0.0115
Echinococcus multilocularis neuropeptide receptor A26 0.0518 0.1952 0.1952
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0027 0.0031
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0056 0.011 0.011
Echinococcus multilocularis g protein coupled receptor 0.003 0.0006 0.0006
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0027 0.0019
Schistosoma mansoni amine GPCR 0.003 0.0006 0.0007
Brugia malayi Serotonin receptor 0.003 0.0006 0.0007
Brugia malayi larval opioid receptor 0.003 0.0006 0.0007
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0051 0.009 0.0107
Brugia malayi GnHR receptor homolog 0.003 0.0006 0.0007
Schistosoma mansoni amine GPCR 0.003 0.0006 0.0007
Brugia malayi Cytochrome P450 family protein 0.0032 0.0011 0.0013
Schistosoma mansoni tyrosine kinase 0.1125 0.437 0.507
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0252 0.0301
Brugia malayi hypothetical protein 0.0126 0.0388 0.0463
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.003 0.0006 0.0006
Loa Loa (eye worm) glutamate receptor 0.0046 0.0068 0.0081
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0123 0.0143
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0118 0.0357 0.0426
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.0693 0.2649 0.2649
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.0032
Echinococcus granulosus epidermal growth factor receptor 0.1145 0.4449 0.5162
Onchocerca volvulus 0.1309 0.5103 0.9678
Onchocerca volvulus 0.0469 0.1756 0.3323
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.0945 0.1099
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.2132 0.8385 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0139 0.0162
Schistosoma mansoni hypothetical protein 0.0032 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Mycobacterium tuberculosis Conserved protein 0.0035 0.0027 0.0019
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0172 0.0206
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0123 0.0143
Trypanosoma cruzi polyprenyl synthase, putative 0.0787 0.3024 0.3599
Brugia malayi Fibronectin type III domain containing protein 0.0088 0.0237 0.0283
Echinococcus multilocularis tachykinin peptides receptor 99D 0.003 0.0006 0.0006
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.003 0.0006 0.0007
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0027 0.0019
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0118 0.0357 0.0426
Loa Loa (eye worm) hypothetical protein 0.0051 0.009 0.0107
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0041 0.0051 0.006
Brugia malayi jmjC domain containing protein 0.0058 0.0118 0.014
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.0375 0.0448
Loa Loa (eye worm) hypothetical protein 0.0117 0.0352 0.042
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0036 0.0012
Loa Loa (eye worm) hypothetical protein 0.0056 0.011 0.0131
Schistosoma mansoni tyrosine kinase 0.2124 0.8352 0.9691
Echinococcus granulosus neuropeptide Y receptor 0.003 0.0006 0.0007
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0056 0.011 0.0197
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.0618 0.0708
Echinococcus granulosus g protein coupled receptor 0.003 0.0006 0.0007
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.1054 0.4087 0.4868
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.003 0.0006 0.0007
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0266 0.0945 0.1128
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.2132 0.8385 1
Brugia malayi Dopamine receptor 0.003 0.0006 0.0007
Schistosoma mansoni peroxidasin 0.0029 0.0001 0.0001
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0027 0.0031
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0006 0.0007
Brugia malayi RNA binding protein 0.0064 0.0139 0.0166
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0139 0.0162
Loa Loa (eye worm) hypothetical protein 0.0051 0.009 0.0107
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0038 0.0038 0.0038
Brugia malayi Cytochrome P450 family protein 0.0032 0.0011 0.0013
Echinococcus granulosus tm gpcr rhodopsin 0.0655 0.2497 0.2898
Echinococcus multilocularis neuropeptide receptor 0.003 0.0006 0.0006
Echinococcus multilocularis G protein coupled receptor 139 0.003 0.0006 0.0006
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.0787 0.3024 0.3509
Brugia malayi Polyprenyl synthetase family protein 0.1054 0.4087 0.4874
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.2132 0.8385 1
Echinococcus granulosus G protein coupled receptor 139 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0051 0.009 0.0107
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.003 0.0006 0.0007
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.2132 0.8385 1
Echinococcus granulosus single minded 2 0.0035 0.0027 0.0031
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0088 0.0238 0.0283
Schistosoma mansoni tyrosine kinase 0.0684 0.2613 0.3031
Echinococcus granulosus fmrfamide receptor 0.003 0.0006 0.0007
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0027 0.0038
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0693 0.2649 0.5
Brugia malayi beta-lactamase 0.0035 0.0027 0.0032
Brugia malayi hypothetical protein 0.003 0.0006 0.0007
Echinococcus multilocularis g protein coupled receptor 0.003 0.0006 0.0006
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0006 0.0006
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0252 0.0293
Brugia malayi beta-lactamase family protein 0.0035 0.0027 0.0032
Brugia malayi Melatonin receptor type 1A 0.003 0.0006 0.0007
Loa Loa (eye worm) hypoxia-induced factor 1 0.0148 0.0476 0.0568
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0036 0.0012
Echinococcus multilocularis somatostatin receptor 0.003 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0175 0.0584 0.0678
Echinococcus multilocularis epidermal growth factor receptor 0.1145 0.4449 0.4449
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Echinococcus multilocularis carbonic anhydrase 0.0118 0.0357 0.0357
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.1145 0.4449 0.5162
Loa Loa (eye worm) neuropeptide F receptor 0.003 0.0006 0.0007
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0051 0.009 0.0107
Echinococcus granulosus voltage dependent calcium channel subunit 0.034 0.1239 0.1437
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0655 0.2497 0.2497
Brugia malayi Immunoglobulin I-set domain containing protein 0.0051 0.009 0.0107
Schistosoma mansoni transcription factor btf3 0.0038 0.0036 0.0042
Mycobacterium ulcerans beta-lactamase 0.0035 0.0027 0.0019
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.0032
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.003 0.0006 0.0007
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0326 0.1184 0.1373
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0027 0.0019
Echinococcus multilocularis carbonic anhydrase 0.0118 0.0357 0.0357
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0006 0.0007
Schistosoma mansoni myosin xvIII 0.003 0.0006 0.0007
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0076 0.0088
Schistosoma mansoni biogenic amine receptor 0.003 0.0006 0.0007
Loa Loa (eye worm) TK/INSR protein kinase 0.0684 0.2613 0.3116
Schistosoma mansoni carbonic anhydrase-related 0.0118 0.0357 0.0415
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0006 0.0007
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.0006 0.0007
Brugia malayi Immunoglobulin I-set domain containing protein 0.0051 0.009 0.0107
Echinococcus multilocularis microtubule associated protein 2 0.2191 0.8619 0.8619
Brugia malayi AKH receptor 0.003 0.0006 0.0007
Schistosoma mansoni amine GPCR 0.003 0.0006 0.0007
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.1054 0.4087 1
Onchocerca volvulus Tyrosine kinase homolog 0.1351 0.5273 1
Brugia malayi sulfakinin receptor protein 0.003 0.0006 0.0007
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0027 0.0019
Brugia malayi Protein kinase domain containing protein 0.0684 0.2613 0.3116
Onchocerca volvulus Huntingtin homolog 0.0126 0.0388 0.0726
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Mycobacterium ulcerans hypothetical protein 0.0035 0.0027 0.0019
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0061 0.0127 0.0139
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0051 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0469 0.1756 0.2095
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.003 0.0006 0.0007
Trypanosoma brucei farnesyl pyrophosphate synthase 0.2132 0.8385 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.0305 0.0364
Echinococcus multilocularis Immunoglobulin 0.0088 0.0237 0.0237
Loa Loa (eye worm) RNA binding protein 0.0064 0.0139 0.0166
Schistosoma mansoni hypothetical protein 0.0347 0.1267 0.147
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.0787 0.3024 0.3607
Leishmania major basic transcription factor 3a, putative 0.0038 0.0036 0.003
Echinococcus multilocularis orexin receptor type 2 0.003 0.0006 0.0006
Echinococcus granulosus basement membrane specific heparan sulfate 0.0034 0.002 0.0023
Echinococcus granulosus muscleblind protein 0.0158 0.0517 0.06
Echinococcus granulosus twitchin 0.0111 0.0327 0.0379
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.1054 0.4087 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0051 0.009 0.0107
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0006 0.0007
Echinococcus granulosus neuroglian 0.0051 0.009 0.0104
Plasmodium falciparum carbonic anhydrase 0.0118 0.0357 0.0385
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0112 0.0112
Echinococcus granulosus voltage dependent calcium channel subunit 0.0747 0.2862 0.332
Schistosoma mansoni neuropeptide F-like receptor 0.003 0.0006 0.0007
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.007 0.007
Schistosoma mansoni growth hormone secretagogue receptor 0.003 0.0006 0.0007
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0027 0.0031
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.1054 0.4087 0.4858
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0006 0.0007
Loa Loa (eye worm) ICD-1 protein 0.0038 0.0036 0.0043
Echinococcus multilocularis neuropeptides capa receptor 0.003 0.0006 0.0006
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.0006 0.0006
Brugia malayi hypothetical protein 0.003 0.0006 0.0007
Echinococcus granulosus thyrotropin releasing hormone receptor 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.014 0.0442 0.0527
Schistosoma mansoni adenoreceptor 0.003 0.0006 0.0007
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0139 0.0162
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0027 0.0019
Schistosoma mansoni hypothetical protein 0.003 0.0006 0.0007
Schistosoma mansoni opsin-like receptor 0.003 0.0006 0.0007
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.1054 0.4087 0.4868
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0011 0.0013
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.1054 0.4087 0.4852
Loa Loa (eye worm) neuropeptide F receptor 0.003 0.0006 0.0007
Schistosoma mansoni biogenic amine receptor 0.003 0.0006 0.0007
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0157 0.0512 0.0512
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0027 0.0027
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.003 0.0006 0.0007
Trypanosoma cruzi solanesyl-diphosphate synthase 0.1054 0.4087 0.4868
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0061 0.0127 0.0152
Schistosoma mansoni tyrosine kinase 0.1145 0.4449 0.5162
Echinococcus granulosus hypothetical protein 0.003 0.0006 0.0007
Echinococcus granulosus biogenic amine 5HT receptor 0.003 0.0006 0.0007
Schistosoma mansoni cell adhesion molecule 0.0051 0.009 0.0104
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Loa Loa (eye worm) melatonin receptor type 1A 0.003 0.0006 0.0007
Schistosoma mansoni septate junction protein 0.0051 0.009 0.0104
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0006 0.0006
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC1 (polyprenyl pyrophosphate synthetase) 0.0361 0.1323 0.1567
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.003 0.0006 0.0007
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0051 0.009 0.009
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0034 0.002 0.002
Schistosoma mansoni roundabout 0.0051 0.009 0.0104
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.1054 0.4087 0.4742
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.0945 0.1099
Echinococcus multilocularis G-protein coupled receptor, putative 0.003 0.0006 0.0006
Brugia malayi Furin-like cysteine rich region family protein 0.2124 0.8352 0.9962
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.2132 0.8385 1
Brugia malayi hypothetical protein 0.003 0.0006 0.0007
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0684 0.2613 0.3031
Loa Loa (eye worm) hypothetical protein 0.0118 0.0357 0.0426
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Loa Loa (eye worm) TK protein kinase 0.0043 0.0055 0.0066
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0093 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0027 0.0019
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0118 0.0357 0.0426
Brugia malayi hypothetical protein 0.003 0.0006 0.0007
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0006 0.0007
Brugia malayi beta-NAC-like protein 0.0038 0.0036 0.0043
Loa Loa (eye worm) hypothetical protein 0.0088 0.0237 0.0283
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0061 0.0127 0.0148
Echinococcus multilocularis roundabout 2 0.0051 0.009 0.009
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.007 0.0081
Echinococcus granulosus peptide allatostatin:somatostatin 0.003 0.0006 0.0007
Echinococcus granulosus neuropeptide receptor 0.003 0.0006 0.0007
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.2132 0.8385 1
Schistosoma mansoni hypothetical protein 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Leishmania major farnesyl pyrophosphate synthase 0.2132 0.8385 1
Echinococcus multilocularis neuropeptide s receptor 0.0518 0.1952 0.1952
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Echinococcus multilocularis insulin receptor 0.0684 0.2613 0.2613
Toxoplasma gondii NAC domain-containing protein 0.0038 0.0036 0.003
Loa Loa (eye worm) hypothetical protein 0.0088 0.0237 0.0283
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Brugia malayi hypothetical protein 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0118 0.0357 0.0426
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.007 0.0051
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Echinococcus multilocularis neuropeptide Y receptor 0.003 0.0006 0.0006
Loa Loa (eye worm) TK/ROR protein kinase 0.0043 0.0055 0.0066
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0034 0.002 0.002
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.0693 0.2649 0.645
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.1054 0.4087 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0252 0.0252
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0118 0.0357 0.0426
Onchocerca volvulus 0.0035 0.0027 0.0039
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0581 0.0663
Loa Loa (eye worm) hypothetical protein 0.014 0.0442 0.0527
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0123 0.0123
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0006 0.0006
Toxoplasma gondii hypothetical protein 0.0118 0.0357 0.0414
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0027 0.0019
Brugia malayi Metabotropic glutamate receptor precursor. 0.0046 0.0068 0.0081
Brugia malayi MH2 domain containing protein 0.0123 0.0375 0.0448
Brugia malayi follicle stimulating hormone receptor 0.003 0.0006 0.0007
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0581 0.0663
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0033 0.0018 0.0022
Brugia malayi Immunoglobulin I-set domain containing protein 0.0043 0.0055 0.0066
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.003 0.0006 0.0007
Schistosoma mansoni trans-prenyltransferase 0.1054 0.4087 0.4742
Brugia malayi Polyprenyl synthetase family protein 0.2132 0.8385 1
Echinococcus granulosus low density lipoprotein receptor ldl 0.0034 0.002 0.0023
Loa Loa (eye worm) TK/EGFR protein kinase 0.2124 0.8352 0.9962
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.1054 0.4087 1
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.0693 0.2649 0.315
Onchocerca volvulus Huntingtin homolog 0.0126 0.0388 0.0726
Echinococcus multilocularis transcription factor btf3 0.0038 0.0036 0.0036
Echinococcus multilocularis lachesin 0.0051 0.009 0.009
Echinococcus multilocularis muscleblind protein 1 0.0158 0.0517 0.0517
Brugia malayi putative neuropeptide receptor 0.003 0.0006 0.0007
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0581 0.0663
Loa Loa (eye worm) G-protein coupled receptor 0.003 0.0006 0.0007
Echinococcus multilocularis dro:myosuppressin receptor 0.003 0.0006 0.0006
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0051 0.009 0.009
Echinococcus granulosus histone acetyltransferase KAT2B 0.0153 0.0494 0.0573
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0006 0.0007
Echinococcus multilocularis voltage dependent calcium channel subunit 0.034 0.1239 0.1239
Brugia malayi Peroxidasin 0.0051 0.009 0.0108
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0581 0.0663
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0118 0.0137
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0252 0.0301
Echinococcus granulosus neuropeptide receptor A26 0.0518 0.1952 0.2265
Onchocerca volvulus Glucosylceramidase homolog 0.0174 0.0581 0.1091
Schistosoma mansoni opsin-like receptor 0.003 0.0006 0.0007
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0123 0.0143
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.003 0.0006 0.0007
Loa Loa (eye worm) polyprenyl synthetase 0.2132 0.8385 1
Schistosoma mansoni hypothetical protein 0.0072 0.0172 0.02
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.0032
Schistosoma mansoni hypothetical protein 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0061 0.0127 0.0139
Schistosoma mansoni biogenic amine receptor 0.003 0.0006 0.0007
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.003 0.0006 0.0007
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0027 0.0019
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0027 0.0032
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0747 0.2862 0.2862
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0088 0.0237 0.0275
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0581 0.0663
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0139 0.0162
Brugia malayi hypothetical protein 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0088 0.0237 0.0283
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0118 0.0118
Echinococcus granulosus metabotropic glutamate receptor 2 0.0038 0.0038 0.0044
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0006 0.0007
Echinococcus multilocularis neuropeptides capa receptor 0.003 0.0006 0.0006
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0118 0.0137
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0054 0.0021
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0051 0.009 0.0104
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.0375 0.0448
Echinococcus granulosus g protein coupled receptor 0.003 0.0006 0.0007
Echinococcus multilocularis biogenic amine (5HT) receptor 0.003 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Schistosoma mansoni nephrin 0.0051 0.009 0.0104
Echinococcus granulosus g protein coupled receptor 0.003 0.0006 0.0007
Schistosoma mansoni tyrosine kinase 0.0071 0.017 0.0197
Schistosoma mansoni hypothetical protein 0.0347 0.1267 0.147
Brugia malayi TAR-binding protein 0.0064 0.0139 0.0166
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.0127 0.0148
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0051 0.009 0.0107
Brugia malayi hypothetical protein 0.0469 0.1756 0.2095
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Echinococcus granulosus cytochrome P450 2K1 0.0032 0.0011 0.0013
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.0693 0.2649 0.315
Trypanosoma brucei transcription factor BTF3, putative 0.0038 0.0036 0.003
Schistosoma mansoni cell adhesion molecule 0.0051 0.009 0.0104
Schistosoma mansoni titin 0.0051 0.009 0.0104
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.2132 0.8385 1
Echinococcus granulosus defective proboscis extension response 0.0088 0.0237 0.0275
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.003 0.0006 0.0007
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0034 0.002 0.0023
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.0945 0.1099
Mycobacterium leprae Probable lipase LipE 0.0035 0.0027 0.0038
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0581 0.0663
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0043 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0161 0.0525 0.0627
Treponema pallidum octaprenyl-diphosphate synthase 0.0787 0.3024 0.5
Loa Loa (eye worm) TYRA-2 protein 0.003 0.0006 0.0007
Brugia malayi basement membrane proteoglycan precursor 0.0034 0.002 0.0024
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.003 0.0006 0.0006
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0043 0.0055 0.0064
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0266 0.0945 0.1128
Loa Loa (eye worm) hypothetical protein 0.0105 0.0305 0.0364
Echinococcus granulosus farnesyl pyrophosphate synthase 0.2132 0.8385 0.9728
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Brugia malayi Immunoglobulin I-set domain containing protein 0.0051 0.009 0.0107
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.0032
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.003 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.2132 0.8385 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0102 0.0292 0.0349
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.0787 0.3024 0.3509
Brugia malayi Immunoglobulin I-set domain containing protein 0.0051 0.009 0.0107
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.0693 0.2649 0.3073
Mycobacterium tuberculosis Conserved protein 0.0035 0.0027 0.0019
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0027 0.0019
Leishmania major carbonic anhydrase-like protein 0.0219 0.0757 0.0891
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.0787 0.3024 0.3024
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Brugia malayi Dopamine receptor protein 1 0.003 0.0006 0.0007
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0117 0.0352 0.0408
Echinococcus granulosus neuropeptides capa receptor 0.003 0.0006 0.0007
Brugia malayi Immunoglobulin I-set domain containing protein 0.0051 0.009 0.0107
Echinococcus granulosus insulin receptor 0.0684 0.2613 0.3031
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Schistosoma mansoni serine-rich repeat protein 0.0175 0.0584 0.0678

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.6 nM In vitro binding affinity of [111In]-DTPA-[Y3]-octreotate to somatostatin receptor in the rat pancreatic tumor cell line, CA20498 ChEMBL. 11985468
IC50 (binding) = 0.6 nM In vitro binding affinity of [111In]-DTPA-[Y3]-octreotate to somatostatin receptor in the rat pancreatic tumor cell line, CA20498 ChEMBL. 11985468

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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