TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 991.1 | Formula: C54H58N10O9
H donors: 9 H acceptors: 7 LogP: 4.94 Rotable bonds: 32
Rule of 5 violations (Lipinski): 3
SMILES: NNC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@@H](Cc1nc[nH]c1)NC(=O)OCc1ccccc1)Cc1ccc(cc1)OCc1ccccc1)COCc1ccccc1)C
InChi: 1S/C54H58N10O9/c1-35(49(65)64-55)59-50(66)46(26-40-28-57-44-20-12-11-19-43(40)44)61-53(69)48(33-71-30-37-13-5-2-6-14-37)62-51(67)45(25-36-21-23-42(24-22-36)72-31-38-15-7-3-8-16-38)60-52(68)47(27-41-29-56-34-58-41)63-54(70)73-32-39-17-9-4-10-18-39/h2-24,28-29,34-35,45-48,57H,25-27,30-33,55H2,1H3,(H,56,58)(H,59,66)(H,60,68)(H,61,69)(H,62,67)(H,63,70)(H,64,65)/t35-,45+,46+,47+,48+/m0/s1
InChiKey: SQDWFLBOYHMJFI-ZQIGARPHSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Protein farnesyltransferase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K05954 farnesyltransferase, CAAX box, beta [EC:2.5.1.58], putative	Get druggable targets OG5_128081	All targets in OG5_128081
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	Get druggable targets OG5_128081	All targets in OG5_128081
Leishmania infantum	farnesyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081
Plasmodium yoelii	Prenyltransferase and squalene oxidase repeat, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Leishmania donovani	farnesyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	Get druggable targets OG5_128081	All targets in OG5_128081
Cryptosporidium hominis	chain B, structure of fpt bound to ggpp	Get druggable targets OG5_128081	All targets in OG5_128081
Plasmodium falciparum	protein farnesyltransferase subunit beta	Get druggable targets OG5_128081	All targets in OG5_128081
Plasmodium knowlesi	protein farnesyltransferase subunit beta, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Leishmania major	farnesyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081
Schistosoma mansoni	protein farnesyltransferase subunit beta	Get druggable targets OG5_128081	All targets in OG5_128081
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Echinococcus granulosus	protein farnesyltransferase subunit beta	Get druggable targets OG5_128081	All targets in OG5_128081
Plasmodium vivax	farnesyltransferase beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Trypanosoma brucei	protein farnesyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081
Theileria parva	farnesyltransferase beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	Get druggable targets OG5_128081	All targets in OG5_128081
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Candida albicans	similar to S. cerevisiae RAM1 (YDL090C) beta subunit of farnesyl transferase (Ram1p+Ram2p), involved in prenylation of RAS prote	Get druggable targets OG5_128081	All targets in OG5_128081
Plasmodium vivax	conserved Plasmodium protein, unknown function	Get druggable targets OG5_128081	All targets in OG5_128081
Trichomonas vaginalis	geranylgeranyl transferase type beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Trypanosoma cruzi	protein farnesyltransferase, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Babesia bovis	prenyltransferase and squalene oxidase repeat family protein	Get druggable targets OG5_128081	All targets in OG5_128081
Echinococcus multilocularis	protein farnesyltransferase subunit beta	Get druggable targets OG5_128081	All targets in OG5_128081
Cryptosporidium parvum	protein geranyl-geranyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081
Plasmodium berghei	protein farnesyltransferase subunit beta, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Candida albicans	similar to S. cerevisiae RAM1 (YDL090C) beta subunit of farnesyl transferase (Ram1p+Ram2p), involved in prenylation of RAS prote	Get druggable targets OG5_128081	All targets in OG5_128081
Neospora caninum	protein farnesyltranstransferase beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Plasmodium knowlesi	conserved Plasmodium protein, unknown function	Get druggable targets OG5_128081	All targets in OG5_128081
Giardia lamblia	Prenyltransferase	Get druggable targets OG5_128081	All targets in OG5_128081
Leishmania braziliensis	farnesyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081
Trypanosoma cruzi	protein farnesyltransferase, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Trypanosoma brucei gambiense	protein farnesyltransferase beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Leishmania mexicana	farnesyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081
Entamoeba histolytica	protein farnesyltransferase beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Trichomonas vaginalis	type I geranylgeranyltransferase beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	methionine aminopeptidase 2, putative	0.0028	0.0525	0.0379
Echinococcus granulosus	methionine aminopeptidase type I	0.0028	0.0525	0.0525
Trypanosoma cruzi	aminopeptidase P1, putative	0.0028	0.0525	0.0379
Trypanosoma cruzi	hypothetical protein, conserved	0.0025	0.0415	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0152	0.0152
Brugia malayi	Probable protein farnesyltransferase beta subunit, putative	0.0018	0.0152	0.0091
Loa Loa (eye worm)	methionine aminopeptidase type I	0.0271	1	1
Onchocerca volvulus	Dipeptidase C homolog	0.0028	0.0525	0.6016
Trypanosoma cruzi	Protein prenyltransferase alpha subunit repeat, putative	0.0025	0.0415	0.0267
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0025	0.0415	0.1377
Trypanosoma cruzi	hypothetical protein, conserved	0.0025	0.0415	0.0267
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0025	0.0415	0.1377
Echinococcus granulosus	protein farnesyltransferase subunit beta	0.0067	0.206	0.206
Schistosoma mansoni	peptidase	0.0028	0.0525	0.0474
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0028	0.0525	0.1955
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.0067	0.206	0.2011
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.0028	0.0525	0.0379
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0028	0.0525	0.1955
Entamoeba histolytica	aminopeptidase, putative	0.0028	0.0525	0.1955
Brugia malayi	metallopeptidase family M24 containing protein	0.0028	0.0525	0.0467
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	0.0067	0.206	0.1937
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0525	0.0525
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	0.022	0.8017	0.8017
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0028	0.0525	0.1955
Trypanosoma cruzi	Metallopeptidase family M24, putative	0.0028	0.0525	0.0379
Mycobacterium tuberculosis	Halimadienyl diphosphate synthase	0.0074	0.2315	0.2388
Schistosoma mansoni	Xaa-Pro dipeptidase (M24 family)	0.0028	0.0525	0.0474
Echinococcus granulosus	geranylgeranyl transferase type 2 subunit alpha	0.0025	0.0415	0.0415
Schistosoma mansoni	aminopeptidase P1 (M24 family)	0.0028	0.0525	0.0474
Brugia malayi	initiation factor 2-associated protein.	0.0028	0.0525	0.0467
Echinococcus multilocularis	FACT complex subunit SPT16	0.0028	0.0525	0.0525
Brugia malayi	intermediate filament protein	0.003	0.0598	0.054
Echinococcus multilocularis	protein farnesyltransferase subunit beta	0.0067	0.206	0.206
Plasmodium vivax	methionine aminopeptidase 1c, putative	0.0028	0.0525	0.0379
Mycobacterium leprae	PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M)	0.022	0.8017	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0525	0.0525
Loa Loa (eye worm)	initiation factor 2-associated protein	0.0028	0.0525	0.0525
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0049	0.135	0.1216
Chlamydia trachomatis	methionine aminopeptidase	0.022	0.8017	1
Trypanosoma cruzi	protein farnesyltransferase, putative	0.0067	0.206	0.1937
Trypanosoma cruzi	Metallopeptidase family M24, putative	0.0028	0.0525	0.0379
Toxoplasma gondii	methionine aminopeptidase	0.0271	1	1
Echinococcus granulosus	Xaa Pro aminopeptidase 3	0.0028	0.0525	0.0525
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.0067	0.206	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0132	0.456	0.456
Plasmodium falciparum	methionine aminopeptidase 1a, putative	0.022	0.8017	0.7987
Schistosoma mansoni	lamin	0.003	0.0598	0.0567
Onchocerca volvulus	FACT complex subunit SPT16 homolog	0.0028	0.0525	0.6016
Schistosoma mansoni	aminopeptidase P homologue (M24 family)	0.0028	0.0525	0.0474
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.0025	0.0415	0.0267
Trypanosoma cruzi	lanosterol synthase, putative	0.0074	0.2315	0.2196
Echinococcus granulosus	Proliferation associated protein 2G4	0.0028	0.0525	0.0525
Echinococcus multilocularis	lamin	0.003	0.0598	0.0598
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0028	0.0525	0.1955
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	0.022	0.8017	1
Trichomonas vaginalis	type I geranylgeranyltransferase beta subunit, putative	0.0067	0.206	1
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	0.0025	0.0415	0.0415
Schistosoma mansoni	lamin	0.003	0.0598	0.0567
Trypanosoma cruzi	metallo- peptidase, Clan MG, Family M24	0.0271	1	1
Toxoplasma gondii	proliferation-associated protein 2G4, putative	0.0028	0.0525	0.0379
Schistosoma mansoni	protein farnesyltransferase alpha subunit	0.0025	0.0415	0.0334
Leishmania major	aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24	0.0028	0.0525	0.0379
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0025	0.0415	0.0334
Trypanosoma brucei	metallo-peptidase, Clan MG, Family M24	0.0028	0.0525	0.0379
Plasmodium vivax	methionine aminopeptidase 1b, putative	0.0271	1	1
Leishmania major	aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24	0.0028	0.0525	0.0379
Echinococcus granulosus	lamin dm0	0.003	0.0598	0.0598
Onchocerca volvulus		0.003	0.0598	1
Onchocerca volvulus		0.003	0.0598	1
Plasmodium vivax	peptidase, putative	0.0028	0.0525	0.0379
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0025	0.0415	0.1377
Leishmania major	farnesyltransferase beta subunit	0.0067	0.206	0.1937
Trypanosoma brucei	protein farnesyltransferase beta subunit	0.0067	0.206	0.1937
Plasmodium falciparum	methionine aminopeptidase 2	0.0028	0.0525	0.0379
Brugia malayi	Intermediate filament tail domain containing protein	0.003	0.0598	0.054
Echinococcus multilocularis	Rab geranylgeranyltransferase, beta subunit	0.0018	0.0152	0.0152
Trypanosoma brucei	hypothetical protein, conserved	0.0051	0.1425	0.1292
Schistosoma mansoni	proliferation-associated protein 2G4 38kDa (M24 family)	0.0028	0.0525	0.0474
Plasmodium falciparum	aminopeptidase P	0.0028	0.0525	0.0379
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.0028	0.0525	0.0379
Plasmodium falciparum	methionine aminopeptidase 1b, putative	0.0271	1	1
Trypanosoma brucei	metallo-peptidase, Clan MG, Family M24	0.0028	0.0525	0.0379
Echinococcus granulosus	protein prenyltransferase alpha subunit	0.0025	0.0415	0.0415
Trypanosoma cruzi	protein farnesyltransferase, putative	0.0067	0.206	0.1937
Entamoeba histolytica	Xaa-Pro dipeptidase, putative	0.0028	0.0525	0.1955
Plasmodium vivax	proliferation-associated protein 2g4, putative	0.0028	0.0525	0.0379
Trichomonas vaginalis	geranylgeranyl transferase type beta subunit, putative	0.0067	0.206	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0051	0.1425	0.1292
Echinococcus multilocularis	Xaa Pro aminopeptidase 3	0.0028	0.0525	0.0525
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.0025	0.0415	0.0267
Treponema pallidum	methionine aminopeptidase (map)	0.022	0.8017	1
Giardia lamblia	Methionine aminopeptidase	0.0028	0.0525	0.1955
Loa Loa (eye worm)	intermediate filament protein	0.003	0.0598	0.0598
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0577	0.0577
Trypanosoma brucei	metallo-peptidase, Clan MG, Family M24	0.0028	0.0525	0.0379
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0028	0.0525	0.1955
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0028	0.0525	0.1955
Mycobacterium tuberculosis	Methionine aminopeptidase MapA (map) (peptidase M) (MetAP)	0.022	0.8017	1
Echinococcus multilocularis	methionine aminopeptidase, type I	0.0028	0.0525	0.0525
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0067	0.206	1
Plasmodium vivax	farnesyltransferase beta subunit, putative	0.0067	0.206	0.1937
Echinococcus multilocularis	xaa Pro dipeptidase	0.0028	0.0525	0.0525
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.0018	0.0152	0.0091
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24, putative	0.0028	0.0525	0.0379
Mycobacterium ulcerans	methionine aminopeptidase	0.022	0.8017	1
Toxoplasma gondii	hypothetical protein	0.0025	0.0415	0.0267
Brugia malayi	metallopeptidase family M24 containing protein	0.0028	0.0525	0.0467
Giardia lamblia	Rab geranylgeranyltransferase	0.0025	0.0415	0.1377
Plasmodium falciparum	protein farnesyltransferase subunit beta	0.0067	0.206	0.1937
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0028	0.0525	0.1955
Plasmodium falciparum	proliferation-associated protein 2g4, putative	0.0028	0.0525	0.0379
Echinococcus multilocularis	protein prenyltransferase alpha subunit	0.0025	0.0415	0.0415
Entamoeba histolytica	methionine aminopeptidase, putative	0.0028	0.0525	0.1955
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0067	0.206	1
Trypanosoma cruzi	metallo- peptidase, Clan MG, Family M24	0.0271	1	1
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0028	0.0525	0.1955
Brugia malayi	metallopeptidase family M24 containing protein	0.0028	0.0525	0.0467
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0016	0.0061	0.0061
Plasmodium falciparum	methionine aminopeptidase 1c, putative	0.0028	0.0525	0.0379
Echinococcus granulosus	xaa pro aminopeptidase	0.0028	0.0525	0.0525
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	0.0271	1	1
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0028	0.0525	0.1955
Onchocerca volvulus	Methionine aminopeptidase 2 homolog	0.0028	0.0525	0.6016
Mycobacterium leprae	PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP)	0.022	0.8017	1
Loa Loa (eye worm)	metallopeptidase family M24 containing protein	0.0028	0.0525	0.0525
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.0028	0.0525	0.0379
Toxoplasma gondii	hypothetical protein	0.0051	0.1425	0.1292
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.0025	0.0415	0.0267
Plasmodium falciparum	protein farnesyltransferase subunit alpha	0.0025	0.0415	0.0267
Trypanosoma cruzi	Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative	0.0028	0.0525	0.0379
Giardia lamblia	Xaa-Pro dipeptidase	0.0028	0.0525	0.1955
Leishmania major	hypothetical protein, conserved	0.0051	0.1425	0.1292
Toxoplasma gondii	peptidase D, putative	0.0028	0.0525	0.0379
Trypanosoma brucei	protein farnesyltransferase alpha subunit, putative	0.0025	0.0415	0.0267
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.0028	0.0525	0.0379
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.0018	0.0152	0.0152
Leishmania major	methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24	0.0271	1	1
Plasmodium vivax	methionine aminopeptidase 1a, putative	0.022	0.8017	0.7987
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0067	0.206	1
Echinococcus multilocularis	methionyl aminopeptidase 2	0.0028	0.0525	0.0525
Mycobacterium tuberculosis	Methionine aminopeptidase MapB (map) (peptidase M)	0.022	0.8017	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0132	0.456	0.456
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0028	0.0525	0.1955
Echinococcus multilocularis	geranylgeranyl transferase type 2 subunit alpha	0.0025	0.0415	0.0415
Echinococcus granulosus	methionyl aminopeptidase 1 M24 family	0.0271	1	1
Leishmania major	protein farnesyltransferase alpha subunit, putative	0.0025	0.0415	0.0267
Entamoeba histolytica	Rab geranylgeranyltransferase alpha subunit, putative	0.0025	0.0415	0.1377
Trypanosoma brucei	Facilitates chromatin transcription complex subunit spt16	0.0028	0.0525	0.0379
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.0067	0.206	0.206
Plasmodium vivax	protein prenyltransferase alpha subunit, putative	0.0025	0.0415	0.0267
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.0025	0.0415	0.0267
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0025	0.0415	0.0415
Schistosoma mansoni	methionyl aminopeptidase 2 (M24 family)	0.0028	0.0525	0.0474
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0025	0.0415	0.0356
Leishmania major	lanosterol synthase, putative	0.0056	0.1604	0.1475
Plasmodium falciparum	FACT complex subunit SPT16, putative	0.0028	0.0525	0.0379
Echinococcus granulosus	xaa Pro dipeptidase	0.0028	0.0525	0.0525
Plasmodium vivax	FACT complex subunit SPT16, putative	0.0028	0.0525	0.0379
Entamoeba histolytica	peptidase, putative	0.0028	0.0525	0.1955
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0152	0.0152
Toxoplasma gondii	methionine aminopeptidase 2, putative	0.0028	0.0525	0.0379
Loa Loa (eye worm)	DNA-binding protein	0.0028	0.0525	0.0525
Giardia lamblia	Rab geranylgeranyltransferase	0.0025	0.0415	0.1377
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0025	0.0415	0.0415
Trypanosoma brucei	Metallopeptidase family M24, putative	0.0028	0.0525	0.0379
Wolbachia endosymbiont of Brugia malayi	methionine aminopeptidase	0.022	0.8017	1
Echinococcus granulosus	FACT complex subunit SPT16	0.0028	0.0525	0.0525
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	0.022	0.8017	1
Giardia lamblia	Xaa-Pro dipeptidase	0.0028	0.0525	0.1955
Trypanosoma cruzi	aminopeptidase P, putative	0.0028	0.0525	0.0379
Plasmodium falciparum	geranylgeranyl transferase type-2 subunit alpha, putative	0.0025	0.0415	0.0267
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0028	0.0525	0.1955
Entamoeba histolytica	hypothetical protein, conserved	0.0028	0.0525	0.1955
Plasmodium falciparum	HP12 protein homolog, putative	0.0051	0.1425	0.1292
Trypanosoma brucei	methionine aminopeptidase, putative	0.0271	1	1
Echinococcus multilocularis	xaa Pro dipeptidase	0.0028	0.0525	0.0525
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.003	0.0598	0.0598
Loa Loa (eye worm)	hypothetical protein	0.003	0.0598	0.0598
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0028	0.0525	0.1955
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0025	0.0415	0.1377
Mycobacterium ulcerans	methionine aminopeptidase MapB	0.022	0.8017	1
Leishmania major	aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24	0.0028	0.0525	0.0379
Plasmodium vivax	methionine aminopeptidase 2, putative	0.0028	0.0525	0.0379
Echinococcus granulosus	intermediate filament protein	0.003	0.0598	0.0598
Plasmodium vivax	hypothetical protein, conserved	0.0051	0.1425	0.1292
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24, putative	0.0028	0.0525	0.0379
Trypanosoma brucei	Xaa-Pro aminopeptidase, putative	0.0028	0.0525	0.0379
Echinococcus multilocularis	lamin dm0	0.003	0.0598	0.0598
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	0.0025	0.0415	0.1377
Echinococcus granulosus	protein farnesyltransferase alpha subunit	0.0025	0.0415	0.0415
Toxoplasma gondii	methionine aminopeptidase, type i, putative	0.022	0.8017	0.7987
Trypanosoma brucei	methionine aminopeptidase, type I, putative	0.0271	1	1
Echinococcus multilocularis	geranylgeranyl transferase type I beta subunit	0.0018	0.0152	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0415	0.0415
Giardia lamblia	Prenyltransferase	0.0067	0.206	1
Echinococcus multilocularis	musashi	0.003	0.0598	0.0598
Leishmania major	hypothetical protein, conserved	0.0028	0.0525	0.0379
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0025	0.0415	0.0356
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0525	0.0525
Trypanosoma cruzi	lanosterol synthase, putative	0.0074	0.2315	0.2196
Trypanosoma brucei	methionine aminopeptidase 2, putative	0.0028	0.0525	0.0379
Schistosoma mansoni	intermediate filament proteins	0.003	0.0598	0.0567
Schistosoma mansoni	chromatin-specific transcription elongation factor 140 kDa subunit (M24 family)	0.0028	0.0525	0.0474
Echinococcus multilocularis	Proliferation associated protein 2G4	0.0028	0.0525	0.0525
Schistosoma mansoni	protein farnesyltransferase subunit beta	0.0067	0.206	0.2426
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0028	0.0525	0.1955
Echinococcus granulosus	geranylgeranyl transferase type I beta subunit	0.0018	0.0152	0.0152
Entamoeba histolytica	protein farnesyltransferase beta subunit, putative	0.0067	0.206	1
Echinococcus granulosus	methionyl aminopeptidase 2	0.0028	0.0525	0.0525
Toxoplasma gondii	methionine aminopeptidase	0.022	0.8017	0.7987
Leishmania major	aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24	0.0028	0.0525	0.0379
Echinococcus multilocularis	xaa pro aminopeptidase	0.0028	0.0525	0.0525
Plasmodium vivax	prenyltransferase alpha subunit, putative	0.0025	0.0415	0.0267
Echinococcus granulosus	xaa Pro dipeptidase	0.0028	0.0525	0.0525
Trypanosoma brucei	metallo- peptidase, Clan MG, Family M24	0.0271	1	1
Trypanosoma brucei	hypothetical protein, conserved	0.0025	0.0415	0.0267
Leishmania major	transcription factor-like protein	0.0028	0.0525	0.0379
Onchocerca volvulus		0.0028	0.0525	0.6016
Brugia malayi	MH2 domain containing protein	0.0132	0.456	0.4527
Toxoplasma gondii	creatinase domain-containing protein	0.0028	0.0525	0.0379
Trypanosoma cruzi	hypothetical protein, conserved	0.0051	0.1425	0.1292
Trypanosoma brucei	lanosterol synthase	0.0074	0.2315	0.2196
Echinococcus granulosus	lamin	0.003	0.0598	0.0598
Schistosoma mansoni	proliferation-associated protein 2G4 38kDa (M24 family)	0.0028	0.0525	0.0474
Brugia malayi	DNA-binding protein, 42 kDa containing protein	0.0028	0.0525	0.0467
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24	0.0028	0.0525	0.0379
Toxoplasma gondii	transcriptional elongation factor FACT140	0.0028	0.0525	0.0379

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.064 uM	Inhibitory concentration against rat brain farnesyltransferase	ChEMBL.	9003517
IC50 (binding)	= 0.064 uM	Inhibitory concentration against rat brain farnesyltransferase	ChEMBL.	9003517

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 379068