Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Luciferase activity (functional) | = 130000 RLU 10s-1 | Compound was tested for luciferase activity in Monkey CV1 Cell Lines | ChEMBL. | 9457245 |
Luciferase activity (functional) | = 1200000 RLU 10s-1 | Luciferase activity in mouse fibroblasts NIH3T3 cells. | ChEMBL. | 9457245 |
Luciferase activity (functional) | = 1200000 RLU 10s-1 | Luciferase activity in mouse fibroblasts NIH3T3 cells. | ChEMBL. | 9457245 |
RLU (functional) | = 130000 | Compound was tested for the impact of introduction of molecular probe as side chain entity in the linker position on expression of luciferase in transfected HeLa cells (RLU = luciferase activity in relative light units (RLU)/10 s for 10E3 plated c | ChEMBL. | 9457245 |
RLU (functional) | = 1200000 | Compound was tested for the impact of introduction of molecular probe as side chain entity in the linker position on expression of luciferase in transfected NIH3T3 cells (RLU = luciferase activity in relative light units (RLU)/10 s for 10E3 plated | ChEMBL. | 9457245 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.