Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0042 | 0 | 0.5 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0058 | 0.0095 | 0.0091 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0846 | 0.4565 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0742 | 0.3977 | 0.3952 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0058 | 0.0093 | 0.0089 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1803 | 1 | 0.5 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0742 | 0.3977 | 0.3975 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0742 | 0.3977 | 0.3975 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0042 | 0 | 0.5 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0846 | 0.4565 | 0.5 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.1803 | 1 | 1 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1803 | 1 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1803 | 1 | 0.5 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0742 | 0.3977 | 0.3975 |
Loa Loa (eye worm) | hypothetical protein | 0.1803 | 1 | 1 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.1803 | 1 | 1 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0742 | 0.3977 | 0.3975 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0173 | 0.0746 | 0.0743 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0046 | 0.0025 | 0.0022 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0742 | 0.3977 | 0.3975 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0095 | 0.0054 |
Chlamydia trachomatis | glutamine binding protein | 0.0042 | 0 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1803 | 1 | 0.5 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.1803 | 1 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0231 | 0.1076 | 0.1073 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0185 | 0.0815 | 0.0812 |
Brugia malayi | CHE-14 protein | 0.0742 | 0.3977 | 0.3952 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0173 | 0.0746 | 0.0743 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0231 | 0.1076 | 0.1073 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0742 | 0.3977 | 0.3952 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0202 | 0.0908 | 0.0905 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.1803 | 1 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.0742 | 0.3977 | 0.3975 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0042 | 0 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0058 | 0.0095 | 0.0091 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0185 | 0.0815 | 0.0812 |
Schistosoma mansoni | patched 1 | 0.0742 | 0.3977 | 0.3975 |
Echinococcus multilocularis | protein patched | 0.0742 | 0.3977 | 0.3975 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0846 | 0.4565 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0742 | 0.3977 | 0.3975 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0042 | 0 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0846 | 0.4565 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Complex formation (functional) | = 290 % | Cellular protein-DNA complex formation at 10 uM. | ChEMBL. | 2158562 |
Complex formation (functional) | = 290 % | Effect on cellular protein DNA complex formation(%) at 10 microM in comparison with etoposide | ChEMBL. | 1312600 |
Complex formation (binding) | = 290 % | Percentage of intracellular covalent DNA-topoisomerase II complexes formed | ChEMBL. | 12014968 |
Complex formation (binding) | = 290 % | Percentage of intracellular covalent DNA-topoisomerase II complexes formed | ChEMBL. | 12014968 |
Complex formation (functional) | = 290 % | Cellular protein-DNA complex formation at 10 uM. | ChEMBL. | 2158562 |
Formation (functional) | = 290 % | Inhibition of cellular protein-DNA complex formation at 10 microM | ChEMBL. | 2167985 |
IC50 (functional) | = 0.45 uM | Concentration required for 50% reduction in KB cell number after 3-day incubation | ChEMBL. | 1312600 |
ID50 (functional) | = 0.45 uM | In vitro cytotoxicity against KB cells after a 3-day incubation. | ChEMBL. | 2158562 |
ID50 (functional) | = 0.45 uM | Concentration for 50% reduction in cell number after 3-day incubation | ChEMBL. | 2167985 |
ID50 (binding) | = 5 uM | Evaluated for inhibitory activity against DNA topoisomerase II | ChEMBL. | 2158562 |
ID50 (binding) | = 5 uM | Evaluated for inhibitory activity against DNA topoisomerase II | ChEMBL. | 2158562 |
ID50 (binding) | = 25 uM | Evaluated for the inhibition of human DNA Topoisomerase II | ChEMBL. | 1312600 |
ID50 (binding) | = 25 uM | Inhibitory activity against human DNA topoisomerase II | ChEMBL. | 2167985 |
ID50 (binding) | = 25 uM | Evaluated for the inhibition of human DNA Topoisomerase II | ChEMBL. | 1312600 |
ID50 (binding) | = 25 uM | Inhibitory activity against human DNA topoisomerase II | ChEMBL. | 2167985 |
Inhibition (binding) | > 75 % | Inhibition of DNA topoisomerase II at 100 uM. | ChEMBL. | 2158562 |
Inhibition (binding) | > 75 % | Inhibition of DNA topoisomerase II at 100 uM. | ChEMBL. | 2158562 |
Protein-DNA complex formation (functional) | = 290 % | Compound tested for ability to form a cellular covalent topoisomerase II-DNA complex. | ChEMBL. | 8691468 |
Protein-DNA complex formation (functional) | = 290 % | Compound tested for ability to form a cellular covalent topoisomerase II-DNA complex. | ChEMBL. | 8691468 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
5 literature references were collected for this gene.