Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0024 | 0.0004 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0809 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Schistosoma mansoni | high voltage-activated calcium channel Cav2A | 0.0078 | 0.0687 | 0.0683 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.0078 | 0.0687 | 0.0683 |
Loa Loa (eye worm) | voltage-dependent calcium channel | 0.0027 | 0.0042 | 0.0042 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0024 | 0.0004 | 0.0004 |
Onchocerca volvulus | 0.0024 | 0.0004 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0024 | 0.0004 | 0.0004 |
Echinococcus granulosus | adenosylhomocysteinase | 0.0809 | 1 | 1 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0809 | 1 | 1 |
Onchocerca volvulus | 0.0024 | 0.0004 | 0.5 | |
Onchocerca volvulus | 0.0024 | 0.0004 | 0.5 | |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.0809 | 1 | 0.5 |
Echinococcus granulosus | ankyrin repeat protein | 0.016 | 0.174 | 0.1737 |
Onchocerca volvulus | 0.0024 | 0.0004 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.0809 | 1 | 0.5 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0809 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0687 | 0.0687 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0809 | 1 | 0.5 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0078 | 0.0687 | 0.0683 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0027 | 0.0042 | 0.0038 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Schistosoma mansoni | voltage-gated cation channel | 0.0078 | 0.0687 | 0.0683 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | calcium channel | 0.0078 | 0.0687 | 0.0687 |
Schistosoma mansoni | adenosylhomocysteinase | 0.05 | 0.6073 | 0.6071 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0024 | 0.0004 | 0.5 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0078 | 0.0687 | 0.0683 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Onchocerca volvulus | 0.0024 | 0.0004 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Schistosoma mansoni | transient receptor potential cation channel subfamily A member | 0.016 | 0.174 | 0.1737 |
Onchocerca volvulus | 0.0024 | 0.0004 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Onchocerca volvulus | 0.0024 | 0.0004 | 0.5 | |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0809 | 1 | 1 |
Schistosoma mansoni | high voltage-activated calcium channel Cav1 | 0.0078 | 0.0687 | 0.0683 |
Echinococcus multilocularis | ankyrin repeat protein | 0.016 | 0.174 | 0.1737 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.0078 | 0.0687 | 0.0683 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Onchocerca volvulus | 0.0024 | 0.0004 | 0.5 | |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0078 | 0.0687 | 0.0683 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0809 | 1 | 1 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0078 | 0.0687 | 0.0683 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0164 | 0.1785 | 0.1782 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Onchocerca volvulus | 0.0024 | 0.0004 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0078 | 0.0687 | 0.0683 |
Schistosoma mansoni | adenosylhomocysteinase | 0.05 | 0.6073 | 0.6071 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.0809 | 1 | 0.5 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0809 | 1 | 0.5 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0809 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0809 | 1 | 1 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0809 | 1 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0024 | 0.0004 | 0.0004 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0078 | 0.0687 | 0.0683 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Onchocerca volvulus | 0.0024 | 0.0004 | 0.5 | |
Onchocerca volvulus | 0.0024 | 0.0004 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Onchocerca volvulus | 0.0024 | 0.0004 | 0.5 | |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0024 | 0.0004 | 0.0004 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0809 | 1 | 1 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0027 | 0.0042 | 0.0042 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0809 | 1 | 0.5 |
Schistosoma mansoni | adenosylhomocysteinase | 0.05 | 0.6073 | 0.6071 |
Onchocerca volvulus | 0.0024 | 0.0004 | 0.5 | |
Onchocerca volvulus | 0.0024 | 0.0004 | 0.5 | |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0809 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Onchocerca volvulus | 0.0024 | 0.0004 | 0.5 | |
Plasmodium falciparum | adenosylhomocysteinase | 0.0809 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Onchocerca volvulus | 0.0024 | 0.0004 | 0.5 | |
Brugia malayi | Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog | 0.0078 | 0.0687 | 0.0683 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Schistosoma mansoni | adenosylhomocysteinase | 0.05 | 0.6073 | 0.6071 |
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.0078 | 0.0687 | 0.0683 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0042 | 0.0042 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0024 | 0.0004 | 0.0004 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0024 | 0.0004 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0164 | 0.1782 | 0.1779 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0078 | 0.0687 | 0.0683 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0004 | 0.0004 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 30 | Inhibition of matrix metalloproteinase-2(Gel.A) | ChEMBL. | 9871766 |
Activity (binding) | = 40 | Inhibition of matrix metalloproteinase-1(HFC) | ChEMBL. | 9871766 |
Activity (binding) | = 50 | Inhibition of matrix metalloproteinase-7(Matrilysin) | ChEMBL. | 9871766 |
Activity (binding) | = 100 | Inhibition of matrix metalloproteinase-3(Strom-1) | ChEMBL. | 9871766 |
Activity (binding) | = 8000 | TNF-alpha convertase activity following phorbol 12-myristate 13-acetate (PMA) stimulation of U937 cells | ChEMBL. | 9871766 |
Activity (binding) | = 30 | Inhibition of matrix metalloproteinase-2(Gel.A) | ChEMBL. | 9871766 |
Activity (binding) | = 40 | Inhibition of matrix metalloproteinase-1(HFC) | ChEMBL. | 9871766 |
Activity (binding) | = 50 | Inhibition of matrix metalloproteinase-7(Matrilysin) | ChEMBL. | 9871766 |
Activity (binding) | = 100 | Inhibition of matrix metalloproteinase-3(Strom-1) | ChEMBL. | 9871766 |
Activity (binding) | = 8000 | TNF-alpha convertase activity following phorbol 12-myristate 13-acetate (PMA) stimulation of U937 cells | ChEMBL. | 9871766 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.