TDR Targets

Basic information

Technical information

TDR Targets ID: 38038
Name: N-[4-[4-(2-methylphenyl)piperazin-1-yl]sulfon ylphenyl]-7-(trifluoromethyl)quinolin-4-amine
MW: 526.573 | Formula: C27H25F3N4O2S
H donors: 1 H acceptors: 3 LogP: 5.72 Rotable bonds: 6
Rule of 5 violations (Lipinski): 2
SMILES: Cc1ccccc1N1CCN(CC1)S(=O)(=O)c1ccc(cc1)Nc1ccnc2c1ccc(c2)C(F)(F)F
InChi: 1S/C27H25F3N4O2S/c1-19-4-2-3-5-26(19)33-14-16-34(17-15-33)37(35,36)22-9-7-21(8-10-22)32-24-12-13-31-25-18-20(27(28,29)30)6-11-23(24)25/h2-13,18H,14-17H2,1H3,(H,31,32)
InChiKey: ILMMTNWHFSVEAA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[4-[4-(o-tolyl)piperazin-1-yl]sulfonylphenyl]-7-(trifluoromethyl)quinolin-4-amine
N-[4-[[4-(o-tolyl)-1-piperazinyl]sulfonyl]phenyl]-7-(trifluoromethyl)-4-quinolinamine
[4-[4-(o-tolyl)piperazino]sulfonylphenyl]-[7-(trifluoromethyl)-4-quinolyl]amine
N-[4-[[4-(2-methylphenyl)-1-piperazinyl]sulfonyl]phenyl]-7-(trifluoromethyl)-4-quinolinamine
[4-[4-(2-methylphenyl)piperazin-1-yl]sulfonylphenyl]-[7-(trifluoromethyl)-4-quinolyl]amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0119	0.0595	0.0617
Leishmania major	DNA polymerase eta, putative	0.0034	0.0081	0.0084
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0056	0.0213	0.0213
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0063	0.0254	0.0254
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.1601	0.9641	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0119	0.0595	0.0617
Echinococcus granulosus	thyroid hormone receptor alpha	0.0056	0.0213	0.0213
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0119	0.0595	0.0617
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0119	0.0595	0.0617
Entamoeba histolytica	Flap nuclease, putative	0.0028	0.0045	0.0046
Entamoeba histolytica	hypothetical protein	0.0039	0.0111	0.0115
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0056	0.0213	0.0213
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.1601	0.9641	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.0119	0.0595	1
Brugia malayi	nuclear hormone receptor	0.0119	0.0595	0.0617
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0119	0.0595	0.0617
Echinococcus granulosus	flap endonuclease 1	0.0028	0.0045	0.0045
Schistosoma mansoni	flap endonuclease-1	0.0026	0.0028	0.0028
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0119	0.0595	0.0617
Echinococcus multilocularis	transcription factor Dp 1	0.0927	0.5526	0.5732
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0056	0.0213	0.0221
Schistosoma mansoni	hypothetical protein	0.0039	0.0111	0.0111
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0176	0.0176
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0254	0.0263
Loa Loa (eye worm)	TAR-binding protein	0.0069	0.0292	0.0303
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.0292	0.0292
Schistosoma mansoni	nuclear hormone receptor	0.0119	0.0595	0.0595
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0111	0.0111
Echinococcus granulosus	nuclear receptor nhr 48	0.0056	0.0213	0.0213
Schistosoma mansoni	nuclear hormone receptor	0.0056	0.0213	0.0213
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0111	0.0111
Brugia malayi	steroid hormone receptor	0.0119	0.0595	0.0617
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0021	0	0.5
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0119	0.0595	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0213	0.0221
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0028	0.0045	0.0046
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.1598	0.9618	0.9976
Brugia malayi	Nuclear hormone receptor E75	0.0056	0.0213	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0595	0.0617
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0119	0.0595	0.0595
Echinococcus multilocularis	geminin	0.0351	0.2014	0.2089
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.1601	0.9641	1
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0028	0.0045	0.1335
Brugia malayi	nuclear receptor RXR	0.0063	0.0254	0.0263
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0021	0	0.5
Brugia malayi	Steroid receptor seven-up type 2	0.0119	0.0595	0.0617
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0056	0.0213	0.0221
Schistosoma mansoni	nuclear receptor	0.0056	0.0213	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0213	0.0221
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0056	0.0213	0.0221
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0119	0.0595	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0213	0.0221
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0119	0.0595	0.0617
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0119	0.0595	0.0617
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0119	0.0595	0.0617
Trypanosoma cruzi	DNA polymerase eta, putative	0.0049	0.0169	0.0175
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0056	0.0213	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0169	0.0175
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.005	0.0176	0.0182
Schistosoma mansoni	hypothetical protein	0.0351	0.2014	0.2014
Entamoeba histolytica	hypothetical protein	0.0039	0.0111	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0595	0.0617
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0176	0.0182
Brugia malayi	nuclear receptor NHR-88	0.0056	0.0213	0.0221
Schistosoma mansoni	DNA polymerase eta	0.0049	0.0169	0.0169
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0119	0.0595	0.0617
Echinococcus multilocularis	nuclear receptor nhr 48	0.0056	0.0213	0.0221
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.1601	0.9641	0.9641
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0176	0.0182
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0119	0.0595	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0595	0.0617
Brugia malayi	Nuclear hormone receptor-like 1	0.0063	0.0254	0.0263
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0069	0.0292	0.0303
Trypanosoma brucei	DNA polymerase eta, putative	0.0049	0.0169	0.0175
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.0292	0.0292
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0119	0.0595	0.0617
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0111	0.0115
Brugia malayi	TAR-binding protein	0.0069	0.0292	0.0303
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0119	0.0595	0.0617
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0176	0.0176
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0119	0.0595	0.0595
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0063	0.0254	0.0263
Trypanosoma cruzi	DNA polymerase eta, putative	0.0034	0.0081	0.0084
Schistosoma mansoni	nuclear receptor	0.0056	0.0213	0.0213
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0176	0.0176
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0063	0.0254	0.0254
Brugia malayi	hypothetical protein	0.0063	0.0254	0.0263
Echinococcus multilocularis	ecdysone induced protein 78C	0.0119	0.0595	0.0617
Plasmodium falciparum	flap endonuclease 1	0.0028	0.0045	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0119	0.0595	0.0595
Brugia malayi	ecdysteroid receptor	0.0119	0.0595	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0213	0.0221
Loa Loa (eye worm)	DR-78	0.0056	0.0213	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0213	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0595	0.0617
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0034	0.0081	1
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0063	0.0254	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0213	0.0221
Brugia malayi	ImpB/MucB/SamB family protein	0.0049	0.0169	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0595	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0213	0.0221
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0119	0.0595	0.0595
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0056	0.0213	0.0213
Brugia malayi	hypothetical protein	0.0027	0.0039	0.0041
Schistosoma mansoni	zinc finger protein	0.0056	0.0213	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0254	0.0263
Brugia malayi	hypothetical protein	0.0039	0.0111	0.0115
Brugia malayi	Nuclear hormone receptor-like 1	0.0063	0.0254	0.0263
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0119	0.0595	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0213	0.0221
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0056	0.0213	0.0221
Schistosoma mansoni	thyroid hormone receptor	0.0119	0.0595	0.0595
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0119	0.0595	0.0595
Loa Loa (eye worm)	nuclear hormone receptor	0.0056	0.0213	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0213	0.0221
Schistosoma mansoni	retinoic acid receptor RXR	0.166	1	1
Trichomonas vaginalis	flap endonuclease-1, putative	0.0028	0.0045	1
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.1601	0.9641	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0119	0.0595	0.0595
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0119	0.0595	0.0617
Schistosoma mansoni	nuclear receptor nhr-48	0.0056	0.0213	0.0213
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0119	0.0595	0.0617
Brugia malayi	RNA binding protein	0.0069	0.0292	0.0303
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0028	0.0045	0.0046
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0056	0.0213	0.0213
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0119	0.0595	0.0617
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.1601	0.9641	1
Giardia lamblia	Flap structure-specific endonuclease	0.0028	0.0045	1
Echinococcus granulosus	dna polymerase eta	0.0049	0.0169	0.0169
Schistosoma mansoni	hypothetical protein	0.0351	0.2014	0.2014
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.0292	0.0292
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0213	0.0221
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0119	0.0595	0.0617
Brugia malayi	conserved hypotetical protein	0.0056	0.0213	0.0221
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0119	0.0595	0.0595
Brugia malayi	nuclear hormone receptor	0.0056	0.0213	0.0221
Plasmodium vivax	flap endonuclease 1, putative	0.0028	0.0045	1
Entamoeba histolytica	hypothetical protein	0.0039	0.0111	0.0115
Echinococcus multilocularis	tar DNA binding protein	0.0069	0.0292	0.0303
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0119	0.0595	0.0617
Schistosoma mansoni	nuclear hormone receptor	0.0056	0.0213	0.0213
Echinococcus granulosus	geminin	0.0351	0.2014	0.2014
Trypanosoma brucei	PAB1-binding protein , putative	0.0027	0.0039	0.0041
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0119	0.0595	0.0617
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0119	0.0595	0.0595
Brugia malayi	hypothetical protein	0.0056	0.0213	0.0221
Echinococcus granulosus	FTZ F1 alpha	0.0119	0.0595	0.0595
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0056	0.0213	0.0221
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0039	0.0041
Brugia malayi	Flap endonuclease-1	0.0028	0.0045	0.0046
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0119	0.0595	0.0595
Mycobacterium ulcerans	DNA polymerase IV	0.0021	0	0.5
Brugia malayi	hypothetical protein	0.0056	0.0213	0.0221
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0056	0.0213	0.0221
Echinococcus granulosus	transcription factor Dp 1	0.0927	0.5526	0.5526
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0028	0.0045	0.0046
Brugia malayi	Nuclear hormone receptor E75	0.0056	0.0213	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0213	0.0221
Onchocerca volvulus		0.0119	0.0595	1
Onchocerca volvulus	Bile acid receptor homolog	0.0119	0.0595	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0254	0.0263
Leishmania major	DNA polymerase eta, putative	0.0049	0.0169	0.0175
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.1601	0.9641	0.9641
Brugia malayi	photoreceptor-specific nuclear receptor	0.0119	0.0595	0.0617
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0119	0.0595	0.0617
Echinococcus granulosus	ecdysone induced protein 78C	0.0119	0.0595	0.0595
Leishmania major	hypothetical protein, conserved	0.0027	0.0039	0.0041
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0119	0.0595	0.0617
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.0292	0.0292
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0119	0.0595	0.0617
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0119	0.0595	0.0595
Echinococcus multilocularis	FTZ F1 alpha	0.0119	0.0595	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0595	0.0617
Brugia malayi	RNA recognition motif domain containing protein	0.0069	0.0292	0.0303
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0119	0.0595	0.0617
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0119	0.0595	0.0617
Loa Loa (eye worm)	steroid hormone receptor	0.0119	0.0595	0.0617
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.1601	0.9641	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0039	0.0041
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.1601	0.9641	1
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.0292	0.0292
Loa Loa (eye worm)	flap endonuclease-1	0.0028	0.0045	0.0046
Schistosoma mansoni	thyroid hormone receptor	0.0119	0.0595	0.0595
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.1601	0.9641	1
Loa Loa (eye worm)	RNA binding protein	0.0069	0.0292	0.0303
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0595	0.0617
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0056	0.0213	0.0221
Brugia malayi	tailless protein	0.0056	0.0213	0.0221
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0056	0.0213	0.0221
Entamoeba histolytica	hypothetical protein	0.0039	0.0111	0.0115
Brugia malayi	ecdysone receptor	0.0056	0.0213	0.0221
Echinococcus multilocularis	dna polymerase eta	0.0049	0.0169	0.0175
Brugia malayi	orphan nuclear receptor NR2E1	0.0056	0.0213	0.0221
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0056	0.0213	0.0213
Mycobacterium ulcerans	DNA polymerase IV	0.0021	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0254	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0119	0.0595	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0213	0.0221
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.005	0.0176	0.0182
Brugia malayi	hypothetical protein	0.0063	0.0254	0.0263
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0039	0.0041
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0119	0.0595	0.0617
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0176	0.0176
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0119	0.0595	0.0617
Brugia malayi	nuclear hormone receptor family member odr-7	0.0056	0.0213	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0254	0.0263
Echinococcus granulosus	tar DNA binding protein	0.0069	0.0292	0.0292
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0119	0.0595	0.0595
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0119	0.0595	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0213	0.0221
Brugia malayi	nuclear receptor NHR-67	0.0056	0.0213	0.0221
Brugia malayi	nuclear receptor NHR-88	0.0119	0.0595	0.0617
Schistosoma mansoni	coup transcription factor	0.0119	0.0595	0.0595
Echinococcus multilocularis	flap endonuclease 1	0.0028	0.0045	0.0046
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0176	0.0176
Brugia malayi	Nuclear hormone receptor-like 1	0.0119	0.0595	0.0617
Brugia malayi	nuclear receptor RXR	0.0056	0.0213	0.0221
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0119	0.0595	1
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0063	0.0254	0.0263

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= -13 mmHg	Hypotensive activity in concious rat 24 hr after 5 mg/kg p.o. administration.	ChEMBL.	3941407
Activity (functional)	= -10 mmHg	Hypotensive activity in concious rat 4 hr after 5 mg/kg p.o. administration.	ChEMBL.	3941407
Activity (functional)	= -1 mmHg	Compound was tested for hypotensive activity by measuring the average change in mean arterial blood pressure in mmHg after 4 hr at 0.5 mg/Kg oral dosing of a conscious rat	ChEMBL.	3941407
Activity (functional)	= 0 mmHg	Compound was tested for hypotensive activity by measuring the average change in mean arterial blood pressure in mmHg after 24 hr at 0.5 mg/Kg oral dosing of a conscious rat	ChEMBL.	3941407

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL287625
PubChem: 13544867

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 38038