Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AP (functional) | = 34.5 uM | Average potency against P388 cells | ChEMBL. | 10212121 |
AP (functional) | = 34.5 uM | Average potency against P388 cells | ChEMBL. | 10212121 |
AP (functional) | = 136 uM | Average potency against CEM cells | ChEMBL. | 10212121 |
AP (functional) | = 136 uM | Average potency against CEM cells | ChEMBL. | 10212121 |
AP (functional) | = 186 uM | Average potency against Molt4/C8cells | ChEMBL. | 10212121 |
AP (functional) | = 186 uM | Average potency against Molt4/C8cells | ChEMBL. | 10212121 |
AP (functional) | = 227 uM | Average potency against L1210 cells | ChEMBL. | 10212121 |
AP (functional) | = 227 uM | Average potency against L1210 cells | ChEMBL. | 10212121 |
GI50 (functional) | -4.739 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.347 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | > 50 uM | Inhibitory activity was tested against P388 cells | ChEMBL. | 10212121 |
IC50 (functional) | > 50 uM | Inhibitory activity was tested against P388 cells | ChEMBL. | 10212121 |
IC50 (functional) | = 110 uM | Inhibitory activity was tested against CEM cells | ChEMBL. | 10212121 |
IC50 (functional) | = 110 uM | Inhibitory activity was tested against CEM cells | ChEMBL. | 10212121 |
IC50 (functional) | = 215 uM | Inhibitory activity was tested against Molt4/C8 cells | ChEMBL. | 10212121 |
IC50 (functional) | = 215 uM | Inhibitory activity was tested against Molt4/C8 cells | ChEMBL. | 10212121 |
IC50 (functional) | = 261 uM | Inhibitory activity was tested against L1210 cells | ChEMBL. | 10212121 |
IC50 (functional) | = 261 uM | Inhibitory activity was tested against L1210 cells | ChEMBL. | 10212121 |
MG MID (functional) | = 91.2 uM | Tested against human tumor cell lines, mean graph mid point values(MG MID) are determined. | ChEMBL. | 10212121 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.