Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Cytochrome P450 19A1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | cytochrome P450 family protein | Cytochrome P450 19A1 | 508 aa | 450 aa | 21.1 % |
Drosophila melanogaster | Cytochrome P450-4d1 | Cytochrome P450 19A1 | 508 aa | 464 aa | 24.6 % |
Dictyostelium discoideum | cytochrome P450 family protein | Cytochrome P450 19A1 | 508 aa | 465 aa | 21.5 % |
Brugia malayi | Cytochrome P450 family protein | Cytochrome P450 19A1 | 508 aa | 448 aa | 20.8 % |
Dictyostelium discoideum | cytochrome P450 family protein | Cytochrome P450 19A1 | 508 aa | 473 aa | 18.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.19559 | 1 | 0.5 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.19559 | 1 | 0.5 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.19559 | 1 | 0.5 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.19559 | 1 | 0.5 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.19559 | 1 | 1 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.19559 | 1 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.155181 | 0.51354 | 0.51354 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.19559 | 1 | 0.5 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.19559 | 1 | 1 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.19559 | 1 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.19559 | 1 | 0.5 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.149328 | 0.443075 | 0.443075 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 0.055 uM | In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome | ChEMBL. | 2296032 |
EC50 (binding) | = 0.055 uM | In vitro inhibition of cytochrome P450 19A1 by rat ovarian microsomes incubated with [3H]-androstenedione and NADPH-generating system. | ChEMBL. | 3612685 |
EC50 (binding) | = 0.055 uM | In vitro Cytochrome P450 19A1 inhibition concentration to decrease aromatization of androstenedione in rat ovarian microsome | ChEMBL. | 2296032 |
EC50 (binding) | = 0.055 uM | In vitro inhibition of cytochrome P450 19A1 by rat ovarian microsomes incubated with [3H]-androstenedione and NADPH-generating system. | ChEMBL. | 3612685 |
GI50 (functional) | -4.925 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.88 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.849 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.799 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.758 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.735 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.717 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.64 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | = 0.6825 uM | DNDI: Inhibition of Chagas Disease parasite Trypanosoma cruzi (Tulahuen LacZ, Clone C4), in vitro. | ChEMBL. | No reference |
IC50 (functional) | = 0.683 uM | Antitrypanosomal activity against trypomastigotes of Trypanosoma cruzi Tulahuen expressing the beta- galactosidase gene infected rat L6 cells after 96 hrs | ChEMBL. | 22536986 |
IC90 (functional) | = 6.78 uM | DNDI: Inhibition of Chagas Disease parasite Trypanosoma cruzi (Tulahuen LacZ, Clone C4), in vitro. | ChEMBL. | No reference |
Ki (binding) | = 29 nM | Binding affinity for Cytochrome P450 19A1 | ChEMBL. | 2231592 |
Ki (binding) | = 29 nM | Binding affinity for Cytochrome P450 19A1 | ChEMBL. | 2231592 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma cruzi | ChEMBL23 | 22536986 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.