Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | CHE-14 protein | 0.0748 | 0.3777 | 0.3777 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0852 | 0.4385 | 0.5 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0748 | 0.3777 | 0.3777 |
Loa Loa (eye worm) | hypothetical protein | 0.0748 | 0.3777 | 0.3777 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0748 | 0.3777 | 0.3777 |
Echinococcus multilocularis | protein patched | 0.0748 | 0.3777 | 0.3777 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1816 | 1 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0852 | 0.4385 | 1 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.1816 | 1 | 0.5 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1816 | 1 | 0.5 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0748 | 0.3777 | 0.3777 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0852 | 0.4385 | 1 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0748 | 0.3777 | 0.3777 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0852 | 0.4385 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.0748 | 0.3777 | 0.3777 |
Schistosoma mansoni | patched 1 | 0.0748 | 0.3777 | 0.3777 |
Loa Loa (eye worm) | hypothetical protein | 0.1816 | 1 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0748 | 0.3777 | 0.3777 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.1816 | 1 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0748 | 0.3777 | 0.3777 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0748 | 0.3777 | 0.3777 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.1816 | 1 | 1 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.1816 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1816 | 1 | 0.5 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1816 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
T1/2 (ADMET) | > 150 min | t1/2 in monkey liver microsomes | ChEMBL. | 7731021 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.