Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
LD50 (ADMET) | = 0.57 mM kg-1 | LD50 value determined intramuscularly in mouse | ChEMBL. | 2016711 |
LD50 (ADMET) | = 0.5700000000000001 mM kg-1 | LD50 value determined intramuscularly in mouse | ChEMBL. | 2016711 |
logD (ADMET) | = -3.3 | Partition coefficient (logD7.4) | ChEMBL. | 2016711 |
Survival (functional) | = 0 | antidotal activity of the compound was measured against tabun in mice and activity expressed as the no. of survivors noted at 24 h out of population of 10 mice each exposed intramuscularly at the dose 1/64 of 2LD50 of the compound | ChEMBL. | 2016711 |
Survival (functional) | = 0 | antidotal activity of the compound was measured against tabun in mice and activity expressed as the no. of survivors noted at 24 h out of population of 10 mice each exposed intramuscularly at the dose 1/16 of 2LD50 of the compound | ChEMBL. | 2016711 |
Survival (functional) | = 1 | antidotal activity of the compound was measured against tabun in mice and activity expressed as the no. of survivors noted at 24 h out of population of 10 mice each exposed intramuscularly at the dose 1/4 of 2LD50 of the compound | ChEMBL. | 2016711 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.