TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 431.275 | Formula: C19H16Cl2N6O2
H donors: 2 H acceptors: 4 LogP: 4.74 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CC(Oc1c2cc(Cl)c(cc2n(c1C(=O)Nc1nn[nH]n1)c1ccccc1)Cl)C
InChi: 1S/C19H16Cl2N6O2/c1-10(2)29-17-12-8-13(20)14(21)9-15(12)27(11-6-4-3-5-7-11)16(17)18(28)22-19-23-25-26-24-19/h3-10H,1-2H3,(H2,22,23,24,25,26,28)
InChiKey: XWLUYKVULONOCC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	chromobox protein 1	0.0069	0.1496	0.1496
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0067	0.1461	0.1461
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0166	0.4667	0.558
Entamoeba histolytica	alkyl sulfatase, putative	0.0034	0.0371	0.0978
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0371	0.0148
Leishmania major	alpha glucosidase II subunit, putative	0.0037	0.0473	0.0347
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.02	0.5742	0.688
Echinococcus multilocularis	GPCR, family 2	0.0063	0.1322	0.1322
Loa Loa (eye worm)	glutaminase 2	0.0279	0.8321	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0039	0.0528	0.1461
Trichomonas vaginalis	glucosylceramidase, putative	0.0269	0.7989	0.9598
Echinococcus granulosus	tumor protein p63	0.0326	0.9847	0.9847
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0521	0.0565
Schistosoma mansoni	hypothetical protein	0.0034	0.0371	0.0371
Trypanosoma cruzi	metallo-beta-lactamase superfamily, putative	0.0034	0.0371	0.0978
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0063	0.1322	0.1322
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0146	0.3999	0.3999
Echinococcus granulosus	lysosomal alpha glucosidase	0.0166	0.4667	0.4667
Mycobacterium tuberculosis	Probable oxidoreductase	0.0098	0.245	0.5367
Entamoeba histolytica	metallo-beta-lactamase family protein	0.0034	0.0371	0.0978
Trypanosoma cruzi	PAB1-binding protein , putative	0.005	0.089	0.2576
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0371	0.0384
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0269	0.7989	0.9588
Brugia malayi	Calcitonin receptor-like protein seb-1	0.02	0.5742	0.688
Trypanosoma cruzi	hydroxyacylglutathione hydrolase, putative	0.0034	0.0371	0.0978
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0124	0.3301	0.3301
Onchocerca volvulus	Glucosylceramidase homolog	0.0177	0.4993	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0473	0.1291
Schistosoma mansoni	hypothetical protein	0.0063	0.1322	0.1322
Schistosoma mansoni	zinc phosphodiesterase	0.0034	0.0371	0.0371
Brugia malayi	hypothetical protein	0.0034	0.0371	0.0384
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0098	0.245	0.5367
Echinococcus multilocularis	tar DNA binding protein	0.0267	0.7919	0.7919
Brugia malayi	glutathione reductase	0.0039	0.0528	0.0574
Echinococcus granulosus	tar DNA binding protein	0.0267	0.7919	0.7919
Echinococcus granulosus	thioredoxin glutathione reductase	0.0039	0.0545	0.0545
Echinococcus granulosus	transcription factor Dp 1	0.0039	0.0541	0.0541
Leishmania major	hypothetical protein, conserved	0.005	0.089	0.1771
Entamoeba histolytica	hypothetical protein, conserved	0.0034	0.0371	0.0978
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0371	0.0384
Trypanosoma brucei	cleavage and polyadenylation specificity factor subunit, putative	0.0034	0.0371	0.0978
Entamoeba histolytica	type A flavoprotein, putative	0.0034	0.0371	0.0978
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0037	0.0473	0.0507
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0615	0.0679
Schistosoma mansoni	ets-related	0.0225	0.6551	0.6551
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1322	0.1326
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0035	0.0421	0.0421
Brugia malayi	follicle stimulating hormone receptor	0.0262	0.7755	0.9315
Mycobacterium tuberculosis	Probable conserved lipoprotein LpqF	0.0074	0.1661	0.3331
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0157	0.0126
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0088	0.2131	0.4544
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0037	0.0473	0.1291
Trichomonas vaginalis	glucosylceramidase, putative	0.0177	0.4993	0.5974
Echinococcus multilocularis	GA binding protein alpha chain	0.0074	0.1672	0.1672
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0371	0.0148
Schistosoma mansoni	hypothetical protein	0.0034	0.0371	0.0371
Leishmania major	eukaryotic initiation factor 4a, putative	0.0124	0.3301	1
Entamoeba histolytica	type A flavoprotein, putative	0.0034	0.0371	0.0978
Echinococcus granulosus	eukaryotic initiation factor 4A	0.0124	0.3301	0.3301
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0024	0.0053	0.0053
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0146	0.3999	0.3999
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0037	0.0473	0.1291
Mycobacterium tuberculosis	Class a beta-lactamase BlaC	0.0153	0.4245	1
Brugia malayi	Heterochromatin protein 1	0.0069	0.1496	0.1745
Onchocerca volvulus		0.0034	0.0371	0.0251
Echinococcus granulosus	chromobox protein 1	0.0069	0.1496	0.1496
Plasmodium vivax	glutathione reductase, putative	0.0039	0.0528	0.0536
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0063	0.1322	0.1322
Echinococcus granulosus	GA binding protein alpha chain	0.0074	0.1672	0.1672
Trypanosoma cruzi	glyoxalase II	0.0034	0.0371	0.0978
Schistosoma mansoni	alpha glucosidase	0.0037	0.0473	0.0473
Brugia malayi	hypothetical protein	0.0032	0.0318	0.032
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0037	0.0473	0.1291
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1325	0.133
Echinococcus granulosus	metallo beta lactamase domain containing protein	0.0034	0.0371	0.0371
Trypanosoma brucei	hydroxyacylglutathione hydrolase, putative	0.0034	0.0371	0.0978
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0035	0.0421	0.0421
Loa Loa (eye worm)	RNA binding protein	0.0267	0.7919	0.9501
Echinococcus granulosus	metallo beta lactamase domain containing protein	0.0034	0.0371	0.0371
Schistosoma mansoni	zinc phosphodiesterase	0.0034	0.0371	0.0371
Loa Loa (eye worm)	fli-1 protein	0.0225	0.6551	0.7806
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0146	0.3999	0.3999
Trichomonas vaginalis	chromobox protein, putative	0.0069	0.1496	0.1745
Brugia malayi	MH2 domain containing protein	0.0279	0.8311	0.9987
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0039	0.0545	0.0545
Toxoplasma gondii	hydroxyacylglutathione hydrolase	0.0034	0.0371	0.0978
Schistosoma mansoni	gabp alpha	0.0074	0.1672	0.1672
Trichomonas vaginalis	glucosylceramidase, putative	0.0269	0.7989	0.9598
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0098	0.245	1
Brugia malayi	chromobox protein homolog 3	0.0038	0.0521	0.0565
Plasmodium vivax	RNA helicase-1, putative	0.0124	0.3301	1
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0037	0.0473	0.0507
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0166	0.4667	0.4667
Echinococcus multilocularis	geminin	0.0331	1	1
Echinococcus granulosus	hydroxyacylglutathione hydrolase	0.0034	0.0371	0.0371
Loa Loa (eye worm)	hypothetical protein	0.0124	0.3301	0.3778
Brugia malayi	metallo-beta-lactamase superfamily protein	0.0034	0.0371	0.0384
Trichomonas vaginalis	glucosylceramidase, putative	0.0269	0.7989	0.9598
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0146	0.3999	0.4644
Trichomonas vaginalis	glucosylceramidase, putative	0.0177	0.4993	0.5974
Brugia malayi	Bromodomain containing protein	0.0038	0.0497	0.0536
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0067	0.1461	0.1461
Trypanosoma brucei	trypanothione reductase	0.0039	0.0528	0.1461
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0371	0.0384
Echinococcus granulosus	eukaryotic initiation factor 4A III	0.0124	0.3301	0.3301
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0088	0.2131	0.4544
Echinococcus multilocularis	metallo beta lactamase domain containing protein	0.0034	0.0371	0.0371
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0067	0.1461	0.4333
Toxoplasma gondii	eukaryotic initiation factor-4A, putative	0.0124	0.3301	1
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0037	0.0473	0.0507
Brugia malayi	Ets-domain containing protein	0.0074	0.1672	0.1958
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0098	0.245	0.5367
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0473	0.1291
Trichomonas vaginalis	glucosylceramidase, putative	0.0177	0.4993	0.5974
Plasmodium falciparum	ataxin-2 like protein, putative	0.005	0.089	0.1771
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0166	0.4667	0.5472
Loa Loa (eye worm)	hypothetical protein	0.007	0.153	0.1584
Schistosoma mansoni	hypothetical protein	0.0136	0.3696	0.3696
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0371	0.0148
Trichomonas vaginalis	glucosylceramidase, putative	0.0186	0.5301	0.6347
Loa Loa (eye worm)	glutaminase	0.0279	0.8321	1
Entamoeba histolytica	metallo-beta-lactamase superfamily protein	0.0034	0.0371	0.0978
Trichomonas vaginalis	beta lactamase domain, putative	0.0034	0.0371	0.0384
Echinococcus multilocularis	ETHE1 protein	0.0034	0.0371	0.0371
Trichomonas vaginalis	disulfide oxidoreductase, putative	0.0037	0.0486	0.0523
Loa Loa (eye worm)	hypothetical protein	0.0136	0.3696	0.4268
Mycobacterium tuberculosis	Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog)	0.0124	0.3301	0.7562
Loa Loa (eye worm)	hypothetical protein	0.02	0.5742	0.6803
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0146	0.3999	0.4773
Echinococcus granulosus	neutral alpha glucosidase AB	0.0037	0.0473	0.0473
Echinococcus multilocularis	transcription factor Dp 1	0.0039	0.0541	0.0541
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0371	0.0384
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0067	0.1461	0.4333
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0157	0.0126
Loa Loa (eye worm)	hypothetical protein	0.004	0.0574	0.04
Schistosoma mansoni	hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II)	0.0034	0.0371	0.0371
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0499	0.0306
Loa Loa (eye worm)	transcription factor SMAD2	0.0279	0.8311	0.9987
Onchocerca volvulus	Eukaryotic initiation factor 4A homolog	0.0124	0.3301	0.643
Echinococcus granulosus	GPCR family 2	0.0063	0.1322	0.1322
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0063	0.1322	0.1326
Schistosoma mansoni	tar DNA-binding protein	0.0267	0.7919	0.7919
Loa Loa (eye worm)	hydroxyacylglutathione hydrolase cytoplasmic	0.0034	0.0371	0.0148
Brugia malayi	Bromodomain containing protein	0.0074	0.1666	0.195
Echinococcus granulosus	chromobox protein 1	0.0069	0.1496	0.1496
Loa Loa (eye worm)	heterochromatin protein 1	0.0069	0.1496	0.1542
Trichomonas vaginalis	beta lactamase domain, putative	0.0034	0.0371	0.0384
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0124	0.3301	0.3301
Brugia malayi	hypothetical protein	0.0149	0.4111	0.4908
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0124	0.3301	0.3927
Entamoeba histolytica	alkyl sulfatase, putative	0.0034	0.0371	0.0978
Giardia lamblia	Translation initiation factor eIF-4A, putative	0.0124	0.3301	1
Trichomonas vaginalis	beta lactamase domain, putative	0.0034	0.0371	0.0384
Brugia malayi	TAR-binding protein	0.0267	0.7919	0.9513
Brugia malayi	Ets-domain containing protein	0.0074	0.1672	0.1958
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0262	0.7755	0.9298
Onchocerca volvulus	Putative hydrolase PNKD	0.0034	0.0371	0.0251
Trichomonas vaginalis	apoptosis inducing factor, putative	0.0037	0.0486	0.0523
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0088	0.2131	0.4544
Trypanosoma brucei	PAB1-binding protein , putative	0.005	0.089	0.2576
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0824	0.0708
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0146	0.3999	0.3999
Schistosoma mansoni	hypothetical protein	0.0331	1	1
Echinococcus multilocularis	chromobox protein 1	0.0069	0.1496	0.1496
Toxoplasma gondii	LsmAD domain-containing protein	0.005	0.089	0.2576
Leishmania major	eukaryotic initiation factor 4a, putative	0.0124	0.3301	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0059	0.1179	0.1179
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0635	0.0475
Schistosoma mansoni	hypothetical protein	0.0034	0.0371	0.0371
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.0824	0.0824
Loa Loa (eye worm)	glutathione reductase	0.0039	0.0528	0.0342
Plasmodium falciparum	thioredoxin reductase	0.0039	0.0528	0.0536
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0067	0.1461	0.1498
Schistosoma mansoni	glutaminase	0.0279	0.8321	0.8321
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0146	0.3999	0.3999
Trypanosoma brucei	glucosidase, putative	0.0037	0.0473	0.1291
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0521	0.0333
Trichomonas vaginalis	glucosylceramidase, putative	0.0177	0.4993	0.5974
Mycobacterium ulcerans	glutaminase	0.0279	0.8321	1
Plasmodium falciparum	glutathione reductase	0.0039	0.0528	0.0536
Schistosoma mansoni	alpha-glucosidase	0.0143	0.3916	0.3916
Toxoplasma gondii	thioredoxin reductase	0.0039	0.0528	0.1461
Schistosoma mansoni	hypothetical protein	0.0063	0.1322	0.1322
Loa Loa (eye worm)	MH2 domain-containing protein	0.0279	0.8311	0.9987
Brugia malayi	RNA recognition motif domain containing protein	0.0267	0.7919	0.9513
Schistosoma mansoni	tar DNA-binding protein	0.0267	0.7919	0.7919
Schistosoma mansoni	hypothetical protein	0.0063	0.1322	0.1322
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0037	0.0473	0.0507
Trichomonas vaginalis	beta lactamase domain, putative	0.0034	0.0371	0.0384
Brugia malayi	Latrophilin receptor protein 2	0.0063	0.1322	0.1534
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0063	0.1322	0.1322
Chlamydia trachomatis	ribonuclease Z	0.0034	0.0371	0.5
Echinococcus multilocularis	eukaryotic initiation factor 4A III	0.0124	0.3301	0.3301
Mycobacterium tuberculosis	Probable dehydrogenase	0.0088	0.2131	0.4544
Echinococcus multilocularis	eukaryotic initiation factor 4A	0.0124	0.3301	0.3301
Entamoeba histolytica	metallo-beta-lactamase family protein	0.0034	0.0371	0.0978
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0037	0.0473	0.0507
Onchocerca volvulus		0.0034	0.0371	0.0251
Toxoplasma gondii	metallo-beta-lactamase domain-containing protein	0.0034	0.0371	0.0978
Brugia malayi	Thioredoxin reductase	0.0039	0.0528	0.0574
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0269	0.7989	0.9598
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0088	0.2131	0.4544
Mycobacterium leprae	PROBABLE CONSERVED LIPOPROTEIN LPQF	0.0074	0.1661	0.6206
Trichomonas vaginalis	chromobox protein, putative	0.0069	0.1496	0.1745
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0267	0.7919	0.9501
Trichomonas vaginalis	glucosylceramidase, putative	0.0269	0.7989	0.9598
Trypanosoma cruzi	metallo-beta-lactamase superfamily, putative	0.0034	0.0371	0.0978
Trypanosoma brucei	beta lactamase	0.0074	0.1661	0.4952
Schistosoma mansoni	hypothetical protein	0.0331	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0521	0.0565
Trypanosoma cruzi	metallo-beta-lactamase-like protein, putative	0.0034	0.0371	0.0978
Onchocerca volvulus	Hydroxyacylglutathione hydrolase, mitochondrial homolog	0.0034	0.0371	0.0251
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0067	0.1461	0.4333
Trypanosoma cruzi	glyoxalase II	0.0034	0.0371	0.0978
Loa Loa (eye worm)	metallo-beta-lactamase superfamily protein	0.0034	0.0371	0.0148
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0039	0.0528	0.0405
Echinococcus multilocularis	serine protein kinase ATM	0.0024	0.0053	0.0053
Onchocerca volvulus		0.0096	0.2394	0.4519
Schistosoma mansoni	chromobox protein	0.0069	0.1496	0.1496
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0371	0.0148
Plasmodium falciparum	ataxin-2 like protein, putative	0.005	0.089	0.1771
Schistosoma mansoni	tar DNA-binding protein	0.0267	0.7919	0.7919
Mycobacterium tuberculosis	Probable reductase	0.0088	0.2131	0.4544
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0615	0.0679
Leishmania major	trypanothione reductase	0.0039	0.0528	0.0536
Trypanosoma brucei	glyoxalase II	0.0034	0.0371	0.0978
Schistosoma mansoni	tar DNA-binding protein	0.0267	0.7919	0.7919
Echinococcus granulosus	serine protein kinase ATM	0.0024	0.0053	0.0053
Entamoeba histolytica	metallo-beta-lactamase superfamily protein	0.0034	0.0371	0.0978
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0473	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0149	0.4111	0.4782
Loa Loa (eye worm)	hydroxyacylglutathione hydrolase	0.0034	0.0371	0.0148
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0146	0.3999	0.3999
Schistosoma mansoni	chromobox protein	0.0069	0.1496	0.1496
Echinococcus granulosus	ETHE1 protein	0.0034	0.0371	0.0371
Loa Loa (eye worm)	hypothetical protein	0.005	0.089	0.0791
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0088	0.2131	0.8468
Wolbachia endosymbiont of Brugia malayi	metallo-beta-lactamase superfamily hydrolase	0.0034	0.0371	0.5
Trichomonas vaginalis	glucosylceramidase, putative	0.0186	0.5301	0.6347
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0074	0.1672	0.176
Trypanosoma cruzi	glyoxalase II	0.0034	0.0371	0.0978
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0037	0.0473	0.0473
Trichomonas vaginalis	glucosylceramidase, putative	0.0177	0.4993	0.5974
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0473	0.0507
Trichomonas vaginalis	beta lactamase domain, putative	0.0034	0.0371	0.0384
Brugia malayi	RNA binding protein	0.0267	0.7919	0.9513
Plasmodium vivax	ataxin-2 like protein, putative	0.005	0.089	0.1771
Plasmodium vivax	thioredoxin reductase, putative	0.0039	0.0528	0.0536
Brugia malayi	glutaminase DH11.1	0.0279	0.8321	1
Schistosoma mansoni	alpha-glucosidase	0.0143	0.3916	0.3916
Mycobacterium ulcerans	class a beta-lactamase, BlaC	0.0153	0.4245	0.4873
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0473	0.0507
Schistosoma mansoni	hypothetical protein	0.0063	0.1322	0.1322
Entamoeba histolytica	DEAD/DEAH box helicase, putative	0.0124	0.3301	1
Echinococcus multilocularis	metallo beta lactamase domain containing protein	0.0034	0.0371	0.0371
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0063	0.1322	0.1534
Trichomonas vaginalis	glucosylceramidase, putative	0.0177	0.4993	0.5974
Echinococcus granulosus	zinc phosphodiesterase	0.0034	0.0371	0.0371
Schistosoma mansoni	bromodomain containing protein	0.0062	0.1293	0.1293
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0038	0.0521	0.0567
Trichomonas vaginalis	glutaminase, putative	0.0279	0.8321	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0269	0.7989	0.9598
Trichomonas vaginalis	beta lactamase domain, putative	0.0034	0.0371	0.0384
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0166	0.4667	0.4667
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0371	0.0384
Brugia malayi	eukaryotic initiation factor 4A	0.0124	0.3301	0.3927
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0037	0.0473	0.0273
Trypanosoma cruzi	PAB1-binding protein , putative	0.005	0.089	0.2576
Plasmodium falciparum	eukaryotic initiation factor 4A	0.0124	0.3301	1
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0615	0.0766
Trichomonas vaginalis	glucosylceramidase, putative	0.0269	0.7989	0.9598
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0067	0.1461	0.3719
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0067	0.1461	0.1461
Brugia malayi	metallo-beta-lactamase superfamily protein	0.0034	0.0371	0.0384
Onchocerca volvulus		0.0149	0.4111	0.8139
Brugia malayi	hypothetical protein	0.005	0.089	0.1012
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0059	0.1179	0.1179
Trichomonas vaginalis	A-type flavoprotein	0.0034	0.0371	0.0384
Echinococcus multilocularis	zinc phosphodiesterase	0.0034	0.0371	0.0371
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0067	0.1461	0.4333
Brugia malayi	latrophilin 2 splice variant baaae	0.0136	0.3696	0.4406
Onchocerca volvulus		0.0048	0.0824	0.1206
Trypanosoma cruzi	hydroxyacylglutathione hydrolase, putative	0.0034	0.0371	0.0978
Loa Loa (eye worm)	thioredoxin reductase	0.0039	0.0528	0.0342
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0063	0.1322	0.1322
Treponema pallidum	ATP-dependent RNA helicase	0.0124	0.3301	1
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0124	0.3301	1
Brugia malayi	Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site.	0.0034	0.0371	0.0384
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0124	0.3301	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0473	0.0507
Loa Loa (eye worm)	TAR-binding protein	0.0267	0.7919	0.9501
Trypanosoma cruzi	metallo-beta-lactamase-like protein, putative	0.0034	0.0371	0.0978
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0067	0.1461	0.1702
Brugia malayi	Fli-1 protein	0.0225	0.6551	0.7859
Echinococcus multilocularis	tumor protein p63	0.0326	0.9847	0.9847
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0473	0.0507
Brugia malayi	PHD-finger family protein	0.0025	0.007	0.002
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0124	0.3301	0.3927
Trypanosoma brucei	metallo-beta-lactamase-like protein, putative	0.0034	0.0371	0.0978
Entamoeba histolytica	metallo-beta-lactamase family protein	0.0034	0.0371	0.0978
Trypanosoma brucei	Eukaryotic initiation factor 4A-1	0.0124	0.3301	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0146	0.3999	0.3999
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.02	0.5742	0.6803
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0124	0.3301	0.3927
Brugia malayi	ethe1-prov protein	0.0034	0.0371	0.0384
Echinococcus multilocularis	hydroxyacylglutathione hydrolase	0.0034	0.0371	0.0371
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0371	0.0384
Trichomonas vaginalis	glucosylceramidase, putative	0.0177	0.4993	0.5974
Schistosoma mansoni	tar DNA-binding protein	0.0267	0.7919	0.7919
Mycobacterium ulcerans	lipoprotein LpqF	0.0074	0.1661	0.1623

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	= 40 %	Inhibition of anti-IgE antibody-stimulated histamine release in human basophills at 10 microM	ChEMBL.	2470904
Inhibition (functional)	= 40 %	Inhibition of anti-IgE antibody-stimulated histamine release in human basophills at 10 microM	ChEMBL.	2470904
Inhibition (functional)	= 84 %	Inhibition of anti-IgE antibody-stimulated histamine release in human basophills at 33 microM	ChEMBL.	2470904
Inhibition (functional)	= 84 %	Inhibition of anti-IgE antibody-stimulated histamine release in human basophills at 33 microM	ChEMBL.	2470904

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL29720

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 38210