Detailed information for compound 38223

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 219.237 | Formula: C12H13NO3
  • H donors: 1 H acceptors: 2 LogP: 2.42 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2cc(O)nc(c2c(c1)OC)C
  • InChi: 1S/C12H13NO3/c1-7-12-8(5-11(14)13-7)4-9(15-2)6-10(12)16-3/h4-6H,1-3H3,(H,13,14)
  • InChiKey: AZWXDYGXDBZITB-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0069 0.0831 0.7149
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0162 0.0161
Loa Loa (eye worm) hypothetical protein 0.0124 0.1588 0.1588
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0011 0.0009
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0069 0.0831 0.1969
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0146 0.1885 1
Echinococcus granulosus acetylcholinesterase 0.0736 1 1
Onchocerca volvulus 0.004 0.0421 0.2601
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0069 0.0831 0.0827
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.004 0.0421 0.3538
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0162 0.0161
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0124 0.1588 0.3895
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0045 0.0502 0.1132
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0011 0.0007
Echinococcus multilocularis neuroligin 0.0124 0.1588 0.1586
Trichomonas vaginalis sentrin/sumo-specific protease, senp8, putative 0.004 0.0421 0.0927
Echinococcus granulosus sentrin specific protease 1 0.004 0.0421 0.0419
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0734 0.073
Trypanosoma cruzi serine/threonine protein phosphatase type 5, putative 0.0023 0.0196 0.1528
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0011 0.0011
Echinococcus multilocularis acetylcholinesterase 0.0736 1 1
Loa Loa (eye worm) hypothetical protein 0.0124 0.1588 0.1588
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0048 0.0536 0.0536
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0162 0.0161
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0069 0.0831 0.1969
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0162 0.0159
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0146 0.1885 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0162 0.0161
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0011
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0069 0.0831 0.7149
Echinococcus multilocularis sentrin specific protease 1 0.004 0.0421 0.0419
Brugia malayi nuclear receptor NHR-88 0.0021 0.0162 0.0161
Brugia malayi nuclear hormone receptor 0.001 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0011
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0162 0.0159
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0162 0.0157
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0162 0.0159
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0011
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0069 0.0831 0.1969
Schistosoma mansoni fructose 16-bisphosphate aldolase 0.0093 0.1154 0.1151
Brugia malayi hypothetical protein 0.0124 0.1588 0.1587
Schistosoma mansoni hypothetical protein 0.0129 0.1647 0.1644
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0094 0.1174 0.2841
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0069 0.0831 0.6681
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0027 0.0027
Schistosoma mansoni neuroligin 3 (S09 family) 0.0124 0.1588 0.1584
Brugia malayi nuclear receptor RXR 0.0011 0.0027 0.0027
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3986 1
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0069 0.0831 0.1969
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0027
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0011 0.0009
Echinococcus granulosus fructose bisphosphate aldolase class I 0.0093 0.1154 0.1152
Toxoplasma gondii fructose-1,6-bisphosphate aldolase 0.0093 0.1154 1
Loa Loa (eye worm) Ulp1 protease 0.0094 0.1174 0.1174
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0336 0.2783
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0336 0.2783
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.004 0.0421 0.0927
Loa Loa (eye worm) hypothetical protein 0.0021 0.0162 0.0162
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0045 0.0502 0.0502
Brugia malayi Carboxylesterase family protein 0.0124 0.1588 0.1587
Schistosoma mansoni cpg binding protein 0.0031 0.0304 0.03
Echinococcus granulosus cpg binding protein 0.0031 0.0304 0.0302
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0011 0.0011
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0094 0.1174 0.2841
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0124 0.1588 0.1586
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0129 0.1647 0.1645
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0069 0.0831 0.0827
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0045 0.0502 0.0502
Onchocerca volvulus 0.0124 0.1588 1
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0069 0.0831 0.0829
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3986 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0162 0.0162
Onchocerca volvulus 0.0021 0.0162 0.0952
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3986 1
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0069 0.0831 0.0829
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0124 0.1588 0.8231
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3986 1
Loa Loa (eye worm) fructose-bisphosphate aldolase 1 0.0093 0.1154 0.1154
Toxoplasma gondii fructose-1,6-bisphosphate aldolase 0.0093 0.1154 1
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0045 0.0502 0.05
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0069 0.0831 0.703
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0011
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0162 0.0159
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.004 0.0421 0.0421
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0069 0.0831 0.1969
Loa Loa (eye worm) Ulp1 protease 0.004 0.0421 0.0421
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0045 0.0502 0.4175
Schistosoma mansoni fructose 16-bisphosphate aldolase 0.0093 0.1154 0.1151
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.004 0.0421 0.0927
Onchocerca volvulus 0.0124 0.1588 1
Trichomonas vaginalis rotamase, putative 0.0034 0.0347 0.0737
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0011
Treponema pallidum fructose-bisphosphate aldolase 0.0299 0.3986 1
Loa Loa (eye worm) acetylcholinesterase 1 0.0736 1 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0162 0.0162
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0011 0.0011
Trichomonas vaginalis rotamase, putative 0.0033 0.0336 0.0709
Loa Loa (eye worm) hypothetical protein 0.0021 0.0162 0.0162
Echinococcus multilocularis cpg binding protein 0.0031 0.0304 0.0302
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0027 0.0027
Loa Loa (eye worm) protein phosphatase 5 0.0022 0.0176 0.0176
Loa Loa (eye worm) hypothetical protein 0.0124 0.1588 0.1588
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0045 0.0502 0.05
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0069 0.0831 0.703
Loa Loa (eye worm) hypothetical protein 0.0021 0.0162 0.0162
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0162 0.0161
Schistosoma mansoni nuclear hormone receptor 0.001 0.0011 0.0007
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0093 0.1154 0.9834
Loa Loa (eye worm) fructose-bisphosphate aldolase 2 0.0093 0.1154 0.1154
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0162 0.0952
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0011 0.0011
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0162 0.0159
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0069 0.0831 0.0827
Loa Loa (eye worm) hypothetical protein 0.0021 0.0162 0.0162
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.004 0.0421 0.0927
Loa Loa (eye worm) hypothetical protein 0.004 0.0421 0.0421
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0162 0.0157
Brugia malayi hypothetical protein 0.001 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0021 0.0162 0.0162
Toxoplasma gondii fructose-bisphosphate aldolase, putative 0.0093 0.1154 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0642 0.5485
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0177 0.2317 0.2314
Brugia malayi fructose-bisphosphate aldolase 1 0.0093 0.1154 0.1154
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0045 0.0502 0.4245
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0347 0.0346
Loa Loa (eye worm) hypothetical protein 0.0736 1 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0421 0.0421
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0124 0.1588 0.1586
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0162 0.0161
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0027
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0027 0.0023
Trypanosoma brucei serine/threonine protein phosphatase 5 0.0023 0.0196 0.1554
Trypanosoma cruzi serine/threonine protein phosphatase type 5, putative 0.0023 0.0196 0.1528
Trichomonas vaginalis Sentrin-specific protease, putative 0.0094 0.1174 0.2841
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0162 0.0157
Loa Loa (eye worm) hypothetical protein 0.0124 0.1588 0.1588
Brugia malayi ecdysone receptor 0.001 0.0011 0.0011
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0069 0.0831 0.1969
Schistosoma mansoni hypothetical protein 0.0418 0.5628 0.5626
Loa Loa (eye worm) carboxylesterase 0.0736 1 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0162 0.0952
Schistosoma mansoni zinc finger protein 0.001 0.0011 0.0007
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0094 0.1174 0.2841
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0093 0.1154 0.1152
Brugia malayi nuclear receptor NHR-67 0.001 0.0011 0.0011
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0021 0.0173 0.1324
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0124 0.1588 0.1584
Brugia malayi Nuclear hormone receptor E75 0.001 0.0011 0.0011
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.004 0.0421 0.0927
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0093 0.1154 0.1152
Loa Loa (eye worm) hypothetical protein 0.004 0.0421 0.0421
Leishmania major fructose-1,6-bisphosphate aldolase 0.0093 0.1154 1
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0069 0.0831 0.1969
Loa Loa (eye worm) hypothetical protein 0.0736 1 1
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0069 0.0831 0.0827
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0162 0.0161
Giardia lamblia Fructose-bisphosphate aldolase 0.0299 0.3986 1
Plasmodium falciparum sentrin-specific protease 1 0.004 0.0421 0.2478
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0011
Echinococcus multilocularis acetylcholinesterase 0.0736 1 1
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0094 0.1174 0.1173
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0093 0.1154 0.1152
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0093 0.1154 0.1152
Schistosoma mansoni cpg binding protein 0.0029 0.0281 0.0277
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0069 0.0831 0.7149
Schistosoma mansoni rotamase 0.0034 0.0347 0.0343
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0347 0.0737
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0069 0.0831 1
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0347 0.0347
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0336 0.2737
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.004 0.0421 0.0417
Brugia malayi conserved hypotetical protein 0.001 0.0011 0.0011
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0069 0.0831 0.6681
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3986 1
Schistosoma mansoni nuclear receptor 0.001 0.0011 0.0007
Echinococcus multilocularis carboxylesterase 5A 0.0736 1 1
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.004 0.0421 0.3538
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0124 0.1588 0.1584
Onchocerca volvulus 0.0029 0.0281 0.1711
Plasmodium falciparum fructose-bisphosphate aldolase 0.0093 0.1154 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0045 0.0502 0.1132
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0162 0.0157
Schistosoma mansoni nuclear receptor 0.001 0.0011 0.0007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0162 0.0159
Loa Loa (eye worm) hypothetical protein 0.0124 0.1588 0.1588
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0162 0.0161
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0162 0.0162
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.004 0.0421 0.0927
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0011 0.0009
Brugia malayi Carboxylesterase family protein 0.0736 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0027
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0069 0.0831 0.083
Onchocerca volvulus 0.0124 0.1588 1
Trichomonas vaginalis spcc417.12 protein, putative 0.0124 0.1588 0.3895
Echinococcus multilocularis thyroid hormone receptor alpha 0.0149 0.1931 0.193
Trypanosoma brucei SUMO1/Ulp2, putative 0.004 0.0421 0.3538
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0011 0.0009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3986 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0027
Echinococcus granulosus para nitrobenzyl esterase 0.0124 0.1588 0.1586
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0011 0.0009
Trypanosoma cruzi SUMO1/Ulp2, putative 0.004 0.0421 0.3479
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0162 0.0159
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0336 0.0709
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0162 0.0157
Brugia malayi fructose-bisphosphate aldolase 2 0.0093 0.1154 0.1154
Brugia malayi Ser/Thr protein phosphatase family protein 0.0009 0.0004 0.0003
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0162 0.0162
Echinococcus granulosus neuroligin 0.0124 0.1588 0.1586
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0069 0.0831 0.7149
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0011
Echinococcus multilocularis dnaJ subfamily B 0.0418 0.5628 0.5627
Echinococcus multilocularis sentrin specific protease 8 0.0094 0.1174 0.1172
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0162 0.0161
Echinococcus granulosus sentrin specific protease 7 0.0177 0.2317 0.2315
Onchocerca volvulus 0.0124 0.1588 1
Loa Loa (eye worm) hypothetical protein 0.0124 0.1588 0.1588
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0162 0.0952
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0069 0.0831 0.7149
Schistosoma mansoni cpg binding protein 0.0031 0.0304 0.03
Loa Loa (eye worm) DR-78 0.001 0.0011 0.0011
Schistosoma mansoni nuclear hormone receptor 0.001 0.0011 0.0007
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0069 0.0831 0.703
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.004 0.0421 0.0421
Plasmodium vivax fructose 1,6-bisphosphate aldolase, putative 0.0093 0.1154 1
Echinococcus multilocularis para nitrobenzyl esterase 0.0124 0.1588 0.1586
Trypanosoma brucei fructose-bisphosphate aldolase, glycosomal, putative 0.0093 0.1154 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0162 0.0162
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.004 0.0421 0.0927
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0162 0.0159
Echinococcus granulosus sentrin specific protease 8 0.0094 0.1174 0.1172
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0069 0.0831 0.703
Brugia malayi Carboxylesterase family protein 0.0124 0.1588 0.1587
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0162 0.0161
Echinococcus granulosus expressed protein 0.0034 0.0347 0.0345
Echinococcus granulosus expressed conserved protein 0.0138 0.1773 0.1771
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0069 0.0831 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0162 0.0159
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0011 0.0009
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0069 0.0831 0.7149
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0162 0.0159
Echinococcus multilocularis expressed protein 0.0034 0.0347 0.0345
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0162 0.0159
Echinococcus granulosus carboxylesterase 5A 0.0736 1 1
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0048 0.0536 0.0536
Brugia malayi Nuclear hormone receptor E75 0.001 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0021 0.0162 0.0162
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0162 0.0161
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.0021 0.0162 0.0162
Echinococcus granulosus acetylcholinesterase 0.0736 1 1
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0094 0.1174 0.2841
Loa Loa (eye worm) serine/threonine protein phosphatase 5 0.0022 0.018 0.018
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0177 0.2317 0.5751
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0027 0.0027
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0336 0.2783
Brugia malayi Carboxylesterase family protein 0.0124 0.1588 0.1587
Echinococcus multilocularis fructose bisphosphate aldolase class I 0.0093 0.1154 0.1152
Brugia malayi steroid hormone receptor 0.0021 0.0162 0.0161
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0027 0.0025
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0011 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0421 0.0927
Mycobacterium tuberculosis Carboxylesterase LipT 0.0124 0.1588 0.8231
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0011
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.004 0.0421 0.0927
Schistosoma mansoni coup transcription factor 0.0021 0.0162 0.0157
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0124 0.1588 0.1584
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0021 0.0173 0.1324
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0162 0.0162
Brugia malayi serine/threonine protein phosphatase 5 0.0022 0.018 0.0179
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3986 1
Schistosoma mansoni thyroid hormone receptor 0.0149 0.1931 0.1928
Onchocerca volvulus 0.0124 0.1588 1
Echinococcus multilocularis BC026374 protein (S09 family) 0.0124 0.1588 0.1586
Schistosoma mansoni thyroid hormone receptor 0.0149 0.1931 0.1928
Brugia malayi tailless protein 0.001 0.0011 0.0011
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0093 0.1154 0.1152
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0011 0.0007
Brugia malayi Carboxylesterase family protein 0.0124 0.1588 0.1587
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0162 0.0161
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0162 0.0159
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0162 0.0157
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0027 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0162 0.0161
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.004 0.0421 0.0927
Echinococcus granulosus BC026374 protein S09 family 0.0124 0.1588 0.1586
Leishmania major SUMO1/Ulp2, putative,cysteine peptidase, Clan CA, family C48, putative 0.004 0.0421 0.3538
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.3986 1
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0011 0.0011
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0011 0.0007
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0069 0.0831 0.0829
Loa Loa (eye worm) carboxylesterase 0.0124 0.1588 0.1588
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0162 0.0161
Loa Loa (eye worm) hypothetical protein 0.0124 0.1588 0.1588
Brugia malayi nuclear receptor NHR-88 0.001 0.0011 0.0011
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0146 0.1885 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0162 0.0159
Loa Loa (eye worm) carboxylesterase 0.0124 0.1588 0.1588
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0011 0.0009
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0069 0.0831 0.703
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0124 0.1588 0.8231
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0045 0.0502 0.4245
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0021 0.0173 0.1324
Brugia malayi hypothetical protein 0.0011 0.0027 0.0027
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0002 0.0002
Schistosoma mansoni protein phosphatase-5 0.0023 0.0196 0.0192
Brugia malayi hypothetical protein 0.001 0.0011 0.0011
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.004 0.0421 0.0927
Brugia malayi nuclear hormone receptor 0.0021 0.0162 0.0161
Leishmania major serine/threonine protein phosphatase type 5, putative 0.0022 0.018 0.1409
Brugia malayi nuclear receptor RXR 0.001 0.0011 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0011
Echinococcus granulosus protein phosphatase 5 0.0022 0.018 0.0178
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0021 0.0173 0.1324
Brugia malayi CXXC zinc finger family protein 0.0029 0.0281 0.028
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0069 0.0831 0.1149
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0011 0.0009
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0093 0.1154 0.9834
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0011
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0011 0.0009
Echinococcus granulosus dnaJ subfamily B 0.0418 0.5628 0.5627
Schistosoma mansoni gliotactin 0.0124 0.1588 0.1584
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0045 0.0502 0.0225
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0094 0.1174 0.117
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0011
Plasmodium vivax sentrin-specific protease 2, putative 0.004 0.0421 0.2478
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0281 0.0281
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0162 0.0157
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0162 0.0157
Echinococcus multilocularis expressed conserved protein 0.0138 0.1773 0.1771
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3986 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0027
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0011 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0162 0.0162
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0069 0.0831 0.7149
Brugia malayi ecdysteroid receptor 0.0021 0.0162 0.0161
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0021 0.0173 0.0172
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.004 0.0421 0.0421
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0069 0.0831 0.1969
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.004 0.0421 0.0417
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0162 0.0157
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0736 1 1
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0093 0.1154 0.9834
Toxoplasma gondii serine/threonine protein phosphatase 0.0022 0.018 0.1409
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0021 0.0173 0.1324
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0162 0.0159
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0162 0.0159
Schistosoma mansoni BC026374 protein (S09 family) 0.0124 0.1588 0.1584
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0011 0.0009
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0069 0.0831 0.703
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0011 0.0009
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0162 0.0159
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0024 0.0206 0.0206
Trypanosoma cruzi hypothetical protein 0.0094 0.1174 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0069 0.0831 0.703
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0162 0.0161
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0162 0.0159
Mycobacterium ulcerans carboxylesterase, LipT 0.0124 0.1588 0.7182
Plasmodium vivax sentrin-specific protease 1, putative 0.004 0.0421 0.2478
Echinococcus multilocularis protein phosphatase 5 0.0022 0.018 0.0178
Loa Loa (eye worm) hypothetical protein 0.0045 0.0502 0.0502
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.004 0.0421 0.0927
Brugia malayi hypothetical protein 0.0011 0.0027 0.0027
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0093 0.1154 0.9834
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.3986 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0027 0.0023
Schistosoma mansoni acetylcholinesterase 0.0124 0.1588 0.1584
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0336 0.2737
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0045 0.0502 0.4175
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0024 0.0206 0.0379
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0011 0.0009
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0162 0.0157
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0011
Echinococcus multilocularis sentrin specific protease 7 0.0177 0.2317 0.2315
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.004 0.0421 0.3538
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0093 0.1154 0.1152
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0162 0.0161
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0129 0.1647 0.1645
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0069 0.0831 0.0829
Trypanosoma cruzi cysteine peptidase, Clan CA, family C48, putative 0.004 0.0421 0.3479

Activities

Activity type Activity value Assay description Source Reference
Change (functional) = -18 % Percent change in mean arterial blood pressure (MAP) in anesthetized open chest dogs iv administration at 0.875 mg/kg ChEMBL. 3385731
Change (functional) = 13 % Percent change in heart rate (HR) in anesthetized open chest dogs after a iv dose of 0.875 mg/kg ChEMBL. 3385731
ED50 (functional) = 375 ug kg-1 50% increase in contractile force in one to three anesthetized dogs administered intravenously ChEMBL. 3385731
IC50 (functional) = 80 uM Inhibition of phosphodiesterase fraction III in anesthetized open chest dogs ChEMBL. 3385731
IC50 (functional) = 80 uM Inhibition of phosphodiesterase fraction III in anesthetized open chest dogs ChEMBL. 3385731
Increase (functional) = 62 % Change in left ventricular pressure of anaesthetized, open chest dogs following 0.875 mg/kg i.v. administration. ChEMBL. 3385731
Increase (functional) = 91 % Change in heart contractile force of anaesthetized, open chest dogs following 0.875 mg/kg i.v. administration. ChEMBL. 3385731

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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