Detailed information for compound 38272

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 300.248 | Formula: C12H17N2O5P
  • H donors: 4 H acceptors: 5 LogP: -5.79 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C1NCCN(C1)Cc1cccc(c1)P(=O)(O)O
  • InChi: 1S/C12H17N2O5P/c15-12(16)11-8-14(5-4-13-11)7-9-2-1-3-10(6-9)20(17,18)19/h1-3,6,11,13H,4-5,7-8H2,(H,15,16)(H2,17,18,19)
  • InChiKey: BKKMWDAMZKKULH-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.016 0.0455
Echinococcus multilocularis Smad4 0.0016 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.016 0.1217
Leishmania major hypothetical protein, conserved 0.0074 0.0751 0.4454
Trichomonas vaginalis ap endonuclease, putative 0.0036 0.0265 0.202
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0038 0.0109
Plasmodium vivax unspecified product 0.0064 0.0627 0.4778
Schistosoma mansoni cathepsin S (C01 family) 0.0028 0.016 0.0255
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0036 0.0265 0.1781
Plasmodium vivax vivapain-2 0.0117 0.1312 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0117 0.1312 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0565 0.3352
Giardia lamblia Cathepsin L precursor 0.0028 0.016 0.1336
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0038 0.0291
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0028 0.016 0.1217
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0565 0.09
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0117 0.1312 1
Toxoplasma gondii prolyl endopeptidase 0.0146 0.1686 1
Echinococcus multilocularis cathepsin L 0.0028 0.016 0.016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0627 0.3719
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0117 0.1312 1
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0186 0.1104
Echinococcus granulosus cysteine protease 0.0064 0.0627 0.0999
Leishmania major oligopeptidase b 0.0058 0.0547 0.3246
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0751 0.1885
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0117 0.1312 1
Entamoeba histolytica cysteine protease, putative 0.0064 0.0627 0.4621
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0751 0.1273
Echinococcus granulosus cathepsin L cysteine proteinase 0.0117 0.1312 0.2091
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0058 0.0547 0.1559
Plasmodium falciparum thioredoxin reductase 0.0046 0.0386 0.2941
Loa Loa (eye worm) inositol-1 0.0036 0.0261 0.065
Entamoeba histolytica cysteine protease, putative 0.0064 0.0627 0.4621
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0261 0.0745
Loa Loa (eye worm) MH2 domain-containing protein 0.0236 0.2851 0.7185
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0751 0.5721
Schistosoma mansoni Smad4 0.0016 0.0004 0.0006
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.016 0.0455
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0966 0.0966
Onchocerca volvulus 0.0117 0.1312 0.7553
Brugia malayi Cathepsin L-like precursor 0.0117 0.1312 0.374
Schistosoma mansoni inositol monophosphatase 0.0036 0.0261 0.0416
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0287 0.3508 0.5591
Brugia malayi Papain family cysteine protease containing protein 0.0117 0.1312 0.374
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0751 0.214
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0423 0.1205
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.016 0.1217
Leishmania major cathepsin L-like protease 0.0117 0.1312 0.7784
Onchocerca volvulus 0.0117 0.1312 0.7553
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0036 0.0263 0.0748
Loa Loa (eye worm) hypothetical protein 0.0117 0.1312 0.3301
Plasmodium falciparum serine repeat antigen 7 0.0028 0.016 0.1217
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0117 0.1312 1
Leishmania major trypanothione reductase 0.0046 0.0386 0.2289
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0064 0.0627 0.0999
Loa Loa (eye worm) hypothetical protein 0.0074 0.0751 0.1885
Plasmodium falciparum cysteine proteinase falcipain 1 0.0064 0.0627 0.4778
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0083 0.0632
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0966 0.2429
Treponema pallidum exodeoxyribonuclease (exoA) 0.0036 0.0265 1
Echinococcus granulosus cathepsin b 0.0287 0.3508 0.5591
Plasmodium vivax unspecified product 0.0028 0.016 0.1217
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0083 0.0492
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0112 0.032
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0036 0.0265 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0117 0.1312 1
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0186 0.1104
Loa Loa (eye worm) hypothetical protein 0.0028 0.016 0.0394
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0028 0.016 0.0954
Brugia malayi Papain family cysteine protease containing protein 0.0064 0.0627 0.1787
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0386 0.0386
Brugia malayi prolyl oligopeptidase family protein 0.0146 0.1686 0.4805
Echinococcus multilocularis prolyl endopeptidase 0.0146 0.1686 0.1686
Giardia lamblia Cathepsin B precursor 0.0028 0.016 0.1336
Echinococcus granulosus cathepsin L 0.0028 0.016 0.0255
Giardia lamblia Cathepsin B precursor 0.0108 0.1195 1
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0751 0.1273
Entamoeba histolytica cysteine protease, putative 0.0028 0.016 0.0954
Entamoeba histolytica cysteine protease, putative 0.0028 0.016 0.0954
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0627 0.3719
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0117 0.1312 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0038 0.0038
Toxoplasma gondii cathepsin B 0.0108 0.1195 0.7092
Schistosoma mansoni hypothetical protein 0.0033 0.0224 0.0357
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0038 0.0227
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0064 0.0627 0.1787
Echinococcus granulosus dna polymerase eta 0.0019 0.0038 0.0061
Giardia lamblia Cathepsin L precursor 0.0028 0.016 0.1336
Entamoeba histolytica hypothetical protein 0.0028 0.016 0.0954
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0058 0.0547 0.3097
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0038 0.0109
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0751 1
Entamoeba histolytica cysteine proteinase, putative 0.0064 0.0627 0.4621
Brugia malayi RNA, U transporter 1 0.0086 0.0907 0.2584
Onchocerca volvulus 0.0074 0.0751 0.3873
Loa Loa (eye worm) hypothetical protein 0.0036 0.0263 0.0653
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0261 0.0261
Toxoplasma gondii thioredoxin reductase 0.0046 0.0386 0.2289
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0627 0.4778
Schistosoma mansoni cathepsin F (C01 family) 0.0117 0.1312 0.2091
Trypanosoma brucei prolyl endopeptidase 0.0146 0.1686 1
Giardia lamblia DINP protein human, muc B family 0.0019 0.0038 0.032
Brugia malayi Cathepsin L-like cysteine proteinase 0.0081 0.0845 0.2408
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0751 0.5721
Brugia malayi Cathepsin L-like precursor 0.0117 0.1312 0.374
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0064 0.0627 0.0999
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0036 0.0265 0.0265
Brugia malayi cathepsin F-like cysteine proteinase 0.0028 0.016 0.0455
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.1142 0.1937
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0751 0.5721
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0146 0.1686 1
Brugia malayi fibroinase precursor 0.0028 0.016 0.0455
Giardia lamblia Cysteine protease 0.0028 0.016 0.1336
Echinococcus multilocularis cathepsin L cysteine protease 0.0117 0.1312 0.1312
Schistosoma mansoni cathepsin C 0.0028 0.016 0.0255
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0028 0.016 0.1217
Schistosoma mansoni cathepsin B (C01 family) 0.0028 0.016 0.0255
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0117 0.1312 1
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0261 0.0416
Plasmodium vivax vivapain-1 0.0064 0.0627 0.4778
Brugia malayi MH2 domain containing protein 0.0016 0.0004 0.001
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0751 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0117 0.1312 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0287 0.3508 0.5591
Schistosoma mansoni cathepsin F (C01 family) 0.0081 0.0845 0.1346
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0028 0.016 0.1217
Mycobacterium ulcerans lipase LipD 0.0074 0.0751 1
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0028 0.016 0.1217
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.1293 0.2191
Loa Loa (eye worm) hypothetical protein 0.0287 0.3508 0.8842
Plasmodium vivax unspecified product 0.0036 0.0263 0.2001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0038 0.0109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.016 0.1217
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0028 0.016 0.1217
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0028 0.016 0.1217
Leishmania major cathepsin L-like protease 0.0117 0.1312 0.7784
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0117 0.1312 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0117 0.1312 1
Entamoeba histolytica cysteine protease, putative 0.0064 0.0627 0.4621
Schistosoma mansoni importin beta-1 0.003 0.0186 0.0297
Entamoeba histolytica cysteine protease, putative 0.0028 0.016 0.0954
Giardia lamblia Cathepsin L precursor 0.0028 0.016 0.1336
Brugia malayi beta-lactamase family protein 0.0074 0.0751 0.214
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0058 0.0547 0.3246
Entamoeba histolytica cysteine protease, putative 0.0064 0.0627 0.4621
Onchocerca volvulus Prolyl endopeptidase homolog 0.0146 0.1686 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0083 0.0694
Echinococcus granulosus geminin 0.0501 0.6275 1
Brugia malayi Smad1 0.0016 0.0004 0.001
Giardia lamblia Cathepsin B precursor 0.0028 0.016 0.1336
Entamoeba histolytica cysteine proteinase, putative 0.0064 0.0627 0.4621
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0565 0.7526
Mycobacterium ulcerans hypothetical protein 0.0074 0.0751 1
Giardia lamblia Cathepsin L precursor 0.0028 0.016 0.1336
Toxoplasma gondii ABC1 family protein 0.0074 0.0751 0.4454
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0028 0.016 0.1217
Trypanosoma brucei prolyl oligopeptidase, putative 0.0058 0.0547 0.3246
Trypanosoma cruzi oligopeptidase b 0.0058 0.0547 0.1559
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0028 0.016 0.0255
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.016 0.1217
Trypanosoma brucei unspecified product 0.0019 0.0038 0.0227
Trypanosoma cruzi cysteine peptidase, putative 0.0117 0.1312 0.374
Brugia malayi cathepsin Z-like cysteine proteinase 0.0028 0.016 0.0455
Giardia lamblia Cysteine protease 0.0028 0.016 0.1336
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0386 0.2941
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0028 0.016 0.0255
Brugia malayi Importin beta-1 subunit 0.003 0.0186 0.0531
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0038 0.0227
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0083 0.02
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0112 0.0855
Onchocerca volvulus 0.0117 0.1312 0.7553
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0038 0.0109
Brugia malayi cathepsin Z-like cysteine proteinase 0.0028 0.016 0.0455
Leishmania major importin beta-1 subunit, putative 0.0025 0.0112 0.0666
Brugia malayi Inositol-1 0.0036 0.0261 0.0745
Echinococcus granulosus dna polymerase kappa 0.0019 0.0038 0.0061
Onchocerca volvulus 0.0074 0.0751 0.3873
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0038 0.0227
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.1142 0.8609
Schistosoma mansoni ran 0.0022 0.0083 0.0132
Loa Loa (eye worm) hypothetical protein 0.0028 0.016 0.0394
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0565 0.3352
Echinococcus multilocularis geminin 0.0501 0.6275 0.6275
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0058 0.0547 0.7287
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0565 0.7526
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0117 0.1312 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0751 0.1196
Entamoeba histolytica hypothetical protein 0.0025 0.0112 0.0581
Giardia lamblia Cathepsin L-like protease 0.0028 0.016 0.1336
Plasmodium falciparum serine repeat antigen 5 0.0028 0.016 0.1217
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0058 0.0547 0.1559
Trypanosoma cruzi cysteine protease, putative 0.0064 0.0627 0.1787
Plasmodium falciparum serine repeat antigen 3 0.0028 0.016 0.1217
Giardia lamblia Hypothetical protein 0.0028 0.016 0.1336
Echinococcus granulosus cathepsin b 0.0287 0.3508 0.5591
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0117 0.1312 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0751 0.1885
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0751 0.5721
Plasmodium vivax glutathione reductase, putative 0.0046 0.0386 0.2941
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0028 0.016 0.0255
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0038 0.0227
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0064 0.0627 0.0999
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0038 0.0109
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0004 0.0006
Mycobacterium tuberculosis Conserved protein 0.0074 0.0751 0.1273
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0038 0.0227
Brugia malayi Cathepsin L-like precursor 0.0117 0.1312 0.374
Loa Loa (eye worm) hypothetical protein 0.0033 0.0224 0.0557
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0117 0.1312 0.7784
Onchocerca volvulus 0.0081 0.0845 0.4491
Trichomonas vaginalis esterase, putative 0.0074 0.0751 0.5721
Brugia malayi Cathepsin L-like precursor 0.0081 0.0845 0.2408
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0028 0.016 0.1336
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0287 0.3508 0.5591
Leishmania major cathepsin L-like protease 0.0117 0.1312 0.7784
Toxoplasma gondii cathepsin CPC2 0.0028 0.016 0.0948
Plasmodium vivax vivapain-2 0.0117 0.1312 1
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0028 0.016 0.1217
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.016 0.1217
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0028 0.016 0.1217
Echinococcus granulosus snurportin 1 0.0323 0.3967 0.6322
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0966 0.154
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0058 0.0547 0.3246
Toxoplasma gondii cathepsin CPC1 0.0028 0.016 0.0948
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0117 0.1312 0.374
Schistosoma mansoni hypothetical protein 0.0501 0.6275 1
Leishmania major cathepsin L-like protease 0.0117 0.1312 0.7784
Echinococcus granulosus cathepsin L 0.0064 0.0627 0.0999
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.016 0.0455
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0117 0.1312 0.7784
Giardia lamblia Cathepsin B precursor 0.0028 0.016 0.1336
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0083 0.0236
Plasmodium falciparum cysteine proteinase falcipain 3 0.0117 0.1312 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0117 0.1312 0.1312
Brugia malayi Papain family cysteine protease containing protein 0.0064 0.0627 0.1787
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0472 0.5899 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0117 0.1312 0.7784
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0036 0.0265 0.0756
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0058 0.0547 0.0927
Giardia lamblia Cathepsin B precursor 0.0028 0.016 0.1336
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0028 0.016 0.0455
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0038 0.0065
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0751 0.1273
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0627 0.4778
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0117 0.1312 0.1312
Entamoeba histolytica cysteine proteinase 1, putative 0.0064 0.0627 0.4621
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0751 0.5721
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0083 0.0632
Plasmodium falciparum serine repeat antigen 8 0.0028 0.016 0.1217
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.1293 1
Trichomonas vaginalis ap endonuclease, putative 0.0036 0.0265 0.202
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0146 0.1686 0.2686
Brugia malayi MH1 domain containing protein 0.0016 0.0004 0.001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0038 0.0109
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0028 0.016 0.1217
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0261 0.155
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0036 0.0265 0.2218
Echinococcus multilocularis smad 0.0016 0.0004 0.0004
Leishmania major GTP-binding protein, putative 0.0022 0.0083 0.0492
Loa Loa (eye worm) hypothetical protein 0.0036 0.0263 0.0653
Loa Loa (eye worm) hypothetical protein 0.003 0.0186 0.0461
Loa Loa (eye worm) cysteine protease 0.0117 0.1312 0.3301
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0038 0.0227
Echinococcus granulosus cathepsin l1 0.0081 0.0845 0.1346
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0004 0.0004
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0038 0.0509
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0261 0.1991
Entamoeba histolytica cysteine protease, putative 0.0064 0.0627 0.4621
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0212 0.036
Brugia malayi glutathione reductase 0.0046 0.0386 0.11
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0751 0.1196
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0117 0.1312 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0117 0.1312 1
Plasmodium falciparum serine repeat antigen 2 0.0028 0.016 0.1217
Trypanosoma cruzi cysteine peptidase, putative 0.0117 0.1312 0.374
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0004 0.0004
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0028 0.016 0.1336
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0028 0.016 0.1217
Echinococcus multilocularis cathepsin b 0.0287 0.3508 0.3508
Plasmodium vivax importin-beta 2, putative 0.003 0.0186 0.1419
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.1142 0.1937
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0036 0.0265 0.0422
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0004 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0028 0.016 0.1217
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0036 0.0265 0.3531
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.016 0.1217
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0146 0.1686 0.2686
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0038 0.0227
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0966 0.154
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0117 0.1312 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0036 0.0263 0.0653
Mycobacterium tuberculosis Conserved protein 0.0074 0.0751 0.1273
Brugia malayi Cathepsin L-like precursor 0.0117 0.1312 0.374
Onchocerca volvulus 0.0117 0.1312 0.7553
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0081 0.0845 0.6439
Loa Loa (eye worm) hypothetical protein 0.0028 0.016 0.0394
Loa Loa (eye worm) hypothetical protein 0.0028 0.016 0.0394
Schistosoma mansoni smad 0.0016 0.0004 0.0006
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0038 0.0038
Entamoeba histolytica cysteine proteinase, putative 0.0081 0.0845 0.6333
Giardia lamblia Cathepsin L-like protease 0.0028 0.016 0.1336
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0751 0.4454
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0323 0.3967 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0036 0.0265 0.202
Brugia malayi beta-lactamase family protein 0.0074 0.0751 0.214
Leishmania major cathepsin L-like protease 0.0117 0.1312 0.7784
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0038 0.0227
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0038 0.0227
Brugia malayi MH2 domain containing protein 0.0236 0.2851 0.8127
Loa Loa (eye worm) hypothetical protein 0.0081 0.0845 0.2123
Echinococcus granulosus smad 0.0016 0.0004 0.0006
Trypanosoma cruzi cysteine peptidase, putative 0.0036 0.0263 0.0748
Entamoeba histolytica cysteine protease, putative 0.0117 0.1312 1
Toxoplasma gondii cathepsin CPL 0.0117 0.1312 0.7784
Plasmodium vivax vivapain-3 0.0064 0.0627 0.4778
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0036 0.0265 0.202
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0751 0.1273
Loa Loa (eye worm) hypothetical protein 0.0028 0.016 0.0394
Plasmodium falciparum glutathione reductase 0.0046 0.0386 0.2941
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.1142 0.1937
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0036 0.0265 0.066
Schistosoma mansoni DNA polymerase eta 0.0019 0.0038 0.0061
Loa Loa (eye worm) hypothetical protein 0.0049 0.0423 0.1057
Brugia malayi Cathepsin L-like precursor 0.0081 0.0845 0.2408
Onchocerca volvulus 0.0074 0.0751 0.3873
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0117 0.1312 0.7784
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0087
Mycobacterium leprae Probable lipase LipE 0.0074 0.0751 0.4982
Schistosoma mansoni hypothetical protein 0.0501 0.6275 1
Onchocerca volvulus 0.0117 0.1312 0.7553
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0261 0.0745
Giardia lamblia Cathepsin B precursor 0.0108 0.1195 1
Echinococcus multilocularis dna polymerase eta 0.0019 0.0038 0.0038
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0627 0.1787
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0117 0.1312 0.7784
Brugia malayi cathepsin L precursor 0.0028 0.016 0.0455
Brugia malayi MH1 domain containing protein 0.0016 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.0028 0.016 0.0394
Schistosoma mansoni hypothetical protein 0.0323 0.3967 0.6322
Plasmodium vivax serine-repeat antigen (SERA) 0.0028 0.016 0.1217
Leishmania major cathepsin L-like protease 0.0117 0.1312 0.7784
Schistosoma mansoni cathepsin F (C01 family) 0.0117 0.1312 0.2091
Loa Loa (eye worm) POT family protein 0.004 0.031 0.0773
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0028 0.016 0.1217
Loa Loa (eye worm) fibroinase 0.0117 0.1312 0.3301
Onchocerca volvulus Cathepsin F homolog 0.0117 0.1312 0.7553
Trypanosoma cruzi oligopeptidase b 0.0058 0.0547 0.1559
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0261 0.155
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0117 0.1312 1
Echinococcus multilocularis snurportin 1 0.0323 0.3967 0.3967
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0038 0.0061
Toxoplasma gondii preprocathepsin c precursor, putative 0.0028 0.016 0.0948
Echinococcus granulosus cathepsin L cysteine protease 0.0064 0.0627 0.0999
Trypanosoma cruzi cysteine proteinase, putative 0.0064 0.0627 0.1787
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0117 0.1312 0.3301
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0028 0.016 0.0255
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0028 0.016 0.1217
Brugia malayi exodeoxyribonuclease III family protein 0.0036 0.0265 0.0756
Echinococcus multilocularis importin subunit beta 1 0.003 0.0186 0.0186
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.016 0.1217
Brugia malayi Cathepsin L-like precursor 0.0036 0.0263 0.0748
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0028 0.016 0.1217
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0117 0.1312 1
Entamoeba histolytica cysteine protease, putative 0.0064 0.0627 0.4621
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0028 0.016 0.0255
Brugia malayi cathepsin L-like precursor 0.0081 0.0845 0.2408
Brugia malayi beta-lactamase 0.0074 0.0751 0.214
Brugia malayi POT family protein 0.004 0.031 0.0884
Schistosoma mansoni inositol monophosphatase 0.0036 0.0261 0.0416
Brugia malayi cathepsin B-like cysteine proteinase 0.0287 0.3508 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0751 0.1885
Entamoeba histolytica cysteine protease, putative 0.0064 0.0627 0.4621
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0117 0.1312 1
Entamoeba histolytica cysteine proteinase, putative 0.0117 0.1312 1
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0038 0.0509
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.1293 0.2191
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0028 0.016 0.1217
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0261 0.1991
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0038 0.0227
Schistosoma mansoni ap endonuclease 0.0036 0.0265 0.0422
Brugia malayi MH2 domain containing protein 0.0016 0.0004 0.001
Entamoeba histolytica cysteine protease, putative 0.0064 0.0627 0.4621
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0117 0.1312 0.7784
Brugia malayi cathepsin L-like cysteine proteinase 0.0028 0.016 0.0455
Giardia lamblia Cathepsin B precursor 0.0028 0.016 0.1336
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.016 0.1217
Mycobacterium tuberculosis Probable peptidase 0.0058 0.0547 0.0927
Schistosoma mansoni smad1 5 8 and 0.0016 0.0004 0.0006
Mycobacterium tuberculosis Probable reductase 0.0104 0.1142 0.1937
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0117 0.1312 0.7784
Echinococcus granulosus cathepsin l1 0.0117 0.1312 0.2091
Giardia lamblia Hypothetical protein 0.0028 0.016 0.1336
Trypanosoma cruzi major cysteine proteinase, putative 0.0028 0.016 0.0455
Loa Loa (eye worm) hypothetical protein 0.0081 0.0845 0.2123
Entamoeba histolytica cysteine protease, putative 0.0028 0.016 0.0954
Trypanosoma cruzi cruzipain precursor, putative 0.0117 0.1312 0.374
Onchocerca volvulus 0.0117 0.1312 0.7553
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0038 0.0109
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0028 0.016 0.0255
Trypanosoma brucei oligopeptidase b 0.0058 0.0547 0.3246
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0112 0.0855
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0108 0.1195 0.3407
Echinococcus multilocularis cathepsin L 0.0064 0.0627 0.0627
Giardia lamblia Cysteine protease 0.0028 0.016 0.1336
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0386 0.0615
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0966 0.154
Trypanosoma cruzi cruzipain precursor, putative 0.0036 0.0263 0.0748
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0038 0.0061
Leishmania major cathepsin L-like protease 0.0117 0.1312 0.7784
Schistosoma mansoni smad1 5 8 and 0.0016 0.0004 0.0006
Loa Loa (eye worm) ctsf protein 0.0117 0.1312 0.3301
Leishmania major DNA polymerase kappa, putative 0.0019 0.0038 0.0227
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0751 0.0751
Mycobacterium ulcerans beta-lactamase 0.0074 0.0751 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0261 0.9856
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0751 0.1196
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0565 0.09
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0565 0.7526
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0423 0.1057
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0565 0.0565
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.016 0.1217
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0751 0.4982
Entamoeba histolytica Ran family GTPase 0.0022 0.0083 0.0351
Trypanosoma cruzi major cysteine proteinase, putative 0.0028 0.016 0.0455
Brugia malayi Cathepsin L-like precursor 0.0117 0.1312 0.374
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0036 0.0265 0.1573
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0028 0.016 0.0394
Trichomonas vaginalis ran, putative 0.0022 0.0083 0.0632
Entamoeba histolytica cysteine protease, putative 0.0064 0.0627 0.4621
Plasmodium vivax serine-repeat antigen (SERA) 0.0028 0.016 0.1217
Plasmodium falciparum serine repeat antigen 4 0.0028 0.016 0.1217
Giardia lamblia Encystation-specific protease 0.0028 0.016 0.1336
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0751 0.214
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0112 0.0855
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.016 0.1217
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0565 0.09
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0081 0.0845 0.6439
Entamoeba histolytica cysteine protease, putative 0.0028 0.016 0.0954
Loa Loa (eye worm) hypothetical protein 0.0074 0.0751 0.1885
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0751 0.1273
Loa Loa (eye worm) hypothetical protein 0.0074 0.0751 0.1885
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0224 0.0639
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0028 0.016 0.1217
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0117 0.1312 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0036 0.0265 0.0449
Echinococcus granulosus cathepsin l cysteine peptidase 0.0117 0.1312 0.2091
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0028 0.016 0.1217
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0108 0.1195 0.7092
Entamoeba histolytica cysteine proteinase, putative 0.0064 0.0627 0.4621
Giardia lamblia Cathepsin B precursor 0.0108 0.1195 1
Trypanosoma cruzi cysteine proteinase, putative 0.0064 0.0627 0.1787
Onchocerca volvulus Cathepsin L homolog 0.0117 0.1312 0.7553
Plasmodium falciparum serine repeat antigen 6 0.0028 0.016 0.1217
Entamoeba histolytica cysteine protease, putative 0.0064 0.0627 0.4621
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0386 0.11
Loa Loa (eye worm) hypothetical protein 0.0081 0.0845 0.2123
Schistosoma mansoni ap endonuclease 0.0036 0.0265 0.0422
Trypanosoma brucei trypanothione reductase 0.0046 0.0386 0.2289
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0028 0.016 0.1336
Plasmodium falciparum importin beta, putative 0.003 0.0186 0.1419
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0083 0.0132
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0038 0.0087
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.016 0.1217
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0036 0.0265 0.1573
Loa Loa (eye worm) transcription factor SMAD2 0.0236 0.2851 0.7185
Brugia malayi Thioredoxin reductase 0.0046 0.0386 0.11
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0083 0.0236
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0966 0.2754
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0108 0.1195 0.911
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.1293 0.2191
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0028 0.016 0.1217
Echinococcus granulosus Smad4 0.0016 0.0004 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0117 0.1312 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0038 0.0227
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0966 0.154
Echinococcus multilocularis cathepsin b 0.0287 0.3508 0.3508
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0751 0.1273
Schistosoma mansoni smad1 5 8 and 0.0016 0.0004 0.0006
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0081 0.0845 0.2408
Trypanosoma cruzi prolyl endopeptidase 0.0146 0.1686 0.4805
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0565 0.0958
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0038 0.0227
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0028 0.016 0.1336
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0108 0.1195 0.1905
Echinococcus multilocularis cysteine protease 0.0117 0.1312 0.1312
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0038 0.0291
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.1142 0.1937
Entamoeba histolytica cysteine protease, putative 0.0028 0.016 0.0954
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0028 0.016 0.0394
Giardia lamblia Cathepsin L precursor 0.0028 0.016 0.1336
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0386 0.0654
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0083 0.0236
Echinococcus multilocularis cysteine protease 0.0117 0.1312 0.1312
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0117 0.1312 0.7784
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0028 0.016 0.1217
Loa Loa (eye worm) beta-lactamase 0.0074 0.0751 0.1885
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0028 0.016 0.0255
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0038 0.0065
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0386 0.0965
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0261 0.1991
Echinococcus granulosus importin subunit beta 1 0.003 0.0186 0.0297
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0036 0.0265 0.0756
Mycobacterium tuberculosis Conserved protein 0.0074 0.0751 0.1273
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0117 0.1312 1
Brugia malayi Cathepsin L-like precursor 0.0117 0.1312 0.374
Entamoeba histolytica cysteine proteinase, putative 0.0064 0.0627 0.4621
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0117 0.1312 1
Entamoeba histolytica cysteine protease, putative 0.0064 0.0627 0.4621
Plasmodium falciparum serine repeat antigen 9 0.0028 0.016 0.1217
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0117 0.1312 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0117 0.1312 0.1312
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0038 0.0227
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0117 0.1312 0.7784
Leishmania major DNA polymerase eta, putative 0.0019 0.0038 0.0227
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0261 0.155
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0038 0.0227
Entamoeba histolytica cysteine proteinase, putative 0.0117 0.1312 1
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0131 0.1487 0.2521
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0966 0.154
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0028 0.016 0.0394
Onchocerca volvulus 0.0117 0.1312 0.7553
Brugia malayi cathepsin F-like cysteine proteinase 0.0036 0.0263 0.0748
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0038 0.0227
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0083 0.0492
Giardia lamblia Cysteine protease 0.0028 0.016 0.1336
Loa Loa (eye worm) cathepsin B 0.0108 0.1195 0.3007
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.1142 0.1937
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0261 0.3481
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0751 0.214
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0117 0.1312 0.7784
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0028 0.016 0.0954
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0287 0.3508 0.5591
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0751 0.5721
Loa Loa (eye worm) hypothetical protein 0.0036 0.0263 0.0653
Onchocerca volvulus Cathepsin L homolog 0.0117 0.1312 0.7553
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0261 0.1751
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0028 0.016 0.1217
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0028 0.016 0.0255
Entamoeba histolytica cysteine protease, putative 0.0064 0.0627 0.4621
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0966 0.0966
Toxoplasma gondii exonuclease III APE 0.0036 0.0265 0.1573
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0117 0.1312 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0117 0.1312 0.7784
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0083 0.0083
Trypanosoma cruzi cysteine peptidase, putative 0.0117 0.1312 0.374
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0004 0.0006
Leishmania major cathepsin L-like protease 0.0117 0.1312 0.7784
Loa Loa (eye worm) glutathione reductase 0.0046 0.0386 0.0965
Entamoeba histolytica cysteine protease, putative 0.0064 0.0627 0.4621
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0186 0.1104
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0117 0.1312 0.3301
Schistosoma mansoni ran 0.0022 0.0083 0.0132
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0751 0.1273
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0117 0.1312 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0423 0.1205
Loa Loa (eye worm) hypothetical protein 0.0146 0.1686 0.4244
Trypanosoma brucei cysteine peptidase C (CPC) 0.0108 0.1195 0.7092
Loa Loa (eye worm) hypothetical protein 0.0074 0.0751 0.1885
Leishmania major cysteine peptidase A (CPA) 0.0117 0.1312 0.7784
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0287 0.3508 1
Echinococcus granulosus prolyl endopeptidase 0.0146 0.1686 0.2686
Plasmodium falciparum serine repeat antigen 1 0.0028 0.016 0.1217
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0117 0.1312 1
Entamoeba histolytica cysteine proteinase 2 0.0064 0.0627 0.4621
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0028 0.016 0.0255
Schistosoma mansoni cathepsin s 0.0036 0.0263 0.0418
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0038 0.0061
Giardia lamblia Cathepsin L precursor 0.0028 0.016 0.1336

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 83 uM Ability to displace [3H]-CPP from NMDA receptor in rat brain membrane ChEMBL. 1533422
IC50 (binding) = 83 uM Ability to displace [3H]-CPP from NMDA receptor in rat brain membrane ChEMBL. 1533422

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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