Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutamate receptor, ionotropic, N-methyl-D-aspartate 3B | No references | |
Homo sapiens | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | No references | |
Homo sapiens | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | No references | |
Rattus norvegicus | Glutamate NMDA receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Glutamate [NMDA] receptor subunit epsilon 1 | Starlite/ChEMBL | References |
Homo sapiens | glutamate receptor, ionotropic, N-methyl-D-aspartate 3A | Starlite/ChEMBL | No references |
Homo sapiens | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0371 | 0.0797 | 0.0712 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0194 | 0.0092 | 0.0092 |
Loa Loa (eye worm) | hypothetical protein | 0.1104 | 0.3715 | 0.3715 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.268 | 1 | 0.5 |
Brugia malayi | CHE-14 protein | 0.1104 | 0.3715 | 0.3715 |
Echinococcus multilocularis | protein dispatched 1 | 0.1104 | 0.3715 | 0.3715 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.1104 | 0.3715 | 0.3657 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.1104 | 0.3715 | 0.3715 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0194 | 0.0092 | 0.0092 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.1104 | 0.3715 | 0.3715 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.1104 | 0.3715 | 0.3715 |
Schistosoma mansoni | glutamate receptor NMDA | 0.029 | 0.0471 | 0.0471 |
Schistosoma mansoni | patched 1 | 0.1104 | 0.3715 | 0.3715 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0194 | 0.0092 | 0.0092 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.1104 | 0.3715 | 0.3657 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.1257 | 0.4329 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0216 | 0.0177 | 0.0177 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0216 | 0.0177 | 0.0087 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.268 | 1 | 1 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.268 | 1 | 1 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.268 | 1 | 0.5 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.268 | 1 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.268 | 1 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.268 | 1 | 0.5 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.1104 | 0.3715 | 0.3715 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.268 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0194 | 0.0092 | 0.0092 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1257 | 0.4329 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.268 | 1 | 1 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0371 | 0.0797 | 0.0797 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1257 | 0.4329 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0371 | 0.0797 | 0.0797 |
Echinococcus granulosus | Protein patched homolog 1 | 0.1104 | 0.3715 | 0.3657 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.1257 | 0.4329 | 1 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0194 | 0.0092 | 0.0092 |
Echinococcus multilocularis | protein patched | 0.1104 | 0.3715 | 0.3715 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.8 mg kg-1 | Tested for the anticonvulsant activity in DBA/2 mice after 30 mins of intraperitoneal administration | ChEMBL. | No reference |
ED50 (functional) | = 0.8 mg kg-1 | Tested for the anticonvulsant activity in DBA/2 mice after 30 mins of intraperitoneal administration | ChEMBL. | No reference |
ED50 (functional) | = 7 mg kg-1 | Tested in vivo for anticonvulsant activity against maximal electroshock in mouse, intravenously | ChEMBL. | No reference |
ED50 (functional) | = 21 mg kg-1 | Tested in vivo for anticonvulsant activity against maximal electroshock in mouse, intravenously | ChEMBL. | No reference |
ED50 (functional) | > 60 mg kg-1 | Tested in vivo for anticonvulsant activity against maximal electroshock in mouse, intravenously | ChEMBL. | No reference |
ED50 (functional) | = 0.02 nM | Tested for the anticonvulsant activity in DBA/2 mice after 15 mins of intracerebroventricular administration at pH 8.0 | ChEMBL. | No reference |
ED50 (functional) | = 0.02 nM | Tested for the anticonvulsant activity in DBA/2 mice after 15 mins of intracerebroventricular administration at pH 8.0 | ChEMBL. | No reference |
IC50 (binding) | = 18 nM | Tested for the inhibitory activity by the inhibition of excitatory [3H]-CGS-19,755 binding to NMDA recognition sites | ChEMBL. | No reference |
IC50 (binding) | = 25.7 nM | Tested for the inhibitory activity by the inhibition of excitatory L-[3H]-Glutamate binding to NMDA recognition sites | ChEMBL. | No reference |
IC50 (binding) | = 0.035 uM | Ability to displace [3H]-CPP from NMDA receptor in rat brain membrane | ChEMBL. | 1533422 |
IC50 (binding) | = 0.035 uM | Ability to displace [3H]-CPP from NMDA receptor in rat brain membrane | ChEMBL. | 1533422 |
IC50 (binding) | = 0.035 uM | Inhibition of [3H]-CPP binding to rat N-methyl-D-aspartic acid receptor 2A | ChEMBL. | 16107147 |
IC50 (binding) | = 0.22 uM | Inhibition of [3H]-Glu binding to rat N-methyl-D-aspartic acid receptor 2A | ChEMBL. | 16107147 |
Kb (functional) | = 0.2 uM | Tested for the antagonistic potency for blockade of NMDA-induced depolarisation in rat cortical slices | ChEMBL. | No reference |
Ki (binding) | = 35 nM | Compound was evaluated for its ability to displace [3H]-CPP ligand from N-methyl-D-aspartate (NMDA) receptor | ChEMBL. | 1533680 |
Ki (binding) | = 35 nM | Compound was evaluated for its ability to displace [3H]-CPP ligand from N-methyl-D-aspartate (NMDA) receptor | ChEMBL. | 1533680 |
Ki (binding) | < 1 uM | Compound was evaluated for its ability to displace [3H]-CPP or [3H]-CGS- 19755 ligand from N-methyl-D-aspartate (NMDA) receptor | ChEMBL. | 1533680 |
Ki (binding) | < 1 uM | Compound was evaluated for its ability to displace [3H]-CPP or [3H]-CGS- 19755 ligand from N-methyl-D-aspartate (NMDA) receptor | ChEMBL. | 1533680 |
Ratio (functional) | = 0.1 | Ratio of ED50 values administered intracerebroventricular to that of antagonistic potency (Kb) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.