TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 435.514 | Formula: C22H33N3O6
H donors: 5 H acceptors: 6 LogP: 2.25 Rotable bonds: 15
Rule of 5 violations (Lipinski): 1
SMILES: CCC(C(C(=O)NC(C(=O)O)C(C)C)NC(=O)[C@H](Cc1ccccc1)CC(=O)NO)C
InChi: 1S/C22H33N3O6/c1-5-14(4)19(21(28)23-18(13(2)3)22(29)30)24-20(27)16(12-17(26)25-31)11-15-9-7-6-8-10-15/h6-10,13-14,16,18-19,31H,5,11-12H2,1-4H3,(H,23,28)(H,24,27)(H,25,26)(H,29,30)/t14?,16-,18?,19?/m1/s1
InChiKey: IEVZTPJUFMSHHO-UOBIKFCOSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Neprilysin	Starlite/ChEMBL	References
Homo sapiens	leucyl/cystinyl aminopeptidase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Onchocerca volvulus		Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	peptidase family M13 containing protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Mycobacterium ulcerans	zinc metalloprotease	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	Get druggable targets OG5_127344	All targets in OG5_127344
Neospora caninum	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Schistosoma japonicum	ko:K01415 endothelin-converting enzyme [EC3.4.24.71], putative	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Schistosoma japonicum	IPR000718,Peptidase M13, neprilysin,domain-containing	Get druggable targets OG5_127344	All targets in OG5_127344
Mycobacterium leprae	probable zinc metalloprotease	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Brugia malayi	Hypothetical zinc metalloproteinase T16A9.4	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Toxoplasma gondii	peptidase family M13 protein	Get druggable targets OG5_127344	All targets in OG5_127344
Echinococcus multilocularis	endothelin converting enzyme 1	Get druggable targets OG5_127344	All targets in OG5_127344
Mycobacterium tuberculosis	Probable zinc metalloprotease Zmp1	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	peptidase family M13 containing protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Brugia malayi	Peptidase family M13 containing protein	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344
Echinococcus granulosus	endothelin converting enzyme 1	Get druggable targets OG5_127344	All targets in OG5_127344
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127344	All targets in OG5_127344

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	Neprilysin	750 aa	778 aa	20.2 %
Onchocerca volvulus		Neprilysin	750 aa	682 aa	31.1 %
Onchocerca volvulus		Neprilysin	750 aa	713 aa	34.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0184	0.6637	1
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Echinococcus multilocularis	endothelin converting enzyme 1	0.0114	0.3663	0.3377
Loa Loa (eye worm)	neuropeptide F receptor	0.0184	0.6637	1
Echinococcus granulosus	Polycystic kidney disease protein	0.0044	0.0689	0.027
Echinococcus granulosus	neuropeptide Y receptor	0.0184	0.6637	0.6486
Echinococcus granulosus	dro:myosuppressin receptor	0.0184	0.6637	0.6486
Echinococcus granulosus	g protein coupled receptor	0.0184	0.6637	0.6486
Loa Loa (eye worm)	hypothetical protein	0.0117	0.3804	0.5732
Brugia malayi	Animal haem peroxidase family protein	0.0117	0.3804	0.5732
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0184	0.6637	1
Echinococcus multilocularis	RUN	0.0044	0.0689	0.027
Loa Loa (eye worm)	hypothetical protein	0.0117	0.3804	0.5732
Echinococcus granulosus	biogenic amine 5HT receptor	0.0184	0.6637	0.6486
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0044	0.0689	0.027
Schistosoma mansoni	cell polarity protein	0.0038	0.0431	0.0431
Schistosoma mansoni	opsin-like receptor	0.0184	0.6637	0.6637
Onchocerca volvulus		0.0184	0.6637	1
Schistosoma mansoni	adenoreceptor	0.0184	0.6637	0.6637
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Onchocerca volvulus		0.0184	0.6637	1
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Brugia malayi	putative neuropeptide receptor	0.0184	0.6637	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0184	0.6637	0.6486
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0184	0.6637	1
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0058	0.1264	0.1264
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0184	0.6637	0.6486
Trypanosoma brucei	Aminopeptidase M1, putative	0.0042	0.061	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0184	0.6637	0.6486
Brugia malayi	hypothetical protein	0.0184	0.6637	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0431	0.0649
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0184	0.6637	0.6486
Schistosoma mansoni	notch	0.0038	0.0431	0.0431
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0184	0.6637	0.6637
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0431	0.0649
Onchocerca volvulus	Peroxidasin homolog	0.0117	0.3804	0.5436
Schistosoma mansoni	neuropeptide F-like receptor	0.0184	0.6637	0.6637
Echinococcus multilocularis	serotonin receptor	0.0184	0.6637	0.6486
Brugia malayi	hypothetical protein	0.0184	0.6637	1
Schistosoma mansoni	neuropeptide receptor	0.0184	0.6637	0.6637
Echinococcus granulosus	tm gpcr rhodopsin	0.0184	0.6637	0.6486
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Brugia malayi	Serotonin receptor	0.0184	0.6637	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0184	0.6637	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0184	0.6637	0.6486
Brugia malayi	G protein-coupled receptor F59B2.13	0.0184	0.6637	1
Schistosoma mansoni	hypothetical protein	0.0038	0.0431	0.0431
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2483	0.3741
Schistosoma mansoni	neuropeptide receptor	0.0184	0.6637	0.6637
Echinococcus granulosus	G protein coupled receptor 139	0.0184	0.6637	0.6486
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2483	0.3741
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Schistosoma mansoni	hypothetical protein	0.003	0.0084	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0184	0.6637	0.6637
Echinococcus granulosus	somatostatin receptor	0.0184	0.6637	0.6486
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0184	0.6637	0.6486
Schistosoma mansoni	septate junction protein	0.0038	0.0431	0.0431
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0431	0.0649
Loa Loa (eye worm)	G-protein coupled receptor	0.0184	0.6637	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0184	0.6637	0.6486
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0184	0.6637	1
Loa Loa (eye worm)	hypothetical protein	0.0117	0.3804	0.5732
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0184	0.6637	0.6486
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0184	0.6637	0.6486
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0431	0.0649
Brugia malayi	Calcium binding EGF domain containing protein	0.0038	0.0431	0.0649
Loa Loa (eye worm)	animal heme peroxidase	0.0117	0.3804	0.5732
Brugia malayi	EGF-like domain containing protein	0.0038	0.0431	0.0649
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.003	0.0084	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0084	0.2399	0.3614
Onchocerca volvulus		0.0184	0.6637	1
Echinococcus multilocularis	orexin receptor type 2	0.0184	0.6637	0.6486
Echinococcus multilocularis	neuropeptides capa receptor	0.0184	0.6637	0.6486
Schistosoma mansoni	polycystin 1-related	0.0044	0.0689	0.0689
Echinococcus granulosus	peroxidasin	0.0117	0.3804	0.3525
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0184	0.6637	0.6637
Brugia malayi	neuropeptide F receptor	0.0184	0.6637	1
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Schistosoma mansoni	opsin-like receptor	0.0184	0.6637	0.6637
Loa Loa (eye worm)	blistered cuticle protein 3	0.0117	0.3804	0.5732
Schistosoma mansoni	notch	0.0038	0.0431	0.0431
Brugia malayi	EGF-like domain containing protein	0.0038	0.0431	0.0649
Schistosoma mansoni	neprilysin	0.003	0.0084	0.0084
Brugia malayi	notch-like transmembrane receptor	0.0038	0.0431	0.0649
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0184	0.6637	1
Onchocerca volvulus		0.0184	0.6637	1
Echinococcus multilocularis	neuropeptide receptor	0.0184	0.6637	0.6486
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0084	0.2399	0.3614
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0184	0.6637	0.6637
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0431	0.0649
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.0042	0.061	0.5
Brugia malayi	G-protein coupled receptor	0.0184	0.6637	1
Schistosoma mansoni	lipoxygenase	0.0263	1	1
Onchocerca volvulus		0.0184	0.6637	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0184	0.6637	0.6637
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0058	0.1264	0.1264
Schistosoma mansoni	opsin-like receptor	0.0184	0.6637	0.6637
Schistosoma mansoni	hypothetical protein	0.003	0.0084	0.0084
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0184	0.6637	0.6637
Loa Loa (eye worm)	hypothetical protein	0.0117	0.3804	0.5732
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Loa Loa (eye worm)	hypothetical protein	0.0117	0.3804	0.5732
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Brugia malayi	AKH receptor	0.0184	0.6637	1
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2483	0.3741
Echinococcus multilocularis	neuropeptide receptor A26	0.0184	0.6637	0.6486
Brugia malayi	hypothetical protein	0.0184	0.6637	1
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Onchocerca volvulus		0.0184	0.6637	1
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Brugia malayi	hypothetical protein	0.0184	0.6637	1
Brugia malayi	follicle stimulating hormone receptor	0.0184	0.6637	1
Schistosoma mansoni	slit	0.0038	0.0431	0.0431
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0184	0.6637	0.6637
Schistosoma mansoni	hypothetical protein	0.003	0.0084	0.0084
Brugia malayi	Animal haem peroxidase family protein	0.0117	0.3804	0.5732
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0184	0.6637	0.6637
Mycobacterium ulcerans	zinc metalloprotease	0.0114	0.3663	1
Echinococcus granulosus	hypothetical protein	0.0184	0.6637	0.6486
Brugia malayi	GCC2 and GCC3 family protein	0.0038	0.0431	0.0649
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0042	0.061	0.061
Echinococcus granulosus	rhodopsin orphan GPCR	0.0184	0.6637	0.6486
Onchocerca volvulus		0.0117	0.3804	0.5436
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0184	0.6637	1
Loa Loa (eye worm)	hypothetical protein	0.0114	0.3663	0.5518
Schistosoma mansoni	histamine h1 receptor	0.0184	0.6637	0.6637
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0431	0.0649
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0431	0.0649
Schistosoma mansoni	hypothetical protein	0.0038	0.0431	0.0431
Brugia malayi	Dopamine receptor protein 1	0.0184	0.6637	1
Onchocerca volvulus		0.0184	0.6637	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0184	0.6637	0.6637
Echinococcus granulosus	rhodopsin orphan GPCR	0.0184	0.6637	0.6486
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0184	0.6637	1
Brugia malayi	Peroxidasin	0.0117	0.3804	0.5732
Onchocerca volvulus		0.0044	0.0689	0.0417
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0042	0.061	0.5
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0184	0.6637	0.6637
Echinococcus granulosus	serotonin receptor	0.0184	0.6637	0.6486
Schistosoma mansoni	loxhd1	0.0044	0.0689	0.0689
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Loa Loa (eye worm)	hypothetical protein	0.0117	0.3804	0.5732
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0184	0.6637	0.6486
Echinococcus granulosus	RUN	0.0044	0.0689	0.027
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0184	0.6637	0.6486
Schistosoma mansoni	hypothetical protein	0.0184	0.6637	0.6637
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0184	0.6637	0.6637
Schistosoma mansoni	notch	0.0038	0.0431	0.0431
Echinococcus granulosus	sex peptide receptor	0.0184	0.6637	0.6486
Brugia malayi	Calcium binding EGF domain containing protein	0.0038	0.0431	0.0649
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0184	0.6637	0.6486
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0431	0.0649
Schistosoma mansoni	amine GPCR	0.0184	0.6637	0.6637
Schistosoma mansoni	rab6-interacting	0.0044	0.0689	0.0689
Echinococcus granulosus	biogenic amine 5HT receptor	0.0184	0.6637	0.6486
Onchocerca volvulus	Peroxidase homolog	0.0117	0.3804	0.5436
Echinococcus multilocularis	allatostatin A receptor	0.0184	0.6637	0.6486
Echinococcus multilocularis	fmrfamide receptor	0.0184	0.6637	0.6486
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0184	0.6637	0.6486
Schistosoma mansoni	myosin xvIII	0.0184	0.6637	0.6637
Echinococcus granulosus	lipoxygenase domain containing protein	0.0044	0.0689	0.027
Brugia malayi	Muscle positioning protein 4	0.0038	0.0431	0.0649
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Brugia malayi	Cadherin domain containing protein	0.0038	0.0431	0.0649
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0184	0.6637	0.6486
Loa Loa (eye worm)	hypothetical protein	0.0117	0.3804	0.5732
Brugia malayi	Blistered cuticle protein 3	0.0117	0.3804	0.5732
Loa Loa (eye worm)	notch protein	0.0038	0.0431	0.0649
Schistosoma mansoni	hypothetical protein	0.0038	0.0431	0.0431
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0184	0.6637	0.6486
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0184	0.6637	0.6637
Echinococcus multilocularis	fmrfamide receptor	0.0184	0.6637	0.6486
Brugia malayi	Delta serrate ligand family protein	0.0038	0.0431	0.0649
Loa Loa (eye worm)	G-protein coupled receptor	0.0184	0.6637	1
Schistosoma mansoni	amine GPCR	0.0184	0.6637	0.6637
Echinococcus granulosus	rhodopsin orphan GPCR	0.0184	0.6637	0.6486
Echinococcus multilocularis	neuropeptide s receptor	0.0184	0.6637	0.6486
Trypanosoma brucei	Aminopeptidase M1, putative	0.0042	0.061	0.5
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0184	0.6637	1
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0042	0.061	0.0187
Schistosoma mansoni	biogenic amine receptor	0.0184	0.6637	0.6637
Schistosoma mansoni	hypothetical protein	0.003	0.0084	0.0084
Echinococcus granulosus	neuropeptide s receptor	0.0184	0.6637	0.6486
Loa Loa (eye worm)	hypothetical protein	0.0084	0.2399	0.3614
Brugia malayi	GnHR receptor homolog	0.0184	0.6637	1
Onchocerca volvulus	Chorion peroxidase homolog	0.0117	0.3804	0.5436
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0184	0.6637	0.6486
Entamoeba histolytica	aminopeptidase, putative	0.0042	0.061	0.5
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0184	0.6637	0.6486
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0042	0.061	0.0187
Loa Loa (eye worm)	TYRA-2 protein	0.0184	0.6637	1
Schistosoma mansoni	biogenic amine receptor	0.0184	0.6637	0.6637
Brugia malayi	hypothetical protein	0.0184	0.6637	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0184	0.6637	0.6637
Brugia malayi	Cadherin domain containing protein	0.0038	0.0431	0.0649
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0184	0.6637	0.6486
Echinococcus granulosus	neuropeptide receptor A26	0.0184	0.6637	0.6486
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1219	0.1837
Schistosoma mansoni	hypothetical protein	0.0038	0.0431	0.0431
Echinococcus multilocularis	neuropeptide receptor	0.0184	0.6637	0.6486
Schistosoma mansoni	hypothetical protein	0.0038	0.0431	0.0431
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0184	0.6637	0.6637
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Echinococcus multilocularis	g-protein coupled receptor	0.0184	0.6637	0.6486
Loa Loa (eye worm)	hypothetical protein	0.0117	0.3804	0.5732
Onchocerca volvulus		0.0042	0.061	0.0288
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0184	0.6637	0.6637
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Mycobacterium leprae	probable zinc metalloprotease	0.0114	0.3663	0.5
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0042	0.061	0.5
Echinococcus multilocularis	sex peptide receptor	0.0184	0.6637	0.6486
Brugia malayi	hypothetical protein	0.0184	0.6637	1
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Brugia malayi	hypothetical protein	0.0184	0.6637	1
Schistosoma mansoni	hypothetical protein	0.0038	0.0431	0.0431
Loa Loa (eye worm)	Notch2	0.0038	0.0431	0.0649
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0184	0.6637	0.6486
Brugia malayi	Peptidase family M1 containing protein	0.0042	0.061	0.0919
Echinococcus granulosus	neuropeptide Y receptor	0.0184	0.6637	0.6486
Echinococcus multilocularis	peroxidasin	0.0117	0.3804	0.3525
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0184	0.6637	0.6486
Echinococcus granulosus	allatostatin A receptor	0.0184	0.6637	0.6486
Brugia malayi	hypothetical protein	0.0117	0.3804	0.5732
Schistosoma mansoni	hypothetical protein	0.0184	0.6637	0.6637
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0431	0.0649
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0084	0.2399	0.3614
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0184	0.6637	0.6486
Loa Loa (eye worm)	hypothetical protein	0.0117	0.3804	0.5732
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0431	0.0649
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Onchocerca volvulus		0.0184	0.6637	1
Brugia malayi	EGF-like domain containing protein	0.0038	0.0431	0.0649
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0042	0.061	0.5
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.0058	0.1264	0.1264
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0431	0.0649
Brugia malayi	Animal haem peroxidase family protein	0.0117	0.3804	0.5732
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0184	0.6637	0.6486
Brugia malayi	ORL1-like opioid receptor	0.0184	0.6637	1
Brugia malayi	EGF-like domain containing protein	0.0038	0.0431	0.0649
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0042	0.061	0.5
Plasmodium vivax	multidomain scavenger receptor, putative	0.0044	0.0689	0.5
Brugia malayi	Peptidase family M13 containing protein	0.0114	0.3663	0.5518
Brugia malayi	G-protein coupled receptor	0.0184	0.6637	1
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0184	0.6637	1
Echinococcus multilocularis	somatostatin receptor	0.0184	0.6637	0.6486
Schistosoma mansoni	amine GPCR	0.0184	0.6637	0.6637
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0184	0.6637	0.6486
Brugia malayi	RE15519p	0.0184	0.6637	1
Loa Loa (eye worm)	hypothetical protein	0.0117	0.3804	0.5732
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0184	0.6637	0.6486
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0431	0.0649
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0184	0.6637	0.6637
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0042	0.061	0.0187
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0184	0.6637	0.6486
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0184	0.6637	0.6486
Onchocerca volvulus	Dual oxidase homolog	0.0117	0.3804	0.5436
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Onchocerca volvulus		0.0117	0.3804	0.5436
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0431	0.0649
Echinococcus granulosus	neuropeptide receptor	0.0184	0.6637	0.6486
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0184	0.6637	0.6637
Echinococcus multilocularis	G protein coupled receptor 139	0.0184	0.6637	0.6486
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0431	0.0649
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0184	0.6637	0.6637
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0042	0.061	0.0187
Echinococcus granulosus	endothelin converting enzyme 1	0.0114	0.3663	0.3377
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0044	0.0689	0.027
Echinococcus multilocularis	dro:myosuppressin receptor	0.0184	0.6637	0.6486
Brugia malayi	Doublecortin family protein	0.0044	0.0689	0.1039
Schistosoma mansoni	Nep2 peptidase (M13 family)	0.0058	0.1264	0.1264
Schistosoma mansoni	amine GPCR	0.0184	0.6637	0.6637
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0184	0.6637	0.6486
Brugia malayi	EGF-like domain containing protein	0.0038	0.0431	0.0649
Schistosoma mansoni	hypothetical protein	0.0184	0.6637	0.6637
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0184	0.6637	0.6637
Brugia malayi	putative neuropeptide receptor NPR1	0.0184	0.6637	1
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0042	0.061	0.0187
Loa Loa (eye worm)	animal heme peroxidase	0.0117	0.3804	0.5732
Brugia malayi	Animal haem peroxidase family protein	0.0117	0.3804	0.5732
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0184	0.6637	0.6486
Schistosoma mansoni	neuropeptide receptor	0.0184	0.6637	0.6637
Echinococcus granulosus	lipoxygenase domain containing protein	0.0044	0.0689	0.027
Loa Loa (eye worm)	animal heme peroxidase	0.0117	0.3804	0.5732
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2483	0.3741
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0184	0.6637	0.6637
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Echinococcus multilocularis	g protein coupled receptor	0.0184	0.6637	0.6486
Loa Loa (eye worm)	hypothetical protein	0.0084	0.2399	0.3614
Schistosoma mansoni	amine GPCR	0.0184	0.6637	0.6637
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Loa Loa (eye worm)	aminopeptidase N	0.0042	0.061	0.0919
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0689	0.1039
Schistosoma mansoni	lipoxygenase	0.0184	0.6636	0.6636
Mycobacterium tuberculosis	Probable zinc metalloprotease Zmp1	0.0114	0.3663	0.5
Onchocerca volvulus		0.0184	0.6637	1
Onchocerca volvulus		0.0184	0.6637	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0042	0.061	0.0187
Schistosoma mansoni	hypothetical protein	0.0044	0.0689	0.0689
Schistosoma mansoni	laminin gamma-3 chain	0.0038	0.0431	0.0431
Onchocerca volvulus		0.0184	0.6637	1
Brugia malayi	Dopamine receptor protein 2	0.0184	0.6637	1
Echinococcus granulosus	fmrfamide receptor	0.0184	0.6637	0.6486
Loa Loa (eye worm)	doublecortin family protein	0.0044	0.0689	0.1039
Plasmodium falciparum	LCCL domain-containing protein	0.0044	0.0689	0.5
Loa Loa (eye worm)	hypothetical protein	0.0117	0.3804	0.5732
Schistosoma mansoni	peroxidasin	0.0117	0.3804	0.3804
Brugia malayi	hypothetical protein	0.0184	0.6637	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0184	0.6637	0.6486
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0184	0.6637	0.6486
Echinococcus granulosus	rhodopsin orphan GPCR	0.0184	0.6637	0.6486
Loa Loa (eye worm)	hypothetical protein	0.0114	0.3663	0.5518
Brugia malayi	hypothetical protein	0.0044	0.0689	0.1039
Echinococcus granulosus	7tm_1 domain containing protein	0.0184	0.6637	0.6486
Schistosoma mansoni	biogenic amine receptor	0.0184	0.6637	0.6637
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0038	0.0431	0.0649
Brugia malayi	Dopamine receptor	0.0184	0.6637	1
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0042	0.061	0.0187
Loa Loa (eye worm)	neuropeptide F receptor	0.0184	0.6637	1
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Onchocerca volvulus		0.0184	0.6637	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0184	0.6637	1
Echinococcus granulosus	aminopeptidase N	0.0042	0.061	0.0187
Brugia malayi	sulfakinin receptor protein	0.0184	0.6637	1
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0042	0.061	0.061
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2483	0.3741
Toxoplasma gondii	peptidase family M13 protein	0.0114	0.3663	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0184	0.6637	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0431	0.0649
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0184	0.6637	0.6637
Echinococcus multilocularis	Polycystic kidney disease protein	0.0044	0.0689	0.027
Loa Loa (eye worm)	hypothetical protein	0.0117	0.3804	0.5732
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0038	0.0431	0.0431
Echinococcus multilocularis	g protein coupled receptor	0.0184	0.6637	0.6486
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0184	0.6637	0.6637
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0431	0.0649
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0184	0.6637	1
Onchocerca volvulus		0.0044	0.0689	0.0417
Trypanosoma cruzi	aminopeptidase, putative	0.0042	0.061	0.5
Brugia malayi	hypothetical protein	0.0044	0.0689	0.1039
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0114	0.3663	0.3663
Schistosoma mansoni	notch	0.0038	0.0431	0.0431
Loa Loa (eye worm)	animal heme peroxidase	0.0117	0.3804	0.5732
Schistosoma mansoni	neprilysin-2 (M13 family)	0.0058	0.1264	0.1264
Echinococcus granulosus	g protein coupled receptor	0.0184	0.6637	0.6486
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Giardia lamblia	High cysteine protein	0.0038	0.0431	0.5
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0184	0.6637	0.6486
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0184	0.6637	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0184	0.6637	0.6486
Onchocerca volvulus		0.0117	0.3804	0.5436
Onchocerca volvulus		0.0184	0.6637	1
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Schistosoma mansoni	hypothetical protein	0.003	0.0084	0.0084
Schistosoma mansoni	neuropeptide f receptor 76f	0.0184	0.6637	0.6637
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0184	0.6637	0.6486
Echinococcus granulosus	g-protein coupled receptor	0.0184	0.6637	0.6486
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0263	1	1
Echinococcus multilocularis	serotonin receptor	0.0184	0.6637	0.6486
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0431	0.0649
Brugia malayi	Calcium binding EGF domain containing protein	0.0038	0.0431	0.0649
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0042	0.061	0.0187
Schistosoma mansoni	notch	0.0038	0.0431	0.0431
Brugia malayi	hypothetical protein	0.0042	0.061	0.0919
Echinococcus granulosus	orexin receptor type 2	0.0184	0.6637	0.6486
Schistosoma mansoni	rab6-interacting	0.0044	0.0689	0.0689
Loa Loa (eye worm)	hypothetical protein	0.0114	0.3663	0.5518
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0042	0.061	0.5
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0184	0.6637	1
Brugia malayi	larval opioid receptor	0.0184	0.6637	1
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0184	0.6637	0.6637
Brugia malayi	Melatonin receptor type 1A	0.0184	0.6637	1
Brugia malayi	Peptidase family M1 containing protein	0.0042	0.061	0.0919
Echinococcus granulosus	neuropeptide receptor	0.0184	0.6637	0.6486
Echinococcus granulosus	g protein coupled receptor	0.0184	0.6637	0.6486
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0431	0.0649
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0042	0.061	0.0187
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0184	0.6637	0.6486
Brugia malayi	EGF-like domain containing protein	0.0038	0.0431	0.0649
Onchocerca volvulus	Peroxidasin homolog	0.0117	0.3804	0.5436
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0431	0.0649
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0184	0.6637	0.6637
Onchocerca volvulus		0.0184	0.6637	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0184	0.6637	0.6486
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0184	0.6637	0.6637
Loa Loa (eye worm)	hypothetical protein	0.0084	0.2399	0.3614
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0042	0.061	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0184	0.6637	0.6486
Brugia malayi	hypothetical protein	0.0184	0.6637	1
Onchocerca volvulus		0.0184	0.6637	1
Brugia malayi	neuropeptide F receptor	0.0184	0.6637	1
Brugia malayi	EGF-like domain containing protein	0.0038	0.0431	0.0649
Echinococcus granulosus	neuropeptides capa receptor	0.0184	0.6637	0.6486
Echinococcus granulosus	rhodopsin orphan GPCR	0.0184	0.6637	0.6486
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0431	0.0649
Onchocerca volvulus	Peroxidase homolog	0.0117	0.3804	0.5436
Echinococcus granulosus	tm gpcr rhodopsin	0.0184	0.6637	0.6486
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0431	0.0649
Onchocerca volvulus		0.0184	0.6637	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0184	0.6637	0.6486
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Loa Loa (eye worm)	hypothetical protein	0.0117	0.3804	0.5732
Brugia malayi	Animal haem peroxidase family protein	0.0117	0.3804	0.5732
Schistosoma mansoni	hypothetical protein	0.0038	0.0431	0.0431
Onchocerca volvulus		0.0042	0.061	0.0288
Brugia malayi	hypothetical protein	0.0184	0.6637	1
Brugia malayi	G protein-coupled receptor	0.0184	0.6637	1
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0042	0.061	0.0187
Echinococcus multilocularis	aminopeptidase N	0.0042	0.061	0.0187
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0184	0.6637	0.6637
Echinococcus granulosus	neuropeptides capa receptor	0.0184	0.6637	0.6486
Schistosoma mansoni	hypothetical protein	0.0184	0.6637	0.6637
Echinococcus granulosus	rhodopsin orphan GPCR	0.0184	0.6637	0.6486
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0184	0.6637	0.6486
Schistosoma mansoni	peroxidasin	0.0117	0.3804	0.3804
Schistosoma mansoni	neuropeptide receptor	0.0184	0.6637	0.6637
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Loa Loa (eye worm)	hypothetical protein	0.0117	0.3804	0.5732
Schistosoma mansoni	notch	0.0038	0.0431	0.0431
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0431	0.0649
Brugia malayi	Serotonin receptor	0.0184	0.6637	1
Brugia malayi	Hypothetical zinc metalloproteinase T16A9.4	0.0114	0.3663	0.5518
Schistosoma mansoni	hypothetical protein	0.003	0.0084	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0086	0.2483	0.3741
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0184	0.6637	0.6637
Onchocerca volvulus		0.0056	0.1219	0.1271
Echinococcus multilocularis	neuropeptides capa receptor	0.0184	0.6637	0.6486
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0184	0.6637	0.6486
Loa Loa (eye worm)	hypothetical protein	0.0184	0.6637	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0689	0.1039
Echinococcus multilocularis	neuropeptide Y receptor	0.0184	0.6637	0.6486

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 3.6	Antinociceptic activity in tail-flick test (jtail withdrawal latency) induced by subcutaneous administration of saline (0.20 mL/20 g) 15 min prior to icv injection of saline (10 microL/mouse)	ChEMBL.	8496905
Activity (functional)	= 3.8	Antinociceptic activity in writhing test induced by subcutaneous administration of naltrexone (1 mg/kg) 15 min prior to icv injection of JMV-390-1 (10 microL/mouse); reported as stretches/ 5 min	ChEMBL.	8496905
Activity (functional)	= 4	Antinociceptic activity in hot-plate test (jump latency) induced by subcutaneous administration of naltrexone (1 mg/kg) 15 min prior to icv injection of naltrexone or saline	ChEMBL.	8496905
Activity (functional)	= 4.4	Antinociceptic activity in writhing test induced by subcutaneous administration of saline (0.20 mL/20 g) 15 min prior to icv injection of JMV-390-1 (10 microL/mouse); reported as stretches/ 5 min	ChEMBL.	8496905
Activity (functional)	= 4.6	Antinociceptic activity in tail-flick test (jtail withdrawal latency) induced by subcutaneous administration of naltrexone (1 mg/kg) 15 min prior to icv injection of JMV-390-1 (10 microL/mouse)	ChEMBL.	8496905
Activity (functional)	= 5.9	Antinociceptic activity in tail-flick test (jtail withdrawal latency) induced by subcutaneous administration of saline (0.20 mL/20 g) 15 min prior to icv injection of JMV-390-1 (10 microL/mouse)	ChEMBL.	8496905
Activity (functional)	= 18.4	Antinociceptic activity in writhing test induced by subcutaneous administration of saline (0.20 mL/20 g) 15 min prior to icv injection of saline (10 microL/mouse); reported as stretches/ 5 min	ChEMBL.	8496905
Activity (functional)	= 30.6	Antinociceptic activity in writhing test induced by subcutaneous administration of naltrexone (1 mg/kg) 15 min prior to icv injection of naltrexone or saline; reported as stretches/ 5 min	ChEMBL.	8496905
Activity (functional)	= 3.6	Antinociceptic activity in tail-flick test (jtail withdrawal latency) induced by subcutaneous administration of saline (0.20 mL/20 g) 15 min prior to icv injection of saline (10 microL/mouse)	ChEMBL.	8496905
Activity (functional)	= 3.8	Antinociceptic activity in writhing test induced by subcutaneous administration of naltrexone (1 mg/kg) 15 min prior to icv injection of JMV-390-1 (10 microL/mouse); reported as stretches/ 5 min	ChEMBL.	8496905
Activity (functional)	= 4	Antinociceptic activity in hot-plate test (jump latency) induced by subcutaneous administration of naltrexone (1 mg/kg) 15 min prior to icv injection of naltrexone or saline	ChEMBL.	8496905
Activity (functional)	= 4.4	Antinociceptic activity in writhing test induced by subcutaneous administration of saline (0.20 mL/20 g) 15 min prior to icv injection of JMV-390-1 (10 microL/mouse); reported as stretches/ 5 min	ChEMBL.	8496905
Activity (functional)	= 4.6	Antinociceptic activity in tail-flick test (jtail withdrawal latency) induced by subcutaneous administration of naltrexone (1 mg/kg) 15 min prior to icv injection of JMV-390-1 (10 microL/mouse)	ChEMBL.	8496905
Activity (functional)	= 5.9	Antinociceptic activity in tail-flick test (jtail withdrawal latency) induced by subcutaneous administration of saline (0.20 mL/20 g) 15 min prior to icv injection of JMV-390-1 (10 microL/mouse)	ChEMBL.	8496905
Activity (functional)	= 18.4	Antinociceptic activity in writhing test induced by subcutaneous administration of saline (0.20 mL/20 g) 15 min prior to icv injection of saline (10 microL/mouse); reported as stretches/ 5 min	ChEMBL.	8496905
Activity (functional)	= 30.6	Antinociceptic activity in writhing test induced by subcutaneous administration of naltrexone (1 mg/kg) 15 min prior to icv injection of naltrexone or saline; reported as stretches/ 5 min	ChEMBL.	8496905
Ki (binding)	nM	Inhibitory activity against post-prolyl depeptidyl aminopeptidase at 10e-4 M; no effect	ChEMBL.	8496905
Ki (binding)	0 nM	Inhibitory activity against post-prolyl depeptidyl aminopeptidase at 10e-4 M; no effect	ChEMBL.	8496905
Ki (binding)	= 31 nM	Inhibitory activity against endopeptidase 24.15	ChEMBL.	8496905
Ki (binding)	= 31 nM	Inhibitory activity against endopeptidase 24.15	ChEMBL.	8496905
Ki (binding)	= 40 nM	Inhibitory activity against endopeptidase 24.11	ChEMBL.	8496905
Ki (binding)	= 40 nM	Inhibitory activity against endopeptidase 24.11	ChEMBL.	8496905
Ki (binding)	= 52 nM	Inhibitory activity against Leucine aminopeptidase	ChEMBL.	8496905
Ki (binding)	= 52 nM	Inhibitory activity against Leucine aminopeptidase	ChEMBL.	8496905
Ki (binding)	= 58 nM	Inhibitory activity against endopeptidase 24.16	ChEMBL.	8496905
Ki (binding)	= 58 nM	Inhibitory activity against endopeptidase 24.16	ChEMBL.	8496905
Ki (binding)	= 70000 nM	Inhibitory activity against angiotensin converting enzyme	ChEMBL.	8496905
Ki (binding)	= 70000 nM	Inhibitory activity against angiotensin converting enzyme	ChEMBL.	8496905
Latency (functional)	= 63	Antinociceptic activity in hot-plate test (jump latency) induced by subcutaneous administration of naltrexone (1 mg/kg) 15 min prior to icv injection of naltrexone or saline	ChEMBL.	8496905
Latency (functional)	= 64	Antinociceptic activity in hot-plate test (jump latency) induced by subcutaneous administration of naltrexone (1 mg/kg) 15 min prior to icv injection of JMV-390-1 (10 microL/mouse)	ChEMBL.	8496905
Latency (functional)	= 79	Antinociceptic activity in hot-plate test (jump latency) induced by icv injection of neuromedin N (1 microg)	ChEMBL.	8496905
Latency (functional)	= 87	Antinociceptic activity in hot-plate test (jump latency) induced by icv injection of saline	ChEMBL.	8496905
Latency (functional)	= 91	Antinociceptic activity in hot-plate test (jump latency) induced by subcutaneous administration of saline (0.20 mL/20 g) 15 min prior to icv injection of saline (10 microL/mouse)	ChEMBL.	8496905
Latency (functional)	= 98	Antinociceptic activity in hot-plate test (jump latency) induced by icv injection of met-enkephalin (30 microg)	ChEMBL.	8496905
Latency (functional)	= 133	Antinociceptic activity in hot-plate test (jump latency) induced by icv injection of compound (10 microg)	ChEMBL.	8496905
Latency (functional)	= 144	Antinociceptic activity in hot-plate test (jump latency) induced by subcutaneous administration of saline (0.20 mL/20 g) 15 min prior to icv injection of JMV-390-1 (10 microL/mouse)	ChEMBL.	8496905
Latency (functional)	= 201	Antinociceptic activity in hot-plate test (jump latency) induced by icv injection of neuromedin N (1 microg) and compound (10 microg)	ChEMBL.	8496905
Latency (functional)	> 240	Antinociceptic activity in hot-plate test (jump latency) induced by icv injection of met-enkephalin (30 microg) and compound (10 microg)	ChEMBL.	8496905
Latency (functional)	= 63	Antinociceptic activity in hot-plate test (jump latency) induced by subcutaneous administration of naltrexone (1 mg/kg) 15 min prior to icv injection of naltrexone or saline	ChEMBL.	8496905
Latency (functional)	= 64	Antinociceptic activity in hot-plate test (jump latency) induced by subcutaneous administration of naltrexone (1 mg/kg) 15 min prior to icv injection of JMV-390-1 (10 microL/mouse)	ChEMBL.	8496905
Latency (functional)	= 79	Antinociceptic activity in hot-plate test (jump latency) induced by icv injection of neuromedin N (1 microg)	ChEMBL.	8496905
Latency (functional)	= 87	Antinociceptic activity in hot-plate test (jump latency) induced by icv injection of saline	ChEMBL.	8496905
Latency (functional)	= 91	Antinociceptic activity in hot-plate test (jump latency) induced by subcutaneous administration of saline (0.20 mL/20 g) 15 min prior to icv injection of saline (10 microL/mouse)	ChEMBL.	8496905
Latency (functional)	= 98	Antinociceptic activity in hot-plate test (jump latency) induced by icv injection of met-enkephalin (30 microg)	ChEMBL.	8496905
Latency (functional)	= 133	Antinociceptic activity in hot-plate test (jump latency) induced by icv injection of compound (10 microg)	ChEMBL.	8496905
Latency (functional)	= 144	Antinociceptic activity in hot-plate test (jump latency) induced by subcutaneous administration of saline (0.20 mL/20 g) 15 min prior to icv injection of JMV-390-1 (10 microL/mouse)	ChEMBL.	8496905
Latency (functional)	= 201	Antinociceptic activity in hot-plate test (jump latency) induced by icv injection of neuromedin N (1 microg) and compound (10 microg)	ChEMBL.	8496905
Latency (functional)	> 240	Antinociceptic activity in hot-plate test (jump latency) induced by icv injection of met-enkephalin (30 microg) and compound (10 microg)	ChEMBL.	8496905

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL286500

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 38353