Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate NMDA receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | type A flavoprotein, putative | 0.0041 | 0.1222 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0041 | 0.1222 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0108 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0053 | 0.2838 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0108 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0108 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0108 | 1 | 1 |
Treponema pallidum | flavodoxin | 0.0041 | 0.1222 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0108 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0041 | 0.1222 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0108 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0041 | 0.1222 | 0.5 |
Echinococcus granulosus | methionine synthase reductase | 0.0067 | 0.4562 | 0.4562 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0041 | 0.1222 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0108 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0067 | 0.4562 | 0.2407 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0108 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0108 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0053 | 0.2838 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0108 | 1 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.0096 | 0.8384 | 0.8159 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0096 | 0.8384 | 0.8159 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0067 | 0.4562 | 0.3805 |
Echinococcus multilocularis | methionine synthase reductase | 0.0067 | 0.4562 | 0.4562 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0108 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0108 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0108 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0067 | 0.4562 | 0.3805 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0096 | 0.8384 | 0.5 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0096 | 0.8384 | 0.8159 |
Brugia malayi | FAD binding domain containing protein | 0.0108 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0096 | 0.8384 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0067 | 0.4562 | 0.5 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0108 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0108 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0108 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0108 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0054 | 0.2946 | 0.0151 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0108 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0108 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0108 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 13810 nM | Displacement of [3H]-CGS-19,755 from glutamate recognition site of N-methyl-D-aspartate glutamate receptor complex | ChEMBL. | 1404235 |
IC50 (binding) | = 13810 nM | Displacement of [3H]-CGS-19,755 from glutamate recognition site of N-methyl-D-aspartate glutamate receptor complex | ChEMBL. | 1404235 |
IC50 (binding) | = 4.08 uM | Ability to displace [3H]-CPP from NMDA receptor in rat brain membrane | ChEMBL. | 1533422 |
IC50 (binding) | = 4.08 uM | Ability to displace [3H]-CPP from NMDA receptor in rat brain membrane | ChEMBL. | 1533422 |
IC50 (functional) | = 34.4 uM | In vitro inhibition of 40 uM NMDA induced depolarization in mouse cortical slices. | ChEMBL. | 1404235 |
MED (functional) | > 160 mg kg-1 | Minimum effective dose measures the in vivo N-methyl-D-aspartate glutamate receptor antagonist activity of compound and its ability to protect mice from lethality induced by 200 mg/kg ip injection of NMDA. | ChEMBL. | 1404235 |
MED (functional) | > 160 mg kg-1 | Minimum effective dose measures the in vivo N-methyl-D-aspartate glutamate receptor antagonist activity of compound and its ability to protect mice from lethality induced by 200 mg/kg ip injection of NMDA. | ChEMBL. | 1404235 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.