Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0023 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0023 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0013 | 0.131 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.1071 | 0.1071 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0023 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0023 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0013 | 0.131 | 0.131 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0023 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.1071 | 0.1071 |
Brugia malayi | hypothetical protein | 0.0012 | 0.1071 | 0.1071 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0023 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0023 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0023 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0023 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0012 | 0.1071 | 0.1071 |
Trypanosoma brucei | cytochrome P450, putative | 0.0013 | 0.131 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0013 | 0.131 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0023 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0023 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0023 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0023 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0023 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0023 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0023 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0023 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0023 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0012 | 0.1071 | 0.1071 |
Brugia malayi | Cytochrome P450 family protein | 0.0013 | 0.131 | 0.131 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0023 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0023 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0023 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0012 | 0.1071 | 0.1071 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0012 | 0.1071 | 0.1071 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0012 | 0.1071 | 0.1071 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0023 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0023 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0023 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0023 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0012 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0023 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0023 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0023 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0023 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0023 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0023 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0023 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0013 | 0.131 | 0.131 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0023 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0023 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0013 | 0.131 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0023 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0023 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0023 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0023 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0023 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0012 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0023 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0023 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.1071 | 0.1071 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0023 | 1 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0012 | 0.1071 | 0.1071 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0023 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0023 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0013 | 0.131 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0023 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0023 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0023 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0013 | 0.131 | 0.131 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0023 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0023 | 1 | 1 |
Onchocerca volvulus | 0.0023 | 1 | 1 | |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0023 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0023 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0023 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0023 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0012 | 0.1071 | 0.1071 |
Schistosoma mansoni | thyroid hormone receptor | 0.0023 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0023 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0023 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0023 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0023 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0023 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0013 | 0.131 | 0.131 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0023 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0023 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 25 % | Inhibition of anti-IgE antibody-stimulated histamine release in human basophills at 10 microM | ChEMBL. | 2470904 |
Inhibition (functional) | = 25 % | Inhibition of anti-IgE antibody-stimulated histamine release in human basophills at 10 microM | ChEMBL. | 2470904 |
Inhibition (functional) | = 37 % | Inhibition of anti-IgE antibody-stimulated histamine release in human basophills at 33 microM | ChEMBL. | 2470904 |
Inhibition (functional) | = 37 % | Inhibition of anti-IgE antibody-stimulated histamine release in human basophills at 33 microM | ChEMBL. | 2470904 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.