TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 329.223 | Formula: C18H14Cl2N2
H donors: 0 H acceptors: 2 LogP: 5.38 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)C(c1ccc(cc1)Cl)(c1cncnc1)C
InChi: 1S/C18H14Cl2N2/c1-18(15-10-21-12-22-11-15,13-2-6-16(19)7-3-13)14-4-8-17(20)9-5-14/h2-12H,1H3
InChiKey: PBJIUWJHFIQGEE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Cytochrome P450 19A1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Cytochrome P450 family protein	Cytochrome P450 19A1	508 aa	448 aa	20.8 %
Drosophila melanogaster	Cytochrome P450-4d1	Cytochrome P450 19A1	508 aa	464 aa	24.6 %
Dictyostelium discoideum	cytochrome P450 family protein	Cytochrome P450 19A1	508 aa	473 aa	18.8 %
Dictyostelium discoideum	cytochrome P450 family protein	Cytochrome P450 19A1	508 aa	465 aa	21.5 %
Loa Loa (eye worm)	cytochrome P450 family protein	Cytochrome P450 19A1	508 aa	450 aa	21.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0538	0.0522
Loa Loa (eye worm)	glutamate receptor	0.0023	0.004	0.0023
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0111	0.0538	0.0522
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0269	0.0252
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0111	0.0538	0.0538
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0051	0.0034
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0111	0.0538	0.0522
Loa Loa (eye worm)	TAR-binding protein	0.0064	0.0269	0.0252
Brugia malayi	nuclear hormone receptor	0.0111	0.0538	0.0538
Brugia malayi	steroid hormone receptor	0.0111	0.0538	0.0538
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0073	0.0323	0.0306
Trichomonas vaginalis	flap endonuclease-1, putative	0.0026	0.0056	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.1552	0.8747	0.8745
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.1772	1	1
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0538	0.0522
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0111	0.0538	0.0522
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0113	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0205	0.0188
Schistosoma mansoni	nuclear receptor nhr-48	0.0052	0.0205	0.0188
Brugia malayi	tailless protein	0.0052	0.0205	0.0205
Schistosoma mansoni	nuclear hormone receptor	0.0111	0.0538	0.0522
Brugia malayi	TAR-binding protein	0.0064	0.0269	0.0269
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.1772	1	1
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0052	0.0205	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0163	0.0146
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0168	0.0151
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0111	0.0538	0.0538
Echinococcus multilocularis	tar DNA binding protein	0.0064	0.0269	0.0252
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0026	0.0056	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0205	0.0188
Brugia malayi	nuclear receptor NHR-88	0.0052	0.0205	0.0205
Loa Loa (eye worm)	flap endonuclease-1	0.0026	0.0056	0.0039
Echinococcus granulosus	tar DNA binding protein	0.0064	0.0269	0.0252
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.0054	0.0213	0.0213
Schistosoma mansoni	metabotropic glutamate receptor	0.005	0.019	0.0173
Brugia malayi	nuclear receptor NHR-88	0.0111	0.0538	0.0538
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0052	0.0205	0.0188
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0111	0.0538	0.0538
Brugia malayi	nuclear receptor RXR	0.0059	0.024	0.024
Brugia malayi	Nuclear hormone receptor E75	0.0052	0.0205	0.0205
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0111	0.0538	0.0522
Brugia malayi	hypothetical protein	0.0025	0.0051	0.0051
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0064	0.0269	0.0252
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0111	0.0538	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0205	0.0188
Loa Loa (eye worm)	nuclear hormone receptor	0.0052	0.0205	0.0188
Echinococcus granulosus	ecdysone induced protein 78C	0.0111	0.0538	0.0522
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0111	0.0538	0.0522
Echinococcus granulosus	thyroid hormone receptor alpha	0.0052	0.0205	0.0188
Entamoeba histolytica	hypothetical protein	0.0036	0.0113	0.0095
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0111	0.0538	0.0522
Brugia malayi	photoreceptor-specific nuclear receptor	0.0111	0.0538	0.0538
Brugia malayi	RNA recognition motif domain containing protein	0.0064	0.0269	0.0269
Schistosoma mansoni	nuclear hormone receptor	0.0052	0.0205	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0538	0.0522
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.1772	1	1
Schistosoma mansoni	coup transcription factor	0.0111	0.0538	0.0522
Brugia malayi	nuclear hormone receptor	0.0052	0.0205	0.0205
Leishmania major	DNA polymerase eta, putative	0.0032	0.0087	0.007
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0073	0.0323	0.0306
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0111	0.0538	0.0522
Schistosoma mansoni	nuclear receptor	0.0052	0.0205	0.0188
Brugia malayi	metabotropic glutamate receptor type 2	0.0029	0.0072	0.0072
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0111	0.0538	0.0522
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.1772	1	1
Giardia lamblia	Flap structure-specific endonuclease	0.0026	0.0056	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0205	0.0188
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0269	0.0252
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0168	0.0151
Schistosoma mansoni	hypothetical protein	0.017	0.0875	0.0859
Echinococcus multilocularis	dna polymerase eta	0.0045	0.0163	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0205	0.0188
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0032	0.0087	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0111	0.0538	0.0522
Schistosoma mansoni	nuclear hormone receptor	0.0052	0.0205	0.0188
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0111	0.0538	0.0522
Onchocerca volvulus		0.0111	0.0538	1
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0067	0.0291	0.0274
Schistosoma mansoni	zinc finger protein	0.0052	0.0205	0.0188
Echinococcus multilocularis	geminin	0.017	0.0875	0.0859
Echinococcus multilocularis	flap endonuclease 1	0.0026	0.0056	0.0039
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0111	0.0538	0.0538
Onchocerca volvulus	Bile acid receptor homolog	0.0111	0.0538	1
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0017	0.5
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0052	0.0205	0.0205
Schistosoma mansoni	metabotropic glutamate receptor	0.0029	0.0072	0.0054
Plasmodium falciparum	flap endonuclease 1	0.0026	0.0056	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0111	0.0538	0.0522
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0059	0.024	0.0224
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0052	0.0205	0.0188
Entamoeba histolytica	Flap nuclease, putative	0.0026	0.0056	0.0039
Schistosoma mansoni	flap endonuclease-1	0.0024	0.0042	0.0024
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0111	0.0538	0.0522
Brugia malayi	hypothetical protein	0.0052	0.0205	0.0205
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0113	0.0095
Echinococcus granulosus	transcription factor Dp 1	0.1026	0.5749	0.5742
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0205	0.0188
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0059	0.024	0.0224
Schistosoma mansoni	RAR-like nuclear receptor	0.0111	0.0538	0.0522
Brugia malayi	Nuclear hormone receptor-like 1	0.0059	0.024	0.024
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0111	0.0538	0.0538
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0111	0.0538	0.0538
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.1772	1	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0168	0.0151
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0111	0.0538	0.0538
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0026	0.0056	0.0039
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0111	0.0538	0.0522
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0111	0.0538	0.0522
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0111	0.0538	0.0522
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0168	0.0151
Loa Loa (eye worm)	RNA binding protein	0.0064	0.0269	0.0252
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0168	0.0151
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0019	0.0017	0.5
Echinococcus multilocularis	ecdysone induced protein 78C	0.0111	0.0538	0.0522
Leishmania major	hypothetical protein, conserved	0.0025	0.0051	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0323	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0538	0.0522
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.005	0.019	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0059	0.024	0.0224
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0052	0.0205	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0059	0.024	0.0224
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0052	0.0205	0.0205
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0113	0.0095
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0017	0.5
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0059	0.024	0.0224
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0111	0.0538	0.0522
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0111	0.0538	0.0522
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0026	0.0056	0.0039
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0111	0.0538	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0205	0.0188
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0052	0.0205	0.0188
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0052	0.0205	0.0188
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0111	0.0538	0.0522
Trypanosoma cruzi	DNA polymerase eta, putative	0.0045	0.0163	0.0146
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0111	0.0538	0.0522
Brugia malayi	nuclear receptor NHR-67	0.0052	0.0205	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0205	0.0188
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0168	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0538	0.0522
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0059	0.024	0.0224
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0051	0.0034
Brugia malayi	hypothetical protein	0.0059	0.024	0.024
Plasmodium vivax	flap endonuclease 1, putative	0.0026	0.0056	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0059	0.024	0.024
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0052	0.0205	0.0188
Loa Loa (eye worm)	DR-78	0.0052	0.0205	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0059	0.024	0.0224
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0059	0.024	0.0224
Echinococcus granulosus	FTZ F1 alpha	0.0111	0.0538	0.0522
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0168	0.0168
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.0017	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0111	0.0538	0.0522
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0017	0.0017
Brugia malayi	Nuclear hormone receptor-like 1	0.0111	0.0538	0.0538
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0059	0.0245	0.0245
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.1772	1	1
Entamoeba histolytica	hypothetical protein	0.0036	0.0113	0.0095
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0052	0.0205	0.0188
Schistosoma mansoni	thyroid hormone receptor	0.0111	0.0538	0.0522
Schistosoma mansoni	retinoic acid receptor RXR	0.1552	0.8747	0.8745
Brugia malayi	nuclear receptor RXR	0.0052	0.0205	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0059	0.024	0.0224
Schistosoma mansoni	hypothetical protein	0.0036	0.0113	0.0095
Onchocerca volvulus	Protein ultraspiracle homolog	0.0111	0.0538	1
Schistosoma mansoni	thyroid hormone receptor	0.0111	0.0538	0.0522
Entamoeba histolytica	hypothetical protein	0.0036	0.0113	0.0095
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0111	0.0538	0.0522
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0051	0.0034
Brugia malayi	ecdysone receptor	0.0052	0.0205	0.0205
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0026	0.0056	0.1335
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0111	0.0538	0.0522
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0111	0.0538	0.0522
Entamoeba histolytica	hypothetical protein	0.0036	0.0113	0.0095
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0111	0.0538	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0538	0.0522
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.1772	1	1
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0051	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0205	0.0188
Schistosoma mansoni	DNA polymerase eta	0.0045	0.0163	0.0146
Trypanosoma brucei	DNA polymerase eta, putative	0.0045	0.0163	0.0146
Echinococcus multilocularis	transcription factor Dp 1	0.1026	0.5749	0.5742
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0052	0.0205	0.0188
Echinococcus granulosus	nuclear receptor nhr 48	0.0052	0.0205	0.0188
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0269	0.0252
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0269	0.0252
Loa Loa (eye worm)	glutamate receptor	0.0059	0.0245	0.0228
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0111	0.0538	0.0538
Leishmania major	DNA polymerase eta, putative	0.0045	0.0163	0.0146
Brugia malayi	nuclear hormone receptor family member odr-7	0.0052	0.0205	0.0205
Schistosoma mansoni	nuclear receptor	0.0052	0.0205	0.0188
Echinococcus granulosus	dna polymerase eta	0.0045	0.0163	0.0146
Echinococcus granulosus	flap endonuclease 1	0.0026	0.0056	0.0039
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0111	0.0538	0.0522
Brugia malayi	Flap endonuclease-1	0.0026	0.0056	0.0056
Brugia malayi	hypothetical protein	0.0059	0.024	0.024
Trypanosoma cruzi	DNA polymerase eta, putative	0.0032	0.0087	0.007
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.1772	1	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0111	0.0538	0.0522
Echinococcus granulosus	geminin	0.017	0.0875	0.0859
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.1493	0.8413	0.8411
Brugia malayi	conserved hypotetical protein	0.0052	0.0205	0.0205
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0111	0.0538	0.0522
Brugia malayi	hypothetical protein	0.0036	0.0113	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0205	0.0188
Brugia malayi	Steroid receptor seven-up type 2	0.0111	0.0538	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0205	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0059	0.024	0.0224
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0052	0.0205	0.0188
Brugia malayi	hypothetical protein	0.0052	0.0205	0.0205
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0111	0.0538	0.0538
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0111	0.0538	0.0538
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0111	0.0538	0.0522
Echinococcus multilocularis	FTZ F1 alpha	0.0111	0.0538	0.0522
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0538	0.0522
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0205	0.0188
Schistosoma mansoni	hypothetical protein	0.017	0.0875	0.0859
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0052	0.0205	0.0188
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0168	0.0151
Brugia malayi	Nuclear hormone receptor E75	0.0052	0.0205	0.0205
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0168	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0538	0.0522
Brugia malayi	ImpB/MucB/SamB family protein	0.0045	0.0163	0.0163
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0111	0.0538	0.0538
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.1772	1	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0052	0.0205	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0205	0.0188
Brugia malayi	orphan nuclear receptor NR2E1	0.0052	0.0205	0.0205
Brugia malayi	ecdysteroid receptor	0.0111	0.0538	0.0538
Echinococcus granulosus	metabotropic glutamate receptor 2	0.005	0.019	0.0173
Echinococcus multilocularis	nuclear receptor nhr 48	0.0052	0.0205	0.0188
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0269	0.0252
Brugia malayi	RNA binding protein	0.0064	0.0269	0.0269
Loa Loa (eye worm)	steroid hormone receptor	0.0111	0.0538	0.0522

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (binding)	= 0.082 uM	In vitro inhibition of cytochrome P450 19A1 by rat ovarian microsomes incubated with [3H]-androstenedione and NADPH-generating system.	ChEMBL.	3612685
EC50 (binding)	= 0.082 uM	In vitro inhibition of cytochrome P450 19A1 by rat ovarian microsomes incubated with [3H]-androstenedione and NADPH-generating system.	ChEMBL.	3612685

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 38421