Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0024 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0024 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0024 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0024 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0024 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0024 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0024 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0013 | 0.131 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0024 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0024 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0024 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0024 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0024 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0024 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0013 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0013 | 0.131 | 0.131 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.1071 | 0.1071 |
Brugia malayi | nuclear receptor RXR | 0.0013 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0024 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0024 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0013 | 0.131 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0024 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0024 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0024 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.1071 | 0.1071 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0024 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0024 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0013 | 0.1071 | 0.1071 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0024 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.1071 | 0.1071 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0024 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0013 | 0.1071 | 0.1071 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0024 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0024 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0024 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0024 | 1 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0013 | 0.131 | 0.131 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0024 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0013 | 0.131 | 0.131 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0024 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0024 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0013 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0024 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0013 | 0.131 | 0.131 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 1 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0013 | 0.1071 | 0.1071 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0024 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0024 | 1 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0013 | 0.131 | 0.5 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0013 | 0.1071 | 0.1071 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0024 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0024 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0024 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0024 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0024 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0024 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0024 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0024 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0024 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0024 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0024 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0024 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0024 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0024 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0013 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0024 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0013 | 0.131 | 0.5 |
Onchocerca volvulus | 0.0024 | 1 | 1 | |
Schistosoma mansoni | coup transcription factor | 0.0024 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0013 | 0.131 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0024 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0024 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0024 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0024 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0024 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0024 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0024 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0013 | 0.131 | 0.131 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0013 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0024 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0024 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0024 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0024 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0013 | 0.1071 | 0.1071 |
Schistosoma mansoni | nuclear hormone receptor | 0.0024 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.1071 | 0.1071 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0024 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
NA (functional) | 0 | Antimalarial activity tested in vitro against Plasmodium falciparum; NA=no activity at 10 microM | ChEMBL. | 11882006 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.