Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | thymidylate kinase | 0.0153 | 0.051 | 1 |
Onchocerca volvulus | 0.0056 | 0.0126 | 0.094 | |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0178 | 0.0607 | 0.0976 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0053 | 0.0518 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0053 | 0.0056 |
Brugia malayi | Deoxynucleoside kinase family protein | 0.0142 | 0.0467 | 0.524 |
Onchocerca volvulus | Putative thymidylate kinase | 0.0153 | 0.051 | 0.5106 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0053 | 0.0114 | 0.1314 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0033 | 0.0038 | 0.0156 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.01 | 0.106 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0045 | 0.0085 | 0.0571 |
Giardia lamblia | Ribonuclease H | 0.0046 | 0.0087 | 0.0015 |
Trypanosoma cruzi | thymidine kinase, putative | 0.1554 | 0.6028 | 1 |
Onchocerca volvulus | 0.0178 | 0.0607 | 0.6158 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 0.0191 | 0.0284 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0072 | 0.0191 | 0.023 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0041 | 0.0069 | 0.0026 |
Giardia lamblia | Deoxyguanosine kinase/deoxyadenosine kinase subunit, putative | 0.0142 | 0.0467 | 0.0398 |
Onchocerca volvulus | 0.0037 | 0.0053 | 0.0148 | |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.1674 | 0.6502 | 0.6863 |
Trypanosoma brucei | unspecified product | 0.0042 | 0.0071 | 0.0085 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.0143 | 0.1129 |
Leishmania major | DNA polymerase eta, putative | 0.0042 | 0.0071 | 0.003 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.006 | 0.0142 | 0.0149 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0042 | 0.0071 | 0.0555 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0105 | 0.0319 | 0.0444 |
Leishmania major | hypothetical protein, conserved | 0.006 | 0.0144 | 0.0151 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0042 | 0.0071 | 0.0727 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0056 | 0.0126 | 0.1367 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0033 | 0.0038 | 0.0156 |
Loa Loa (eye worm) | deoxynucleoside kinase | 0.0142 | 0.0467 | 0.5326 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0119 | 0.0375 | 0.0396 |
Schistosoma mansoni | family S10 unassigned peptidase (S10 family) | 0.0041 | 0.0069 | 0.0073 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0142 | 0.0467 | 0.0692 |
Echinococcus granulosus | lamin dm0 | 0.0056 | 0.0126 | 0.0133 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0105 | 0.032 | 0.3501 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.01 | 0.0106 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0119 | 0.0375 | 0.0538 |
Entamoeba histolytica | hypothetical protein | 0.0142 | 0.0467 | 0.0692 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.0053 | 0.0056 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0042 | 0.0071 | 0.003 |
Entamoeba histolytica | hypothetical protein | 0.0142 | 0.0467 | 0.0692 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0042 | 0.0071 | 0.0323 |
Schistosoma mansoni | glycogen phosphorylase | 0.0105 | 0.0319 | 0.0336 |
Trichomonas vaginalis | thymidylate kinase, putative | 0.0153 | 0.051 | 0.0764 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0143 | 0.161 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0153 | 0.051 | 0.0764 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0034 | 0.004 | 0.0042 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.004 | 0.0042 |
Echinococcus multilocularis | musashi | 0.0056 | 0.0126 | 0.0133 |
Schistosoma mansoni | thymidylate kinase | 0.0153 | 0.051 | 0.0538 |
Echinococcus granulosus | Thymidine kinase 2 mitochondrial | 0.2429 | 0.9475 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0142 | 0.0467 | 0.0692 |
Trypanosoma cruzi | UMP-CMP kinase, mitochondrial, putative | 0.006 | 0.0144 | 0.0151 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.006 | 0.0142 | 0.1321 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.006 | 0.0142 | 0.1321 |
Echinococcus granulosus | glycogen phosphorylase | 0.0105 | 0.0319 | 0.0336 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0178 | 0.0607 | 1 |
Trichomonas vaginalis | thymidylate kinase, putative | 0.0153 | 0.051 | 0.0764 |
Echinococcus granulosus | GPCR family 2 | 0.0033 | 0.0038 | 0.004 |
Trypanosoma brucei | thymidine kinase | 0.1554 | 0.6028 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.004 | 0.0042 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0053 | 0.0114 | 0.0102 |
Onchocerca volvulus | 0.0037 | 0.0053 | 0.0148 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0142 | 0.0467 | 0.0692 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0042 | 0.0071 | 0.0075 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0037 | 0.0053 | 0.0056 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0038 | 0.004 |
Onchocerca volvulus | 0.0267 | 0.0961 | 1 | |
Trypanosoma brucei | hypothetical protein, conserved | 0.0037 | 0.0053 | 0.0055 |
Brugia malayi | hypothetical protein | 0.0053 | 0.0114 | 0.1064 |
Brugia malayi | RNase H family protein | 0.0046 | 0.0087 | 0.0734 |
Entamoeba histolytica | glycogenphosphorylase, putative | 0.0045 | 0.0085 | 0.0053 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 0.0191 | 0.0284 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0053 | 0.0114 | 0.1314 |
Brugia malayi | Serine carboxypeptidase F41C3.5 precursor | 0.0041 | 0.0069 | 0.0529 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0042 | 0.0071 | 0.0227 |
Brugia malayi | intermediate filament protein | 0.0056 | 0.0126 | 0.1206 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.014 | 0.0459 | 0.0484 |
Trypanosoma brucei | RNA helicase, putative | 0.0319 | 0.1162 | 0.1901 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0042 | 0.0071 | 0.0075 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0119 | 0.0375 | 0.0538 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.006 | 0.0142 | 0.0571 |
Trichomonas vaginalis | thymidine kinase, putative | 0.1554 | 0.6028 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0105 | 0.0319 | 0.0444 |
Leishmania major | thymidylate kinase-like protein | 0.0153 | 0.051 | 0.0764 |
Echinococcus multilocularis | lysosomal protective protein | 0.0041 | 0.0069 | 0.0073 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0178 | 0.0607 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0042 | 0.0071 | 0.0085 |
Echinococcus granulosus | dna polymerase eta | 0.0042 | 0.0071 | 0.0075 |
Mycobacterium tuberculosis | Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) | 0.0153 | 0.051 | 0.5786 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0071 | 0.0085 |
Entamoeba histolytica | hypothetical protein | 0.0142 | 0.0467 | 0.0692 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.0053 | 0.0056 |
Leishmania major | DNA polymerase kappa, putative | 0.0042 | 0.0071 | 0.003 |
Schistosoma mansoni | NADH-ubiquinone oxidoreductase | 0.0142 | 0.0467 | 0.0493 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0053 | 0.0115 | 0.0157 |
Plasmodium vivax | hypothetical protein, conserved | 0.0037 | 0.0053 | 0.0241 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0053 | 0.0341 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0042 | 0.0071 | 0.0085 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0037 | 0.0053 | 0.0518 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0053 | 0.0115 | 0.0157 |
Echinococcus multilocularis | GPCR, family 2 | 0.0033 | 0.0038 | 0.004 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0071 | 0.0085 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0119 | 0.0375 | 0.0538 |
Brugia malayi | hypothetical protein | 0.0085 | 0.024 | 0.2552 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.006 | 0.0142 | 0.181 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0105 | 0.032 | 0.362 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0103 | 0.0109 |
Giardia lamblia | Glycogen phosphorylase | 0.0105 | 0.0319 | 0.0249 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.0038 | 0.004 |
Brugia malayi | thymidylate kinase | 0.0153 | 0.051 | 0.5751 |
Schistosoma mansoni | lipoxygenase | 0.0057 | 0.0132 | 0.0139 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.0189 | 0.02 |
Echinococcus multilocularis | thymidylate synthase | 0.0178 | 0.0607 | 0.064 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.006 | 0.0142 | 0.015 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0122 | 0.132 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0042 | 0.0071 | 0.0085 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0042 | 0.0071 | 0.0075 |
Schistosoma mansoni | phosphoglucomutase | 0.0046 | 0.0087 | 0.0091 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0119 | 0.0375 | 0.0538 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.0574 | 0.0606 |
Trypanosoma brucei | unspecified product | 0.0053 | 0.0115 | 0.0157 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0119 | 0.0375 | 0.0539 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.0038 | 0.004 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0041 | 0.0069 | 0.0026 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0042 | 0.0071 | 0.0555 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0119 | 0.0375 | 0.0538 |
Mycobacterium ulcerans | thymidylate synthase | 0.0178 | 0.0607 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0053 | 0.0115 | 0.0157 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0053 | 0.0056 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0053 | 0.0343 |
Trichomonas vaginalis | set domain proteins, putative | 0.0267 | 0.0961 | 0.1518 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.006 | 0.0142 | 0.0149 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0053 | 0.0518 |
Leishmania major | hypothetical protein, conserved | 0.0053 | 0.0114 | 0.0102 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.014 | 0.0459 | 0.0484 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0041 | 0.0069 | 0.0081 |
Echinococcus granulosus | dna polymerase kappa | 0.0042 | 0.0071 | 0.0075 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 0.0191 | 0.0284 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0037 | 0.0053 | 0.0056 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0056 | 0.0126 | 0.1206 |
Schistosoma mansoni | hypothetical protein | 0.0153 | 0.051 | 0.0538 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.01 | 0.0106 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0053 | 0.0518 |
Entamoeba histolytica | hypothetical protein | 0.0142 | 0.0467 | 0.0692 |
Echinococcus multilocularis | ribonuclease H1 | 0.0046 | 0.0087 | 0.0091 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0037 | 0.0053 | 0.0343 |
Schistosoma mansoni | phosphoglucomutase | 0.0046 | 0.0087 | 0.0091 |
Brugia malayi | RNase H family protein | 0.0046 | 0.0087 | 0.0734 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0072 | 0.0189 | 0.1953 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.006 | 0.0142 | 0.0149 |
Echinococcus granulosus | family S10 non peptidase ue S10 family | 0.0037 | 0.0053 | 0.0056 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0143 | 0.015 |
Brugia malayi | Pre-SET motif family protein | 0.0235 | 0.0833 | 0.9574 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.006 | 0.0142 | 0.1128 |
Echinococcus granulosus | thymidine kinase | 0.2429 | 0.9475 | 1 |
Echinococcus granulosus | geminin | 0.0344 | 0.1264 | 0.1334 |
Toxoplasma gondii | exonuclease III APE | 0.006 | 0.0142 | 0.181 |
Entamoeba histolytica | thymidine kinase, putative | 0.1554 | 0.6028 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0072 | 0.0191 | 0.023 |
Echinococcus granulosus | thymidylate synthase | 0.0178 | 0.0607 | 0.064 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0038 | 0.004 |
Loa Loa (eye worm) | intermediate filament protein | 0.0056 | 0.0126 | 0.1367 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0042 | 0.0071 | 0.0227 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.0053 | 0.0056 |
Giardia lamblia | CDC8 | 0.0153 | 0.051 | 0.0442 |
Echinococcus granulosus | ribonuclease H1 | 0.0046 | 0.0087 | 0.0091 |
Schistosoma mansoni | glycogen phosphorylase | 0.0105 | 0.0319 | 0.0336 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0105 | 0.0319 | 0.3604 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0178 | 0.0607 | 0.7014 |
Trypanosoma cruzi | thymidine kinase, putative | 0.1554 | 0.6028 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0042 | 0.0071 | 0.0075 |
Leishmania major | cathepsin L-like protease | 0.0072 | 0.0191 | 0.023 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0071 | 0.0085 |
Schistosoma mansoni | hypothetical protein | 0.014 | 0.0459 | 0.0484 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0053 | 0.0518 |
Loa Loa (eye worm) | thymidylate kinase | 0.0153 | 0.051 | 0.5828 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0153 | 0.051 | 0.0764 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 0.0191 | 0.0284 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0042 | 0.0071 | 0.0085 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.005 | 0.0103 | 0.0932 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0046 | 0.0087 | 0.0055 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0142 | 0.0467 | 0.0692 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0178 | 0.0607 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0034 | 0.004 | 0.0181 |
Treponema pallidum | thymidylate kinase (tmk) | 0.0153 | 0.051 | 1 |
Giardia lamblia | Hypothetical protein | 0.0142 | 0.0467 | 0.0398 |
Brugia malayi | RNase H family protein | 0.0046 | 0.0087 | 0.0734 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0053 | 0.0115 | 0.0157 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0142 | 0.0467 | 0.0692 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.0038 | 0.004 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0042 | 0.0071 | 0.003 |
Schistosoma mansoni | intermediate filament proteins | 0.0056 | 0.0126 | 0.0133 |
Echinococcus multilocularis | thymidine kinase | 0.2429 | 0.9475 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.003 | 0.0025 | 0.0182 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0106 | 0.0326 | 0.4926 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0237 | 0.0842 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0053 | 0.0518 |
Onchocerca volvulus | Uncharacterized serine carboxypeptidase homolog | 0.0041 | 0.0069 | 0.0319 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.016 | 0.0537 | 0.0567 |
Schistosoma mansoni | family S10 non-peptidase homologue (S10 family) | 0.0041 | 0.0069 | 0.0073 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0042 | 0.0071 | 0.003 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0046 | 0.0087 | 0.0055 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.006 | 0.0142 | 0.1554 |
Plasmodium falciparum | thymidylate kinase | 0.0153 | 0.051 | 0.8034 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0105 | 0.0319 | 0.0336 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0038 | 0.0336 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0046 | 0.0087 | 0.0507 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 0.0191 | 0.0284 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0071 | 0.0085 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0038 | 0.004 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0066 | 0.0166 | 0.0189 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0041 | 0.0069 | 0.0081 |
Schistosoma mansoni | thymidylate kinase | 0.0153 | 0.051 | 0.0538 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.004 | 0.0042 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.01 | 0.0106 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0178 | 0.0607 | 0.064 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0105 | 0.0319 | 0.0336 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0178 | 0.0607 | 0.0926 |
Echinococcus multilocularis | lamin dm0 | 0.0056 | 0.0126 | 0.0133 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0071 | 0.0085 |
Entamoeba histolytica | hypothetical protein | 0.0142 | 0.0467 | 0.0692 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0069 | 0.0702 |
Entamoeba histolytica | hypothetical protein | 0.0142 | 0.0467 | 0.0692 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0142 | 0.0467 | 0.0692 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 0.0191 | 0.0284 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.0143 | 0.0149 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.01 | 0.0106 |
Chlamydia trachomatis | thymidylate kinase | 0.0153 | 0.051 | 1 |
Schistosoma mansoni | phosphoglucomutase | 0.0046 | 0.0087 | 0.0091 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.0038 | 0.004 |
Echinococcus multilocularis | geminin | 0.0344 | 0.1264 | 0.1334 |
Echinococcus multilocularis | transfer RNA-Ile | 0.2429 | 0.9475 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0057 | 0.0132 | 0.0139 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0041 | 0.0069 | 0.0026 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 0.0191 | 0.0284 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0042 | 0.0071 | 0.003 |
Schistosoma mansoni | thyroid hormone receptor | 0.016 | 0.0537 | 0.0567 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0085 | 0.024 | 0.0312 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0034 | 0.004 | 0.0042 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0053 | 0.0114 | 0.0102 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.004 | 0.036 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0085 | 0.024 | 0.2364 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0105 | 0.032 | 0.3501 |
Trichomonas vaginalis | thymidine kinase, putative | 0.1554 | 0.6028 | 1 |
Echinococcus granulosus | NADH ubiquinone oxidoreductase 42 kDa subunit | 0.0142 | 0.0467 | 0.0493 |
Trichomonas vaginalis | ap endonuclease, putative | 0.006 | 0.0142 | 0.0149 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0027 | 0.0013 | 0.0014 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0057 | 0.0132 | 0.0139 |
Leishmania major | cathepsin L-like protease | 0.0072 | 0.0191 | 0.023 |
Echinococcus multilocularis | NADH ubiquinone oxidoreductase 42 kDa subunit | 0.0142 | 0.0467 | 0.0493 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0045 | 0.0085 | 0.04 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 0.0191 | 0.0284 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0053 | 0.0056 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0244 | 0.0869 | 0.0917 |
Schistosoma mansoni | glycogen phosphorylase | 0.0045 | 0.0085 | 0.009 |
Brugia malayi | beta-lactamase | 0.0037 | 0.0053 | 0.0343 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0053 | 0.0518 |
Echinococcus granulosus | thymidylate kinase | 0.0153 | 0.051 | 0.0538 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0126 | 0.1367 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0057 | 0.013 | 0.0128 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0046 | 0.0087 | 0.0055 |
Loa Loa (eye worm) | beta-lactamase | 0.0037 | 0.0053 | 0.0518 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0119 | 0.0375 | 0.6814 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0178 | 0.0607 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0053 | 0.0343 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.01 | 0.0106 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0142 | 0.0467 | 0.0692 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0189 | 0.21 |
Echinococcus granulosus | intermediate filament protein | 0.0056 | 0.0126 | 0.0133 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0038 | 0.004 |
Toxoplasma gondii | thymidylate kinase | 0.0153 | 0.051 | 0.8292 |
Echinococcus multilocularis | thymidylate kinase | 0.0153 | 0.051 | 0.0538 |
Leishmania major | thymidine kinase, putative | 0.1554 | 0.6028 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0143 | 0.161 |
Schistosoma mansoni | lamin | 0.0056 | 0.0126 | 0.0133 |
Toxoplasma gondii | ribonuclease HI protein | 0.0046 | 0.0087 | 0.0824 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0042 | 0.0071 | 0.003 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0244 | 0.0869 | 0.0917 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0033 | 0.0038 | 0.0336 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0143 | 0.015 |
Leishmania major | ribonuclease H1, putative | 0.0046 | 0.0087 | 0.0055 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.006 | 0.0142 | 0.015 |
Schistosoma mansoni | inositol monophosphatase | 0.0119 | 0.0375 | 0.0396 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0178 | 0.0607 | 0.0926 |
Schistosoma mansoni | ap endonuclease | 0.006 | 0.0142 | 0.015 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.01 | 0.0106 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0119 | 0.0375 | 0.0396 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 0.0191 | 0.0284 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0071 | 0.0085 |
Brugia malayi | carbohydrate phosphorylase | 0.0105 | 0.0319 | 0.3485 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0032 | 0.0035 | 0.0037 |
Trypanosoma brucei | thymidylate kinase, putative | 0.0153 | 0.051 | 0.0815 |
Echinococcus multilocularis | dna polymerase kappa | 0.0042 | 0.0071 | 0.0075 |
Entamoeba histolytica | Thymidylate kinase, putative | 0.0153 | 0.051 | 0.0764 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0034 | 0.004 | 0.0042 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0235 | 0.0833 | 0.9582 |
Echinococcus granulosus | glycogen phosphorylase | 0.0105 | 0.0319 | 0.0336 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0119 | 0.0375 | 0.5812 |
Loa Loa (eye worm) | inositol-1 | 0.0119 | 0.0375 | 0.4259 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.006 | 0.0142 | 0.0149 |
Schistosoma mansoni | hypothetical protein | 0.0344 | 0.1264 | 0.1334 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0027 | 0.0013 | 0.0014 |
Echinococcus multilocularis | dna polymerase eta | 0.0042 | 0.0071 | 0.0075 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0114 | 0.1227 |
Schistosoma mansoni | lamin | 0.0056 | 0.0126 | 0.0133 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0042 | 0.0071 | 0.0323 |
Echinococcus multilocularis | family S10 non peptidase ue (S10 family) | 0.0037 | 0.0053 | 0.0056 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0071 | 0.0727 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0105 | 0.0319 | 0.3029 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0119 | 0.0375 | 0.0538 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0071 | 0.0085 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.0143 | 0.015 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0042 | 0.0071 | 0.003 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.01 | 0.0894 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.032 | 0.362 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0041 | 0.0193 |
Leishmania major | serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 | 0.0041 | 0.0069 | 0.0026 |
Onchocerca volvulus | 0.005 | 0.0103 | 0.0688 | |
Schistosoma mansoni | thymidine kinase | 0.2429 | 0.9475 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.006 | 0.0142 | 0.1397 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.01 | 0.0106 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0119 | 0.0375 | 0.059 |
Schistosoma mansoni | survival motor neuron protein | 0.005 | 0.0103 | 0.0109 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0071 | 0.0085 |
Schistosoma mansoni | hypothetical protein | 0.0344 | 0.1264 | 0.1334 |
Onchocerca volvulus | 0.0056 | 0.0126 | 0.094 | |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0072 | 0.0191 | 0.023 |
Schistosoma mansoni | hypothetical protein | 0.0319 | 0.1162 | 0.1227 |
Brugia malayi | hypothetical protein | 0.0244 | 0.0869 | 1 |
Giardia lamblia | Thymidine kinase | 0.1554 | 0.6028 | 0.5999 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0072 | 0.0191 | 0.023 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.0143 | 0.1812 |
Mycobacterium ulcerans | thymidylate kinase | 0.0153 | 0.051 | 0.825 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.006 | 0.0142 | 0.0203 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0013 | 0.0047 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0042 | 0.0071 | 0.003 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0071 | 0.0085 |
Trichomonas vaginalis | thymidine kinase, putative | 0.1554 | 0.6028 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.016 | 0.0537 | 0.0567 |
Trypanosoma cruzi | UMP-CMP kinase, mitochondrial, putative | 0.006 | 0.0144 | 0.0151 |
Trypanosoma brucei | thymidylate kinase, putative | 0.0153 | 0.051 | 0.0815 |
Echinococcus multilocularis | lamin | 0.0056 | 0.0126 | 0.0133 |
Echinococcus multilocularis | thymidine kinase | 0.2429 | 0.9475 | 1 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0105 | 0.0319 | 0.0336 |
Schistosoma mansoni | ap endonuclease | 0.006 | 0.0142 | 0.015 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0041 | 0.0069 | 0.0081 |
Entamoeba histolytica | hypothetical protein | 0.0142 | 0.0467 | 0.0692 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0119 | 0.0375 | 0.5913 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0142 | 0.0467 | 0.0692 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0042 | 0.0071 | 0.003 |
Leishmania major | cathepsin L-like protease | 0.0072 | 0.0191 | 0.023 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0085 | 0.024 | 0.0312 |
Trypanosoma brucei | ribonuclease H1 | 0.0046 | 0.0087 | 0.011 |
Schistosoma mansoni | inositol monophosphatase | 0.0119 | 0.0375 | 0.0396 |
Echinococcus granulosus | lamin | 0.0056 | 0.0126 | 0.0133 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0053 | 0.0114 | 0.0156 |
Loa Loa (eye worm) | thymidylate synthase | 0.0178 | 0.0607 | 0.6955 |
Brugia malayi | thymidylate synthase | 0.0178 | 0.0607 | 0.6898 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0106 | 0.0326 | 0.3455 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0045 | 0.0085 | 0.0053 |
Onchocerca volvulus | 0.0037 | 0.0053 | 0.0148 | |
Echinococcus granulosus | lysosomal protective protein | 0.0041 | 0.0069 | 0.0073 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0142 | 0.0467 | 0.0692 |
Entamoeba histolytica | hypothetical protein | 0.0142 | 0.0467 | 0.0692 |
Plasmodium vivax | thymidylate kinase, putative | 0.0153 | 0.051 | 0.8292 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0045 | 0.0085 | 0.0053 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0142 | 0.0467 | 0.0692 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0105 | 0.0319 | 0.0444 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0042 | 0.0071 | 0.0085 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0105 | 0.0319 | 0.0444 |
Brugia malayi | Inositol-1 | 0.0119 | 0.0375 | 0.4153 |
Toxoplasma gondii | ABC1 family protein | 0.0037 | 0.0053 | 0.0241 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0042 | 0.0071 | 0.003 |
Loa Loa (eye worm) | hypothetical protein | 0.0244 | 0.0869 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.006 | 0.0142 | 0.1608 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.0143 | 0.015 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.006 | 0.0142 | 0.0072 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0042 | 0.0071 | 0.0075 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 0.0191 | 0.0284 |
Giardia lamblia | Hypothetical protein | 0.0142 | 0.0467 | 0.0398 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0041 | 0.0069 | 0.0026 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0105 | 0.0319 | 0.0336 |
Echinococcus granulosus | thymidine kinase | 0.2429 | 0.9475 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.006 | 0.0142 | 0.0149 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0143 | 0.161 |
Mycobacterium leprae | probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) | 0.0153 | 0.051 | 0.825 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0034 | 0.004 | 0.0042 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0072 | 0.0191 | 0.0284 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AB50 (functional) | = 34 mg kg-1 | Concentration required to produce 50% block in avoidance responding in conditioned avoidance response test in rat | ChEMBL. | 2898533 |
Ki (binding) | = 14 nM | In vitro inhibition of [3H]-spiperone binding to 5-hydroxytryptamine 1A receptor from rat hippocampal tissue. | ChEMBL. | 2898533 |
Ki (binding) | = 140 nM | In vitro inhibition of [3H]-spiperone binding to Dopamine receptor D2 from rat brain limbic tissue | ChEMBL. | 2898533 |
logP (ADMET) | = 1.83 | Partition coefficient (logP) | ChEMBL. | 2898533 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.