Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | geranylgeranyl transferase type 2 subunit alpha | 0.0125 | 0.105 | 0.105 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0065 | 0.0281 | 0.0242 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0286 | 0.3122 | 0.3095 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0065 | 0.0281 | 0.0242 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0281 | 0.0242 |
Entamoeba histolytica | protein farnesyltransferase alpha subunit, putative | 0.0362 | 0.4098 | 1 |
Brugia malayi | Muscleblind-like protein | 0.015 | 0.1377 | 0.1342 |
Entamoeba histolytica | protein farnesyltransferase beta subunit, putative | 0.0255 | 0.2719 | 0.6032 |
Brugia malayi | Protein prenyltransferase alpha subunit repeat containing protein | 0.0125 | 0.105 | 0.1014 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0362 | 0.4098 | 1 |
Entamoeba histolytica | Rab geranylgeranyltransferase alpha subunit, putative | 0.0125 | 0.105 | 0.1232 |
Brugia malayi | Prenyltransferase and squalene oxidase repeat family protein | 0.0261 | 0.2806 | 0.2777 |
Schistosoma mansoni | geranylgeranyl transferase type I beta subunit | 0.0261 | 0.2806 | 0.2777 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0237 | 0.2498 | 0.6096 |
Echinococcus multilocularis | protein farnesyltransferase subunit beta | 0.0255 | 0.2719 | 0.2689 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0065 | 0.0281 | 0.0242 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.004 | 0.004 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0146 | 0.1319 | 0.1284 |
Trypanosoma cruzi | protein farnesyltransferase, putative | 0.0255 | 0.2719 | 1 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0065 | 0.0281 | 0.0242 |
Trichomonas vaginalis | protein farnesyltransferase beta subunit, putative | 0.0091 | 0.0622 | 0.1518 |
Schistosoma mansoni | protein farnesyltransferase alpha subunit | 0.0362 | 0.4098 | 0.4074 |
Brugia malayi | Variant SH3 domain containing protein | 0.0065 | 0.0281 | 0.0242 |
Echinococcus granulosus | protein farnesyltransferase alpha subunit | 0.0362 | 0.4098 | 0.4098 |
Echinococcus granulosus | protein prenyltransferase alpha subunit | 0.0125 | 0.105 | 0.105 |
Trypanosoma brucei | Protein prenyltransferase alpha subunit repeat, putative | 0.0125 | 0.105 | 0.2042 |
Trypanosoma brucei | lanosterol synthase | 0.0184 | 0.1807 | 0.5653 |
Plasmodium vivax | prenyltransferase alpha subunit, putative | 0.0362 | 0.4098 | 1 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0286 | 0.3122 | 0.3095 |
Plasmodium vivax | conserved Plasmodium protein, unknown function | 0.0163 | 0.1547 | 0.3775 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.0822 | 1 | 1 |
Plasmodium falciparum | geranylgeranyl transferase type-2 subunit alpha, putative | 0.0125 | 0.105 | 0.1232 |
Plasmodium falciparum | protein farnesyltransferase subunit beta | 0.0255 | 0.2719 | 0.6032 |
Schistosoma mansoni | tyrosine kinase | 0.0065 | 0.0281 | 0.0242 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0065 | 0.0281 | 0.0281 |
Toxoplasma gondii | prenyltransferase and squalene oxidase repeat-containing protein | 0.0255 | 0.2719 | 1 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0125 | 0.105 | 0.2563 |
Toxoplasma gondii | Rab geranylgeranyl transferase type II beta subunit, putative | 0.0091 | 0.0622 | 0.2288 |
Trypanosoma brucei | protein farnesyltransferase beta subunit | 0.0255 | 0.2719 | 1 |
Echinococcus multilocularis | Rab geranylgeranyltransferase, beta subunit | 0.0091 | 0.0622 | 0.0584 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0125 | 0.105 | 0.2042 |
Toxoplasma gondii | hypothetical protein | 0.0237 | 0.2498 | 0.9188 |
Mycobacterium tuberculosis | Halimadienyl diphosphate synthase | 0.0184 | 0.1807 | 0.5 |
Schistosoma mansoni | adapter molecule crk | 0.0065 | 0.0281 | 0.0242 |
Plasmodium vivax | geranylgeranyl transferase type2 beta subunit, putative | 0.0091 | 0.0622 | 0.1518 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0065 | 0.0281 | 0.0242 |
Schistosoma mansoni | nck2/grb4 | 0.0065 | 0.0281 | 0.0242 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0622 | 0.0584 |
Leishmania major | protein farnesyltransferase alpha subunit, putative | 0.0125 | 0.105 | 0.2042 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0065 | 0.0281 | 0.0242 |
Echinococcus granulosus | muscleblind protein | 0.015 | 0.1377 | 0.1377 |
Trypanosoma cruzi | Protein prenyltransferase alpha subunit repeat, putative | 0.0125 | 0.105 | 0.2042 |
Loa Loa (eye worm) | hypothetical protein | 0.0362 | 0.4098 | 0.4074 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0125 | 0.105 | 0.2042 |
Entamoeba histolytica | geranylgeranyl transferase beta subunit | 0.0261 | 0.2806 | 0.6284 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0065 | 0.0281 | 0.0281 |
Trichomonas vaginalis | geranylgeranyl transferase type II beta subunit, putative | 0.0255 | 0.2719 | 0.6635 |
Schistosoma mansoni | tyrosine kinase | 0.0065 | 0.0281 | 0.0242 |
Plasmodium vivax | protein prenyltransferase alpha subunit, putative | 0.0125 | 0.105 | 0.2563 |
Echinococcus multilocularis | protein prenyltransferase alpha subunit | 0.0125 | 0.105 | 0.1014 |
Plasmodium vivax | geranylgeranyltransferase, putative | 0.0091 | 0.0622 | 0.1518 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0146 | 0.1319 | 0.1284 |
Trypanosoma cruzi | protein farnesyltransferase, putative | 0.0255 | 0.2719 | 1 |
Toxoplasma gondii | prenyltransferase and squalene oxidase repeat-containing protein | 0.0091 | 0.0622 | 0.2288 |
Loa Loa (eye worm) | acetyltransferase | 0.0146 | 0.1319 | 0.1284 |
Loa Loa (eye worm) | prenyltransferase and squalene oxidase repeat family protein | 0.0255 | 0.2719 | 0.2689 |
Brugia malayi | Prenyltransferase and squalene oxidase repeat family protein | 0.0255 | 0.2719 | 0.2689 |
Echinococcus granulosus | growth factor receptor bound protein 2 | 0.0822 | 1 | 1 |
Brugia malayi | Protein prenyltransferase alpha subunit repeat containing protein | 0.0362 | 0.4098 | 0.4074 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0125 | 0.105 | 0.2042 |
Trichomonas vaginalis | geranylgeranyl transferase type beta subunit, putative | 0.0255 | 0.2719 | 0.6635 |
Plasmodium falciparum | protein farnesyltransferase subunit alpha | 0.0362 | 0.4098 | 1 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0184 | 0.1807 | 0.5653 |
Leishmania major | lanosterol synthase, putative | 0.0092 | 0.0635 | 0.0064 |
Trichomonas vaginalis | protein farnesyltransferase beta subunit, putative | 0.0091 | 0.0622 | 0.1518 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0146 | 0.1319 | 0.1284 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0822 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0065 | 0.0281 | 0.0281 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0142 | 0.1267 | 0.1267 |
Trichomonas vaginalis | geranylgeranyl transferase type II beta subunit, putative | 0.0255 | 0.2719 | 0.6635 |
Leishmania major | farnesyltransferase beta subunit | 0.0255 | 0.2719 | 1 |
Echinococcus multilocularis | protein farnesyltransferase alpha subunit | 0.0362 | 0.4098 | 0.4074 |
Echinococcus granulosus | c src tyrosine kinase | 0.0065 | 0.0281 | 0.0281 |
Plasmodium vivax | farnesyltransferase beta subunit, putative | 0.0255 | 0.2719 | 0.6635 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0362 | 0.4098 | 1 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0822 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0065 | 0.0281 | 0.0242 |
Toxoplasma gondii | hypothetical protein | 0.0125 | 0.105 | 0.3863 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0065 | 0.0281 | 0.0281 |
Echinococcus multilocularis | muscleblind protein | 0.015 | 0.1377 | 0.1342 |
Trypanosoma cruzi | protein farnesyltransferase alpha subunit, putative | 0.0125 | 0.105 | 0.2042 |
Loa Loa (eye worm) | prenyltransferase alpha subunit repeat containing protein | 0.0125 | 0.105 | 0.1014 |
Echinococcus multilocularis | muscleblind protein 1 | 0.015 | 0.1377 | 0.1342 |
Echinococcus granulosus | geranylgeranyl transferase type I beta subunit | 0.0261 | 0.2806 | 0.2806 |
Brugia malayi | Variant SH3 domain containing protein | 0.0065 | 0.0281 | 0.0242 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase abl1 | 0.0065 | 0.0281 | 0.0242 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.004 | 0.004 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0065 | 0.0281 | 0.0281 |
Giardia lamblia | Rab geranylgeranyltransferase | 0.0125 | 0.105 | 0.1232 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0065 | 0.0281 | 0.0242 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0622 | 0.0584 |
Schistosoma mansoni | protein farnesyltransferase subunit beta | 0.0255 | 0.2719 | 0.2689 |
Schistosoma mansoni | geranylgeranyl transferase type I beta subunit | 0.0261 | 0.2806 | 0.2777 |
Trichomonas vaginalis | geranylgeranyl transferase type I beta subunit, putative | 0.0261 | 0.2806 | 0.6848 |
Onchocerca volvulus | 0.0125 | 0.105 | 0.5 | |
Brugia malayi | Probable protein farnesyltransferase beta subunit, putative | 0.0091 | 0.0622 | 0.0584 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0362 | 0.4098 | 1 |
Loa Loa (eye worm) | prenyltransferase and squalene oxidase repeat family protein | 0.0261 | 0.2806 | 0.2777 |
Giardia lamblia | Rab geranylgeranyltransferase | 0.0362 | 0.4098 | 1 |
Brugia malayi | SRC-1 | 0.0065 | 0.0281 | 0.0242 |
Echinococcus multilocularis | geranylgeranyl transferase type 2 subunit alpha | 0.0125 | 0.105 | 0.1014 |
Trypanosoma brucei | Protein prenyltransferase alpha subunit repeat, putative | 0.0125 | 0.105 | 0.2042 |
Loa Loa (eye worm) | prenyltransferase alpha subunit repeat containing protein | 0.0362 | 0.4098 | 0.4074 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0184 | 0.1807 | 0.5653 |
Trichomonas vaginalis | geranylgeranyl transferase type II beta subunit, putative | 0.0255 | 0.2719 | 0.6635 |
Trichomonas vaginalis | type I geranylgeranyltransferase beta subunit, putative | 0.0255 | 0.2719 | 0.6635 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0065 | 0.0281 | 0.0242 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0065 | 0.0281 | 0.0281 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0065 | 0.0281 | 0.0242 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0065 | 0.0281 | 0.0242 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0065 | 0.0281 | 0.0242 |
Echinococcus multilocularis | growth factor receptor bound protein 2 | 0.0822 | 1 | 1 |
Echinococcus granulosus | NCK adaptor protein | 0.0065 | 0.0281 | 0.0281 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0065 | 0.0281 | 0.0281 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0286 | 0.3122 | 0.3095 |
Trichomonas vaginalis | geranylgeranyl transferase type I beta subunit, putative | 0.0255 | 0.2719 | 0.6635 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0065 | 0.0281 | 0.0242 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0065 | 0.0281 | 0.0281 |
Echinococcus granulosus | protein farnesyltransferase subunit beta | 0.0255 | 0.2719 | 0.2719 |
Brugia malayi | hypothetical protein | 0.0256 | 0.2742 | 0.2713 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0065 | 0.0281 | 0.0281 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0286 | 0.3122 | 0.3122 |
Echinococcus multilocularis | NCK adaptor protein | 0.0065 | 0.0281 | 0.0242 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0065 | 0.0281 | 0.0242 |
Schistosoma mansoni | tyrosine kinase | 0.0065 | 0.0281 | 0.0242 |
Loa Loa (eye worm) | SRC-1 | 0.0065 | 0.0281 | 0.0242 |
Schistosoma mansoni | tyrosine kinase | 0.0065 | 0.0281 | 0.0242 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.1377 | 0.1342 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0125 | 0.105 | 0.1014 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.1377 | 0.1342 |
Trypanosoma cruzi | protein farnesyltransferase alpha subunit, putative | 0.0125 | 0.105 | 0.2042 |
Trypanosoma brucei | protein farnesyltransferase alpha subunit, putative | 0.0125 | 0.105 | 0.2042 |
Schistosoma mansoni | geranylgeranyl transferase type II beta subunit | 0.0091 | 0.0622 | 0.0584 |
Echinococcus multilocularis | geranylgeranyl transferase type I beta subunit | 0.0261 | 0.2806 | 0.2777 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0065 | 0.0281 | 0.0242 |
Giardia lamblia | Prenyltransferase | 0.0255 | 0.2719 | 0.6032 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 0.8 mM | Inhibition of aminopeptidase M or membrane leucine aminopeptidase; Ki value reporting the slope effect(Kis) | ChEMBL. | 2566685 |
Ki (binding) | = 0.24 mM | Competitive inhibition of leucine aminopeptidase; Ki value reporting the slope effect(Kis) | ChEMBL. | 2566685 |
Ki (binding) | = 0.26 mM | Non-competitive inhibition of aminopeptidase M or membrane leucine aminopeptidase; Ki value reporting the intercept effect(Kii) | ChEMBL. | 2566685 |
Ki (binding) | = 0.17 uM | Competitive inhibition of aminopeptidase B or arginyl aminopeptidase purified from rat liver; Ki value reporting the slope effect(Kis) | ChEMBL. | 2566685 |
Ki (binding) | = 0.77 uM | Competitive inhibition of aminopeptidase B or arginyl aminopeptidase purified from rat liver; Ki value reporting the slope effect(Kis) | ChEMBL. | 2566685 |
Ki (binding) | = 57 uM | Competitive inhibition of leucine aminopeptidase; Ki value reporting the slope effect(Kis) | ChEMBL. | 2566685 |
Ki (binding) | = 79 uM | Non-competitive inhibition of aminopeptidase M or membrane leucine aminopeptidase; Ki value reporting the slope effect(Kis) | ChEMBL. | 2566685 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.