Detailed information for compound 38717

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 368.474 | Formula: C24H24N4
  • H donors: 1 H acceptors: 1 LogP: 4.37 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(cc1)c1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2
  • InChi: 1S/C24H24N4/c1-2-5-19(6-3-1)20-8-10-22(11-9-20)28-15-13-27(14-16-28)18-21-17-26-24-23(21)7-4-12-25-24/h1-12,17H,13-16,18H2,(H,25,26)
  • InChiKey: KGZWRXWYLPRJCF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Dopamine D4 receptor Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled Starlite/ChEMBL References
Homo sapiens glutamate receptor, ionotropic, N-methyl-D-aspartate 3B References
Homo sapiens glutamate receptor, ionotropic, N-methyl-D-aspartate 3A Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled Starlite/ChEMBL References
Rattus norvegicus Dopamine D2 receptor Starlite/ChEMBL References
Homo sapiens cholinergic receptor, muscarinic 5 Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled Starlite/ChEMBL References
Homo sapiens cholinergic receptor, muscarinic 4 Starlite/ChEMBL References
Homo sapiens cholinergic receptor, muscarinic 2 Starlite/ChEMBL References
Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 1 References
Homo sapiens histamine receptor H1 Starlite/ChEMBL References
Rattus norvegicus Dopamine D5 receptor Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled Starlite/ChEMBL References
Rattus norvegicus Glutamate NMDA receptor Starlite/ChEMBL References
Homo sapiens cholinergic receptor, muscarinic 3 Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled Starlite/ChEMBL References
Homo sapiens cholinergic receptor, muscarinic 1 Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled Starlite/ChEMBL References
Homo sapiens opioid receptor, kappa 1 Starlite/ChEMBL References
Rattus norvegicus Dopamine D3 receptor Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled Starlite/ChEMBL References
Homo sapiens opioid receptor, mu 1 Starlite/ChEMBL References
Rattus norvegicus Dopamine D1 receptor Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled Starlite/ChEMBL References
Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 2C References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled Starlite/ChEMBL References
Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 2B References
Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 2A References
Homo sapiens opioid receptor, delta 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus nmda type glutamate receptor Get druggable targets OG5_133478 All targets in OG5_133478
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_134111 All targets in OG5_134111
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma mansoni biogenic amine (5HT) receptor Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus granulosus biogenic amine 5HT receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum 5-hydroxytryptamine receptor, putative Get druggable targets OG5_133680 All targets in OG5_133680
Echinococcus granulosus tm gpcr rhodopsin Get druggable targets OG5_139759 All targets in OG5_139759
Echinococcus multilocularis glutamate (NMDA) receptor subunit Get druggable targets OG5_129290 All targets in OG5_129290
Brugia malayi Dopamine receptor protein 1 Get druggable targets OG5_134111 All targets in OG5_134111
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_141128 All targets in OG5_141128
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Brugia malayi Serotonin receptor Get druggable targets OG5_135430 All targets in OG5_135430
Schistosoma japonicum expressed protein Get druggable targets OG5_133478 All targets in OG5_133478
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor Get druggable targets OG5_141128 All targets in OG5_141128
Echinococcus granulosus glutamate receptor NMDA Get druggable targets OG5_133478 All targets in OG5_133478
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Get druggable targets OG5_145685 All targets in OG5_145685
Schistosoma japonicum 5-hydroxytryptamine receptor, putative Get druggable targets OG5_132667 All targets in OG5_132667
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133264 All targets in OG5_133264
Echinococcus granulosus biogenic amine 5HT receptor Get druggable targets OG5_133074 All targets in OG5_133074
Schistosoma japonicum ko:K04165 Oamb gene product from transcript, putative Get druggable targets OG5_141128 All targets in OG5_141128
Echinococcus multilocularis nmda type glutamate receptor Get druggable targets OG5_133478 All targets in OG5_133478
Schistosoma japonicum Glutamate [NMDA] receptor subunit zeta-1 precursor, putative Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus multilocularis nmda type glutamate receptor Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus granulosus nmda type glutamate receptor Get druggable targets OG5_133478 All targets in OG5_133478
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_141128 All targets in OG5_141128
Echinococcus granulosus glutamate NMDA receptor subunit Get druggable targets OG5_129290 All targets in OG5_129290
Schistosoma japonicum Octopamine receptor, putative Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum ko:K05314 glutamate receptor, ionotropic, N-methyl-D-aspartate 2, invertebrate, putative Get druggable targets OG5_129290 All targets in OG5_129290
Echinococcus multilocularis glutamate receptor NMDA Get druggable targets OG5_133478 All targets in OG5_133478
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133264 All targets in OG5_133264
Brugia malayi Serotonin/octopamine receptor family protein 7 Get druggable targets OG5_141128 All targets in OG5_141128
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133680 All targets in OG5_133680
Schistosoma mansoni glutamate receptor NMDA Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Get druggable targets OG5_139759 All targets in OG5_139759
Schistosoma japonicum Glutamate [NMDA] receptor subunit zeta-1 precursor, putative Get druggable targets OG5_133478 All targets in OG5_133478
Schistosoma japonicum Glutamate [NMDA] receptor subunit zeta-1 precursor, putative Get druggable targets OG5_133478 All targets in OG5_133478
Echinococcus granulosus tm gpcr rhodopsin Get druggable targets OG5_145685 All targets in OG5_145685
Schistosoma mansoni biogenic amine (5HT) receptor Get druggable targets OG5_133074 All targets in OG5_133074
Schistosoma mansoni glutamate receptor NMDA Get druggable targets OG5_129290 All targets in OG5_129290
Schistosoma japonicum ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum expressed protein Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis biogenic amine (5HT) receptor Get druggable targets OG5_133074 All targets in OG5_133074
Schistosoma japonicum 5-hydroxytryptamine receptor 1, putative Get druggable targets OG5_132667 All targets in OG5_132667
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Dopamine D2 receptor   444 aa 386 aa 19.7 %
Echinococcus granulosus thyrotropin releasing hormone receptor Dopamine D4 receptor   387 aa 356 aa 23.6 %
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor Dopamine D2 receptor   444 aa 487 aa 23.8 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Dopamine D1 receptor   446 aa 407 aa 33.7 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Dopamine D4 receptor   387 aa 347 aa 23.3 %
Onchocerca volvulus Dopamine D4 receptor   387 aa 391 aa 30.7 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Dopamine D1 receptor   446 aa 373 aa 25.5 %
Echinococcus multilocularis dro:myosuppressin receptor 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled 365 aa 348 aa 22.1 %
Brugia malayi Serotonin/octopamine receptor family protein 7 Dopamine D4 receptor   387 aa 373 aa 29.0 %
Echinococcus granulosus alpha 1A adrenergic receptor Dopamine D3 receptor   446 aa 460 aa 21.1 %
Schistosoma mansoni biogenic amine (5HT) receptor Dopamine D1 receptor   446 aa 394 aa 29.9 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Dopamine D4 receptor   387 aa 349 aa 31.2 %
Onchocerca volvulus RB1-inducible coiled-coil protein 1 homolog Dopamine D3 receptor   446 aa 478 aa 22.8 %
Onchocerca volvulus Dopamine D3 receptor   446 aa 434 aa 19.4 %
Schistosoma japonicum Octopamine receptor, putative Dopamine D3 receptor   446 aa 501 aa 28.5 %
Brugia malayi sulfakinin receptor protein Dopamine D4 receptor   387 aa 316 aa 22.8 %
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) Dopamine D3 receptor   446 aa 463 aa 25.5 %
Echinococcus granulosus biogenic amine 5HT receptor Dopamine D2 receptor   444 aa 429 aa 31.7 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Dopamine D3 receptor   446 aa 463 aa 29.8 %
Echinococcus multilocularis alpha 1A adrenergic receptor Dopamine D3 receptor   446 aa 473 aa 21.6 %
Echinococcus multilocularis biogenic amine (5HT) receptor Dopamine D3 receptor   446 aa 499 aa 30.9 %
Loa Loa (eye worm) TYRA-2 protein Dopamine D3 receptor   446 aa 494 aa 24.3 %
Onchocerca volvulus 26S proteasome non-ATPase regulatory subunit 1 homolog Dopamine D4 receptor   387 aa 371 aa 27.0 %
Echinococcus granulosus g protein coupled receptor Dopamine D4 receptor   387 aa 342 aa 21.3 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Dopamine D4 receptor   387 aa 356 aa 26.4 %
Onchocerca volvulus Dopamine D1 receptor   446 aa 357 aa 21.0 %
Schistosoma mansoni biogenic amine (dopamine) receptor Dopamine D2 receptor   444 aa 494 aa 26.3 %
Onchocerca volvulus Dopamine D3 receptor   446 aa 462 aa 26.0 %
Brugia malayi AT19640p 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 390 aa 335 aa 21.8 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Dopamine D1 receptor   446 aa 366 aa 35.2 %
Onchocerca volvulus Glycoprotein hormone beta 5 homolog Dopamine D3 receptor   446 aa 489 aa 22.9 %
Echinococcus multilocularis serotonin receptor Dopamine D2 receptor   444 aa 428 aa 31.3 %
Echinococcus multilocularis g protein coupled receptor Dopamine D2 receptor   444 aa 465 aa 21.5 %
Onchocerca volvulus Dopamine D4 receptor   387 aa 346 aa 34.1 %
Loa Loa (eye worm) hypothetical protein Dopamine D4 receptor   387 aa 368 aa 26.9 %
Schistosoma mansoni biogenic amine receptor Dopamine D3 receptor   446 aa 455 aa 28.6 %
Loa Loa (eye worm) hypothetical protein Dopamine D1 receptor   446 aa 370 aa 24.9 %
Schistosoma mansoni amine GPCR Dopamine D3 receptor   446 aa 420 aa 31.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) G-protein coupled receptor 0.0103 0.0458 0.0263
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0103 0.0458 0.0339
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0103 0.0458 0.0275
Echinococcus multilocularis rhodopsin orphan GPCR 0.0103 0.0458 0.0275
Loa Loa (eye worm) hypothetical protein 0.025 0.1861 0.1722
Schistosoma mansoni amine GPCR 0.0103 0.0458 0.0362
Echinococcus granulosus g protein coupled receptor 0.0103 0.0458 0.0339
Loa Loa (eye worm) hypothetical protein 0.0103 0.0458 0.0263
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0103 0.0458 0.0275
Loa Loa (eye worm) hypothetical protein 0.0268 0.203 0.1897
Echinococcus multilocularis allatostatin A receptor 0.0103 0.0458 0.0275
Loa Loa (eye worm) hypothetical protein 0.0103 0.0458 0.0263
Echinococcus granulosus alpha 1A adrenergic receptor 0.0103 0.0458 0.0339
Loa Loa (eye worm) hypothetical protein 0.0103 0.0458 0.0263
Trypanosoma brucei monoglyceride lipase, putative 0.0378 0.3086 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0103 0.0458 0.0339
Echinococcus multilocularis rhodopsin orphan GPCR 0.0103 0.0458 0.0275
Loa Loa (eye worm) hypothetical protein 0.0103 0.0458 0.0263
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0103 0.0458 0.0362
Schistosoma mansoni tyrosinase precursor 0.0095 0.0381 0.0283
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0143 0.0464
Echinococcus granulosus rhodopsin orphan GPCR 0.0103 0.0458 0.0339
Echinococcus granulosus 7TM GPCR rhodopsin 0.0103 0.0458 0.0339
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0103 0.0458 0.0275
Brugia malayi G-protein coupled receptor 0.0103 0.0458 0.0383
Brugia malayi Serotonin/octopamine receptor family protein 7 0.046 0.3866 0.3882
Echinococcus multilocularis glutamate receptor 2 0.0187 0.1256 0.1089
Schistosoma mansoni biogenic amine (5HT) receptor 0.0558 0.4795 0.4825
Brugia malayi RE15519p 0.0103 0.0458 0.0383
Echinococcus multilocularis G-protein coupled receptor, putative 0.0103 0.0458 0.0275
Brugia malayi Protein kinase c protein 2 0.0113 0.0557 0.0484
Loa Loa (eye worm) hypothetical protein 0.0091 0.0346 0.0147
Echinococcus multilocularis protein kinase c iota type 0.0078 0.0218 0.003
Loa Loa (eye worm) hypothetical protein 0.025 0.1861 0.1722
Plasmodium falciparum lysophospholipase, putative 0.0378 0.3086 1
Trypanosoma cruzi amidase, putative 0.0131 0.0723 0.2344
Echinococcus granulosus nmda type glutamate receptor 0.0118 0.0603 0.0486
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0103 0.0458 0.0339
Brugia malayi hypothetical protein 0.0103 0.0458 0.0383
Echinococcus multilocularis glutamate receptor NMDA 0.0095 0.0384 0.0199
Echinococcus granulosus fatty acid amide hydrolase 1 0.1085 0.9825 0.9823
Loa Loa (eye worm) TYRA-2 protein 0.0103 0.0458 0.0263
Loa Loa (eye worm) hypothetical protein 0.0603 0.5229 0.5223
Loa Loa (eye worm) hypothetical protein 0.0313 0.2465 0.2349
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.021 0.1476 0.1312
Loa Loa (eye worm) hypothetical protein 0.0103 0.0458 0.0263
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0103 0.0458 0.0383
Schistosoma mansoni glutamate receptor kainate 0.0187 0.1256 0.1183
Echinococcus multilocularis expressed protein 0.0754 0.6667 0.6603
Schistosoma mansoni neuropeptide f receptor 76f 0.0103 0.0458 0.0362
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0131 0.0723 0.0546
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0728 0.6422 0.6353
Loa Loa (eye worm) hypothetical protein 0.0079 0.0231 0.0027
Echinococcus multilocularis fmrfamide receptor 0.0103 0.0458 0.0275
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0098 0.0407 0.0224
Loa Loa (eye worm) melatonin receptor type 1A 0.0103 0.0458 0.0263
Loa Loa (eye worm) hypothetical protein 0.0103 0.0458 0.0263
Echinococcus granulosus L aminoadipate semialdehyde 0.0091 0.0346 0.0226
Echinococcus multilocularis rhodopsin orphan GPCR 0.0103 0.0458 0.0275
Brugia malayi Serotonin receptor 0.0103 0.0458 0.0383
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0131 0.0723 0.0546
Trypanosoma cruzi amidase, putative 0.0131 0.0723 0.2344
Onchocerca volvulus 0.0103 0.0458 0.1919
Trypanosoma cruzi cruzipain precursor, putative 0.007 0.0143 0.0464
Echinococcus granulosus fatty acid amide hydrolase 1 0.0131 0.0723 0.0608
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0158 0.0983 0.081
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0131 0.0723 0.0635
Loa Loa (eye worm) hypothetical protein 0.0103 0.0458 0.0263
Echinococcus granulosus neuropeptide Y receptor 0.0103 0.0458 0.0339
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0103 0.0458 0.0362
Schistosoma mansoni serine/threonine protein kinase 0.0158 0.0983 0.0901
Echinococcus granulosus peptide allatostatin:somatostatin 0.0103 0.0458 0.0339
Loa Loa (eye worm) hypothetical protein 0.0103 0.0458 0.0263
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0081 0.0249 0.0046
Echinococcus multilocularis rhodopsin orphan GPCR 0.0103 0.0458 0.0275
Brugia malayi hypothetical protein 0.0103 0.0458 0.0383
Echinococcus granulosus neuropeptide receptor 0.0103 0.0458 0.0339
Echinococcus multilocularis neuropeptide Y receptor 0.0103 0.0458 0.0275
Schistosoma mansoni hypothetical protein 0.0103 0.0458 0.0362
Loa Loa (eye worm) hypothetical protein 0.0103 0.0458 0.0263
Onchocerca volvulus 0.0103 0.0458 0.1919
Loa Loa (eye worm) hypothetical protein 0.056 0.4821 0.4799
Echinococcus granulosus rhodopsin orphan GPCR 0.0103 0.0458 0.0339
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0103 0.0458 0.0362
Echinococcus multilocularis orexin receptor type 2 0.0103 0.0458 0.0275
Echinococcus granulosus sex peptide receptor 0.0103 0.0458 0.0339
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0081 0.0252 0.0131
Echinococcus multilocularis serotonin receptor 0.025 0.1861 0.1706
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0095 0.0381 0.0304
Loa Loa (eye worm) amidase 0.0131 0.0723 0.0539
Loa Loa (eye worm) hypothetical protein 0.0603 0.5229 0.5223
Loa Loa (eye worm) hypothetical protein 0.0103 0.0458 0.0263
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0103 0.0458 0.0275
Brugia malayi Dopamine receptor protein 2 0.0103 0.0458 0.0383
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0103 0.0458 0.0362
Echinococcus granulosus rhodopsin orphan GPCR 0.0103 0.0458 0.0339
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0387 0.3165 0.3034
Brugia malayi Tachykinin-like peptides receptor 99D 0.0103 0.0458 0.0383
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0077 0.0205 0.0017
Echinococcus granulosus protein kinase c epsilon type 0.0148 0.0891 0.0778
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0075 0.0188 0.0066
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.021 0.1476 0.1369
Echinococcus granulosus biogenic amine 5HT receptor 0.0558 0.4795 0.4731
Schistosoma mansoni glutamate receptor AMPA 0.0187 0.1256 0.1183
Echinococcus granulosus Protein kinase C brain isozyme 0.0158 0.0983 0.087
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0081 0.0252 0.0065
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0103 0.0458 0.0362
Echinococcus multilocularis fatty acid amide hydrolase 1 0.1085 0.9825 0.9821
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0103 0.0458 0.0339
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.021 0.1476 0.1312
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.021 0.1476 0.1369
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0103 0.0458 0.0362
Echinococcus granulosus tachykinin peptides receptor 99D 0.0103 0.0458 0.0339
Loa Loa (eye worm) hypothetical protein 0.0095 0.0381 0.0183
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0103 0.0458 0.0383
Loa Loa (eye worm) hypothetical protein 0.0103 0.0458 0.0263
Loa Loa (eye worm) hypothetical protein 0.0103 0.0458 0.0263
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0131 0.0723 0.5
Schistosoma mansoni fatty-acid amide hydrolase 0.0131 0.0723 0.0635
Echinococcus multilocularis neuropeptide receptor 0.0103 0.0458 0.0275
Loa Loa (eye worm) G-protein coupled receptor 0.0103 0.0458 0.0263
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0143 0.0464
Echinococcus granulosus allatostatin A receptor 0.0103 0.0458 0.0339
Brugia malayi Serotonin receptor 0.0659 0.5759 0.5826
Schistosoma mansoni glutamate receptor kainate 0.0187 0.1256 0.1183
Schistosoma mansoni opsin-like receptor 0.0103 0.0458 0.0362
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0131 0.0723 0.0608
Onchocerca volvulus 0.0103 0.0458 0.1919
Echinococcus multilocularis serotonin receptor 0.025 0.1861 0.1706
Schistosoma mansoni neuropeptide receptor 0.0103 0.0458 0.0362
Schistosoma mansoni amidase 0.1085 0.9825 1
Onchocerca volvulus 0.0103 0.0458 0.1919
Loa Loa (eye worm) hypothetical protein 0.0103 0.0458 0.0263
Onchocerca volvulus 0.0095 0.0381 0.1522
Brugia malayi hypothetical protein 0.0103 0.0458 0.0383
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0103 0.0458 0.0362
Echinococcus granulosus neuropeptide receptor A26 0.0103 0.0458 0.0339
Schistosoma mansoni amine GPCR 0.0103 0.0458 0.0362
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0064 0.0085 0.0276
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0103 0.0458 0.0362
Echinococcus granulosus somatostatin receptor 0.0103 0.0458 0.0339
Brugia malayi G protein-coupled receptor 0.0103 0.0458 0.0383
Trypanosoma cruzi monoglyceride lipase, putative 0.0378 0.3086 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0103 0.0458 0.0339
Schistosoma mansoni biogenic amine receptor 0.0103 0.0458 0.0362
Loa Loa (eye worm) neuropeptide F receptor 0.0103 0.0458 0.0263
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0095 0.0381 0.0304
Brugia malayi hypothetical protein 0.0103 0.0458 0.0383
Mycobacterium ulcerans hypothetical protein 0.0378 0.3086 1
Echinococcus granulosus neuropeptides capa receptor 0.0103 0.0458 0.0339
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0103 0.0458 0.0263
Loa Loa (eye worm) hypothetical protein 0.0103 0.0458 0.0263
Echinococcus granulosus fatty acid amide hydrolase 1 0.1085 0.9825 0.9823
Brugia malayi Glutamate receptor 2 precursor 0.0187 0.1256 0.1202
Loa Loa (eye worm) hypothetical protein 0.0103 0.0458 0.0263
Echinococcus granulosus nmda type glutamate receptor 0.0193 0.1316 0.1208
Echinococcus granulosus fmrfamide receptor 0.0103 0.0458 0.0339
Schistosoma mansoni glutamate receptor NMDA 0.0387 0.3165 0.3147
Echinococcus granulosus tm gpcr rhodopsin 0.0728 0.6422 0.6377
Schistosoma mansoni glutamate receptor NMDA 0.0305 0.2384 0.2344
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0558 0.4795 0.4696
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0103 0.0458 0.0362
Trichomonas vaginalis conserved hypothetical protein 0.0378 0.3086 0.5
Loa Loa (eye worm) hypothetical protein 0.0268 0.203 0.1897
Echinococcus granulosus 7tm_1 domain containing protein 0.0103 0.0458 0.0339
Schistosoma mansoni atypical protein kinase C 0.0078 0.0218 0.0114
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0095 0.0381 0.0304
Schistosoma mansoni hypothetical protein 0.0103 0.0458 0.0362
Loa Loa (eye worm) hypothetical protein 0.0103 0.0458 0.0263
Echinococcus multilocularis g protein coupled receptor 0.0103 0.0458 0.0275
Schistosoma mansoni ATP-binding cassette transporter 0.0187 0.1256 0.1183
Brugia malayi G-protein coupled receptor 0.0103 0.0458 0.0383
Loa Loa (eye worm) hypothetical protein 0.0103 0.0458 0.0263
Brugia malayi sulfakinin receptor protein 0.0103 0.0458 0.0383
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0148 0.0891 0.0714
Loa Loa (eye worm) hypothetical protein 0.046 0.3866 0.3806
Loa Loa (eye worm) hypothetical protein 0.0416 0.344 0.3363
Schistosoma mansoni fatty-acid amide hydrolase 0.1085 0.9825 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0103 0.0458 0.0362
Echinococcus granulosus dro:myosuppressin receptor 0.0103 0.0458 0.0339
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0091 0.0346 0.0268
Brugia malayi small heat shock protein 0.056 0.4821 0.4863
Loa Loa (eye worm) hypothetical protein 0.0103 0.0458 0.0263
Loa Loa (eye worm) hypothetical protein 0.0103 0.0458 0.0263
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0131 0.0723 0.5
Onchocerca volvulus 0.0095 0.0381 0.1522
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.021 0.1476 0.1312
Leishmania major hypothetical protein, conserved 0.0131 0.0723 0.1972
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0378 0.3086 0.5
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0103 0.0458 0.0275
Echinococcus granulosus biogenic amine 5HT receptor 0.025 0.1861 0.176
Loa Loa (eye worm) hypothetical protein 0.0103 0.0458 0.0263
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0378 0.3086 0.5
Echinococcus granulosus hypothetical protein 0.0103 0.0458 0.0339
Loa Loa (eye worm) hypothetical protein 0.0103 0.0458 0.0263
Echinococcus multilocularis fatty acid amide hydrolase 1 0.1085 0.9825 0.9821
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0103 0.0458 0.0263
Echinococcus multilocularis somatostatin receptor 0.0103 0.0458 0.0275
Loa Loa (eye worm) hypothetical protein 0.0103 0.0458 0.0263
Schistosoma mansoni biogenic amine receptor 0.0103 0.0458 0.0362
Echinococcus multilocularis G protein coupled receptor 139 0.0103 0.0458 0.0275
Echinococcus multilocularis rhodopsin orphan GPCR 0.0103 0.0458 0.0275
Schistosoma mansoni myosin xvIII 0.0103 0.0458 0.0362
Echinococcus granulosus glutamate NMDA receptor subunit 0.0387 0.3165 0.308
Plasmodium falciparum lysophospholipase, putative 0.0378 0.3086 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0103 0.0458 0.0362
Schistosoma mansoni tyrosinase precursor 0.0095 0.0381 0.0283
Loa Loa (eye worm) glutamate receptor 2 0.0187 0.1256 0.1093
Brugia malayi Common central domain of tyrosinase family protein 0.0095 0.0381 0.0304
Loa Loa (eye worm) hypothetical protein 0.046 0.3866 0.3806
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0103 0.0458 0.0263
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0103 0.0458 0.0362
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0103 0.0458 0.0362
Echinococcus granulosus g-protein coupled receptor 0.0103 0.0458 0.0339
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0131 0.0723 0.5
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0131 0.0723 0.1972
Loa Loa (eye worm) hypothetical protein 0.03 0.2337 0.2217
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0095 0.0381 0.0304
Onchocerca volvulus 0.0268 0.203 1
Echinococcus multilocularis sex peptide receptor 0.0103 0.0458 0.0275
Loa Loa (eye worm) ShTK domain-containing protein 0.0095 0.0381 0.0183
Echinococcus granulosus RNA directed DNA polymerase 0.0077 0.0205 0.0083
Onchocerca volvulus 0.0103 0.0458 0.1919
Schistosoma mansoni neuropeptide F-like receptor 0.0103 0.0458 0.0362
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0103 0.0458 0.0383
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.046 0.3866 0.3869
Loa Loa (eye worm) tyrosinase 1 0.0095 0.0381 0.0183
Loa Loa (eye worm) hypothetical protein 0.0603 0.5229 0.5223
Loa Loa (eye worm) hypothetical protein 0.0103 0.0458 0.0263
Schistosoma mansoni biogenic amine (5HT) receptor 0.025 0.1861 0.1806
Echinococcus multilocularis serine threonine protein kinase 0.0126 0.0675 0.0496
Echinococcus granulosus neuropeptide receptor 0.0103 0.0458 0.0339
Echinococcus multilocularis neuropeptide Y receptor 0.0103 0.0458 0.0275
Echinococcus multilocularis g protein coupled receptor 0.0103 0.0458 0.0275
Echinococcus granulosus rhodopsin orphan GPCR 0.0103 0.0458 0.0339
Loa Loa (eye worm) hypothetical protein 0.0103 0.0458 0.0263
Plasmodium falciparum lysophospholipase, putative 0.0378 0.3086 1
Loa Loa (eye worm) hypothetical protein 0.0103 0.0458 0.0263
Echinococcus granulosus g protein coupled receptor 0.0103 0.0458 0.0339
Onchocerca volvulus 0.0103 0.0458 0.1919
Echinococcus multilocularis jun protein 0.0081 0.0252 0.0065
Brugia malayi putative neuropeptide receptor NPR1 0.0103 0.0458 0.0383
Echinococcus granulosus glutamate receptor NMDA 0.0095 0.0384 0.0264
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0103 0.0458 0.0275
Brugia malayi ShTK domain containing protein 0.0095 0.0381 0.0304
Schistosoma mansoni neuropeptide receptor 0.0103 0.0458 0.0362
Schistosoma mansoni alpha-1 adrenergic receptor 0.0103 0.0458 0.0362
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0103 0.0458 0.0275
Plasmodium vivax PST-A protein 0.0378 0.3086 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.021 0.1476 0.1369
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0103 0.0458 0.0275
Onchocerca volvulus 0.0103 0.0458 0.1919
Schistosoma mansoni hypothetical protein 0.0075 0.0188 0.0084
Brugia malayi hypothetical protein 0.0103 0.0458 0.0383
Echinococcus multilocularis L aminoadipate semialdehyde 0.0091 0.0346 0.0161
Echinococcus granulosus G protein coupled receptor 139 0.0103 0.0458 0.0339
Onchocerca volvulus 0.0103 0.0458 0.1919
Brugia malayi follicle stimulating hormone receptor 0.0103 0.0458 0.0383
Schistosoma mansoni hypothetical protein 0.0103 0.0458 0.0362
Onchocerca volvulus 0.0103 0.0458 0.1919
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0103 0.0458 0.0275
Loa Loa (eye worm) hypothetical protein 0.0103 0.0458 0.0263
Loa Loa (eye worm) ShTK domain-containing protein 0.0095 0.0381 0.0183
Loa Loa (eye worm) neuropeptide F receptor 0.0103 0.0458 0.0263
Brugia malayi Amidase family protein 0.0131 0.0723 0.0655
Brugia malayi protein kinase C II. 0.0148 0.0891 0.0828
Brugia malayi neuropeptide F receptor 0.0103 0.0458 0.0383
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0103 0.0458 0.0362
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0103 0.0458 0.0362
Loa Loa (eye worm) hypothetical protein 0.0103 0.0458 0.0263
Echinococcus granulosus jun protein 0.0081 0.0252 0.0131
Loa Loa (eye worm) hypothetical protein 0.0103 0.0458 0.0263
Brugia malayi GnHR receptor homolog 0.0103 0.0458 0.0383
Brugia malayi G protein-coupled receptor F59B2.13 0.0103 0.0458 0.0383
Schistosoma mansoni opsin-like receptor 0.0103 0.0458 0.0362
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0378 0.3086 1
Echinococcus multilocularis g protein coupled receptor 0.0103 0.0458 0.0275
Echinococcus multilocularis neuropeptides capa receptor 0.0103 0.0458 0.0275
Loa Loa (eye worm) hypothetical protein 0.0103 0.0458 0.0263
Echinococcus multilocularis glutamate receptor 2 0.0135 0.0762 0.0586
Echinococcus multilocularis nmda type glutamate receptor 0.0118 0.0603 0.0423
Echinococcus granulosus neuropeptides capa receptor 0.0103 0.0458 0.0339
Onchocerca volvulus Neuropeptide F receptor homolog 0.0103 0.0458 0.1919
Brugia malayi Glutamate receptor 1 precursor 0.0187 0.1256 0.1202
Plasmodium falciparum esterase, putative 0.0378 0.3086 1
Brugia malayi hypothetical protein 0.0103 0.0458 0.0383
Echinococcus multilocularis neuropeptide receptor A26 0.0103 0.0458 0.0275
Loa Loa (eye worm) hypothetical protein 0.0268 0.203 0.1897
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0103 0.0458 0.0362
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0103 0.0458 0.0383
Loa Loa (eye worm) hypothetical protein 0.0103 0.0458 0.0263
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0378 0.3086 0.5
Brugia malayi hypothetical protein 0.0103 0.0458 0.0383
Echinococcus multilocularis RNA directed DNA polymerase 0.0077 0.0205 0.0017
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0378 0.3086 0.5
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0103 0.0458 0.0339
Echinococcus granulosus g protein coupled receptor 0.0103 0.0458 0.0339
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.021 0.1476 0.1369
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0378 0.3086 1
Echinococcus multilocularis g-protein coupled receptor 0.0103 0.0458 0.0275
Schistosoma mansoni biogenic amine receptor 0.0103 0.0458 0.0362
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0103 0.0458 0.0339
Brugia malayi Dopamine receptor protein 1 0.0603 0.5229 0.5282
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0103 0.0458 0.0339
Leishmania major monoglyceride lipase, putative 0.0378 0.3086 1
Schistosoma mansoni neuropeptide receptor 0.0103 0.0458 0.0362
Schistosoma mansoni neuropeptide F-like receptor 0.0103 0.0458 0.0362
Brugia malayi Dopamine receptor 0.0103 0.0458 0.0383
Loa Loa (eye worm) glutamate receptor 1 0.0187 0.1256 0.1093
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0103 0.0458 0.0275
Echinococcus multilocularis neuropeptide receptor 0.0103 0.0458 0.0275
Echinococcus granulosus glutamate receptor subunit protein glur 0.0075 0.0188 0.0066
Schistosoma mansoni glutamate receptor kainate 0.0187 0.1256 0.1183
Loa Loa (eye worm) hypothetical protein 0.0109 0.0512 0.032
Onchocerca volvulus 0.0103 0.0458 0.1919
Schistosoma mansoni serine/threonine protein kinase 0.0148 0.0891 0.0808
Schistosoma mansoni serine/threonine protein kinase 0.0158 0.0983 0.0901
Brugia malayi hypothetical protein 0.0103 0.0458 0.0383
Brugia malayi bZIP transcription factor family protein 0.0081 0.0252 0.0171
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.021 0.1476 0.1312
Loa Loa (eye worm) hypothetical protein 0.0103 0.0458 0.0263
Echinococcus multilocularis fmrfamide receptor 0.0103 0.0458 0.0275
Onchocerca volvulus 0.0103 0.0458 0.1919
Mycobacterium ulcerans lysophospholipase 0.0378 0.3086 1
Mycobacterium tuberculosis Possible lysophospholipase 0.0378 0.3086 1
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0075 0.0188 0.0066
Echinococcus multilocularis dro:myosuppressin receptor 0.0103 0.0458 0.0275
Onchocerca volvulus 0.0103 0.0458 0.1919
Brugia malayi larval opioid receptor 0.0103 0.0458 0.0383
Onchocerca volvulus 0.0103 0.0458 0.1919
Brugia malayi Amidase family protein 0.0131 0.0723 0.0655
Loa Loa (eye worm) hypothetical protein 0.0095 0.0381 0.0183
Echinococcus multilocularis rhodopsin orphan GPCR 0.0103 0.0458 0.0275
Echinococcus granulosus neuropeptide s receptor 0.0103 0.0458 0.0339
Onchocerca volvulus 0.0103 0.0458 0.1919
Echinococcus granulosus glutamate receptor 2 0.021 0.1476 0.1369
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0103 0.0458 0.0263
Schistosoma mansoni adenoreceptor 0.0103 0.0458 0.0362
Brugia malayi amidase 0.1085 0.9825 1
Schistosoma mansoni opsin-like receptor 0.0103 0.0458 0.0362
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0103 0.0458 0.0362
Onchocerca volvulus 0.0095 0.0381 0.1522
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0378 0.3086 1
Loa Loa (eye worm) hypothetical protein 0.0103 0.0458 0.0263
Brugia malayi putative amidase 0.0131 0.0723 0.0655
Loa Loa (eye worm) hypothetical protein 0.1085 0.9825 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0103 0.0458 0.1919
Onchocerca volvulus 0.0095 0.0381 0.1522
Loa Loa (eye worm) hypothetical protein 0.0103 0.0458 0.0263
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0103 0.0458 0.0362
Echinococcus granulosus glutamate receptor 2 0.0135 0.0762 0.0647
Trypanosoma brucei monoglyceride lipase, putative 0.0378 0.3086 1
Schistosoma mansoni amine GPCR 0.0103 0.0458 0.0362
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0378 0.3086 0.5
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0103 0.0458 0.0362
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0103 0.0458 0.0362
Echinococcus granulosus rhodopsin orphan GPCR 0.0103 0.0458 0.0339
Brugia malayi hypothetical protein 0.0103 0.0458 0.0383
Onchocerca volvulus 0.0103 0.0458 0.1919
Loa Loa (eye worm) hypothetical protein 0.0103 0.0458 0.0263
Echinococcus multilocularis neuropeptide s receptor 0.0103 0.0458 0.0275
Echinococcus multilocularis rhodopsin orphan GPCR 0.0103 0.0458 0.0275
Echinococcus multilocularis rhodopsin orphan GPCR 0.0103 0.0458 0.0275
Echinococcus granulosus serotonin receptor 0.0103 0.0458 0.0339
Echinococcus multilocularis neuropeptides capa receptor 0.0103 0.0458 0.0275
Loa Loa (eye worm) amidase 0.0131 0.0723 0.0539
Echinococcus granulosus expressed protein 0.0754 0.6667 0.6625
Brugia malayi neuropeptide F receptor 0.0103 0.0458 0.0383
Brugia malayi putative neuropeptide receptor 0.0103 0.0458 0.0383
Schistosoma mansoni histamine h1 receptor 0.0103 0.0458 0.0362
Loa Loa (eye worm) hypothetical protein 0.0103 0.0458 0.0263
Echinococcus granulosus protein kinase C gamma type 0.0126 0.0675 0.0559
Echinococcus granulosus orexin receptor type 2 0.0103 0.0458 0.0339
Loa Loa (eye worm) hypothetical protein 0.0103 0.0458 0.0263
Onchocerca volvulus 0.0103 0.0458 0.1919
Echinococcus multilocularis serine:threonine protein kinase N2 0.0113 0.0549 0.0368
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0103 0.0458 0.0263
Loa Loa (eye worm) hypothetical protein 0.0103 0.0458 0.0263
Brugia malayi AKH receptor 0.0103 0.0458 0.0383
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0103 0.0458 0.0362
Schistosoma mansoni amine GPCR 0.0103 0.0458 0.0362
Echinococcus granulosus neuropeptide Y receptor 0.0103 0.0458 0.0339
Echinococcus granulosus protein kinase c iota type 0.0078 0.0218 0.0096
Echinococcus granulosus tm gpcr rhodopsin 0.0103 0.0458 0.0339
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1103 1 1
Echinococcus multilocularis glutamate receptor 2 0.021 0.1476 0.1312
Schistosoma mansoni amine GPCR 0.0103 0.0458 0.0362
Schistosoma mansoni glutamate receptor AMPA 0.0187 0.1256 0.1183
Brugia malayi Melatonin receptor type 1A 0.0103 0.0458 0.0383
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0103 0.0458 0.0275
Schistosoma mansoni hypothetical protein 0.0103 0.0458 0.0362
Trichomonas vaginalis conserved hypothetical protein 0.0378 0.3086 0.5
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0378 0.3086 0.5
Echinococcus multilocularis neuropeptide FF receptor 2 0.0103 0.0458 0.0275
Brugia malayi ORL1-like opioid receptor 0.0103 0.0458 0.0383
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0075 0.0188 0.0066
Echinococcus multilocularis protein kinase c epsilon type 0.0148 0.0891 0.0717
Onchocerca volvulus 0.0103 0.0458 0.1919
Echinococcus granulosus neuropeptide FF receptor 2 0.0103 0.0458 0.0339
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0103 0.0458 0.0362
Echinococcus multilocularis nmda type glutamate receptor 0.0193 0.1316 0.115
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0143 0.0464
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0091 0.0346 0.0246
Brugia malayi hypothetical protein 0.0103 0.0458 0.0383
Schistosoma mansoni neuropeptide receptor 0.0103 0.0458 0.0362
Onchocerca volvulus 0.0091 0.0346 0.134

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 148 nM In vitro binding affinity to rat Dopamine receptor D4 measured by displacement of the radioligand [3H]-spiperone ChEMBL. 11378358
Ki (binding) = 148 nM In vitro binding affinity to rat Dopamine receptor D4 measured by displacement of the radioligand [3H]-spiperone ChEMBL. 11378358
Ki (binding) = 1932 nM Binding affinity to cloned human 5-hydroxytryptamine 2A receptor ChEMBL. 11378358
Ki (binding) = 1932 nM Binding affinity to cloned human 5-hydroxytryptamine 2A receptor ChEMBL. 11378358
Ki (binding) > 10000 nM In vitro binding affinity to rat Dopamine receptor D2 measured by displacement of the radioligand [3H]-spiperone ChEMBL. 11378358
Ki (binding) > 10000 nM In vitro binding affinity to cloned rat Dopamine receptor D3 measured by displacement of the radioligand [3H]-sulpiride ChEMBL. 11378358
Ki (binding) > 10000 nM In vitro binding affinity to human 5-hydroxytryptamine 1A receptor ChEMBL. 11378358
Ki (binding) > 10000 nM In vitro binding affinity to human 5-hydroxytryptamine 6 receptor ChEMBL. 11378358
Ki (binding) > 10000 nM In vitro binding affinity to human 5-hydroxytryptamine 7 receptor ChEMBL. 11378358
Ki (binding) > 10000 nM In vitro binding affinity to rat Dopamine receptor D2 measured by displacement of the radioligand [3H]-spiperone ChEMBL. 11378358
Ki (binding) > 10000 nM In vitro binding affinity to cloned rat Dopamine receptor D3 measured by displacement of the radioligand [3H]-sulpiride ChEMBL. 11378358
Ki (binding) > 10000 nM In vitro binding affinity to human 5-hydroxytryptamine 1A receptor ChEMBL. 11378358
Ki (binding) > 10000 nM In vitro binding affinity to human 5-hydroxytryptamine 6 receptor ChEMBL. 11378358
Ki (binding) > 10000 nM In vitro binding affinity to human 5-hydroxytryptamine 7 receptor ChEMBL. 11378358
Ki (binding) > 10 uM In vitro binding affinity to cloned rat Dopamine receptor D1 measured by displacement of radioligand [3H]-SCH-23,982 ChEMBL. 11378358
Ki (binding) > 10 uM In vitro binding affinity to cloned rat D5 receptor measured by displacement of radioligand [3H]-SCH-23,982 ChEMBL. 11378358
Ki (binding) > 10 uM Binding affinity to cloned human 5-hydroxytryptamine 1B receptor ChEMBL. 11378358
Ki (binding) > 10 uM In vitro binding affinity to human 5-hydroxytryptamine 1D receptor ChEMBL. 11378358
Ki (binding) > 10 uM Binding affinity to cloned human 5-hydroxytryptamine 1E receptor ChEMBL. 11378358
Ki (binding) > 10 uM Binding affinity to cloned human 5-hydroxytryptamine 2C receptor ChEMBL. 11378358
Ki (binding) > 10 uM Binding affinity to cloned human 5-hydroxytryptamine 5A receptor ChEMBL. 11378358
Ki (binding) > 10 uM Binding affinity of the compound to cloned Opioid receptor kappa 1 ChEMBL. 11378358
Ki (binding) > 10 uM Binding affinity to cloned Opioid receptor delta 1 ChEMBL. 11378358
Ki (binding) > 10 uM Binding affinity to cloned Opioid receptor mu 1 ChEMBL. 11378358
Ki (binding) > 10 uM Binding affinity to cloned Histamine H1 receptor ChEMBL. 11378358
Ki (binding) > 10 uM Binding affinity for N-methyl-D-aspartate glutamate receptor ChEMBL. 11378358
Ki (binding) > 10 uM Binding affinity to cloned Muscarinic acetylcholine receptor M1 ChEMBL. 11378358
Ki (binding) > 10 uM Binding affinity to cloned Muscarinic acetylcholine receptor M2 ChEMBL. 11378358
Ki (binding) > 10 uM Binding affinity to cloned Muscarinic acetylcholine receptor M3 ChEMBL. 11378358
Ki (binding) > 10 uM Binding affinity to cloned Muscarinic acetylcholine receptor M4 ChEMBL. 11378358
Ki (binding) > 10 uM Binding affinity to cloned Muscarinic acetylcholine receptor M5 ChEMBL. 11378358
Ki (binding) > 10 uM Binding affinity to cloned Nicotinic acetylcholine receptors ChEMBL. 11378358
Ki (binding) > 10 uM Binding affinity to PCP site of rat N-methyl-D-aspartate glutamate receptor ChEMBL. 11378358
Ki (binding) > 10 uM In vitro binding affinity to cloned rat Dopamine receptor D1 measured by displacement of radioligand [3H]-SCH-23,982 ChEMBL. 11378358
Ki (binding) > 10 uM In vitro binding affinity to cloned rat D5 receptor measured by displacement of radioligand [3H]-SCH-23,982 ChEMBL. 11378358
Ki (binding) > 10 uM Binding affinity to cloned human 5-hydroxytryptamine 1B receptor ChEMBL. 11378358
Ki (binding) > 10 uM In vitro binding affinity to human 5-hydroxytryptamine 1D receptor ChEMBL. 11378358
Ki (binding) > 10 uM Binding affinity to cloned human 5-hydroxytryptamine 1E receptor ChEMBL. 11378358
Ki (binding) > 10 uM Binding affinity to cloned human 5-hydroxytryptamine 2C receptor ChEMBL. 11378358
Ki (binding) > 10 uM Binding affinity to cloned human 5-hydroxytryptamine 5A receptor ChEMBL. 11378358
Ki (binding) > 10 uM Binding affinity of the compound to cloned Opioid receptor kappa 1 ChEMBL. 11378358
Ki (binding) > 10 uM Binding affinity to cloned Opioid receptor delta 1 ChEMBL. 11378358
Ki (binding) > 10 uM Binding affinity to cloned Opioid receptor mu 1 ChEMBL. 11378358
Ki (binding) > 10 uM Binding affinity to cloned Histamine H1 receptor ChEMBL. 11378358
Ki (binding) > 10 uM Binding affinity for N-methyl-D-aspartate glutamate receptor ChEMBL. 11378358
Ki (binding) > 10 uM Binding affinity to cloned Muscarinic acetylcholine receptor M1 ChEMBL. 11378358
Ki (binding) > 10 uM Binding affinity to cloned Muscarinic acetylcholine receptor M2 ChEMBL. 11378358
Ki (binding) > 10 uM Binding affinity to cloned Muscarinic acetylcholine receptor M3 ChEMBL. 11378358
Ki (binding) > 10 uM Binding affinity to cloned Muscarinic acetylcholine receptor M4 ChEMBL. 11378358
Ki (binding) > 10 uM Binding affinity to cloned Muscarinic acetylcholine receptor M5 ChEMBL. 11378358
Ki (binding) > 10 uM Binding affinity to PCP site of rat N-methyl-D-aspartate glutamate receptor ChEMBL. 11378358

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.