Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0081 | 0.8808 | 0.8284 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0081 | 0.8808 | 0.8284 |
Brugia malayi | steroid hormone receptor | 0.0081 | 0.8808 | 0.8808 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 0.5892 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0081 | 0.8808 | 0.8284 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0081 | 0.8808 | 0.8284 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0081 | 0.8808 | 0.8808 |
Echinococcus granulosus | FTZ F1 alpha | 0.0081 | 0.8808 | 0.8284 |
Brugia malayi | conserved hypotetical protein | 0.0038 | 0.3057 | 0.3057 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0081 | 0.8808 | 0.8808 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0081 | 0.8808 | 0.8808 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0081 | 0.8808 | 0.8808 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0081 | 0.8808 | 0.8808 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0081 | 0.8808 | 0.8284 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.8808 | 0.8808 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0043 | 0.3672 | 0.0887 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0081 | 0.8808 | 0.8808 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.3057 | 0.3057 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.8808 | 0.8808 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0081 | 0.8808 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0081 | 0.8808 | 0.8284 |
Onchocerca volvulus | 0.0081 | 0.8808 | 1 | |
Brugia malayi | nuclear receptor RXR | 0.0038 | 0.3057 | 0.3057 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0081 | 0.8808 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0081 | 0.8808 | 0.8284 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0081 | 0.8808 | 0.8808 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.5892 | 0.4083 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.009 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.5892 | 0.4083 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0081 | 0.8808 | 0.8284 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0081 | 0.8808 | 0.8284 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0081 | 0.8808 | 0.8284 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0038 | 0.3057 | 0.3057 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0038 | 0.3057 | 0.3057 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0081 | 0.8808 | 0.8284 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0081 | 0.8808 | 0.8808 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0081 | 0.8808 | 0.8808 |
Brugia malayi | nuclear receptor NHR-67 | 0.0038 | 0.3057 | 0.3057 |
Brugia malayi | ecdysone receptor | 0.0038 | 0.3057 | 0.3057 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.3057 | 0.3057 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0081 | 0.8808 | 0.8284 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0081 | 0.8808 | 0.8284 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0081 | 0.8808 | 0.8808 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0038 | 0.3057 | 0.3057 |
Trypanosoma brucei | cytochrome P450, putative | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0081 | 0.8808 | 0.8284 |
Brugia malayi | nuclear hormone receptor | 0.0038 | 0.3057 | 0.3057 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.5892 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0081 | 0.8808 | 0.8284 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.3057 | 0.3057 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.8808 | 0.8808 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0081 | 0.8808 | 0.8808 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0081 | 0.8808 | 0.8284 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.009 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.009 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.3057 | 0.3057 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.3057 | 0.3057 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0081 | 0.8808 | 0.8284 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0038 | 0.3057 | 0.3057 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0038 | 0.3057 | 0.3057 |
Schistosoma mansoni | nuclear hormone receptor | 0.0081 | 0.8808 | 0.8284 |
Brugia malayi | hypothetical protein | 0.0043 | 0.3672 | 0.3672 |
Brugia malayi | nuclear hormone receptor | 0.0081 | 0.8808 | 0.8808 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0081 | 0.8808 | 0.8284 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0081 | 0.8808 | 0.8808 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0081 | 0.8808 | 0.8808 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0043 | 0.3672 | 0.3672 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.5892 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.3672 | 0.3672 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0081 | 0.8808 | 0.8808 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0026 | 0.1355 | 0.1355 |
Brugia malayi | tailless protein | 0.0038 | 0.3057 | 0.3057 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.3057 | 0.3057 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0059 | 0.5892 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.3057 | 0.3057 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0081 | 0.8808 | 0.8284 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0081 | 0.8808 | 0.8284 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.3057 | 0.3057 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0043 | 0.3672 | 0.3672 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.8808 | 0.8808 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0081 | 0.8808 | 0.8284 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0081 | 0.8808 | 0.8808 |
Schistosoma mansoni | thyroid hormone receptor | 0.0081 | 0.8808 | 0.8284 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.3057 | 0.3057 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0081 | 0.8808 | 0.8284 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0015 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0081 | 0.8808 | 0.8284 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0081 | 0.8808 | 0.8808 |
Brugia malayi | nuclear receptor NHR-88 | 0.0081 | 0.8808 | 0.8808 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.8808 | 0.8808 |
Loa Loa (eye worm) | DR-78 | 0.0038 | 0.3057 | 0.3057 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.3057 | 0.3057 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.3672 | 0.3672 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.009 | 1 | 1 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0038 | 0.3057 | 0.3057 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0081 | 0.8808 | 0.8808 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.5892 | 0.4083 |
Brugia malayi | nuclear receptor RXR | 0.0043 | 0.3672 | 0.3672 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.8808 | 0.8808 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.8808 | 0.8808 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0043 | 0.3672 | 0.0887 |
Schistosoma mansoni | coup transcription factor | 0.0081 | 0.8808 | 0.8284 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0038 | 0.3057 | 0.3057 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0081 | 0.8808 | 0.8808 |
Brugia malayi | ecdysteroid receptor | 0.0081 | 0.8808 | 0.8808 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0081 | 0.8808 | 0.8284 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0038 | 0.3057 | 0.3057 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0081 | 0.8808 | 0.8808 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.009 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.5892 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.3057 | 0.3057 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0081 | 0.8808 | 0.8808 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.8808 | 0.8808 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0081 | 0.8808 | 0.8808 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0081 | 0.8808 | 0.8284 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0081 | 0.8808 | 0.8808 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0043 | 0.3672 | 0.3672 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 0.5892 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0038 | 0.3057 | 0.3057 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.3672 | 0.3672 |
Brugia malayi | hypothetical protein | 0.0038 | 0.3057 | 0.3057 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0043 | 0.3672 | 0.0887 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0043 | 0.3672 | 0.0887 |
Brugia malayi | hypothetical protein | 0.0043 | 0.3672 | 0.3672 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0081 | 0.8808 | 0.8284 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.3057 | 0.3057 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0038 | 0.3057 | 0.3057 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0081 | 0.8808 | 0.8284 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0081 | 0.8808 | 0.8808 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0081 | 0.8808 | 0.8808 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.5892 | 0.4083 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.3672 | 0.3672 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0081 | 0.8808 | 1 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0038 | 0.3057 | 0.3057 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.3672 | 0.3672 |
Brugia malayi | Cytochrome P450 family protein | 0.0026 | 0.1355 | 0.1355 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.3057 | 0.3057 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 0.6 mM | Inhibition of aminopeptidase B or arginyl aminopeptidase purified from rat liver | ChEMBL. | 2566685 |
IC50 (binding) | > 0.6 mM | Inhibition of aminopeptidase B or arginyl aminopeptidase purified from rat liver | ChEMBL. | 2566685 |
IC50 (binding) | > 0.8 mM | Inhibition of leucine aminopeptidase; Ki value reporting the slope effect(Kis) | ChEMBL. | 2566685 |
IC50 (binding) | > 0.8 mM | Inhibition of leucine aminopeptidase; Ki value reporting the slope effect(Kis) | ChEMBL. | 2566685 |
Ki (binding) | = 0.17 mM | Competitive inhibition of aminopeptidase M or membrane leucine aminopeptidase; Ki value reporting the slope effect(Kis) | ChEMBL. | 2566685 |
Ki (binding) | = 0.17 mM | Competitive inhibition of aminopeptidase M or membrane leucine aminopeptidase; Ki value reporting the slope effect(Kis) | ChEMBL. | 2566685 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.