Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0591 | 0 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.4478 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.4478 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.4478 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1241 | 0.1674 | 0.1674 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.3266 | 0.6883 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.3266 | 0.6883 | 0.5 |
Brugia malayi | thymidylate synthase | 0.1241 | 0.1674 | 0.1674 |
Echinococcus multilocularis | dihydrofolate reductase | 0.4478 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.4478 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3266 | 0.6883 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.4478 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.3266 | 0.6883 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.4478 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.4478 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.3266 | 0.6883 | 0.5 |
Onchocerca volvulus | 0.1241 | 0.1674 | 0.5 | |
Chlamydia trachomatis | dihydrofolate reductase | 0.4478 | 1 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3266 | 0.6883 | 0.5 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 10890167 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.