Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thromboxane A synthase 1 (platelet) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | cytochrome P450, putative | thromboxane A synthase 1 (platelet) | 534 aa | 498 aa | 21.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0014 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0014 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0014 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0014 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0014 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0014 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0014 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0014 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0014 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.1 mg kg-1 | Inhibition of serum TXB2 production in the rats after intravenous administration | ChEMBL. | 11992782 |
ED50 (functional) | = 0.7 mg kg-1 | Ability to protect mice from the lethal effect of Platelet activating factor on iv administration of compound | ChEMBL. | 11992782 |
ED50 (functional) | = 0.7 mg kg-1 | Ability to protect mice from the lethal effect of Platelet activating factor on iv administration of compound | ChEMBL. | 11992782 |
ED50 (functional) | > 10 mg kg-1 | Ability to protect mice from the lethal effect of Platelet activating factor on po administration of compound | ChEMBL. | 11992782 |
ED50 (functional) | > 10 mg kg-1 | Inhibition of serum TXB2 production in the rats after peroral administration | ChEMBL. | 11992782 |
ED50 (functional) | > 10 mg kg-1 | Ability to protect mice from the lethal effect of Platelet activating factor on po administration of compound | ChEMBL. | 11992782 |
IC50 (binding) | = 0.062 uM | Thromboxane A2 synthase inhibitory activity was measured from inhibition of thromboxane B2 production in human platelet microsomes | ChEMBL. | 11992782 |
IC50 (binding) | = 0.062 uM | Thromboxane A2 synthase inhibitory activity was measured from inhibition of thromboxane B2 production in human platelet microsomes | ChEMBL. | 11992782 |
IC50 (functional) | = 0.139 uM | The compound was tested for inhibition of Platelet activating factor (PAF) induced platelet aggregation in rabbit platelet rich plasma | ChEMBL. | 11992782 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.