TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 1041.19 | Formula: C44H44AuClN8P4
H donors: 0 H acceptors: 8 LogP: 6.66 Rotable bonds: 8
Rule of 5 violations (Lipinski): 2
SMILES: c1ccc(nc1)P1(CCP([Au+]21P(CCP2(c1ccccn1)c1ccccn1)(c1ccccn1)c1ccccn1)(c1ccccn1)c1ccccn1)c1ccccn1.[Cl-]
InChi: 1S/2C22H20N4P2.Au.ClH/c2*1-5-13-23-19(9-1)27(20-10-2-6-14-24-20)17-18-28(21-11-3-7-15-25-21)22-12-4-8-16-26-22;;/h2*1-16H,17-18H2;;1H/q;;-3;/p+3
InChiKey: CDINMKXOKBTKID-UHFFFAOYSA-Q

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	Thymidylate kinase, putative	0.03	0.1914	0.5569
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0028	0.0108	0.0104
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.1516	1	1
Entamoeba histolytica	DNA polymerase alpha catalytic subunit, putative	0.0015	0.0025	0.0007
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0028	0.0108	0.0104
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0105	0.0622	0.06
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0108	0.0104
Brugia malayi	putative neuropeptide receptor NPR1	0.0028	0.0108	0.0132
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0016	0.0028	0.0006
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0016	0.0028	0.0005
Brugia malayi	Melatonin receptor type 1A	0.0028	0.0108	0.0132
Leishmania major	DNA polymerase I alpha catalytic subunit, putative	0.0024	0.0081	0.0058
Echinococcus granulosus	neuropeptide s receptor	0.0028	0.0108	0.0104
Schistosoma mansoni	nicotinate phosphoribosyltransferase related pre-B cell enhancing factor	0.0766	0.5017	0.6102
Brugia malayi	hypothetical protein	0.0028	0.0108	0.0132
Onchocerca volvulus		0.0028	0.0108	0.0104
Trichomonas vaginalis	nicotinate phosphoribosyltransferase, putative	0.0142	0.0868	0.2199
Brugia malayi	Dopamine receptor protein 1	0.0028	0.0108	0.0132
Schistosoma mansoni	neuropeptide receptor	0.0028	0.0108	0.0104
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0028	0.0108	0.0104
Brugia malayi	DNA polymerase alpha catalytic subunit	0.0044	0.0217	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Trypanosoma brucei	thymidylate kinase, putative	0.03	0.1914	0.1895
Echinococcus granulosus	neuropeptide receptor	0.0028	0.0108	0.0104
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0028	0.0108	0.0104
Wolbachia endosymbiont of Brugia malayi	thymidylate kinase	0.03	0.1914	1
Echinococcus granulosus	hypothetical protein	0.0028	0.0108	0.0104
Onchocerca volvulus		0.0028	0.0108	0.0104
Brugia malayi	neuropeptide F receptor	0.0028	0.0108	0.0132
Echinococcus multilocularis	G protein coupled receptor 139	0.0028	0.0108	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0028	0.0108	0.0104
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0028	0.0108	0.0104
Echinococcus multilocularis	neuropeptide receptor A26	0.0028	0.0108	0.0104
Echinococcus granulosus	dro:myosuppressin receptor	0.0028	0.0108	0.0104
Brugia malayi	larval opioid receptor	0.0028	0.0108	0.0132
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0108	0.0104
Trichomonas vaginalis	thymidine kinase, putative	0.0526	0.3418	0.884
Onchocerca volvulus		0.0028	0.0108	0.0104
Brugia malayi	G protein-coupled receptor	0.0028	0.0108	0.0132
Schistosoma mansoni	biogenic amine receptor	0.0028	0.0108	0.0104
Mycobacterium tuberculosis	Nicotinic acid phosphoribosyltransferase PncB1	0.0142	0.0868	0.1027
Loa Loa (eye worm)	dihydrofolate reductase	0.0507	0.3295	0.3998
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0028	0.001
Schistosoma mansoni	growth hormone secretagogue receptor	0.0028	0.0108	0.0104
Echinococcus granulosus	g-protein coupled receptor	0.0028	0.0108	0.0104
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0028	0.0108	0.0132
Entamoeba histolytica	phosphofructokinase, putative	0.0105	0.0622	0.1764
Onchocerca volvulus	DNA polymerase alpha catalytic subunit homolog	0.0075	0.0422	0.0487
Schistosoma mansoni	myosin xvIII	0.0028	0.0108	0.0104
Mycobacterium tuberculosis	Hypothetical protein	0.0593	0.3864	0.469
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0016	0.0028	0.0005
Brugia malayi	DNA polymerase family B, exonuclease domain containing protein	0.0015	0.0023	0.0028
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0046	0.0227	0.0243
Schistosoma mansoni	opsin-like receptor	0.0028	0.0108	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Onchocerca volvulus		0.1246	0.8207	1
Echinococcus multilocularis	neuropeptide s receptor	0.0028	0.0108	0.0104
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0028	0.0108	0.0104
Echinococcus granulosus	g protein coupled receptor	0.0028	0.0108	0.0104
Schistosoma mansoni	thymidylate kinase	0.03	0.1914	0.231
Brugia malayi	thymidylate synthase	0.1246	0.8207	1
Brugia malayi	hypothetical protein	0.0028	0.0108	0.0132
Brugia malayi	AKH receptor	0.0028	0.0108	0.0132
Treponema pallidum	thymidylate kinase (tmk)	0.03	0.1914	1
Onchocerca volvulus		0.0028	0.0108	0.0104
Echinococcus multilocularis	thymidylate kinase	0.03	0.1914	0.231
Schistosoma mansoni	nicotinate phosphoribosyltransferase related pre-B cell enhancing factor	0.0142	0.0868	0.1032
Schistosoma mansoni	6-phosphofructokinase	0.0105	0.0622	0.0732
Echinococcus granulosus	tm gpcr rhodopsin	0.0028	0.0108	0.0104
Onchocerca volvulus		0.0028	0.0108	0.0104
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0028	0.0108	0.0104
Schistosoma mansoni	neuropeptide f receptor 76f	0.0028	0.0108	0.0104
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0016	0.0028	0.0006
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0108	0.0104
Schistosoma mansoni	biogenic amine receptor	0.0028	0.0108	0.0104
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0028	0.0111	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Echinococcus multilocularis	somatostatin receptor	0.0028	0.0108	0.0104
Echinococcus multilocularis	O glycosyltransferase	0.004	0.0187	0.0201
Schistosoma mansoni	neuropeptide receptor	0.0028	0.0108	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Brugia malayi	G protein-coupled receptor F59B2.13	0.0028	0.0108	0.0132
Mycobacterium ulcerans	thymidylate synthase	0.1246	0.8207	1
Loa Loa (eye worm)	6-phosphofructokinase	0.0105	0.0622	0.0732
Wolbachia endosymbiont of Brugia malayi	hypothetical protein	0.0016	0.0026	0.0000050117
Trichomonas vaginalis	glutathione reductase, putative	0.0016	0.0028	0.0013
Schistosoma mansoni	amine GPCR	0.0028	0.0108	0.0104
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0028	0.0111	0.0261
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0108	0.0104
Echinococcus multilocularis	fmrfamide receptor	0.0028	0.0108	0.0104
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0104	0.0616	0.0719
Schistosoma mansoni	amine GPCR	0.0028	0.0108	0.0104
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0116	0.0694	0.0814
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0028	0.0108	0.0104
Trichomonas vaginalis	DNA polymerase alpha catalytic subunit, putative	0.0024	0.0081	0.0152
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0108	0.0104
Brugia malayi	phosphofructokinase	0.0105	0.0622	0.0758
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0108	0.0104
Echinococcus multilocularis	DNA polymerase alpha catalytic subunit	0.0055	0.0286	0.0321
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0105	0.0622	0.06
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0108	0.0104
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0028	0.0108	0.0104
Brugia malayi	glutathione reductase	0.0046	0.0227	0.0276
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0016	0.0028	0.0005
Echinococcus granulosus	neuropeptide receptor	0.0028	0.0108	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Loa Loa (eye worm)	thymidylate kinase	0.03	0.1914	0.231
Mycobacterium tuberculosis	Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK)	0.03	0.1914	0.2305
Treponema pallidum	hypothetical protein	0.0016	0.0026	0.0000050117
Schistosoma mansoni	amine GPCR	0.0028	0.0108	0.0104
Schistosoma mansoni	nicotinate phosphoribosyltransferase	0.0142	0.0868	0.1032
Loa Loa (eye worm)	glutathione reductase	0.0046	0.0227	0.0249
Echinococcus granulosus	fmrfamide receptor	0.0028	0.0108	0.0104
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0108	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0028	0.0108	0.0132
Onchocerca volvulus	Putative thymidylate kinase	0.03	0.1914	0.231
Echinococcus multilocularis	g protein coupled receptor	0.0028	0.0108	0.0104
Onchocerca volvulus		0.0028	0.0108	0.0104
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0108	0.0104
Brugia malayi	G-protein coupled receptor	0.0028	0.0108	0.0132
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0116	0.0694	0.0814
Trypanosoma brucei	DNA polymerase alpha catalytic subunit	0.0024	0.0081	0.0058
Giardia lamblia	Thymidine kinase	0.0526	0.3418	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Toxoplasma gondii	6-phosphofructokinase	0.0028	0.0111	0.0089
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0028	0.0108	0.0104
Leishmania major	ATP-dependent phosphofructokinase	0.0105	0.0622	0.06
Onchocerca volvulus		0.0028	0.0108	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Plasmodium vivax	6-phosphofructokinase, putative	0.0028	0.0111	0.0089
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0028	0.0108	0.0104
Trichomonas vaginalis	thymidine kinase, putative	0.0526	0.3418	0.884
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Brugia malayi	RE15519p	0.0028	0.0108	0.0132
Echinococcus multilocularis	g protein coupled receptor	0.0028	0.0108	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Loa Loa (eye worm)	G-protein coupled receptor	0.0028	0.0108	0.0104
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0016	0.0028	0.0002
Giardia lamblia	CDC8	0.03	0.1914	0.5569
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0028	0.0108	0.0104
Plasmodium vivax	thioredoxin reductase, putative	0.0046	0.0227	0.0204
Echinococcus granulosus	O glycosyltransferase	0.004	0.0187	0.0201
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0028	0.0005
Echinococcus multilocularis	sex peptide receptor	0.0028	0.0108	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Echinococcus granulosus	thymidylate synthase	0.1246	0.8207	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.0507	0.3295	0.3996
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.1516	1	1
Echinococcus granulosus	nicotinamide phosphoribosyltransferase	0.0766	0.5017	0.6102
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0016	0.0028	0.0005
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0028	0.0108	0.0104
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0028	0.0108	0.0104
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0028	0.0108	0.0132
Brugia malayi	G-protein coupled receptor	0.0028	0.0108	0.0132
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0108	0.0104
Echinococcus granulosus	g protein coupled receptor	0.0028	0.0108	0.0104
Mycobacterium ulcerans	thymidylate kinase	0.03	0.1914	0.2307
Entamoeba histolytica	phosphofructokinase, putative	0.0105	0.0622	0.1764
Plasmodium falciparum	nicotinate phosphoribosyltransferase, putative	0.0142	0.0868	0.0847
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0028	0.0108	0.0104
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0028	0.0108	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Echinococcus multilocularis	dihydrofolate reductase	0.0507	0.3295	0.3998
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0028	0.0108	0.0104
Echinococcus multilocularis	fmrfamide receptor	0.0028	0.0108	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Echinococcus multilocularis	nicotinamide phosphoribosyltransferase	0.0766	0.5017	0.6102
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0028	0.0108	0.0104
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0016	0.0028	0.0002
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0028	0.0108	0.0132
Brugia malayi	Dopamine receptor	0.0028	0.0108	0.0132
Schistosoma mansoni	neuropeptide F-like receptor	0.0028	0.0108	0.0104
Mycobacterium tuberculosis	Probable oxidoreductase	0.0116	0.0694	0.0814
Schistosoma mansoni	neuropeptide receptor	0.0028	0.0108	0.0104
Leishmania major	nicotinate phosphoribosyltransferase, putative	0.0142	0.0868	0.0847
Brugia malayi	GnHR receptor homolog	0.0028	0.0108	0.0132
Brugia malayi	hypothetical protein	0.0028	0.0108	0.0132
Onchocerca volvulus		0.0028	0.0108	0.0104
Schistosoma mansoni	6-phosphofructokinase	0.0105	0.0622	0.0732
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0016	0.0028	0.0005
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0016	0.0028	0.0005
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0028	0.0108	0.0104
Echinococcus granulosus	somatostatin receptor	0.0028	0.0108	0.0104
Leishmania major	trypanothione reductase	0.0046	0.0227	0.0204
Loa Loa (eye worm)	thioredoxin reductase	0.0046	0.0227	0.0249
Trypanosoma brucei	thymidylate kinase, putative	0.03	0.1914	0.1895
Echinococcus multilocularis	neuropeptide Y receptor	0.0028	0.0108	0.0104
Echinococcus granulosus	allatostatin A receptor	0.0028	0.0108	0.0104
Onchocerca volvulus		0.0028	0.0108	0.0104
Plasmodium vivax	6-phosphofructokinase, putative	0.0028	0.0111	0.0089
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0108	0.0104
Brugia malayi	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase	0.004	0.0186	0.0227
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0104	0.0616	0.0719
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0028	0.0108	0.0104
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0028	0.0108	0.0104
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0016	0.0028	0.0006
Echinococcus granulosus	orexin receptor type 2	0.0028	0.0108	0.0104
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.0507	0.3295	0.3994
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0028	0.0108	0.0104
Schistosoma mansoni	amine GPCR	0.0028	0.0108	0.0104
Onchocerca volvulus		0.0028	0.0108	0.0104
Schistosoma mansoni	neuropeptide F-like receptor	0.0028	0.0108	0.0104
Schistosoma mansoni	DNA polymerase alpha catalytic subunit	0.0055	0.0286	0.0321
Brugia malayi	Dihydrofolate reductase	0.0507	0.3295	0.4015
Toxoplasma gondii	phosphofructokinase PFKII	0.0028	0.0111	0.0089
Brugia malayi	sulfakinin receptor protein	0.0028	0.0108	0.0132
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0028	0.0111	0.0089
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0104	0.0616	0.0719
Onchocerca volvulus		0.0028	0.0108	0.0104
Mycobacterium leprae	probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK)	0.03	0.1914	0.1709
Entamoeba histolytica	phosphofructokinase, putative	0.0105	0.0622	0.1764
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0028	0.0108	0.0104
Echinococcus granulosus	neuropeptides capa receptor	0.0028	0.0108	0.0104
Brugia malayi	Dopamine receptor protein 2	0.0028	0.0108	0.0132
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0028	0.0108	0.0104
Brugia malayi	hypothetical protein	0.0028	0.0108	0.0132
Schistosoma mansoni	opsin-like receptor	0.0028	0.0108	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Toxoplasma gondii	O-linked N-acetylglucosamine transferase	0.0039	0.0184	0.0162
Schistosoma mansoni	thymidylate kinase	0.03	0.1914	0.231
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0016	0.0028	0.0006
Brugia malayi	thymidylate kinase	0.03	0.1914	0.2332
Echinococcus multilocularis	g protein coupled receptor	0.0028	0.0108	0.0104
Echinococcus granulosus	serotonin receptor	0.0028	0.0108	0.0104
Brugia malayi	DNA polymerase family B containing protein	0.0015	0.0023	0.0028
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.1246	0.8207	1
Schistosoma mansoni	DNA polymerase alpha catalytic subunit	0.002	0.0059	0.0044
Trichomonas vaginalis	conserved hypothetical protein	0.0593	0.3864	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0108	0.0104
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0028	0.0111	0.0261
Echinococcus multilocularis	neuropeptides capa receptor	0.0028	0.0108	0.0104
Trichomonas vaginalis	mercuric reductase, putative	0.0016	0.0028	0.0013
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0105	0.0622	0.0726
Echinococcus granulosus	7tm_1 domain containing protein	0.0028	0.0108	0.0104
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0028	0.0108	0.0104
Onchocerca volvulus		0.0028	0.0108	0.0104
Schistosoma mansoni	o-linked n-acetylglucosamine transferase ogt	0.004	0.0187	0.0201
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0108	0.0104
Toxoplasma gondii	thioredoxin reductase	0.0046	0.0227	0.0204
Brugia malayi	Pre-B cell enhancing factor precursor	0.0766	0.5017	0.6113
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0028	0.0005
Echinococcus multilocularis	6 phosphofructokinase	0.0105	0.0622	0.0732
Trichomonas vaginalis	phosphofructokinase, putative	0.0028	0.0111	0.0231
Brugia malayi	ORL1-like opioid receptor	0.0028	0.0108	0.0132
Echinococcus multilocularis	serotonin receptor	0.0028	0.0108	0.0104
Plasmodium falciparum	thymidylate kinase	0.03	0.1914	0.1895
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0028	0.0005
Echinococcus multilocularis	orexin receptor type 2	0.0028	0.0108	0.0104
Echinococcus granulosus	thymidylate kinase	0.03	0.1914	0.231
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0104	0.0616	0.0719
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Brugia malayi	follicle stimulating hormone receptor	0.0028	0.0108	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Brugia malayi	hypothetical protein	0.0028	0.0108	0.0132
Brugia malayi	hypothetical protein	0.0028	0.0108	0.0132
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0108	0.0104
Leishmania major	thymidine kinase, putative	0.0526	0.3418	0.3403
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0028	0.0108	0.0104
Schistosoma mansoni	amine GPCR	0.0028	0.0108	0.0104
Echinococcus granulosus	tm gpcr rhodopsin	0.0028	0.0108	0.0104
Trypanosoma cruzi	thymidylate kinase, putative	0.03	0.1914	0.1895
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.1246	0.8207	1
Mycobacterium tuberculosis	Nicotinic acid phosphoribosyltransferase PncB2	0.0142	0.0868	0.1027
Trichomonas vaginalis	phosphofructokinase, putative	0.0028	0.0111	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Brugia malayi	hypothetical protein	0.0028	0.0108	0.0132
Trypanosoma cruzi	UMP-CMP kinase, mitochondrial, putative	0.0118	0.0704	0.0683
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Echinococcus granulosus	neuropeptide receptor A26	0.0028	0.0108	0.0104
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0028	0.0108	0.0104
Echinococcus granulosus	7TM GPCR rhodopsin	0.0028	0.0108	0.0104
Brugia malayi	6-phosphofructokinase	0.0105	0.0622	0.0758
Echinococcus granulosus	neuropeptide FF receptor 2	0.0028	0.0108	0.0104
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0108	0.0104
Onchocerca volvulus		0.0028	0.0108	0.0104
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.1516	1	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Leishmania major	hypothetical protein, conserved	0.0118	0.0704	0.0683
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Trypanosoma cruzi	thymidylate kinase, putative	0.03	0.1914	0.1895
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0028	0.0108	0.0104
Schistosoma mansoni	hypothetical protein	0.03	0.1914	0.231
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0028	0.0108	0.0104
Loa Loa (eye worm)	phosphofructokinase	0.0105	0.0622	0.0732
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0016	0.0028	0.0005
Entamoeba histolytica	thymidine kinase, putative	0.0526	0.3418	1
Plasmodium vivax	glutathione reductase, putative	0.0046	0.0227	0.0204
Echinococcus granulosus	tm gpcr rhodopsin	0.0028	0.0108	0.0104
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0028	0.0111	0.0089
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0028	0.0108	0.0104
Plasmodium vivax	thymidylate kinase, putative	0.03	0.1914	0.1895
Schistosoma mansoni	hypothetical protein	0.0028	0.0108	0.0104
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0016	0.0028	0.0002
Echinococcus multilocularis	dro:myosuppressin receptor	0.0028	0.0108	0.0104
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0028	0.0108	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0028	0.0108	0.0104
Echinococcus granulosus	biogenic amine 5HT receptor	0.0028	0.0108	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0016	0.0028	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0028	0.0005
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0016	0.0028	0.0005
Trichomonas vaginalis	thymidylate kinase, putative	0.03	0.1914	0.4923
Schistosoma mansoni	neuropeptide receptor	0.0028	0.0108	0.0104
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0028	0.0111	0.0261
Trypanosoma brucei	nicotinate phosphoribosyltransferase, putative	0.0142	0.0868	0.0847
Echinococcus granulosus	biogenic amine 5HT receptor	0.0028	0.0108	0.0104
Loa Loa (eye worm)	UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase	0.004	0.0186	0.0199
Brugia malayi	6-phosphofructokinase	0.0105	0.0622	0.0758
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0116	0.0694	0.0102
Brugia malayi	neuropeptide F receptor	0.0028	0.0108	0.0132
Loa Loa (eye worm)	neuropeptide F receptor	0.0028	0.0108	0.0104
Schistosoma mansoni	histamine h1 receptor	0.0028	0.0108	0.0104
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0028	0.0108	0.0104
Trypanosoma cruzi	DNA polymerase I alpha catalytic subunit, putative	0.0024	0.0081	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Brugia malayi	hypothetical protein	0.0028	0.0108	0.0132
Toxoplasma gondii	DNA polymerase (pol2) superfamily protein	0.0044	0.0217	0.0195
Chlamydia trachomatis	dihydrofolate reductase	0.0507	0.3295	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0028	0.0108	0.0104
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0028	0.0108	0.0104
Echinococcus multilocularis	g-protein coupled receptor	0.0028	0.0108	0.0104
Echinococcus granulosus	dihydrofolate reductase	0.0507	0.3295	0.3998
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0028	0.0108	0.0104
Trichomonas vaginalis	phosphofructokinase, putative	0.0105	0.0622	0.1559
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0028	0.0108	0.0104
Echinococcus granulosus	neuropeptide Y receptor	0.0028	0.0108	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0028	0.0108	0.0104
Loa Loa (eye worm)	thymidylate synthase	0.1246	0.8207	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0028	0.0108	0.0104
Toxoplasma gondii	thymidylate kinase	0.03	0.1914	0.1895
Plasmodium vivax	DNA polymerase alpha, putative	0.0044	0.0217	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Echinococcus multilocularis	thymidylate synthase	0.1246	0.8207	1
Trypanosoma cruzi	nicotinate phosphoribosyltransferase, putative	0.0142	0.0868	0.0847
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0028	0.0111	0.0089
Brugia malayi	DNA polymerase delta catalytic subunit	0.0015	0.0023	0.0028
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0028	0.0108	0.0104
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0108	0.0104
Brugia malayi	hypothetical protein	0.0593	0.3864	0.4708
Onchocerca volvulus		0.0028	0.0108	0.0104
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0108	0.0104
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.1246	0.8207	1
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0016	0.0028	0.0015
Trichomonas vaginalis	thymidine kinase, putative	0.0526	0.3418	0.884
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Treponema pallidum	nicotinate phosphoribosyltransferase	0.0142	0.0868	0.4458
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Loa Loa (eye worm)	G-protein coupled receptor	0.0028	0.0108	0.0104
Trypanosoma cruzi	trypanothione reductase, putative	0.0016	0.0028	0.0005
Giardia lamblia	O-linked GlcNAc transferase	0.0039	0.0184	0.0475
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0028	0.0108	0.0104
Trichomonas vaginalis	phosphofructokinase, putative	0.0105	0.0622	0.1559
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0105	0.0622	0.3156
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0105	0.0622	0.0007
Giardia lamblia	O-linked GlcNAc transferase	0.0023	0.0076	0.0155
Loa Loa (eye worm)	TYRA-2 protein	0.0028	0.0108	0.0104
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0016	0.0028	0.0005
Trichomonas vaginalis	DNA polymerase II, putative	0.0024	0.0081	0.0152
Trypanosoma cruzi	UMP-CMP kinase, mitochondrial, putative	0.0118	0.0704	0.0683
Trypanosoma brucei	RNA helicase, putative	0.0138	0.0839	0.0818
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0108	0.0104
Trichomonas vaginalis	thymidylate kinase, putative	0.03	0.1914	0.4923
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0028	0.0108	0.0104
Giardia lamblia	DNA polymerase alpha subunit A	0.0046	0.023	0.061
Echinococcus granulosus	DNA polymerase alpha catalytic subunit	0.0055	0.0286	0.0321
Trypanosoma cruzi	trypanothione reductase, putative	0.0046	0.0227	0.0204
Trypanosoma cruzi	thymidine kinase, putative	0.0526	0.3418	0.3403
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0108	0.0104
Brugia malayi	hypothetical protein	0.0028	0.0108	0.0132
Schistosoma mansoni	hypothetical protein	0.0028	0.0108	0.0104
Onchocerca volvulus		0.0028	0.0108	0.0104
Echinococcus granulosus	6 phosphofructokinase	0.0105	0.0622	0.0732
Echinococcus multilocularis	neuropeptides capa receptor	0.0028	0.0108	0.0104
Echinococcus granulosus	thioredoxin glutathione reductase	0.0046	0.0227	0.0249
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.0507	0.3295	0.3529
Brugia malayi	dihydrofolate reductase family protein	0.0507	0.3295	0.4015
Brugia malayi	putative neuropeptide receptor	0.0028	0.0108	0.0132
Echinococcus multilocularis	neuropeptide receptor	0.0028	0.0108	0.0104
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0028	0.0108	0.0132
Schistosoma mansoni	hypothetical protein	0.0138	0.0839	0.0998
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0016	0.0028	0.0005
Mycobacterium ulcerans	6-phosphofructokinase	0.0105	0.0622	0.0728
Echinococcus granulosus	neuropeptide Y receptor	0.0028	0.0108	0.0104
Toxoplasma gondii	NADPH-glutathione reductase	0.0016	0.0028	0.0005
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.1516	1	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Brugia malayi	Thioredoxin reductase	0.0046	0.0227	0.0276
Schistosoma mansoni	adenoreceptor	0.0028	0.0108	0.0104
Brugia malayi	Serotonin receptor	0.0028	0.0108	0.0132
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0028	0.0108	0.0104
Chlamydia trachomatis	thymidylate kinase	0.03	0.1914	0.5775
Trichomonas vaginalis	phosphofructokinase, putative	0.0028	0.0111	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Echinococcus granulosus	G protein coupled receptor 139	0.0028	0.0108	0.0104
Trichomonas vaginalis	phosphofructokinase, putative	0.0028	0.0111	0.0231
Schistosoma mansoni	hypothetical protein	0.0028	0.0108	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Trichomonas vaginalis	phosphofructokinase, putative	0.0028	0.0111	0.0231
Mycobacterium tuberculosis	Probable reductase	0.0104	0.0616	0.0719
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0028	0.0111	0.0261
Schistosoma mansoni	dihydrofolate reductase	0.0507	0.3295	0.3998
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0016	0.0028	0.0005
Echinococcus multilocularis	serotonin receptor	0.0028	0.0108	0.0104
Echinococcus multilocularis	neuropeptide receptor	0.0028	0.0108	0.0104
Schistosoma mansoni	hypothetical protein	0.0028	0.0108	0.0104
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0108	0.0104
Trypanosoma brucei	thymidine kinase	0.0526	0.3418	0.3403
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Plasmodium falciparum	DNA polymerase alpha catalytic subunit A	0.0015	0.0025	0.0003
Trichomonas vaginalis	phosphofructokinase, putative	0.0028	0.0111	0.0231
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0028	0.0005
Plasmodium falciparum	thioredoxin reductase	0.0046	0.0227	0.0204
Entamoeba histolytica	nicotinate phosphoribosyltransferase, putative	0.0142	0.0868	0.2488
Echinococcus granulosus	neuropeptides capa receptor	0.0028	0.0108	0.0104
Leishmania major	thymidylate kinase-like protein	0.03	0.1914	0.1895
Brugia malayi	Serotonin receptor	0.0028	0.0108	0.0132
Schistosoma mansoni	biogenic amine receptor	0.0028	0.0108	0.0104
Echinococcus multilocularis	allatostatin A receptor	0.0028	0.0108	0.0104
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0028	0.001
Trichomonas vaginalis	phosphofructokinase, putative	0.0105	0.0622	0.1559
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0028	0.0108	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Plasmodium falciparum	glutathione reductase	0.0016	0.0028	0.0005
Plasmodium falciparum	thioredoxin reductase	0.0016	0.0028	0.0005
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0108	0.0104
Onchocerca volvulus		0.0028	0.0108	0.0104
Brugia malayi	hypothetical protein	0.0028	0.0108	0.0132
Echinococcus multilocularis	neuropeptide Y receptor	0.0028	0.0108	0.0104
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0016	0.0028	0.0005
Treponema pallidum	NADH oxidase	0.0016	0.0028	0.001
Trypanosoma cruzi	thymidine kinase, putative	0.0526	0.3418	0.3403
Plasmodium falciparum	glutathione reductase	0.0046	0.0227	0.0204
Loa Loa (eye worm)	6-phosphofructokinase	0.0105	0.0622	0.0732
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0422	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0593	0.3864	0.385
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0028	0.0108	0.0104
Echinococcus granulosus	sex peptide receptor	0.0028	0.0108	0.0104
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0016	0.0028	0.0034
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0016	0.0028	0.0005
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0028	0.0111	0.0453
Echinococcus granulosus	g protein coupled receptor	0.0028	0.0108	0.0104
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0028	0.0108	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.1516	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0108	0.0104
Mycobacterium tuberculosis	Probable dehydrogenase	0.0104	0.0616	0.0719
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0028	0.0108	0.0104
Onchocerca volvulus		0.0028	0.0108	0.0104
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0028	0.0108	0.0104
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0108	0.0104
Loa Loa (eye worm)	pre-B cell enhancing factor	0.0766	0.5017	0.6102
Trypanosoma brucei	trypanothione reductase	0.0046	0.0227	0.0204
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0028	0.0108	0.0104
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0016	0.0028	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0108	0.0104
Schistosoma mansoni	opsin-like receptor	0.0028	0.0108	0.0104
Trichomonas vaginalis	phosphofructokinase, putative	0.0105	0.0622	0.1559
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0028	0.0005
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0028	0.0108	0.0104
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0108	0.0104
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0046	0.0227	0.0249

Activities

Activity type	Activity value	Assay description	Source	Reference
ILS (functional)	= 0 %	In vitro maximum increase in lifespan produced in mice bearing M5076 reticulum cell sarcoma implanted tumor; Inactive	ChEMBL.	2329559
ILS (binding)	= 43 %	In vitro maximum increase in lifespan produced in mice bearing ip B16 melanoma implanted tumor	ChEMBL.	2329559
ILS (functional)	= 75 %	In vitro maximum increase in lifespan produced in mice bearing ip P388 leukemia	ChEMBL.	2329559
MTD (functional)	= 8 uM day-1 kg-1	In vitro maximally tolerated dose for B6D2F1 mice on an ip P388 leukemia every day for 5 days regimen	ChEMBL.	2329559
MTD (functional)	= 8 uM day-1 kg-1	In vitro maximally tolerated dose for B6D2F mice on an every day ip for 10 days regimen.	ChEMBL.	2329559

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 141180

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 39281