Detailed information for compound 39559

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 339.41 | Formula: C15H21N3O4S
  • H donors: 4 H acceptors: 4 LogP: -0.97 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)/C=C\C(=O)O.NCCN/C(=N/c1ccc(cc1C)C)/S
  • InChi: 1S/C11H17N3S.C4H4O4/c1-8-3-4-10(9(2)7-8)14-11(15)13-6-5-12;5-3(6)1-2-4(7)8/h3-4,7H,5-6,12H2,1-2H3,(H2,13,14,15);1-2H,(H,5,6)(H,7,8)/b;2-1-
  • InChiKey: PEHMUVDNRSIQBE-BTJKTKAUSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0042 0.0042
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0015 0.0015
Brugia malayi nuclear receptor NHR-88 0.001 0.0039 0.0039
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0056 0.0056
Trichomonas vaginalis fk506-binding protein, putative 0.12 0.9994 1
Schistosoma mansoni nuclear hormone receptor 0.001 0.0039 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0039 0.0039
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0116 0.0116
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0029 0.0029
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0116 0.0117
Schistosoma mansoni hypothetical protein 0.0396 0.327 0.3272
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0039 0.0039
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0116 0.0117
Trypanosoma brucei hypothetical protein, conserved 0.0165 0.1338 0.129
Onchocerca volvulus 0.0165 0.1338 1
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.12 0.9994 1
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.1035 0.8612 0.8618
Brugia malayi Ets-domain containing protein 0.001 0.0042 0.0042
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0039 0.0039
Trypanosoma brucei macrophage infectivity potentiator, precursor, putative 0.0165 0.1338 0.129
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type (slyD) 0.0165 0.1338 0.1243
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0039 0.0039
Echinococcus granulosus ETS domain containing protein Elk 1 0.001 0.0042 0.0042
Trichomonas vaginalis fk506 binding protein, putative 0.0165 0.1338 0.1331
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.045 0.045
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.12 0.9994 1
Schistosoma mansoni ets-related 0.001 0.0042 0.0042
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0165 0.1338 1
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.12 0.9994 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0165 0.1338 0.1338
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0042 0.0042
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0165 0.1338 1
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.12 0.9994 0.9994
Echinococcus multilocularis ETS transcription factor Elf 1 0.001 0.0042 0.0042
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.12 0.9994 1
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33 0.0165 0.1338 0.1338
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0042 0.0042
Loa Loa (eye worm) FKBP5 protein 0.12 0.9994 0.9994
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0109 0.0053
Plasmodium vivax peptidyl-prolyl cis-trans isomerase, putative 0.0165 0.1338 0.1243
Loa Loa (eye worm) hypothetical protein 0.001 0.0039 0.0039
Brugia malayi Ets-domain containing protein 0.007 0.0543 0.0543
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0039 0.0039
Echinococcus granulosus ewsr:fli fusion protein type 0.001 0.0042 0.0042
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-33 0.0165 0.1338 0.1338
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0029 0.0029
Brugia malayi Ets-domain containing protein 0.007 0.0543 0.0543
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0039 0.0039
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0039 0.0039
Echinococcus multilocularis GA binding protein alpha chain 0.007 0.0543 0.0544
Trichomonas vaginalis fk506-binding protein, putative 0.0165 0.1338 0.1331
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0039 0.0039
Schistosoma mansoni rab6-interacting 0.0019 0.0116 0.0117
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase, putative 0.0165 0.1338 0.1243
Leishmania major peptidylprolyl isomerase-like protein 0.12 0.9994 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0015 0.0015
Schistosoma mansoni ap endonuclease 0.0018 0.0109 0.0109
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0165 0.1338 0.1243
Mycobacterium leprae PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG 0.0165 0.1338 0.5
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.12 0.9994 1
Schistosoma mansoni cpg binding protein 0.0029 0.0203 0.0203
Brugia malayi F/Y-rich N-terminus family protein 0.0008 0.0028 0.0028
Schistosoma mansoni fk506 binding protein 0.0165 0.1338 0.1339
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0109 0.0053
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0039 0.0039
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0015 0.0015
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0116 0.0007
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0039 0.0039
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-13 0.0165 0.1338 0.1338
Brugia malayi hypothetical protein 0.0019 0.0116 0.0116
Brugia malayi ecdysteroid receptor 0.001 0.0039 0.0039
Echinococcus granulosus ETS transcription factor Elf 1 0.001 0.0042 0.0042
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.1201 1 1
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0039 0.0039
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0109 0.0109
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0116 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0039 0.0039
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0039 0.0039
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.12 0.9994 1
Echinococcus multilocularis dnaJ subfamily B 0.0396 0.327 0.3272
Loa Loa (eye worm) ets-domain-containing protein 0.001 0.0042 0.0042
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0165 0.1338 0.129
Schistosoma mansoni thyroid hormone receptor 0.001 0.0039 0.0039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0039 0.0039
Echinococcus granulosus FTZ F1 alpha 0.001 0.0039 0.0039
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0053 0.0404 0.0404
Schistosoma mansoni ets-related 0.0213 0.1738 0.1739
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0109 0.0053
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0039 0.0039
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.12 0.9994 1
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-30 0.0165 0.1338 0.1338
Echinococcus multilocularis protein C ets 2 0.001 0.0042 0.0042
Schistosoma mansoni elf1 0.001 0.0042 0.0042
Echinococcus granulosus ETS transcription factor Elf 5 0.001 0.0042 0.0042
Echinococcus granulosus GA binding protein alpha chain 0.007 0.0543 0.0544
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.12 0.9994 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.001 0.0039 0.0039
Echinococcus multilocularis ets variant gene 4 0.001 0.0042 0.0042
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0042 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.1338 0.1331
Schistosoma mansoni coup transcription factor 0.001 0.0039 0.0039
Leishmania major FKBP-type peptidyl-prolyl cis-trans isomerase, putative 0.0165 0.1338 0.129
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0109 0.0109
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0165 0.1338 1
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13 0.0165 0.1338 0.1338
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0165 0.1338 0.129
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.12 0.9994 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0039 0.0039
Schistosoma mansoni rab6-interacting 0.0019 0.0116 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0039 0.0039
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.1035 0.8612 0.8612
Schistosoma mansoni hypothetical protein 0.0164 0.1329 0.133
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0165 0.1338 0.1243
Giardia lamblia Hypothetical protein 0.0165 0.1338 0.1243
Onchocerca volvulus 0.0165 0.1338 1
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.12 0.9994 1
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0165 0.1338 1
Brugia malayi DNA-binding protein D-ETS-3 0.001 0.0042 0.0042
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0116 0.0117
Schistosoma mansoni cpg binding protein 0.0028 0.0189 0.0189
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0039 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0039 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0039 0.0039
Echinococcus multilocularis ewsr:fli fusion protein type 0.001 0.0042 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0039 0.0039
Schistosoma mansoni immunophilin 0.1035 0.8612 0.8618
Trichomonas vaginalis fk506-binding protein, putative 0.0165 0.1338 0.1331
Onchocerca volvulus 0.0019 0.0116 0.0599
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0039 0.0039
Trypanosoma brucei FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0165 0.1338 0.129
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0165 0.1338 0.129
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0039 0.0039
Schistosoma mansoni ets 0.001 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.001 0.0039 0.0039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0039 0.0039
Brugia malayi nuclear hormone receptor 0.001 0.0039 0.0039
Schistosoma mansoni hypothetical protein 0.0165 0.1338 0.1339
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0165 0.1338 0.129
Schistosoma mansoni hypothetical protein 0.001 0.0042 0.0042
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.001 0.0042 0.0042
Echinococcus granulosus cpg binding protein 0.0029 0.0203 0.0203
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0116 0.0007
Schistosoma mansoni cpg binding protein 0.0029 0.0203 0.0203
Schistosoma mansoni hypothetical protein 0.001 0.0042 0.0042
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0189 0.0189
Loa Loa (eye worm) D-ets-2 protein 0.001 0.0042 0.0042
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0029 0.0029
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0109 0.01
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.007 0.0543 0.0543
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.12 0.9994 1
Schistosoma mansoni hypothetical protein 0.0019 0.0116 0.0117
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0165 0.1338 0.129
Brugia malayi transcription factor E74 isoform 0.001 0.0042 0.0042
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0039 0.0039
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.12 0.9994 1
Brugia malayi Doublecortin family protein 0.0019 0.0116 0.0116
Echinococcus multilocularis 0.0165 0.1338 0.1339
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0042
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.12 0.9994 1
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0165 0.1338 1
Brugia malayi Fli-1 protein 0.0213 0.1738 0.1738
Schistosoma mansoni polycystin 1-related 0.0019 0.0116 0.0117
Echinococcus granulosus dnaJ subfamily B 0.0396 0.327 0.3272
Brugia malayi hypothetical protein 0.0019 0.0116 0.0116
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.12 0.9994 0.9994
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30 0.0165 0.1338 0.1338
Brugia malayi Cytochrome P450 family protein 0.0012 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.001 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0039 0.0039
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0056 0.0056
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0165 0.1338 0.1243
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0039 0.0039
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0165 0.1338 0.1243
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.001 0.0042 0.0042
Onchocerca volvulus 0.0019 0.0116 0.0599
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.1035 0.8612 0.8618
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.12 0.9994 1
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0109 0.01
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0039 0.0039
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0109 0.0053
Echinococcus multilocularis FK506 binding protein 8, 38 kDa 0.0165 0.1338 0.1339
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.12 0.9994 1
Echinococcus granulosus FK506 binding protein 8 38 kDa 0.0165 0.1338 0.1339
Echinococcus granulosus FK506 binding protein 2 0.0165 0.1338 0.1339
Loa Loa (eye worm) fli-1 protein 0.0213 0.1738 0.1738
Schistosoma mansoni loxhd1 0.0019 0.0116 0.0117
Trypanosoma cruzi macrophage infectivity potentiator, precursor, putative 0.0165 0.1338 0.129
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.006 0.0458 0.0458
Loa Loa (eye worm) hypothetical protein 0.0008 0.0028 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0039 0.0039
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0116 0.0117
Echinococcus granulosus protein C ets 2 0.001 0.0042 0.0042
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0116 0.0117
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0039 0.0039
Echinococcus granulosus geminin 0.0164 0.1329 0.133
Loa Loa (eye worm) hypothetical protein 0.0019 0.0116 0.0116
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.12 0.9994 1
Schistosoma mansoni hypothetical protein 0.0164 0.1329 0.133
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0039 0.0039
Mycobacterium ulcerans hypothetical protein 0.0165 0.1338 0.129
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0053 0.0404 0.0404
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.12 0.9994 0.9994
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.12 0.9994 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0015 0.0015
Toxoplasma gondii peptidyl-prolyl isomerase FKBP12, putative 0.0165 0.1338 1
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.1338 0.1331
Echinococcus multilocularis RUN 0.0019 0.0116 0.0117
Schistosoma mansoni immunophilin 0.12 0.9994 1
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0039 0.0039
Leishmania major fk506-binding protein 1-like protein 0.12 0.9994 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0109 0.0109
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0039 0.0039
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0039 0.0039
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0039 0.0039
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0039 0.0039
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0039 0.0039
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0109 0.0109
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0039 0.0039
Schistosoma mansoni lipoxygenase 0.0019 0.0116 0.0117
Schistosoma mansoni gabp alpha 0.007 0.0543 0.0544
Schistosoma mansoni immunophilin 0.12 0.9994 1
Schistosoma mansoni lipoxygenase 0.0053 0.0404 0.0404
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0165 0.1338 0.129
Echinococcus multilocularis fk506 binding protein 0.12 0.9994 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0039 0.0039
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0397 0.2347
Onchocerca volvulus 0.0028 0.0189 0.116
Chlamydia trachomatis peptidyl-prolyl cis-trans isomerase 0.0165 0.1338 0.5
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.001 0.0042 0.0042
Schistosoma mansoni ap endonuclease 0.0018 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.001 0.0039 0.0039
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.12 0.9994 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0039 0.0039
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0039 0.0039
Schistosoma mansoni thyroid hormone receptor 0.001 0.0039 0.0039
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0165 0.1338 0.1243
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0039 0.0039
Echinococcus multilocularis ETS domain containing protein Elk 1 0.001 0.0042 0.0042
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.12 0.9994 1
Echinococcus multilocularis cpg binding protein 0.0029 0.0203 0.0203
Echinococcus multilocularis ETS transcription factor Elf 5 0.001 0.0042 0.0042
Echinococcus granulosus RUN 0.0019 0.0116 0.0117
Brugia malayi Cytochrome P450 family protein 0.0012 0.0056 0.0056
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0039 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0039 0.0039
Leishmania major peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative 0.0165 0.1338 0.129
Mycobacterium tuberculosis Probable trigger factor (TF) protein Tig 0.0165 0.1338 1
Trichomonas vaginalis immunophilin, putative 0.12 0.9994 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0039 0.0039
Brugia malayi CXXC zinc finger family protein 0.0028 0.0189 0.0189
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0039 0.0039
Brugia malayi steroid hormone receptor 0.001 0.0039 0.0039
Echinococcus multilocularis geminin 0.0164 0.1329 0.133
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.12 0.9994 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0056 0.0056
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0039 0.0039
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0039 0.0039
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0109 0.0053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0039 0.0039
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.001 0.0039 0.0039

Activities

Activity type Activity value Assay description Source Reference
Effect (functional) < 10 % Compound is measured for oral antihypertensive activity in groups of 6-12 conscious spontaneously hypertensive rats at 100 mg/kg ChEMBL. 7452693

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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