Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.5448 | 0.3633 | 0.2353 |
Trypanosoma brucei | DNA topoisomerase ii | 0.153 | 0.0945 | 0.2597 |
Loa Loa (eye worm) | hypothetical protein | 0.153 | 0.0945 | 0.2597 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.7022 | 0.4713 | 1 |
Brugia malayi | Probable DNA topoisomerase II | 0.153 | 0.0945 | 0.2597 |
Echinococcus multilocularis | S adenosylmethionine synthase type 1 | 0.0155 | 0.0003 | 0.0007 |
Echinococcus granulosus | thymidylate synthase | 0.5448 | 0.3633 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit A | 1.4732 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.5448 | 0.3633 | 0.3631 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.153 | 0.0945 | 0.2602 |
Schistosoma mansoni | S-adenosylmethionine synthetase | 0.0155 | 0.0003 | 0.0007 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 1.4732 | 1 | 1 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.153 | 0.0945 | 0.0943 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 1.4732 | 1 | 1 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.153 | 0.0945 | 0.2602 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.5448 | 0.3633 | 0.3631 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.2592 | 0.1674 | 0.4604 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.153 | 0.0945 | 0.2597 |
Brugia malayi | hypothetical protein | 0.2592 | 0.1674 | 0.4604 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.153 | 0.0945 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.5448 | 0.3633 | 1 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.153 | 0.0945 | 0.5641 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.153 | 0.0945 | 0.2597 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 1.4732 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.5448 | 0.3633 | 1 |
Plasmodium vivax | DNA gyrase subunit A, putative | 1.4732 | 1 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.153 | 0.0945 | 0.2597 |
Plasmodium falciparum | DNA gyrase subunit A | 1.4732 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.5448 | 0.3633 | 1 |
Leishmania major | DNA topoisomerase ii | 0.153 | 0.0945 | 0.2597 |
Onchocerca volvulus | 0.5448 | 0.3633 | 1 | |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.153 | 0.0945 | 0.2597 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.5448 | 0.3633 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.153 | 0.0945 | 0.2597 |
Schistosoma mansoni | DNA topoisomerase II | 0.153 | 0.0945 | 0.2602 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.153 | 0.0945 | 0.0943 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.5448 | 0.3633 | 0.3631 |
Loa Loa (eye worm) | thymidylate synthase | 0.5448 | 0.3633 | 1 |
Echinococcus granulosus | S adenosylmethionine synthase type 1 | 0.0155 | 0.0003 | 0.0007 |
Loa Loa (eye worm) | hypothetical protein | 0.153 | 0.0945 | 0.2597 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.153 | 0.0945 | 0.0943 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.153 | 0.0945 | 0.2597 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.153 | 0.0945 | 0.2597 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.153 | 0.0945 | 0.2597 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.5448 | 0.3633 | 0.3631 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.153 | 0.0945 | 0.2597 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.5448 | 0.3633 | 1 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.153 | 0.0945 | 0.2597 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 1.4732 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.5448 | 0.3633 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.2592 | 0.1674 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.153 | 0.0945 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 14 mg kg-1 day-1 | Antitumor activity against transplanted tumor sarcoma 180 expressed as effective dose. | ChEMBL. | 2521251 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.