Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thromboxane A synthase 1 (platelet) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | cytochrome P450, putative | thromboxane A synthase 1 (platelet) | 534 aa | 498 aa | 21.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | epidermal growth factor receptor | 0.0079 | 0.3079 | 0.3079 |
Schistosoma mansoni | tyrosine kinase | 0.0078 | 0.3002 | 0.2906 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0079 | 0.3079 | 0.2983 |
Schistosoma mansoni | tyrosine kinase | 0.0079 | 0.3079 | 0.2983 |
Schistosoma mansoni | tyrosine kinase | 0.0078 | 0.3002 | 0.2906 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0154 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0078 | 0.3002 | 0.2906 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0154 | 1 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0154 | 1 | 1 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0154 | 1 | 1 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0154 | 1 | 1 |
Leishmania major | 0.0154 | 1 | 0.5 | |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0154 | 1 | 1 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0154 | 1 | 1 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0079 | 0.3079 | 0.2983 |
Echinococcus multilocularis | insulin receptor | 0.0047 | 0.0135 | 0.0135 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0147 | 0.9333 | 0.9333 |
Schistosoma mansoni | tyrosine kinase | 0.0147 | 0.9333 | 0.9323 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0147 | 0.9333 | 0.9323 |
Schistosoma mansoni | tyrosine kinase | 0.0079 | 0.3079 | 0.2983 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0047 | 0.0135 | 0.0135 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0147 | 0.9333 | 0.9323 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0154 | 1 | 1 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0147 | 0.9333 | 0.9323 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.2 uM | Inhibitory concentration required for the inhibition of U-46,619 induced aggregation of human platelets. | ChEMBL. | 9871770 |
IC50 (functional) | = 1.2 uM | Inhibitory concentration required for the inhibition of U-46,619 induced aggregation of human platelets. | ChEMBL. | 9871770 |
IC50 (binding) | > 5 uM | Anti-synthetase activity against TXA2 synthase in human whole blood assay | ChEMBL. | 9871770 |
IC50 (binding) | > 5 uM | Anti-synthetase activity against TXA2 synthase in human whole blood assay | ChEMBL. | 9871770 |
pA2 (functional) | = 8.7 | Inhibition of U-46,619 induced contraction of isolated rabbit saphenous vein. | ChEMBL. | 9871770 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 9871770 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.