Detailed information for compound 400059

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1046.26 | Formula: C47H71N11O12S2
  • H donors: 14 H acceptors: 12 LogP: -2.53 Rotable bonds: 22
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@@H](C(=O)N[C@H](C(=O)O)CCCCN)NC(=O)[C@H]1CSSC[C@@H](N)C(=O)N[C@H]([C@H](CC)C)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](C(=O)N1)Cc1ccccc1)CO)Cc1ccc(cc1)O
  • InChi: 1S/C47H71N11O12S2/c1-3-27(2)39-46(68)56-34(22-29-15-17-30(60)18-16-29)41(63)51-23-38(61)52-36(24-59)44(66)55-35(21-28-11-5-4-6-12-28)43(65)57-37(26-72-71-25-31(50)40(62)58-39)45(67)53-32(13-7-9-19-48)42(64)54-33(47(69)70)14-8-10-20-49/h4-6,11-12,15-18,27,31-37,39,59-60H,3,7-10,13-14,19-26,48-50H2,1-2H3,(H,51,63)(H,52,61)(H,53,67)(H,54,64)(H,55,66)(H,56,68)(H,57,65)(H,58,62)(H,69,70)/t27-,31+,32-,33-,34-,35+,36-,37+,39+/m0/s1
  • InChiKey: KKTXISFUUUAHPL-HOSDHGKZSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SRC proto-oncogene, non-receptor tyrosine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi protein-tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K08892 fyn-related kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Lyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Srms Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase Yrk, putative Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FGR, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Cathepsin L homolog 0.1005 1 1
Schistosoma mansoni cathepsin C 0.0189 0.1794 0.1794
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0674 0.6673 0.5946
Trypanosoma cruzi cysteine proteinase, putative 0.052 0.5121 0.4054
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.052 0.5121 0.5121
Brugia malayi cathepsin Z-like cysteine proteinase 0.0189 0.1794 0.1794
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0674 0.6673 0.5946
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0229 0.22 0.0494
Entamoeba histolytica cysteine protease, putative 0.052 0.5121 0.4989
Trypanosoma cruzi cysteine peptidase, putative 0.1005 1 1
Loa Loa (eye worm) cathepsin B 0.0229 0.22 0.1988
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1005 1 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.004 0.0297 0.0297
Entamoeba histolytica cysteine proteinase, putative 0.052 0.5121 0.4989
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0319 0.3105 0.3105
Echinococcus granulosus cathepsin L cysteine proteinase 0.1005 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0354 0.0354
Loa Loa (eye worm) hypothetical protein 0.0674 0.6673 0.6583
Onchocerca volvulus 0.1005 1 1
Entamoeba histolytica cysteine proteinase, putative 0.052 0.5121 0.4989
Echinococcus granulosus cathepsin L cysteine protease 0.052 0.5121 0.5121
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1005 1 1
Brugia malayi protein-tyrosine kinase 0.0041 0.0309 0.0309
Leishmania major cathepsin L-like protease 0.1005 1 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0229 0.22 0.0494
Echinococcus granulosus cathepsin L 0.0189 0.1794 0.1794
Echinococcus multilocularis tyrosine protein kinase HCK 0.0036 0.0264 0.0264
Leishmania major cathepsin L-like protease 0.1005 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.1005 1 1
Brugia malayi cathepsin L-like precursor 0.0674 0.6673 0.6673
Brugia malayi Cathepsin L-like precursor 0.0331 0.3224 0.3224
Schistosoma mansoni cathepsin F (C01 family) 0.1005 1 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0354 0.0354
Plasmodium falciparum cysteine proteinase falcipain 3 0.1005 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0674 0.6673 0.6583
Echinococcus granulosus tyrosine protein kinase Blk 0.0041 0.0309 0.0309
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0045 0.0354 0.0354
Onchocerca volvulus Cathepsin F homolog 0.1005 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1005 1 1
Brugia malayi Cathepsin L-like precursor 0.0674 0.6673 0.6673
Onchocerca volvulus 0.1005 1 1
Onchocerca volvulus 0.1005 1 1
Loa Loa (eye worm) SRC-1 0.0045 0.0354 0.0093
Trypanosoma cruzi cysteine peptidase, putative 0.1005 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1005 1 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0189 0.1794 0.1794
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1005 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1005 1 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1005 1 1
Entamoeba histolytica cysteine protease, putative 0.0189 0.1794 0.1572
Plasmodium vivax unspecified product 0.0331 0.3224 0.1742
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0331 0.3224 0.304
Entamoeba histolytica cysteine proteinase 1, putative 0.052 0.5121 0.4989
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1005 1 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0674 0.6673 0.6673
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1005 1 1
Entamoeba histolytica cysteine protease, putative 0.052 0.5121 0.4989
Brugia malayi cathepsin Z-like cysteine proteinase 0.0189 0.1794 0.1794
Brugia malayi fibroinase precursor 0.0189 0.1794 0.1794
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1005 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1005 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0354 0.0354
Echinococcus granulosus cathepsin b 0.0319 0.3105 0.3105
Entamoeba histolytica hypothetical protein 0.0189 0.1794 0.1572
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0189 0.1794 0.1572
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.052 0.5121 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1005 1 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0331 0.3224 0.3224
Entamoeba histolytica cysteine protease, putative 0.0189 0.1794 0.1572
Leishmania major cathepsin L-like protease 0.1005 1 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0045 0.0354 0.0354
Trypanosoma cruzi cruzipain precursor, putative 0.0331 0.3224 0.1742
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0189 0.1794 0.1794
Brugia malayi Cathepsin L-like precursor 0.1005 1 1
Plasmodium vivax unspecified product 0.052 0.5121 0.4054
Echinococcus multilocularis tyrosine protein kinase Srms 0.0041 0.0309 0.0309
Loa Loa (eye worm) hypothetical protein 0.0674 0.6673 0.6583
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1005 1 1
Entamoeba histolytica cysteine proteinase, putative 0.052 0.5121 0.4989
Brugia malayi Cathepsin L-like precursor 0.1005 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1005 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1005 1 1
Loa Loa (eye worm) hypothetical protein 0.0189 0.1794 0.1572
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1005 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0189 0.1794 0.1794
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1005 1 1
Onchocerca volvulus 0.1005 1 1
Loa Loa (eye worm) cysteine protease 0.1005 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1005 1 1
Leishmania major cathepsin L-like protease 0.1005 1 1
Brugia malayi cathepsin B-like cysteine proteinase 0.0319 0.3105 0.3105
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1005 1 1
Entamoeba histolytica cysteine protease, putative 0.0189 0.1794 0.1572
Brugia malayi Cathepsin L-like precursor 0.1005 1 1
Loa Loa (eye worm) hypothetical protein 0.0331 0.3224 0.304
Entamoeba histolytica cysteine protease, putative 0.0189 0.1794 0.1572
Toxoplasma gondii cathepsin CPL 0.1005 1 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0354 0.0354
Leishmania major cathepsin L-like protease 0.1005 1 1
Brugia malayi Papain family cysteine protease containing protein 0.052 0.5121 0.5121
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0674 0.6673 0.5946
Brugia malayi cathepsin L precursor 0.0189 0.1794 0.1794
Loa Loa (eye worm) ctsf protein 0.1005 1 1
Loa Loa (eye worm) hypothetical protein 0.0189 0.1794 0.1572
Entamoeba histolytica cysteine protease, putative 0.0189 0.1794 0.1572
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0045 0.0354 0.0354
Plasmodium vivax vivapain-1 0.052 0.5121 0.4054
Schistosoma mansoni cathepsin F (C01 family) 0.1005 1 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.052 0.5121 0.5121
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1005 1 1
Trypanosoma cruzi cruzipain precursor, putative 0.1005 1 1
Echinococcus multilocularis cysteine protease 0.1005 1 1
Loa Loa (eye worm) hypothetical protein 0.0189 0.1794 0.1572
Echinococcus multilocularis cathepsin b 0.0319 0.3105 0.3105
Loa Loa (eye worm) hypothetical protein 0.1005 1 1
Schistosoma mansoni tyrosine kinase 0.0045 0.0354 0.0354
Brugia malayi Papain family cysteine protease containing protein 0.1005 1 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0189 0.1794 0.1794
Trypanosoma cruzi cysteine peptidase, putative 0.0331 0.3224 0.1742
Echinococcus granulosus cathepsin L 0.052 0.5121 0.5121
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1005 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1005 1 1
Loa Loa (eye worm) hypothetical protein 0.0189 0.1794 0.1572
Echinococcus multilocularis cathepsin L 0.052 0.5121 0.5121
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0045 0.0354 0.0354
Entamoeba histolytica cysteine protease, putative 0.052 0.5121 0.4989
Brugia malayi SRC-1 0.0045 0.0354 0.0354
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0189 0.1794 0.1794
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.052 0.5121 0.3745
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.0309 0.0309
Trypanosoma cruzi cysteine peptidase, putative 0.052 0.5121 0.4054
Plasmodium vivax vivapain-3 0.052 0.5121 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.052 0.5121 0.4054
Entamoeba histolytica cysteine protease, putative 0.052 0.5121 0.4989
Entamoeba histolytica cysteine protease, putative 0.1005 1 1
Brugia malayi cathepsin L-like cysteine proteinase 0.0189 0.1794 0.1794
Echinococcus granulosus tyrosine protein kinase Lyn 0.0045 0.0354 0.0354
Entamoeba histolytica cysteine proteinase, putative 0.1005 1 1
Echinococcus granulosus tyrosine kinase 0.0041 0.0309 0.0309
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0045 0.0354 0.0354
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1005 1 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0045 0.0354 0.0354
Echinococcus multilocularis cathepsin L cysteine protease 0.1005 1 1
Entamoeba histolytica cysteine protease, putative 0.052 0.5121 0.4989
Entamoeba histolytica cysteine protease, putative 0.052 0.5121 0.4989
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0189 0.1794 0.1572
Echinococcus multilocularis tyrosine protein kinase Src42A 0.004 0.0297 0.0297
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0189 0.1794 0.1572
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1005 1 1
Onchocerca volvulus 0.0674 0.6673 0.5946
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0189 0.1794 0.1572
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0045 0.0354 0.0354
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1005 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0354 0.0354
Trypanosoma cruzi cysteine peptidase, putative 0.1005 1 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.1005 1 1
Giardia lamblia Cathepsin B precursor 0.0229 0.22 1
Entamoeba histolytica cysteine protease, putative 0.052 0.5121 0.4989
Giardia lamblia Cathepsin B precursor 0.0229 0.22 1
Entamoeba histolytica cysteine protease, putative 0.052 0.5121 0.4989
Entamoeba histolytica cysteine protease, putative 0.052 0.5121 0.4989
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0189 0.1794 0.1572
Echinococcus granulosus tyrosine protein kinase HCK 0.0036 0.0264 0.0264
Echinococcus granulosus tyrosine protein kinase Src42A 0.0045 0.0354 0.0354
Entamoeba histolytica cysteine proteinase, putative 0.052 0.5121 0.4989
Onchocerca volvulus Cathepsin L homolog 0.1005 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1005 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0189 0.1794 0.1794
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1005 1 1
Brugia malayi Papain family cysteine protease containing protein 0.052 0.5121 0.5121
Echinococcus granulosus cysteine protease 0.052 0.5121 0.5121
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.052 0.5121 0.5121
Loa Loa (eye worm) TK protein kinase 0.0041 0.0309 0.0047
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0189 0.1794 0.1794
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1005 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0189 0.1794 0.1794
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.052 0.5121 0.3745
Entamoeba histolytica cysteine protease, putative 0.0189 0.1794 0.1572
Schistosoma mansoni tyrosine kinase 0.0045 0.0354 0.0354
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1005 1 1
Plasmodium vivax vivapain-2 0.1005 1 1
Brugia malayi Cathepsin L-like precursor 0.1005 1 1
Onchocerca volvulus 0.1005 1 1
Entamoeba histolytica cysteine proteinase, putative 0.1005 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1005 1 1
Entamoeba histolytica cysteine protease, putative 0.052 0.5121 0.4989
Schistosoma mansoni cathepsin B (C01 family) 0.0189 0.1794 0.1794
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0319 0.3105 0.3105
Trypanosoma cruzi cysteine proteinase, putative 0.052 0.5121 0.4054
Plasmodium falciparum cysteine proteinase falcipain 1 0.052 0.5121 0.4054
Entamoeba histolytica cysteine proteinase 2 0.052 0.5121 0.4989
Entamoeba histolytica cysteine protease, putative 0.052 0.5121 0.4989
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1005 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.1005 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1005 1 1
Onchocerca volvulus 0.1005 1 1
Entamoeba histolytica cysteine protease, putative 0.052 0.5121 0.4989
Leishmania major cathepsin L-like protease 0.1005 1 1
Loa Loa (eye worm) fibroinase 0.1005 1 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0319 0.3105 0.1597
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0229 0.22 0.22
Brugia malayi Papain family cysteine protease containing protein 0.0189 0.1794 0.1794
Loa Loa (eye worm) hypothetical protein 0.0319 0.3105 0.2918
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1005 1 1
Loa Loa (eye worm) hypothetical protein 0.0189 0.1794 0.1572
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1005 1 1
Plasmodium vivax vivapain-2 0.1005 1 1
Trypanosoma cruzi cysteine protease, putative 0.052 0.5121 0.4054
Giardia lamblia Cathepsin B precursor 0.0229 0.22 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1005 1 1
Loa Loa (eye worm) hypothetical protein 0.0331 0.3224 0.304
Toxoplasma gondii cathepsin B 0.0229 0.22 0.0494
Echinococcus granulosus cathepsin b 0.0319 0.3105 0.3105
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0041 0.0309 0.0309
Schistosoma mansoni cathepsin F (C01 family) 0.0674 0.6673 0.6673
Echinococcus granulosus cathepsin l1 0.0674 0.6673 0.6673
Leishmania major cathepsin L-like protease 0.1005 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1005 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1005 1 1
Brugia malayi Cathepsin L-like precursor 0.0674 0.6673 0.6673
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0319 0.3105 0.3105
Echinococcus granulosus tyrosine protein kinase Src64B 0.0045 0.0354 0.0354
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0189 0.1794 0.1794
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1005 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1005 1 1
Schistosoma mansoni cathepsin S (C01 family) 0.0189 0.1794 0.1794
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0045 0.0354 0.0354
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1005 1 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0331 0.3224 0.3224
Leishmania major cathepsin L-like protease 0.1005 1 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0189 0.1794 0.1794
Leishmania major cysteine peptidase A (CPA) 0.1005 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0189 0.1794 0.1794
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0354 0.0354
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1005 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1005 1 1
Echinococcus multilocularis cysteine protease 0.1005 1 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0041 0.0309 0.0309
Echinococcus multilocularis cathepsin L 0.0189 0.1794 0.1794
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.052 0.5121 0.4054
Loa Loa (eye worm) hypothetical protein 0.0189 0.1794 0.1572
Brugia malayi Cathepsin L-like precursor 0.1005 1 1
Loa Loa (eye worm) hypothetical protein 0.0331 0.3224 0.304
Echinococcus multilocularis cathepsin b 0.0319 0.3105 0.3105
Loa Loa (eye worm) hypothetical protein 0.0674 0.6673 0.6583
Entamoeba histolytica cysteine protease, putative 0.052 0.5121 0.4989
Onchocerca volvulus 0.1005 1 1
Echinococcus granulosus cathepsin l1 0.1005 1 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0189 0.1794 0.1794
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0319 0.3105 0.3105
Schistosoma mansoni cathepsin s 0.0331 0.3224 0.3224
Brugia malayi Papain family cysteine protease containing protein 0.0189 0.1794 0.1794

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2.7 uM Inhibition of c-Src tyrosine kinase. ChEMBL. 9632358
IC50 (binding) = 2.7 uM Inhibition of c-Src tyrosine kinase. ChEMBL. 9632358

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.