Detailed information for compound 400119

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1065.22 | Formula: C49H64N10O13S2
  • H donors: 15 H acceptors: 13 LogP: -1.78 Rotable bonds: 19
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@@H]1NC(=O)[C@H](NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@@H](NC(=O)[C@H](NC1=O)[C@H](O)C)C(=O)N[C@H](C(=O)O)[C@H](O)C)NC(=O)[C@@H](Cc1ccc(cc1)O)N)Cc1c[nH]c2c1cccc2
  • InChi: 1S/C49H64N10O13S2/c1-25(60)40-48(70)57-39(47(69)59-41(26(2)61)49(71)72)24-74-73-23-38(56-42(64)33(51)19-27-10-14-30(62)15-11-27)46(68)54-36(20-28-12-16-31(63)17-13-28)44(66)55-37(21-29-22-52-34-8-4-3-7-32(29)34)45(67)53-35(43(65)58-40)9-5-6-18-50/h3-4,7-8,10-17,22,25-26,33,35-41,52,60-63H,5-6,9,18-21,23-24,50-51H2,1-2H3,(H,53,67)(H,54,68)(H,55,66)(H,56,64)(H,57,70)(H,58,65)(H,59,69)(H,71,72)/t25-,26-,33-,35+,36+,37-,38+,39-,40-,41+/m1/s1
  • InChiKey: NBMOVRAPBWKSOS-RZJCKZIGSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Mu opioid receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Mu opioid receptor   398 aa 356 aa 23.9 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Mu opioid receptor   398 aa 334 aa 23.1 %
Onchocerca volvulus Programmed cell death protein 5 homolog Mu opioid receptor   398 aa 323 aa 24.1 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Mu opioid receptor   398 aa 371 aa 27.0 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Mu opioid receptor   398 aa 334 aa 24.9 %
Echinococcus granulosus allatostatin A receptor Mu opioid receptor   398 aa 346 aa 29.5 %
Schistosoma mansoni neuropeptide F-like receptor Mu opioid receptor   398 aa 335 aa 20.6 %
Echinococcus granulosus thyrotropin releasing hormone receptor Mu opioid receptor   398 aa 370 aa 27.3 %
Onchocerca volvulus Mu opioid receptor   398 aa 376 aa 26.3 %
Schistosoma japonicum Rhodopsin, putative Mu opioid receptor   398 aa 328 aa 23.2 %
Onchocerca volvulus Mu opioid receptor   398 aa 333 aa 26.4 %
Echinococcus multilocularis allatostatin A receptor Mu opioid receptor   398 aa 341 aa 29.3 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Mu opioid receptor   398 aa 397 aa 22.7 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni septate junction protein 0.0051 0.009 0.0104
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.0787 0.3024 0.3607
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0252 0.0293
Echinococcus multilocularis lachesin 0.0051 0.009 0.009
Echinococcus granulosus muscleblind protein 0.0158 0.0517 0.06
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.0693 0.2649 0.315
Brugia malayi Immunoglobulin I-set domain containing protein 0.0051 0.009 0.0107
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.0032
Mycobacterium tuberculosis Conserved protein 0.0035 0.0027 0.0019
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.0693 0.2649 0.645
Brugia malayi Immunoglobulin I-set domain containing protein 0.0051 0.009 0.0107
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0581 0.0663
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0054 0.0021
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.1054 0.4087 0.4087
Brugia malayi Immunoglobulin I-set domain containing protein 0.0029 0.0001 0.0001
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.003 0.0006 0.0007
Brugia malayi Muscleblind-like protein 0.0158 0.0517 0.0617
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0043 0.0055 0.0055
Echinococcus granulosus tachykinin peptides receptor 99D 0.003 0.0006 0.0007
Schistosoma mansoni carbonic anhydrase-related 0.0118 0.0357 0.0415
Mycobacterium ulcerans beta-lactamase 0.0035 0.0027 0.0019
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Echinococcus multilocularis roundabout 2 0.0051 0.009 0.009
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0252 0.0293
Mycobacterium ulcerans lipase LipD 0.0035 0.0027 0.0019
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.0787 0.3024 0.3024
Echinococcus granulosus defective proboscis extension response 0.0088 0.0237 0.0275
Loa Loa (eye worm) hypothetical protein 0.0072 0.0172 0.0206
Echinococcus multilocularis Immunoglobulin 0.0088 0.0237 0.0237
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0006 0.0007
Brugia malayi beta-lactamase 0.0035 0.0027 0.0032
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.003 0.0006 0.0006
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0326 0.1184 0.1373
Schistosoma mansoni amine GPCR 0.003 0.0006 0.0007
Schistosoma mansoni cell adhesion molecule 0.0051 0.009 0.0104
Echinococcus multilocularis g protein coupled receptor 0.003 0.0006 0.0006
Schistosoma mansoni tyrosine kinase 0.1125 0.437 0.507
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.003 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0051 0.009 0.0108
Loa Loa (eye worm) hypothetical protein 0.014 0.0442 0.0527
Loa Loa (eye worm) hypothetical protein 0.0051 0.009 0.0107
Echinococcus multilocularis geminin 0.0347 0.1267 0.1267
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0006 0.0007
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0118 0.0137
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.1054 0.4087 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0219 0.0757 0.0878
Brugia malayi hypothetical protein 0.003 0.0006 0.0007
Echinococcus granulosus thyrotropin releasing hormone receptor 0.003 0.0006 0.0007
Echinococcus multilocularis fmrfamide receptor 0.003 0.0006 0.0006
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.007 0.0051
Brugia malayi Cache domain containing protein 0.015 0.0485 0.0578
Schistosoma mansoni tyrosine kinase 0.2124 0.8352 0.9691
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.003 0.0006 0.0006
Brugia malayi hypothetical protein 0.0088 0.0237 0.0283
Schistosoma mansoni tyrosine kinase 0.0684 0.2613 0.3031
Onchocerca volvulus 0.0035 0.0027 0.0039
Echinococcus granulosus orexin receptor type 2 0.003 0.0006 0.0007
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0097 0.0115
Brugia malayi AKH receptor 0.003 0.0006 0.0007
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0118 0.0137
Echinococcus granulosus neuropeptide receptor 0.003 0.0006 0.0007
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0006 0.0007
Schistosoma mansoni amine GPCR 0.003 0.0006 0.0007
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0684 0.2613 0.3031
Loa Loa (eye worm) hypothetical protein 0.0126 0.0388 0.0463
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0581 0.0663
Echinococcus granulosus allatostatin A receptor 0.003 0.0006 0.0007
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.1054 0.4087 1
Echinococcus multilocularis GPCR, family 2 0.0033 0.0018 0.0018
Schistosoma mansoni hypothetical protein 0.003 0.0006 0.0007
Schistosoma mansoni opsin-like receptor 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Schistosoma mansoni tyrosine kinase 0.0684 0.2613 0.3031
Brugia malayi RNA binding protein 0.0064 0.0139 0.0166
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0655 0.2497 0.2497
Schistosoma mansoni hypothetical protein 0.003 0.0006 0.0007
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0034 0.002 0.0023
Echinococcus multilocularis neuropeptide receptor A26 0.0518 0.1952 0.1952
Schistosoma mansoni hypothetical protein 0.0072 0.0172 0.02
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.1054 0.4087 0.4868
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0139 0.0162
Loa Loa (eye worm) TK/INSR protein kinase 0.0684 0.2613 0.3116
Echinococcus granulosus voltage dependent calcium channel subunit 0.0747 0.2862 0.332
Brugia malayi G-protein coupled receptor 0.003 0.0006 0.0007
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.1054 0.4087 0.4852
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.0127 0.0148
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0123 0.0134
Echinococcus multilocularis roundabout 2 0.014 0.0442 0.0442
Echinococcus multilocularis neuropeptide receptor 0.003 0.0006 0.0006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0252 0.0252
Echinococcus multilocularis g protein coupled receptor 0.003 0.0006 0.0006
Loa Loa (eye worm) TK/ROR protein kinase 0.0043 0.0055 0.0066
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0038 0.0038 0.0038
Echinococcus granulosus lysine specific demethylase 5A 0.0058 0.0118 0.0137
Echinococcus multilocularis serotonin receptor 0.003 0.0006 0.0006
Brugia malayi gonadotropin-releasing hormone receptor 2 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0581 0.0663
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0006 0.0006
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0027 0.0019
Leishmania major polyprenyl synthase, putative 0.0787 0.3024 0.3599
Onchocerca volvulus 0.0469 0.1756 0.3323
Trypanosoma cruzi polyprenyl synthase, putative 0.0787 0.3024 0.3599
Loa Loa (eye worm) hypothetical protein 0.0051 0.009 0.0107
Brugia malayi Protein kinase domain containing protein 0.0684 0.2613 0.3116
Echinococcus granulosus neuropeptides capa receptor 0.003 0.0006 0.0007
Mycobacterium ulcerans hypothetical protein 0.0035 0.0027 0.0019
Echinococcus granulosus cytochrome P450 2K1 0.0032 0.0011 0.0013
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0219 0.0757 0.0878
Brugia malayi hypothetical protein 0.003 0.0006 0.0007
Trypanosoma cruzi solanesyl-diphosphate synthase 0.1054 0.4087 0.4868
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.0127 0.0127
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.0618 0.0708
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0051 0.009 0.009
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0117 0.0352 0.0408
Schistosoma mansoni alpha-1 adrenergic receptor 0.003 0.0006 0.0007
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0747 0.2862 0.2862
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.0032
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0693 0.2649 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.003 0.0006 0.0006
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0118 0.0137
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0123 0.0134
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0123 0.0143
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0219 0.0757 0.0891
Echinococcus granulosus neuropeptide receptor A26 0.0518 0.1952 0.2265
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.0375 0.0448
Onchocerca volvulus Huntingtin homolog 0.0126 0.0388 0.0726
Brugia malayi Immunoglobulin I-set domain containing protein 0.0051 0.009 0.0107
Echinococcus multilocularis neuropeptide s receptor 0.0518 0.1952 0.1952
Brugia malayi Fibronectin type III domain containing protein 0.0088 0.0237 0.0283
Echinococcus granulosus peroxidasin 0.0051 0.009 0.0105
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Trypanosoma brucei farnesyl pyrophosphate synthase 0.2132 0.8385 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0153 0.0494 0.0573
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0006 0.0006
Echinococcus granulosus somatostatin receptor 0.003 0.0006 0.0007
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.003 0.0006 0.0007
Schistosoma mansoni hypothetical protein 0.0033 0.0018 0.0021
Brugia malayi Furin-like cysteine rich region family protein 0.2124 0.8352 0.9962
Loa Loa (eye worm) hypothetical protein 0.014 0.0442 0.0527
Plasmodium falciparum carbonic anhydrase 0.0118 0.0357 0.0385
Echinococcus granulosus neuropeptide s receptor 0.0518 0.1952 0.2265
Brugia malayi Cytochrome P450 family protein 0.0032 0.0011 0.0013
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.0006 0.0007
Schistosoma mansoni single-minded 0.0048 0.0076 0.0088
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.2132 0.8385 1
Leishmania major solanesyl-diphosphate synthase, putative 0.1054 0.4087 0.4868
Brugia malayi GnHR receptor homolog 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0034 0.002 0.002
Brugia malayi Immunoglobulin I-set domain containing protein 0.0051 0.009 0.0107
Loa Loa (eye worm) carbonic anhydrase 3 0.0219 0.0757 0.0903
Echinococcus multilocularis carbonic anhydrase II 0.0219 0.0757 0.0757
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0252 0.0301
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.2132 0.8385 1
Schistosoma mansoni trans-prenyltransferase 0.1054 0.4087 0.4742
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0118 0.014
Schistosoma mansoni hypothetical protein 0.0347 0.1267 0.147
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0027 0.0019
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0027 0.0027
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0051 0.009 0.0104
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0139 0.0162
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0118 0.0118
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.003 0.0006 0.0006
Schistosoma mansoni nephrin 0.0111 0.0327 0.0379
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0157 0.0512 0.0512
Schistosoma mansoni amine GPCR 0.003 0.0006 0.0007
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Echinococcus multilocularis g-protein coupled receptor 0.003 0.0006 0.0006
Brugia malayi larval opioid receptor 0.003 0.0006 0.0007
Echinococcus multilocularis G protein coupled receptor 139 0.003 0.0006 0.0006
Loa Loa (eye worm) melatonin receptor type 1A 0.003 0.0006 0.0007
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.0945 0.1099
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.003 0.0006 0.0007
Schistosoma mansoni biogenic amine receptor 0.003 0.0006 0.0007
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.0127 0.0139
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0051 0.009 0.0107
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0123 0.0123
Schistosoma mansoni carbonic anhydrase-related 0.0118 0.0357 0.0415
Brugia malayi PAS domain containing protein 0.0048 0.0076 0.0091
Brugia malayi G protein-coupled receptor F59B2.13 0.003 0.0006 0.0007
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0027 0.0019
Leishmania major basic transcription factor 3a, putative 0.0038 0.0036 0.003
Trypanosoma cruzi polyprenyl synthase, putative 0.0787 0.3024 0.3599
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.007 0.0051
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0252 0.0293
Onchocerca volvulus Tyrosine kinase homolog 0.1351 0.5273 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0018 0.0018
Echinococcus granulosus neuropeptide Y receptor 0.003 0.0006 0.0007
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0123 0.0134
Echinococcus multilocularis Immunoglobulin 0.0088 0.0237 0.0237
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0056 0.011 0.011
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0036 0.003
Echinococcus granulosus farnesyl pyrophosphate synthase 0.2132 0.8385 0.9728
Brugia malayi neuropeptide F receptor 0.003 0.0006 0.0007
Schistosoma mansoni metabotropic glutamate receptor 0.0038 0.0038 0.0044
Schistosoma mansoni hypothetical protein 0.0175 0.0584 0.0678
Loa Loa (eye worm) acetyltransferase 0.0157 0.0512 0.061
Brugia malayi Immunoglobulin I-set domain containing protein 0.0043 0.0055 0.0066
Echinococcus multilocularis voltage dependent calcium channel subunit 0.034 0.1239 0.1239
Echinococcus granulosus tar DNA binding protein 0.0064 0.0139 0.0162
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0034 0.002 0.0023
Brugia malayi Cytochrome P450 family protein 0.0032 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0006 0.0007
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0027 0.0031
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0027 0.0019
Loa Loa (eye worm) hypothetical protein 0.0118 0.0357 0.0426
Loa Loa (eye worm) hypothetical protein 0.0117 0.0352 0.042
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0054 0.0044
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0139 0.0139
Brugia malayi Cytochrome P450 family protein 0.0032 0.0011 0.0013
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.003 0.0006 0.0007
Treponema pallidum octaprenyl-diphosphate synthase 0.0787 0.3024 0.5
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Brugia malayi cytochrome P450 0.0032 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Schistosoma mansoni tyrosine kinase 0.1125 0.437 0.507
Schistosoma mansoni biogenic amine receptor 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0088 0.0237 0.0283
Echinococcus multilocularis G-protein coupled receptor, putative 0.003 0.0006 0.0006
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.007 0.0051
Brugia malayi beta-lactamase family protein 0.0035 0.0027 0.0032
Schistosoma mansoni vesicular amine transporter 0.0088 0.0237 0.0275
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0027 0.0031
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0018 0.0022
Brugia malayi TAR-binding protein 0.0064 0.0139 0.0166
Schistosoma mansoni hypothetical protein 0.0033 0.0018 0.0021
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0051 0.009 0.0107
Echinococcus granulosus peptide allatostatin:somatostatin 0.003 0.0006 0.0007
Loa Loa (eye worm) ICD-1 protein 0.0038 0.0036 0.0043
Schistosoma mansoni carbonic anhydrase 0.0118 0.0357 0.0415
Brugia malayi Immunoglobulin I-set domain containing protein 0.1446 0.5649 0.6738
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0123 0.0134
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Echinococcus granulosus g protein coupled receptor 0.003 0.0006 0.0007
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.1145 0.4449 0.5162
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.1054 0.4087 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0051 0.009 0.0107
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Toxoplasma gondii hypothetical protein 0.0118 0.0357 0.0414
Schistosoma mansoni tyrosine kinase 0.1145 0.4449 0.5162
Schistosoma mansoni tyrosine kinase 0.1145 0.4449 0.5162
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.0305 0.0364
Echinococcus multilocularis tyrosine protein kinase otk 0.0051 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0105 0.0305 0.0364
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.0618 0.0708
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0093 0.0257 0.0257
Brugia malayi Serotonin receptor 0.003 0.0006 0.0007
Schistosoma mansoni cytochrome P450 0.0032 0.0011 0.0013
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.003 0.0006 0.0007
Schistosoma mansoni biogenic amine (5HT) receptor 0.003 0.0006 0.0007
Echinococcus granulosus sex peptide receptor 0.003 0.0006 0.0007
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0118 0.0357 0.0426
Schistosoma mansoni cell adhesion molecule 0.0117 0.0352 0.0408
Brugia malayi neuropeptide F receptor 0.003 0.0006 0.0007
Brugia malayi Serotonin receptor 0.003 0.0006 0.0007
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC1 (polyprenyl pyrophosphate synthetase) 0.0361 0.1323 0.1567
Loa Loa (eye worm) hypothetical protein 0.0088 0.0238 0.0283
Brugia malayi Melatonin receptor type 1A 0.003 0.0006 0.0007
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.003 0.0006 0.0007
Schistosoma mansoni neuropeptide receptor 0.003 0.0006 0.0007
Brugia malayi hypothetical protein 0.003 0.0006 0.0007
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.1054 0.4087 1
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0118 0.0357 0.0426
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0041 0.0051 0.006
Echinococcus granulosus twitchin 0.0111 0.0327 0.0379
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.0945 0.1099
Echinococcus granulosus neuropeptides capa receptor 0.003 0.0006 0.0007
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.003 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.0032
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0006 0.0007
Onchocerca volvulus Huntingtin homolog 0.0126 0.0388 0.0726
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0006 0.0007
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.0127 0.0139
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0076 0.0088
Echinococcus granulosus dro:myosuppressin receptor 0.003 0.0006 0.0007
Echinococcus granulosus roundabout 2 0.014 0.0442 0.0512
Schistosoma mansoni carbonic anhydrase-related 0.0118 0.0357 0.0415
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Loa Loa (eye worm) TK/EGFR protein kinase 0.2124 0.8352 0.9962
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.003 0.0006 0.0006
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0027 0.0038
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0051 0.009 0.0104
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.003 0.0006 0.0007
Echinococcus multilocularis hemicentin 1 0.0051 0.009 0.009
Brugia malayi basement membrane proteoglycan precursor 0.0034 0.002 0.0024
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0051 0.009 0.009
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0252 0.0293
Loa Loa (eye worm) hypothetical protein 0.0056 0.011 0.0131
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.003 0.0006 0.0007
Giardia lamblia Farnesyl diphosphate synthase 0.2132 0.8385 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.0237 0.0283
Echinococcus multilocularis neuropeptide Y receptor 0.003 0.0006 0.0006
Brugia malayi RE15519p 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Brugia malayi Polyprenyl synthetase family protein 0.1054 0.4087 0.4874
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0139 0.0162
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0027 0.0031
Schistosoma mansoni opsin-like receptor 0.003 0.0006 0.0007
Plasmodium vivax basic transcription factor 3b, putative 0.0038 0.0036 0.0012
Echinococcus granulosus roundabout 2 0.0051 0.009 0.0104
Echinococcus granulosus carbonic anhydrase 0.0118 0.0357 0.0415
Schistosoma mansoni amine GPCR 0.003 0.0006 0.0007
Echinococcus granulosus GPCR family 2 0.0033 0.0018 0.0021
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0123 0.0143
Echinococcus granulosus fmrfamide receptor 0.003 0.0006 0.0007
Schistosoma mansoni hypothetical protein 0.0033 0.0018 0.0021
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Echinococcus granulosus neuroglian 0.0051 0.009 0.0104
Leishmania major carbonic anhydrase-like protein 0.0219 0.0757 0.0891
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0139 0.0162
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0051 0.009 0.0107
Echinococcus granulosus carbonic anhydrase 0.0118 0.0357 0.0415
Echinococcus granulosus Immunoglobulin 0.0088 0.0237 0.0275
Echinococcus granulosus hypothetical protein 0.003 0.0006 0.0007
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0018 0.0022
Brugia malayi putative neuropeptide receptor NPR1 0.003 0.0006 0.0007
Echinococcus multilocularis orexin receptor type 2 0.003 0.0006 0.0006
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Echinococcus multilocularis hemicentin 1 0.0051 0.009 0.009
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0006 0.0007
Echinococcus granulosus metabotropic glutamate receptor 5 0.0056 0.011 0.0127
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0112 0.0112
Echinococcus multilocularis epidermal growth factor receptor 0.1145 0.4449 0.4449
Onchocerca volvulus 0.0035 0.0027 0.0039
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0266 0.0945 0.1128
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.1054 0.4087 0.4742
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.1054 0.4087 0.4858
Loa Loa (eye worm) hypothetical protein 0.0158 0.0517 0.0617
Brugia malayi Dopamine receptor 0.003 0.0006 0.0007
Echinococcus multilocularis muscleblind protein 1 0.0158 0.0517 0.0517
Loa Loa (eye worm) hypoxia-induced factor 1 0.0148 0.0476 0.0568
Toxoplasma gondii NAC domain-containing protein 0.0038 0.0036 0.003
Brugia malayi hypothetical protein 0.003 0.0006 0.0007
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0123 0.0134
Onchocerca volvulus Glucosylceramidase homolog 0.0174 0.0581 0.1091
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.0693 0.2649 0.315
Echinococcus multilocularis neuropeptides capa receptor 0.003 0.0006 0.0006
Echinococcus granulosus epidermal growth factor receptor 0.1145 0.4449 0.5162
Echinococcus granulosus microtubule associated protein 2 0.2191 0.8619 1
Echinococcus multilocularis carbonic anhydrase 0.0118 0.0357 0.0357
Loa Loa (eye worm) RNA binding protein 0.0064 0.0139 0.0166
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Echinococcus multilocularis g protein coupled receptor 0.003 0.0006 0.0006
Echinococcus multilocularis muscleblind protein 0.0158 0.0517 0.0517
Brugia malayi Immunoglobulin I-set domain containing protein 0.0051 0.009 0.0107
Echinococcus multilocularis alpha 1A adrenergic receptor 0.003 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0088 0.0237 0.0283
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0088 0.0237 0.0275
Brugia malayi jmjC domain containing protein 0.0058 0.0118 0.014
Onchocerca volvulus 0.1309 0.5103 0.9678
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0027 0.0019
Echinococcus granulosus neuropeptide receptor 0.003 0.0006 0.0007
Loa Loa (eye worm) polyprenyl synthetase 0.1054 0.4087 0.4874
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0051 0.009 0.009
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.0945 0.1099
Loa Loa (eye worm) glutamate receptor 0.0046 0.0068 0.0081
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0051 0.009 0.009
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0112 0.013
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.003 0.0006 0.0007
Echinococcus granulosus g protein coupled receptor 0.003 0.0006 0.0007
Echinococcus granulosus 7TM GPCR rhodopsin 0.003 0.0006 0.0007
Echinococcus multilocularis neuropeptide receptor 0.003 0.0006 0.0006
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.0787 0.3024 0.3509
Brugia malayi Immunoglobulin I-set domain containing protein 0.0102 0.0292 0.0349
Schistosoma mansoni neuropeptide receptor 0.003 0.0006 0.0007
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0011 0.0013
Schistosoma mansoni neuropeptide F-like receptor 0.003 0.0006 0.0007
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0219 0.0757 0.0903
Echinococcus granulosus G protein coupled receptor 139 0.003 0.0006 0.0007
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0027 0.0019
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.003 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.0032
Schistosoma mansoni adenoreceptor 0.003 0.0006 0.0007
Echinococcus multilocularis roundabout 2 0.0051 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.0305 0.0364
Loa Loa (eye worm) hypothetical protein 0.0034 0.002 0.0024
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.003 0.0006 0.0007
Brugia malayi MH2 domain containing protein 0.0123 0.0375 0.0448
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0036 0.003
Schistosoma mansoni neuropeptide F-like receptor 0.003 0.0006 0.0007
Brugia malayi Immunoglobulin I-set domain containing protein 0.0051 0.009 0.0107
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0581 0.0663
Echinococcus granulosus tyrosine protein kinase otk 0.0051 0.009 0.0104
Schistosoma mansoni peptide (allatostatin)-like receptor 0.003 0.0006 0.0007
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.1054 0.4087 0.4868
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0011 0.0013
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.2132 0.8385 0.8385
Echinococcus multilocularis allatostatin A receptor 0.003 0.0006 0.0006
Echinococcus granulosus roundabout 2 0.0051 0.009 0.0104
Schistosoma mansoni nephrin 0.0051 0.009 0.0104
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.0375 0.0448
Loa Loa (eye worm) G-protein coupled receptor 0.003 0.0006 0.0007
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0027 0.0019
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0219 0.0757 0.0891
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.0945 0.1099
Echinococcus granulosus transcription factor btf3 0.0038 0.0036 0.0042
Schistosoma mansoni hypothetical protein 0.0118 0.0357 0.0415
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0139 0.0166
Echinococcus multilocularis carbonic anhydrase 0.0118 0.0357 0.0357
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0006 0.0007
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0056 0.011 0.0197
Echinococcus multilocularis microtubule associated protein 2 0.2191 0.8619 0.8619
Brugia malayi Metabotropic glutamate receptor precursor. 0.0046 0.0068 0.0081
Brugia malayi beta-lactamase family protein 0.0035 0.0027 0.0032
Echinococcus granulosus epidermal growth factor receptor 0.2124 0.8352 0.9691
Echinococcus multilocularis neuropeptide Y receptor 0.003 0.0006 0.0006
Loa Loa (eye worm) polyprenyl synthetase 0.2132 0.8385 1
Schistosoma mansoni neuroglian 0.0051 0.009 0.0104
Schistosoma mansoni hypothetical protein 0.0033 0.0018 0.0021
Brugia malayi Serotonin/octopamine receptor family protein 7 0.003 0.0006 0.0007
Schistosoma mansoni cell adhesion molecule 0.0051 0.009 0.0104
Echinococcus granulosus neuropeptide Y receptor 0.003 0.0006 0.0007
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0061 0.0127 0.0139
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0027 0.0019
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0006 0.0007
Echinococcus granulosus lachesin 0.0051 0.009 0.0104
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0139 0.0166
Leishmania major hypothetical protein, conserved 0.0035 0.0027 0.0019
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.1054 0.4087 0.4868
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.003 0.0006 0.0007
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.2132 0.8385 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0252 0.0301
Echinococcus granulosus metabotropic glutamate receptor 2 0.0038 0.0038 0.0044
Echinococcus granulosus contactin 0.0051 0.009 0.0104
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0684 0.2613 0.2613
Echinococcus multilocularis transcription factor btf3 0.0038 0.0036 0.0036
Brugia malayi hypothetical protein 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Schistosoma mansoni hypothetical protein 0.0032 0.0011 0.0013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0252 0.0293
Brugia malayi ORL1-like opioid receptor 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0118 0.0357 0.0426
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Echinococcus granulosus g-protein coupled receptor 0.003 0.0006 0.0007
Loa Loa (eye worm) cytochrome P450 0.0032 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.0693 0.2649 0.315
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0006 0.0007
Onchocerca volvulus 0.0035 0.0027 0.0039
Echinococcus multilocularis sex peptide receptor 0.003 0.0006 0.0006
Schistosoma mansoni neuropeptide f receptor 76f 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Schistosoma mansoni opsin-like receptor 0.003 0.0006 0.0007
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0018 0.0021
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0006 0.0006
Echinococcus granulosus serotonin receptor 0.003 0.0006 0.0007
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.0787 0.3024 0.3509
Brugia malayi Immunoglobulin I-set domain containing protein 0.0051 0.009 0.0107
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.0006 0.0006
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.003 0.0006 0.0007
Schistosoma mansoni septate junction protein 0.0051 0.009 0.0104
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.0788 0.0927
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.2132 0.8385 1
Schistosoma mansoni histamine h1 receptor 0.003 0.0006 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0006 0.0007
Loa Loa (eye worm) G-protein coupled receptor 0.003 0.0006 0.0007
Brugia malayi Dopamine receptor protein 2 0.003 0.0006 0.0007
Brugia malayi hypothetical protein 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0469 0.1756 0.2095
Brugia malayi Prion-like- 0.0051 0.009 0.0107
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Brugia malayi jmjC domain containing protein 0.0058 0.0118 0.014
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0036 0.0012
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0027 0.0032
Echinococcus granulosus insulin receptor 0.0684 0.2613 0.3031
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.0693 0.2649 0.2649
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0006 0.0007
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.0693 0.2649 0.315
Mycobacterium leprae Probable lipase LipE 0.0035 0.0027 0.0038
Loa Loa (eye worm) hypothetical protein 0.0158 0.0517 0.0617
Echinococcus multilocularis insulin receptor 0.0684 0.2613 0.2613
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.003 0.0006 0.0007
Echinococcus granulosus neuroglian 0.0111 0.0327 0.0379
Schistosoma mansoni biogenic amine (5HT) receptor 0.003 0.0006 0.0007
Schistosoma mansoni microtubule-associated protein tau 0.2191 0.8619 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0006 0.0006
Echinococcus multilocularis carbonic anhydrase 0.0118 0.0357 0.0357
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0118 0.0357 0.0426
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0034 0.002 0.002
Echinococcus granulosus single minded 2 0.0035 0.0027 0.0031
Echinococcus granulosus 7tm_1 domain containing protein 0.003 0.0006 0.0007
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.2132 0.8385 1
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0051 0.009 0.0107
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0123 0.0143
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0219 0.0757 0.0903
Schistosoma mansoni farnesyl pyrophosphate synthase 0.2132 0.8385 0.9728
Brugia malayi G-protein coupled receptor 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0088 0.0237 0.0283
Loa Loa (eye worm) hypothetical protein 0.0051 0.009 0.0107
Brugia malayi hypothetical protein 0.003 0.0006 0.0007
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.003 0.0006 0.0007
Schistosoma mansoni transcription factor btf3 0.0038 0.0036 0.0042
Brugia malayi hypothetical protein 0.0126 0.0388 0.0463
Schistosoma mansoni titin 0.0051 0.009 0.0104
Trypanosoma brucei transcription factor BTF3, putative 0.0038 0.0036 0.003
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0027 0.0019
Echinococcus multilocularis somatostatin receptor 0.003 0.0006 0.0006
Echinococcus granulosus alpha 1A adrenergic receptor 0.003 0.0006 0.0007
Mycobacterium tuberculosis Conserved protein 0.0035 0.0027 0.0019
Echinococcus granulosus carbonic anhydrase II 0.0219 0.0757 0.0878
Toxoplasma gondii ABC1 family protein 0.0035 0.0027 0.0019
Schistosoma mansoni growth hormone secretagogue receptor 0.003 0.0006 0.0007
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0161 0.0525 0.0627
Brugia malayi Tachykinin-like peptides receptor 99D 0.003 0.0006 0.0007
Brugia malayi follicle stimulating hormone receptor 0.003 0.0006 0.0007
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Schistosoma mansoni roundabout 0.0051 0.009 0.0104
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.1054 0.4087 0.4868
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0266 0.0945 0.1128
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0006 0.0006
Echinococcus granulosus voltage dependent calcium channel subunit 0.034 0.1239 0.1437
Echinococcus multilocularis 0.0032 0.0011 0.0011
Echinococcus multilocularis tachykinin peptides receptor 99D 0.003 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0126 0.0388 0.0463
Echinococcus granulosus geminin 0.0347 0.1267 0.147
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.2132 0.8385 1
Brugia malayi hypothetical protein 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Echinococcus multilocularis neuroglian 0.0051 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0051 0.009 0.0107
Loa Loa (eye worm) beta-lactamase 0.0035 0.0027 0.0032
Brugia malayi hypothetical protein 0.003 0.0006 0.0007
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0018 0.0018
Schistosoma mansoni hypothetical protein 0.003 0.0006 0.0007
Schistosoma mansoni biogenic amine receptor 0.003 0.0006 0.0007
Loa Loa (eye worm) TYRA-2 protein 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.015 0.0485 0.0578
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.0945 0.1099
Echinococcus granulosus hemicentin 1 0.0051 0.009 0.0104
Brugia malayi Peroxidasin 0.0051 0.009 0.0108
Schistosoma mansoni tyrosine kinase 0.1125 0.437 0.507
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0027 0.0032
Echinococcus granulosus basement membrane specific heparan sulfate 0.0034 0.002 0.0023
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0139 0.0162
Loa Loa (eye worm) TK protein kinase 0.0043 0.0055 0.0066
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.0945 0.1099
Brugia malayi acetyltransferase, GNAT family protein 0.0157 0.0512 0.061
Schistosoma mansoni cell adhesion molecule 0.0051 0.009 0.0104
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.007 0.007
Schistosoma mansoni neuropeptide receptor 0.003 0.0006 0.0007
Schistosoma mansoni serine-rich repeat protein 0.0175 0.0584 0.0678
Schistosoma mansoni lipoxygenase 0.0057 0.0112 0.013
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0051 0.009 0.0104
Schistosoma mansoni amine GPCR 0.003 0.0006 0.0007
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0027 0.0019
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0051 0.009 0.0107
Schistosoma mansoni peroxidasin 0.0029 0.0001 0.0001
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.003 0.0006 0.0007
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.1054 0.4087 0.4868
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.0032
Echinococcus multilocularis 0.0655 0.2496 0.2496
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0219 0.0757 0.0903
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0061 0.0127 0.0148
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.003 0.0006 0.0007
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.0693 0.2649 0.3073
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.2132 0.8385 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0011 0.0013
Loa Loa (eye worm) follicle stimulating hormone receptor 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Leishmania major farnesyl pyrophosphate synthase 0.2132 0.8385 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.003 0.0006 0.0007
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.007 0.0081
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0088 0.0237 0.0283
Brugia malayi beta-NAC-like protein 0.0038 0.0036 0.0043
Brugia malayi putative neuropeptide receptor 0.003 0.0006 0.0007
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0061 0.0127 0.0139
Brugia malayi sulfakinin receptor protein 0.003 0.0006 0.0007
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.2132 0.8385 1
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0581 0.0663
Schistosoma mansoni hypothetical protein 0.003 0.0006 0.0007
Trypanosoma brucei carbonic anhydrase-like protein 0.0219 0.0757 0.0891
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0118 0.0137
Loa Loa (eye worm) hypothetical protein 0.0033 0.0018 0.0022
Brugia malayi hypothetical protein 0.0469 0.1756 0.2095
Mycobacterium tuberculosis Conserved protein 0.0035 0.0027 0.0019
Echinococcus multilocularis peroxidasin 0.0051 0.009 0.009
Echinococcus granulosus neuropeptide FF receptor 2 0.003 0.0006 0.0007
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.0787 0.3024 0.3607
Schistosoma mansoni myosin xvIII 0.003 0.0006 0.0007
Echinococcus granulosus low density lipoprotein receptor ldl 0.0034 0.002 0.0023
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.0032
Brugia malayi G protein-coupled receptor 0.003 0.0006 0.0007
Echinococcus multilocularis dro:myosuppressin receptor 0.003 0.0006 0.0006
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0006 0.0006
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0118 0.0357 0.0426
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0006 0.0007
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0006 0.0006
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0043 0.0055 0.0064
Brugia malayi Immunoglobulin I-set domain containing protein 0.0051 0.009 0.0107
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0061 0.0127 0.0152
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.2132 0.8385 1
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0027 0.0019
Echinococcus granulosus tm gpcr rhodopsin 0.0655 0.2497 0.2898
Schistosoma mansoni neuropeptide receptor 0.003 0.0006 0.0007
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0088 0.0237 0.0275
Brugia malayi Dopamine receptor protein 1 0.003 0.0006 0.0007
Echinococcus granulosus biogenic amine 5HT receptor 0.003 0.0006 0.0007
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0018 0.0021
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0027 0.0032
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0034 0.002 0.0023
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0157 0.0512 0.0594
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0006 0.0007
Onchocerca volvulus 0.0035 0.0027 0.0039
Echinococcus granulosus carbonic anhydrase 0.0118 0.0357 0.0415
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.003 0.0006 0.0006
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0018 0.0022
Loa Loa (eye worm) CYP4Cod1 0.0032 0.0011 0.0013
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0006 0.0007
Brugia malayi hypothetical protein 0.003 0.0006 0.0007
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.0006 0.0006
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0172 0.0206
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.003 0.0006 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0036 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0036 0.0012
Echinococcus multilocularis serotonin receptor 0.003 0.0006 0.0006
Brugia malayi Cytochrome P450 family protein 0.0032 0.0011 0.0013
Schistosoma mansoni hypothetical protein 0.0347 0.1267 0.147
Echinococcus granulosus g protein coupled receptor 0.003 0.0006 0.0007
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0118 0.0357 0.0426
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0123 0.0134
Schistosoma mansoni glutathione synthetase 0.0693 0.2649 0.3073
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0581 0.0663
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0027 0.0019
Brugia malayi Polyprenyl synthetase family protein 0.2132 0.8385 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0006 0.0007
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.2132 0.8385 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.1446 0.5649 0.6738
Echinococcus multilocularis neuroglian 0.0111 0.0327 0.0327
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0051 0.009 0.009
Loa Loa (eye worm) neuropeptide F receptor 0.003 0.0006 0.0007
Loa Loa (eye worm) neuropeptide F receptor 0.003 0.0006 0.0007
Brugia malayi hypothetical protein 0.0161 0.0525 0.0627
Loa Loa (eye worm) hypothetical protein 0.0051 0.009 0.0107
Loa Loa (eye worm) hypothetical protein 0.0051 0.009 0.0107
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.2132 0.8385 1
Echinococcus multilocularis epidermal growth factor receptor 0.2124 0.8352 0.8352
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0581 0.0663
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.007 0.007
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0139 0.0166
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Brugia malayi hypoxia-induced factor 1 0.0148 0.0476 0.0568
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.003 0.0006 0.0007
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.0305 0.0364
Echinococcus multilocularis fmrfamide receptor 0.003 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0007
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0164 0.054 0.0626
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0027 0.0019
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0052 0.0093 0.0108
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0118 0.0357 0.0426
Echinococcus multilocularis biogenic amine (5HT) receptor 0.003 0.0006 0.0006
Echinococcus multilocularis neuropeptide FF receptor 2 0.003 0.0006 0.0006
Echinococcus granulosus biogenic amine 5HT receptor 0.003 0.0006 0.0007
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0118 0.0357 0.0426
Schistosoma mansoni tyrosine kinase 0.0071 0.017 0.0197

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 9100 nM Inhibition of binding of [3H]-naloxone to Opioid receptor mu 1 of rat brain membranes ChEMBL. 2878079
IC50 (binding) = 9100 nM Inhibition of binding of [3H]-naloxone to Opioid receptor mu 1 of rat brain membranes ChEMBL. 2878079
IC50 (functional) = 18500 nM Compound was evaluated for the inhibition of binding of [125I]CGP23,996 to rat brain membranes ChEMBL. 2878079
IC50 (binding) = 27500 nM Inhibition of [3H]-DPDPE binding to Opioid receptor delta 1 of rat brain membranes ChEMBL. 2878079
IC50 (binding) = 27500 nM Inhibition of [3H]-DPDPE binding to Opioid receptor delta 1 of rat brain membranes ChEMBL. 2878079
Ratio (binding) = 2 Ratio of receptor binding inhibitory concentrations of the compound against somatostatin receptors and mu opioid receptors from rat brain IC50 (vs [3H]-CGP-23,996) / IC50(vs [3H]-naloxone) ChEMBL. 2878079
Ratio (binding) = 3 Ratio of receptor binding inhibitory concentrations against mu and delta opioid receptors from rat brain as IC50 (vs [3H]-DPDPE) / IC50 (vs [3H]-naloxone) ChEMBL. 2878079

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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