Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | pantoate-beta-alanine ligase | 0.3263 | 0.5 | 0.5 |
Mycobacterium ulcerans | pantoate--beta-alanine ligase | 0.3263 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | 0.3263 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Displacement (binding) | = 40 % | Displacement of [3H]-Angiotensin II (300 ng/mL) from rabbit adrenal cortex | ChEMBL. | 1875337 |
IC50 (functional) | = 330 nM | Inhibitory activity as antagonist of AII on guinea pig ileum | ChEMBL. | 1875337 |
IC50 (functional) | = 345 nM | The compound was tested for its inhibitory activity as antagonist of AI on guinea pig ileum | ChEMBL. | 1875337 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.