TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 1022.2 | Formula: C46H63N13O10S2
H donors: 12 H acceptors: 11 LogP: -2.2 Rotable bonds: 28
Rule of 5 violations (Lipinski): 4
SMILES: CNCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H]1CSS[C@H]2CN(C(=O)[C@H](NC1=O)Cc1nc[nH]c1)[C@@H](C2)C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1ccc(cc1)O)C(C)C)CCCN=C(N)N
InChi: 1S/C46H63N13O10S2/c1-25(2)38(58-39(62)31(53-37(61)21-49-3)10-7-15-51-46(47)48)43(66)54-32(16-27-11-13-29(60)14-12-27)40(63)57-35-23-70-71-30-19-36(42(65)56-34(45(68)69)17-26-8-5-4-6-9-26)59(22-30)44(67)33(55-41(35)64)18-28-20-50-24-52-28/h4-6,8-9,11-14,20,24-25,30-36,38,49,60H,7,10,15-19,21-23H2,1-3H3,(H,50,52)(H,53,61)(H,54,66)(H,55,64)(H,56,65)(H,57,63)(H,58,62)(H,68,69)(H4,47,48,51)/t30-,31+,32+,33-,34+,35-,36+,38+/m1/s1
InChiKey: GAWPPECSMHTNBB-ZJDLZPLCSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	angiotensin II receptor, type 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	angiotensin II receptor, type 1	359 aa	403 aa	19.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.012	0.0865	0.428
Brugia malayi	sulfakinin receptor protein	0.012	0.0865	0.0859
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0612	0.4665	0.4661
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0116	0.0416
Onchocerca volvulus		0.0043	0.0271	0.0976
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0043	0.0271	0.0737
Echinococcus granulosus	cpg binding protein	0.0033	0.0194	0.0187
Loa Loa (eye worm)	G-protein coupled receptor	0.012	0.0865	0.0859
Schistosoma mansoni	ap endonuclease	0.002	0.0097	0.009
Loa Loa (eye worm)	hypothetical protein	0.0612	0.4665	0.4661
Entamoeba histolytica	fatty acid elongase, putative	0.0048	0.0308	0.3614
Brugia malayi	hypothetical protein	0.012	0.0865	0.0859
Schistosoma mansoni	cpg binding protein	0.0031	0.018	0.0173
Brugia malayi	hypothetical protein	0.002	0.0095	0.0088
Loa Loa (eye worm)	neuropeptide F receptor	0.012	0.0865	0.0859
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0116	0.0416
Echinococcus multilocularis	g protein coupled receptor	0.012	0.0865	0.0859
Echinococcus multilocularis	serotonin receptor	0.012	0.0865	0.0859
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0116	0.0109
Echinococcus granulosus	lipoxygenase domain containing protein	0.002	0.0095	0.0088
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.012	0.0865	0.0859
Schistosoma mansoni	hypothetical protein	0.0164	0.1204	0.1197
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.012	0.0865	0.0859
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0013	0.0006
Schistosoma mansoni	loxhd1	0.002	0.0095	0.0088
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.012	0.0865	0.0859
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.012	0.0865	0.0859
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0071	0.0064
Schistosoma mansoni	cpg binding protein	0.0033	0.0194	0.0187
Onchocerca volvulus		0.012	0.0865	0.428
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0036	0.0217	0.2067
Echinococcus granulosus	g protein coupled receptor	0.012	0.0865	0.0859
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Schistosoma mansoni	biogenic amine receptor	0.012	0.0865	0.0859
Schistosoma mansoni	carbonic anhydrase-related	0.0612	0.4665	0.4661
Echinococcus multilocularis	eukaryotic initiation factor 4A III	0.0096	0.068	0.0674
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.012	0.0865	0.0859
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0096	0.068	0.0674
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.012	0.0865	0.0859
Echinococcus granulosus	neuropeptide receptor	0.012	0.0865	0.0859
Mycobacterium tuberculosis	Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog)	0.0096	0.068	0.2447
Brugia malayi	GnHR receptor homolog	0.012	0.0865	0.0859
Echinococcus granulosus	fmrfamide receptor	0.012	0.0865	0.0859
Loa Loa (eye worm)	hypothetical protein	0.0612	0.4665	0.4661
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Echinococcus granulosus	dnaJ subfamily B	0.0445	0.3377	0.3372
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Entamoeba histolytica	fatty acid elongase, putative	0.0048	0.0308	0.3614
Brugia malayi	MH2 domain containing protein	0.013	0.0942	0.0936
Echinococcus granulosus	neuropeptide Y receptor	0.012	0.0865	0.0859
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0039	0.0237	0.023
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0116	0.0416
Echinococcus granulosus	neuropeptide receptor A26	0.012	0.0865	0.0859
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.012	0.0865	0.0859
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Brugia malayi	G-protein coupled receptor	0.012	0.0865	0.0859
Onchocerca volvulus		0.0043	0.0271	0.0976
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.012	0.0865	0.0859
Echinococcus multilocularis	rhodopsin orphan GPCR	0.012	0.0865	0.0859
Echinococcus granulosus	carbonic anhydrase	0.0612	0.4665	0.4661
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.012	0.0865	0.0859
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0043	0.0271	0.0264
Plasmodium falciparum	transporter, putative	0.0043	0.0271	0.0435
Schistosoma mansoni	neuropeptide F-like receptor	0.012	0.0865	0.0859
Onchocerca volvulus		0.012	0.0865	0.428
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Schistosoma mansoni	amine GPCR	0.012	0.0865	0.0859
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0043	0.0271	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0116	0.0109
Schistosoma mansoni	neuropeptide receptor	0.012	0.0865	0.0859
Echinococcus granulosus	neuropeptides capa receptor	0.012	0.0865	0.0859
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Echinococcus granulosus	rhodopsin orphan GPCR	0.012	0.0865	0.0859
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.018	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0116	0.0109
Onchocerca volvulus		0.012	0.0865	0.428
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0116	0.0416
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.012	0.0865	0.0859
Schistosoma mansoni	sex comb on midleg homolog	0.0046	0.0295	0.0288
Schistosoma mansoni	polycystin 1-related	0.002	0.0095	0.0088
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Echinococcus multilocularis	somatostatin receptor	0.012	0.0865	0.0859
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0097	0.0056
Echinococcus multilocularis	orexin receptor type 2	0.012	0.0865	0.0859
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0043	0.0271	0.0264
Echinococcus granulosus	serotonin receptor	0.012	0.0865	0.0859
Echinococcus granulosus	RUN	0.002	0.0095	0.0088
Toxoplasma gondii	MAPEG family protein	0.0115	0.0826	0.1596
Echinococcus granulosus	sodium and chloride dependent glycine	0.0043	0.0271	0.0264
Schistosoma mansoni	hypothetical protein	0.0445	0.3377	0.3372
Entamoeba histolytica	fatty acid elongase, putative	0.0048	0.0308	0.3614
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.012	0.0865	0.0859
Plasmodium vivax	beta-ketoacyl-acyl carrier protein synthase III precursor, putative	0.0368	0.278	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.012	0.0865	0.0859
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0046	0.0295	0.0288
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0011	0.0025	0.0018
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.1302	1	1
Echinococcus multilocularis	lipoxygenase domain containing protein	0.002	0.0095	0.0088
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0064	0.0229
Echinococcus multilocularis	serotonin transporter	0.0253	0.1894	0.1888
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0116	0.5
Echinococcus multilocularis	neuropeptide s receptor	0.012	0.0865	0.0859
Echinococcus multilocularis	carbonic anhydrase	0.0612	0.4665	0.4661
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0043	0.0271	0.0264
Plasmodium vivax	RNA helicase-1, putative	0.0096	0.068	0.2249
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0066	0.0451	0.0444
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0253	0.1894	0.1888
Brugia malayi	eukaryotic initiation factor 4A	0.0096	0.068	0.0674
Schistosoma mansoni	neuropeptide receptor	0.012	0.0865	0.0859
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Schistosoma mansoni	voltage-gated potassium channel	0.0011	0.0025	0.0018
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0064	0.0229
Echinococcus granulosus	carbonic anhydrase II	0.1302	1	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0271	0.0264
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0186	0.1374	0.1368
Loa Loa (eye worm)	hypothetical protein	0.002	0.0095	0.0088
Schistosoma mansoni	sodium/chloride dependent transporter	0.0043	0.0271	0.0264
Brugia malayi	Dopamine receptor protein 2	0.012	0.0865	0.0859
Plasmodium falciparum	eukaryotic initiation factor 4A	0.0096	0.068	0.1326
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0013	0.0006
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0043	0.0271	0.0264
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.0097	0.009
Loa Loa (eye worm)	hypothetical protein	0.0612	0.4665	0.4661
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0116	0.0416
Plasmodium vivax	multidomain scavenger receptor, putative	0.002	0.0095	0.0089
Loa Loa (eye worm)	hypothetical protein	0.002	0.0095	0.0088
Onchocerca volvulus		0.0253	0.1894	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0071	0.0064
Echinococcus multilocularis	fmrfamide receptor	0.012	0.0865	0.0859
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0043	0.0271	0.0264
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Brugia malayi	mbt repeat family protein	0.0046	0.0295	0.0288
Onchocerca volvulus		0.012	0.0865	0.428
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Echinococcus multilocularis	rhodopsin orphan GPCR	0.012	0.0865	0.0859
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Schistosoma mansoni	neuropeptide receptor	0.012	0.0865	0.0859
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.012	0.0865	0.0859
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Echinococcus granulosus	allatostatin A receptor	0.012	0.0865	0.0859
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.0271	0.0737
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.012	0.0865	0.0859
Loa Loa (eye worm)	hypothetical protein	0.0253	0.1894	0.1888
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0096	0.068	0.0589
Onchocerca volvulus		0.012	0.0865	0.428
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.012	0.0865	0.428
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.012	0.0865	0.0859
Echinococcus multilocularis	g-protein coupled receptor	0.012	0.0865	0.0859
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.012	0.0865	0.0859
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.0264	0.0258
Echinococcus multilocularis	rhodopsin orphan GPCR	0.012	0.0865	0.0859
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0295	0.0288
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.012	0.0865	0.0859
Schistosoma mansoni	lipoxygenase	0.0085	0.0592	0.0586
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.012	0.0865	0.0859
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Brugia malayi	Doublecortin family protein	0.002	0.0095	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0253	0.1894	0.1888
Brugia malayi	hypothetical protein	0.012	0.0865	0.0859
Onchocerca volvulus		0.012	0.0865	0.428
Echinococcus multilocularis	polycomb protein SCMH1	0.0046	0.0295	0.0288
Schistosoma mansoni	myosin xvIII	0.012	0.0865	0.0859
Echinococcus granulosus	lipoxygenase domain containing protein	0.002	0.0095	0.0088
Plasmodium falciparum	beta-ketoacyl-ACP synthase III	0.0368	0.278	0.5896
Loa Loa (eye worm)	neuropeptide F receptor	0.012	0.0865	0.0859
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.012	0.0865	0.0859
Leishmania major	carbonic anhydrase-like protein	0.1302	1	1
Onchocerca volvulus		0.012	0.0865	0.428
Loa Loa (eye worm)	hypothetical protein	0.0253	0.1894	0.1888
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0052	0.0344	0.0337
Echinococcus multilocularis	G-protein coupled receptor, putative	0.012	0.0865	0.0859
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.012	0.0865	0.0859
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0253	0.1894	0.1888
Brugia malayi	hypothetical protein	0.012	0.0865	0.0859
Giardia lamblia	Translation initiation factor eIF-4A, putative	0.0096	0.068	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0096	0.068	0.0674
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.012	0.0865	0.0859
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0271	0.0264
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Plasmodium falciparum	carbonic anhydrase	0.0612	0.4665	1
Echinococcus multilocularis	carbonic anhydrase	0.0612	0.4665	0.4661
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Loa Loa (eye worm)	melatonin receptor type 1A	0.012	0.0865	0.0859
Brugia malayi	AKH receptor	0.012	0.0865	0.0859
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.012	0.0865	0.0859
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0116	0.0109
Entamoeba histolytica	DEAD/DEAH box helicase, putative	0.0096	0.068	1
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0059	0.0396	0.0655
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0271	0.0264
Brugia malayi	hypothetical protein	0.012	0.0865	0.0859
Echinococcus granulosus	rhodopsin orphan GPCR	0.012	0.0865	0.0859
Schistosoma mansoni	hypothetical protein	0.012	0.0865	0.0859
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.012	0.0865	0.0859
Loa Loa (eye worm)	mbt repeat family protein	0.0046	0.0295	0.0288
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0043	0.0271	0.0264
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0253	0.1894	0.1888
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0071	0.0064
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0116	0.0416
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0013	0.0006
Plasmodium falciparum	amino acid transporter, putative	0.0043	0.0271	0.0435
Mycobacterium tuberculosis	3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III)	0.0368	0.278	1
Schistosoma mansoni	hypothetical protein	0.012	0.0865	0.0859
Brugia malayi	larval opioid receptor	0.012	0.0865	0.0859
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.012	0.0865	0.0859
Onchocerca volvulus		0.012	0.0865	0.428
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0344	0.0337
Schistosoma mansoni	growth hormone secretagogue receptor	0.012	0.0865	0.0859
Wolbachia endosymbiont of Brugia malayi	3-oxoacyl-ACP synthase	0.0368	0.278	1
Echinococcus granulosus	g protein coupled receptor	0.012	0.0865	0.0859
Echinococcus granulosus	peptide allatostatin:somatostatin	0.012	0.0865	0.0859
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0271	0.0264
Echinococcus multilocularis	allatostatin A receptor	0.012	0.0865	0.0859
Brugia malayi	G-protein coupled receptor	0.012	0.0865	0.0859
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.0116	0.0324
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.012	0.0865	0.0859
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0017	0.0071	0.0255
Echinococcus granulosus	microsomal glutathione S transferase 3	0.0115	0.0826	0.0819
Loa Loa (eye worm)	G-protein coupled receptor	0.012	0.0865	0.0859
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.1302	1	1
Echinococcus multilocularis	eukaryotic initiation factor 4A	0.0096	0.068	0.0674
Echinococcus granulosus	neuropeptides capa receptor	0.012	0.0865	0.0859
Brugia malayi	G protein-coupled receptor F59B2.13	0.012	0.0865	0.0859
Schistosoma mansoni	microsomal glutathione s-transferase	0.0115	0.0826	0.0819
Echinococcus multilocularis	rhodopsin orphan GPCR	0.012	0.0865	0.0859
Schistosoma mansoni	opsin-like receptor	0.012	0.0865	0.0859
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Schistosoma mansoni	rab6-interacting	0.002	0.0095	0.0088
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0612	0.4665	0.4661
Schistosoma mansoni	amine GPCR	0.012	0.0865	0.0859
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0046	0.0295	0.0288
Trypanosoma brucei	Eukaryotic initiation factor 4A-1	0.0096	0.068	0.0589
Brugia malayi	ORL1-like opioid receptor	0.012	0.0865	0.0859
Schistosoma mansoni	biogenic amine receptor	0.012	0.0865	0.0859
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0116	0.0109
Mycobacterium ulcerans	3-oxoacyl-ACP synthase	0.0368	0.278	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0271	0.0264
Echinococcus multilocularis	fmrfamide receptor	0.012	0.0865	0.0859
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0612	0.4665	0.4661
Echinococcus multilocularis	rhodopsin orphan GPCR	0.012	0.0865	0.0859
Onchocerca volvulus		0.012	0.0865	0.428
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0116	0.0416
Brugia malayi	CXXC zinc finger family protein	0.0031	0.018	0.0173
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.012	0.0865	0.0859
Treponema pallidum	sodium- and chloride- dependent transporter	0.0253	0.1894	1
Loa Loa (eye worm)	MBCTL1	0.0052	0.0344	0.0337
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0116	0.0324
Schistosoma mansoni	neuropeptide f receptor 76f	0.012	0.0865	0.0859
Brugia malayi	Dopamine receptor	0.012	0.0865	0.0859
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.002	0.0097	0.0348
Brugia malayi	hypothetical protein	0.012	0.0865	0.0859
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0043	0.0271	0.0381
Loa Loa (eye worm)	hypothetical protein	0.0096	0.068	0.0674
Onchocerca volvulus		0.012	0.0865	0.428
Onchocerca volvulus		0.012	0.0865	0.428
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0116	0.0416
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0043	0.0271	0.0264
Schistosoma mansoni	hypothetical protein	0.0612	0.4665	0.4661
Echinococcus granulosus	sex peptide receptor	0.012	0.0865	0.0859
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.012	0.0865	0.0859
Onchocerca volvulus		0.012	0.0865	0.428
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.012	0.0865	0.0859
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0043	0.0271	0.0264
Echinococcus multilocularis	rhodopsin orphan GPCR	0.012	0.0865	0.0859
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.1302	1	1
Echinococcus granulosus	neuropeptide Y receptor	0.012	0.0865	0.0859
Echinococcus multilocularis	g protein coupled receptor	0.012	0.0865	0.0859
Brugia malayi	Tachykinin-like peptides receptor 99D	0.012	0.0865	0.0859
Brugia malayi	hypothetical protein	0.012	0.0865	0.0859
Schistosoma mansoni	biogenic amine (5HT) receptor	0.012	0.0865	0.0859
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.012	0.0865	0.0859
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.012	0.0865	0.0859
Echinococcus granulosus	rhodopsin orphan GPCR	0.012	0.0865	0.0859
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0116	0.0324
Schistosoma mansoni	membrane associated proteins in eicosanoid and glutathione metabolism family member	0.0501	0.381	0.3806
Echinococcus granulosus	biogenic amine 5HT receptor	0.012	0.0865	0.0859
Echinococcus multilocularis	neuropeptide FF receptor 2	0.012	0.0865	0.0859
Echinococcus granulosus	carbonic anhydrase	0.0612	0.4665	0.4661
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0043	0.0271	0.0264
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0116	0.0416
Echinococcus multilocularis	RUN	0.002	0.0095	0.0088
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Brugia malayi	Melatonin receptor type 1A	0.012	0.0865	0.0859
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.012	0.0865	0.0859
Echinococcus granulosus	neuropeptide FF receptor 2	0.012	0.0865	0.0859
Onchocerca volvulus		0.0043	0.0271	0.0976
Entamoeba histolytica	fatty acid elongase, putative	0.0048	0.0308	0.3614
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0036	0.0217	0.2067
Echinococcus granulosus	orexin receptor type 2	0.012	0.0865	0.0859
Echinococcus multilocularis	g protein coupled receptor	0.012	0.0865	0.0859
Echinococcus multilocularis	geminin	0.0164	0.1204	0.1197
Echinococcus multilocularis	G protein coupled receptor 139	0.012	0.0865	0.0859
Onchocerca volvulus		0.012	0.0865	0.428
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.012	0.0865	0.0859
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0043	0.0271	0.0264
Onchocerca volvulus		0.012	0.0865	0.428
Echinococcus granulosus	G protein coupled receptor 139	0.012	0.0865	0.0859
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.1302	1	1
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.002	0.0097	0.0348
Echinococcus multilocularis	microsomal glutathione S transferase 3	0.0115	0.0826	0.0819
Brugia malayi	hypothetical protein	0.002	0.0095	0.0088
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.012	0.0865	0.0859
Loa Loa (eye worm)	doublecortin family protein	0.002	0.0095	0.0088
Echinococcus granulosus	tachykinin peptides receptor 99D	0.012	0.0865	0.0859
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0043	0.0271	0.0264
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0043	0.0271	0.0264
Schistosoma mansoni	voltage-gated potassium channel	0.0011	0.0025	0.0018
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.012	0.0865	0.0859
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.012	0.0865	0.0859
Loa Loa (eye worm)	norepinephrine transporter	0.0253	0.1894	0.1888
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Schistosoma mansoni	histamine h1 receptor	0.012	0.0865	0.0859
Loa Loa (eye worm)	carbonic anhydrase 3	0.1302	1	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Echinococcus multilocularis	carbonic anhydrase	0.0612	0.4665	0.4661
Echinococcus multilocularis	cpg binding protein	0.0033	0.0194	0.0187
Echinococcus multilocularis	carbonic anhydrase II	0.1302	1	1
Echinococcus granulosus	somatostatin receptor	0.012	0.0865	0.0859
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Plasmodium falciparum	LCCL domain-containing protein	0.002	0.0095	0.0052
Schistosoma mansoni	carbonic anhydrase-related	0.0612	0.4665	0.4661
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0097	0.0095
Schistosoma mansoni	cpg binding protein	0.0033	0.0194	0.0187
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0043	0.0271	0.0264
Echinococcus granulosus	tm gpcr rhodopsin	0.012	0.0865	0.0859
Schistosoma mansoni	hypothetical protein	0.002	0.0095	0.0088
Schistosoma mansoni	hypothetical protein	0.0164	0.1204	0.1197
Schistosoma mansoni	biogenic amine receptor	0.012	0.0865	0.0859
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.012	0.0865	0.0859
Schistosoma mansoni	hypothetical protein	0.012	0.0865	0.0859
Echinococcus granulosus	SAM and MBT domain containing protein	0.0046	0.0295	0.0288
Echinococcus granulosus	hypothetical protein	0.012	0.0865	0.0859
Echinococcus multilocularis	neuropeptide Y receptor	0.012	0.0865	0.0859
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.012	0.0865	0.0859
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0271	0.0264
Echinococcus multilocularis	rhodopsin orphan GPCR	0.012	0.0865	0.0859
Echinococcus granulosus	Polycystic kidney disease protein	0.002	0.0095	0.0088
Echinococcus granulosus	rhodopsin orphan GPCR	0.012	0.0865	0.0859
Schistosoma mansoni	amine GPCR	0.012	0.0865	0.0859
Schistosoma mansoni	ap endonuclease	0.002	0.0097	0.009
Echinococcus granulosus	tm gpcr rhodopsin	0.012	0.0865	0.0859
Schistosoma mansoni	amine GPCR	0.012	0.0865	0.0859
Brugia malayi	G protein-coupled receptor	0.012	0.0865	0.0859
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.012	0.0865	0.0859
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0043	0.0271	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0271	0.0264
Echinococcus granulosus	geminin	0.0164	0.1204	0.1197
Chlamydia trachomatis	oxoacyl-ACP synthase III	0.0368	0.278	1
Echinococcus granulosus	polycomb protein SCMH1	0.0046	0.0295	0.0288
Brugia malayi	putative neuropeptide receptor NPR1	0.012	0.0865	0.0859
Echinococcus granulosus	7TM GPCR rhodopsin	0.012	0.0865	0.0859
Echinococcus granulosus	g protein coupled receptor	0.012	0.0865	0.0859
Brugia malayi	Serotonin receptor	0.012	0.0865	0.0859
Echinococcus multilocularis	neuropeptide receptor A26	0.012	0.0865	0.0859
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0039	0.0237	0.023
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.0071	0.0255
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.012	0.0865	0.0859
Brugia malayi	hypothetical protein	0.0043	0.0271	0.0264
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Echinococcus multilocularis	serotonin receptor	0.012	0.0865	0.0859
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0052	0.0344	0.0337
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0116	0.0019
Brugia malayi	RE15519p	0.012	0.0865	0.0859
Schistosoma mansoni	hypothetical protein	0.0284	0.2135	0.213
Echinococcus granulosus	dro:myosuppressin receptor	0.012	0.0865	0.0859
Echinococcus multilocularis	neuropeptide receptor	0.012	0.0865	0.0859
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.012	0.0865	0.0859
Schistosoma mansoni	carbonic anhydrase	0.0612	0.4665	0.4661
Echinococcus granulosus	eukaryotic initiation factor 4A III	0.0096	0.068	0.0674
Echinococcus granulosus	rhodopsin orphan GPCR	0.012	0.0865	0.0859
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0011	0.0025	0.0018
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.012	0.0865	0.0859
Brugia malayi	follicle stimulating hormone receptor	0.012	0.0865	0.0859
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0043	0.0271	0.0264
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0096	0.068	0.0589
Echinococcus granulosus	rhodopsin orphan GPCR	0.012	0.0865	0.0859
Schistosoma mansoni	opsin-like receptor	0.012	0.0865	0.0859
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Loa Loa (eye worm)	serotonin transporter b	0.0253	0.1894	0.1888
Brugia malayi	putative neuropeptide receptor	0.012	0.0865	0.0859
Trypanosoma brucei	carbonic anhydrase-like protein	0.1302	1	1
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0043	0.0271	0.0264
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.012	0.0865	0.0859
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.012	0.0865	0.0859
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0039	0.0237	0.023
Echinococcus multilocularis	neuropeptides capa receptor	0.012	0.0865	0.0859
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0043	0.0271	0.0381
Brugia malayi	hypothetical protein	0.012	0.0865	0.0859
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Echinococcus multilocularis	rhodopsin orphan GPCR	0.012	0.0865	0.0859
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0116	0.0019
Toxoplasma gondii	hypothetical protein	0.0612	0.4665	1
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0097	0.009
Entamoeba histolytica	fatty acid elongase, putative	0.0048	0.0308	0.3614
Schistosoma mansoni	rab6-interacting	0.002	0.0095	0.0088
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0116	0.0416
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.012	0.0865	0.0859
Mycobacterium ulcerans	beta-ketoacyl synthase-like protein	0.0368	0.278	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Onchocerca volvulus		0.012	0.0865	0.428
Echinococcus multilocularis	dnaJ subfamily B	0.0445	0.3377	0.3372
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0052	0.0344	0.0337
Echinococcus multilocularis	Polycystic kidney disease protein	0.002	0.0095	0.0088
Echinococcus granulosus	eukaryotic initiation factor 4A	0.0096	0.068	0.0674
Schistosoma mansoni	hypothetical protein	0.012	0.0865	0.0859
Brugia malayi	mbt repeat family protein	0.0046	0.0295	0.0288
Leishmania major	eukaryotic initiation factor 4a, putative	0.0096	0.068	0.0589
Echinococcus granulosus	g-protein coupled receptor	0.012	0.0865	0.0859
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0096	0.068	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0116	0.0019
Brugia malayi	hypothetical protein	0.012	0.0865	0.0859
Echinococcus multilocularis	lipoxygenase domain containing protein	0.002	0.0095	0.0088
Echinococcus granulosus	rhodopsin orphan GPCR	0.012	0.0865	0.0859
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0064	0.0229
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0121	0.0874	0.0867
Leishmania major	eukaryotic initiation factor 4a, putative	0.0096	0.068	0.0589
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0186	0.1374	0.1368
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.012	0.0865	0.0859
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0116	0.5
Onchocerca volvulus		0.0046	0.0295	0.111
Onchocerca volvulus		0.012	0.0865	0.428
Loa Loa (eye worm)	TYRA-2 protein	0.012	0.0865	0.0859
Echinococcus granulosus	neuropeptide s receptor	0.012	0.0865	0.0859
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0071	0.0064
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0198	0.0191
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0043	0.0271	0.0264
Treponema pallidum	ATP-dependent RNA helicase	0.0096	0.068	0.3246
Echinococcus multilocularis	sex peptide receptor	0.012	0.0865	0.0859
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0612	0.4665	0.4661
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0612	0.4665	0.4661
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0121	0.0874	0.0867
Brugia malayi	hypothetical protein	0.012	0.0865	0.0859
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0043	0.0271	0.0264
Echinococcus granulosus	7tm_1 domain containing protein	0.012	0.0865	0.0859
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.0097	0.009
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Schistosoma mansoni	carbonic anhydrase-related	0.0612	0.4665	0.4661
Mycobacterium ulcerans	3-oxoacyl-ACP synthase	0.0368	0.278	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0043	0.0271	0.0264
Brugia malayi	neuropeptide F receptor	0.012	0.0865	0.0859
Echinococcus granulosus	sodium and chloride dependent glycine	0.0043	0.0271	0.0264
Echinococcus multilocularis	dro:myosuppressin receptor	0.012	0.0865	0.0859
Schistosoma mansoni	alpha-1 adrenergic receptor	0.012	0.0865	0.0859
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0096	0.068	1
Schistosoma mansoni	neuropeptide F-like receptor	0.012	0.0865	0.0859
Brugia malayi	Dopamine receptor protein 1	0.012	0.0865	0.0859
Echinococcus multilocularis	voltage gated potassium channel	0.0011	0.0025	0.0018
Onchocerca volvulus	Eukaryotic initiation factor 4A homolog	0.0096	0.068	0.3253
Brugia malayi	Serotonin receptor	0.012	0.0865	0.0859
Echinococcus multilocularis	neuropeptide Y receptor	0.012	0.0865	0.0859
Echinococcus multilocularis	neuropeptide receptor	0.012	0.0865	0.0859
Schistosoma mansoni	amine GPCR	0.012	0.0865	0.0859
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0043	0.0271	0.0264
Echinococcus granulosus	biogenic amine 5HT receptor	0.012	0.0865	0.0859
Schistosoma mansoni	neuropeptide receptor	0.012	0.0865	0.0859
Echinococcus granulosus	tm gpcr rhodopsin	0.012	0.0865	0.0859
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.012	0.0865	0.0859
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.012	0.0865	0.0859
Echinococcus granulosus	alpha 1A adrenergic receptor	0.012	0.0865	0.0859
Echinococcus granulosus	serotonin transporter	0.0253	0.1894	0.1888
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0039	0.0237	0.023
Onchocerca volvulus	Neuropeptide F receptor homolog	0.012	0.0865	0.428
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.012	0.0865	0.0859
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.0097	0.009
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0071	0.0064
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.1302	1	1
Toxoplasma gondii	hypothetical protein	0.0043	0.0271	0.0381
Schistosoma mansoni	sex comb on midleg homolog	0.0046	0.0295	0.0288
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0052	0.0344	0.0337
Loa Loa (eye worm)	transcription factor SMAD2	0.013	0.0942	0.0936
Schistosoma mansoni	biogenic amine (5HT) receptor	0.012	0.0865	0.0859
Loa Loa (eye worm)	hypothetical protein	0.012	0.0865	0.0859
Schistosoma mansoni	adenoreceptor	0.012	0.0865	0.0859
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.0264	0.0258
Onchocerca volvulus		0.0031	0.018	0.0473
Brugia malayi	hypothetical protein	0.012	0.0865	0.0859
Echinococcus multilocularis	neuropeptides capa receptor	0.012	0.0865	0.0859
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0043	0.0271	0.0264
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0011	0.0025	0.0018
Schistosoma mansoni	opsin-like receptor	0.012	0.0865	0.0859
Plasmodium vivax	amine transporter, putative	0.0043	0.0271	0.0737
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0064	0.0229
Toxoplasma gondii	hypothetical protein	0.0043	0.0271	0.0381
Toxoplasma gondii	eukaryotic initiation factor-4A, putative	0.0096	0.068	0.1277
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0043	0.0271	0.0381
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.012	0.0865	0.0859
Schistosoma mansoni	lipoxygenase	0.0121	0.0874	0.0867
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.012	0.0865	0.0859
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0025	0.0018
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.012	0.0865	0.0859
Echinococcus granulosus	carbonic anhydrase	0.0612	0.4665	0.4661
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0116	0.0109
Echinococcus granulosus	neuropeptide receptor	0.012	0.0865	0.0859
Brugia malayi	neuropeptide F receptor	0.012	0.0865	0.0859
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.1302	1	1
Schistosoma mansoni	sodium/chloride dependent transporter	0.0043	0.0271	0.0264
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0043	0.0271	0.0264
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0043	0.0271	0.0264
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0012	0.0005
Echinococcus granulosus	voltage gated potassium channel	0.0011	0.0025	0.0018
Onchocerca volvulus		0.0023	0.0116	0.0115
Echinococcus granulosus	histone acetyltransferase MYST2	0.0052	0.0344	0.0337
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.012	0.0865	0.0859
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0096	0.068	1
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0052	0.0344	0.0337
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0612	0.4665	0.4661
Loa Loa (eye worm)	MH2 domain-containing protein	0.013	0.0942	0.0936
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0046	0.0295	0.111
Schistosoma mansoni	sodium/chloride dependent transporter	0.0253	0.1894	0.1888

Activities

Activity type	Activity value	Assay description	Source	Reference
Kd (binding)	> 10000 nM	Binding affinity was determined against Angiotensin II receptor, type 1	ChEMBL.	8709104
Kd (binding)	> 10000 nM	Binding affinity was determined against Angiotensin II receptor, type 1	ChEMBL.	8709104

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 400572