Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hexokinase 2 | 0.0508 | 0.637 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0508 | 0.637 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0233 | 0.1322 | 0.2075 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0233 | 0.1322 | 0.2075 |
Entamoeba histolytica | hexokinase 1 | 0.0508 | 0.637 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0233 | 0.1322 | 0.2075 |
Plasmodium falciparum | V-type H(+)-translocating pyrophosphatase, putative | 0.0705 | 1 | 1 |
Trichomonas vaginalis | geranylgeranyl diphosphate synthase, putative | 0.0205 | 0.0808 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0508 | 0.637 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0346 | 0.3401 | 0.5339 |
Leishmania major | hexokinase, putative | 0.0508 | 0.637 | 0.6051 |
Echinococcus granulosus | hexokinase | 0.0508 | 0.637 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0233 | 0.1322 | 0.0925 |
Echinococcus granulosus | hexokinase type 2 | 0.0508 | 0.637 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.0508 | 0.637 | 0.6051 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.0205 | 0.0808 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0508 | 0.637 | 0.6051 |
Loa Loa (eye worm) | hexokinase type II | 0.0508 | 0.637 | 1 |
Toxoplasma gondii | V-type H(+)-translocating pyrophosphatase VP1 | 0.0705 | 1 | 1 |
Plasmodium vivax | V-type H(+)-translocating pyrophosphatase, putative | 0.0705 | 1 | 1 |
Trypanosoma brucei | Pyrophosphate-energized vacuolar membrane proton pump 1 | 0.0705 | 1 | 1 |
Plasmodium falciparum | V-type K+-independent H+-translocating inorganic pyrophosphatase | 0.0705 | 1 | 1 |
Trypanosoma cruzi | Vacuolar proton pyrophosphatase 1, putative | 0.0705 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.0319 | 0.289 | 0.4537 |
Trypanosoma cruzi | hexokinase, putative | 0.0508 | 0.637 | 0.6051 |
Loa Loa (eye worm) | polyprenyl synthetase | 0.0205 | 0.0808 | 0.1268 |
Brugia malayi | thymidylate synthase | 0.0331 | 0.3118 | 0.4895 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0233 | 0.1322 | 0.0925 |
Mycobacterium ulcerans | thymidylate synthase | 0.0331 | 0.3118 | 1 |
Plasmodium vivax | hexokinase, putative | 0.0508 | 0.637 | 0.6051 |
Loa Loa (eye worm) | hexokinase | 0.0508 | 0.637 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0319 | 0.289 | 0.4537 |
Onchocerca volvulus | 0.0331 | 0.3118 | 0.0656 | |
Brugia malayi | hexokinase | 0.0508 | 0.637 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0233 | 0.1322 | 0.056 |
Leishmania major | hexokinase, putative | 0.0508 | 0.637 | 0.6051 |
Brugia malayi | Polyprenyl synthetase family protein | 0.0205 | 0.0808 | 0.1268 |
Echinococcus multilocularis | hexokinase | 0.0508 | 0.637 | 1 |
Giardia lamblia | Farnesyl diphosphate synthase | 0.0205 | 0.0808 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0331 | 0.3118 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0233 | 0.1322 | 0.056 |
Echinococcus granulosus | hexokinase | 0.0508 | 0.637 | 1 |
Echinococcus multilocularis | hexokinase | 0.0508 | 0.637 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0466 | 0.5601 | 0.5214 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0233 | 0.1322 | 0.2075 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0466 | 0.5601 | 0.5214 |
Loa Loa (eye worm) | thymidylate synthase | 0.0331 | 0.3118 | 0.4895 |
Trichomonas vaginalis | geranylgeranyl pyrophosphate synthase, putative | 0.0205 | 0.0808 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0508 | 0.637 | 0.6051 |
Echinococcus multilocularis | hexokinase type 2 | 0.0508 | 0.637 | 1 |
Onchocerca volvulus | 0.0508 | 0.637 | 1 | |
Echinococcus granulosus | hexokinase | 0.0508 | 0.637 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0331 | 0.3118 | 0.4154 |
Trypanosoma brucei | Pyrophosphate-energized vacuolar membrane proton pump 2, putative | 0.0705 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0233 | 0.1322 | 0.0925 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0466 | 0.5601 | 0.5214 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0331 | 0.3118 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0331 | 0.3118 | 0.4154 |
Plasmodium falciparum | hexokinase | 0.0508 | 0.637 | 0.6051 |
Leishmania major | carbonic anhydrase-like protein | 0.0233 | 0.1322 | 0.056 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0466 | 0.5601 | 0.5214 |
Echinococcus granulosus | thymidylate synthase | 0.0331 | 0.3118 | 0.4154 |
Trypanosoma cruzi | vacuolar-type proton translocating pyrophosphatase 1 | 0.0705 | 1 | 1 |
Trypanosoma brucei | hexokinase, putative | 0.0508 | 0.637 | 0.6051 |
Echinococcus granulosus | carbonic anhydrase II | 0.0233 | 0.1322 | 0.0925 |
Schistosoma mansoni | hexokinase | 0.0508 | 0.637 | 1 |
Echinococcus multilocularis | hexokinase | 0.0508 | 0.637 | 1 |
Treponema pallidum | hexokinase (hxk) | 0.0508 | 0.637 | 0.5 |
Plasmodium vivax | vacuolar-type H+ pumping pyrophosphatase, putative | 0.0705 | 1 | 1 |
Onchocerca volvulus | 0.0508 | 0.637 | 1 | |
Toxoplasma gondii | hexokinase | 0.0508 | 0.637 | 0.6051 |
Onchocerca volvulus | 0.0508 | 0.637 | 1 | |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0466 | 0.5601 | 0.5214 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0233 | 0.1322 | 0.056 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0466 | 0.5601 | 0.5214 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED85 (functional) | = 0.063 mg kg-1 | Tested in vivo for the biological efficacy using Trichostrongylus colubriformis gerbil assay | ChEMBL. | No reference |
IC100 (functional) | = 870 ng ml-1 | Tested in vitro for the biological efficacy using Artemia salina (brine shrimp) immobilization assay | ChEMBL. | No reference |
IC50 (functional) | = 0.351 ng ml-1 | Tested in vitro for the biological efficacy using Caenorhabditis elegans binding assay | ChEMBL. | No reference |
IC50 (functional) | = 0.351 ng ml-1 | Tested in vitro for the biological efficacy using Caenorhabditis elegans binding assay | ChEMBL. | No reference |
Mortality (functional) | = 64 % | Tested for acaricidal efficacy using a Tetranychus urticae (two-spotted spider mite, TSSM) contact assay | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Caenorhabditis elegans | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.