Detailed information for compound 400813

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1719.04 | Formula: C79H119N19O20S2
  • H donors: 19 H acceptors: 20 LogP: -5.13 Rotable bonds: 51
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@H](C(=O)N1CCC[C@@H]1C(=O)N(C(C(=O)N[C@@H]1C(=O)N2CCC[C@@H]2C(=O)N[C@@H](Cc2c[nH]c3c2cccc3)C(=O)N[C@H](C(SSC1(C)C)(C)C)C(=O)N[C@H](C(=O)O)CC(C)C)CCCN=C(N)N)C)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](CCC(=O)O)N)CC(C)C)Cc1ccc(cc1)O)CCC(=O)O)CC(=O)N
  • InChi: 1S/C79H119N19O20S2/c1-41(2)35-51(89-64(105)47(81)27-29-60(101)102)66(107)90-52(37-43-23-25-45(99)26-24-43)67(108)87-49(28-30-61(103)104)65(106)91-54(39-59(82)100)68(109)88-50(19-12-13-31-80)73(114)98-34-16-22-58(98)74(115)96(9)56(20-14-32-85-77(83)84)70(111)95-63-75(116)97-33-15-21-57(97)71(112)92-53(38-44-40-86-48-18-11-10-17-46(44)48)69(110)94-62(78(5,6)119-120-79(63,7)8)72(113)93-55(76(117)118)36-42(3)4/h10-11,17-18,23-26,40-42,47,49-58,62-63,86,99H,12-16,19-22,27-39,80-81H2,1-9H3,(H2,82,100)(H,87,108)(H,88,109)(H,89,105)(H,90,107)(H,91,106)(H,92,112)(H,93,113)(H,94,110)(H,95,111)(H,101,102)(H,103,104)(H,117,118)(H4,83,84,85)/t47-,49-,50-,51-,52-,53-,54-,55-,56?,57+,58-,62+,63-/m0/s1
  • InChiKey: BEIBERORDHXDAS-YHFYXGBTSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.004 0.0019 0.0032
Echinococcus granulosus rho guanine nucleotide exchange factor 7 0.003 0.0007 0.0011
Trypanosoma brucei guanylate kinase, putative 0.004 0.0019 0.0047
Loa Loa (eye worm) hypothetical protein 0.0067 0.0053 0.0095
Schistosoma mansoni amine GPCR 0.0082 0.0071 0.0069
Brugia malayi protein-tyrosine kinase 0.003 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0648 0.0779 0.1425
Schistosoma mansoni hypothetical protein 0.0032 0.0008 0.0007
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0017 0.0038
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.0071 0.0069
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Echinococcus multilocularis intersectin 2 0.003 0.0007 0.0009
Brugia malayi RNase H family protein 0.0047 0.0027 0.0048
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0082 0.0071 0.0118
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Echinococcus multilocularis carboxylesterase 5A 0.007 0.0056 0.0092
Loa Loa (eye worm) integrin alpha pat-2 0.0228 0.0253 0.0462
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0049 0.003 0.0049
Onchocerca volvulus Huntingtin homolog 0.0107 0.0102 0.1796
Loa Loa (eye worm) aspartyl protease 6 0.046 0.0543 0.0994
Loa Loa (eye worm) raf kinase 0.0038 0.0016 0.0027
Echinococcus multilocularis G protein coupled receptor 139 0.0082 0.0071 0.0116
Brugia malayi Dopamine receptor 0.0082 0.0071 0.0127
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0049 0.003 0.0051
Echinococcus multilocularis nostrin 0.003 0.0007 0.0009
Brugia malayi Protein kinase domain containing protein 0.0041 0.0019 0.0033
Leishmania major guanylate kinase, putative 0.004 0.0019 0.0047
Onchocerca volvulus 0.0082 0.0071 0.1234
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0082 0.0071 0.0127
Echinococcus multilocularis replication protein A 70 kDa DNA binding 0.0036 0.0014 0.0021
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.014 0.0144 0.0239
Schistosoma mansoni hypothetical protein 0.0082 0.0071 0.0069
Loa Loa (eye worm) p53BP2 0.003 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.0049 0.003 0.0051
Echinococcus multilocularis integrin alpha 3 0.0113 0.011 0.0183
Echinococcus granulosus biogenic amine 5HT receptor 0.0082 0.0071 0.0118
Brugia malayi Animal haem peroxidase family protein 0.0067 0.0053 0.0095
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.046 0.0543 0.0542
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Echinococcus granulosus tyrosine kinase 0.0083 0.0072 0.0121
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.2089 0.258 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0205 0.0225 0.0377
Schistosoma mansoni hypothetical protein 0.0205 0.0225 0.0224
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0091 0.0083 0.0082
Loa Loa (eye worm) hypothetical protein 0.0049 0.003 0.0053
Onchocerca volvulus 0.0036 0.0014 0.0225
Schistosoma mansoni ets-related 0.0214 0.0236 0.0235
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0113 0.011 0.0183
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0185 0.0199 0.0332
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0082 0.0071 0.0069
Brugia malayi Peptidase family M1 containing protein 0.0049 0.003 0.0053
Echinococcus granulosus high voltage activated calcium channel beta 0.004 0.0019 0.0031
Entamoeba histolytica aminopeptidase, putative 0.014 0.0144 0.7106
Echinococcus multilocularis thyroid hormone receptor alpha 0.0144 0.0149 0.0247
Leishmania major guanylate kinase-like protein 0.004 0.0019 0.0047
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.046 0.0543 0.0542
Echinococcus granulosus Spectrin alpha actinin 0.003 0.0007 0.0011
Plasmodium falciparum plasmepsin VIII, putative 0.046 0.0543 0.5904
Echinococcus granulosus fch and double sh3 domains protein 2 0.003 0.0007 0.0011
Echinococcus multilocularis disks large 3 0.0148 0.0153 0.0255
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0754 0.0911 0.091
Schistosoma mansoni phosphoglucomutase 0.0047 0.0027 0.0026
Brugia malayi neuropeptide F receptor 0.0082 0.0071 0.0127
Echinococcus granulosus replication protein A 70 kDa DNA binding 0.0036 0.0014 0.0023
Entamoeba histolytica protein kinase, putative 0.0067 0.0053 0.2389
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0754 0.0911 0.1525
Echinococcus granulosus growth factor receptor bound protein 2 0.0046 0.0027 0.0044
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.001
Echinococcus granulosus intersectin 2 0.003 0.0007 0.0011
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0133 0.0135 0.0133
Echinococcus multilocularis cathepsin b 0.0133 0.0135 0.0223
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0024 0.0042
Loa Loa (eye worm) hypothetical protein 0.2089 0.258 0.4726
Echinococcus granulosus nostrin 0.003 0.0007 0.0011
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0028 0.0004 0.0005
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0251 0.0283 0.0473
Schistosoma mansoni biogenic amine receptor 0.0082 0.0071 0.0069
Loa Loa (eye worm) hypothetical protein 0.0067 0.0053 0.0095
Echinococcus granulosus breast cancer anti estrogen resistance protein 0.003 0.0007 0.0011
Echinococcus granulosus neuropeptide receptor 0.0082 0.0071 0.0118
Echinococcus granulosus rhodopsin orphan GPCR 0.0082 0.0071 0.0118
Onchocerca volvulus 0.0082 0.0071 0.1234
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0121 0.012 0.0198
Echinococcus multilocularis neuropeptide s receptor 0.0082 0.0071 0.0116
Schistosoma mansoni hypothetical protein 0.0443 0.0522 0.0521
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0044 0.0023 0.014
Echinococcus multilocularis rhodopsin orphan GPCR 0.0082 0.0071 0.0116
Trypanosoma brucei aminopeptidase, putative 0.0049 0.003 0.0091
Echinococcus granulosus tyrosine protein kinase Src64B 0.0113 0.011 0.0185
Echinococcus granulosus orexin receptor type 2 0.0082 0.0071 0.0118
Loa Loa (eye worm) hypothetical protein 0.0067 0.0053 0.0095
Plasmodium falciparum plasmepsin II 0.0754 0.0911 1
Loa Loa (eye worm) TK protein kinase 0.0067 0.0053 0.0094
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0091 0.0082 0.0293
Trypanosoma brucei Aminopeptidase M1, putative 0.014 0.0144 0.0532
Schistosoma mansoni niemann-pick C1 (NPC1) 0.086 0.1044 0.1043
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0091 0.0082 0.0136
Brugia malayi G protein-coupled receptor 0.0082 0.0071 0.0127
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0159 0.0167 0.0304
Loa Loa (eye worm) hypothetical protein 0.0049 0.003 0.0053
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0024 0.0023
Loa Loa (eye worm) hypothetical protein 0.0133 0.0135 0.0246
Onchocerca volvulus 0.014 0.0144 0.2535
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0205 0.0225 0.0377
Echinococcus granulosus endothelin converting enzyme 1 0.0091 0.0083 0.0138
Schistosoma mansoni hypothetical protein 0.003 0.0007 0.0006
Giardia lamblia Cathepsin B precursor 0.0044 0.0023 0.0058
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0036 0.0014 0.006
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0046 0.0026 0.0025
Schistosoma mansoni myosin xvIII 0.0082 0.0071 0.0069
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0036 0.0014 0.0139
Loa Loa (eye worm) hypothetical protein 0.0067 0.0053 0.0095
Schistosoma mansoni hypothetical protein 0.0175 0.0188 0.0187
Echinococcus multilocularis somatostatin receptor 0.0082 0.0071 0.0116
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Brugia malayi Proteasome A-type and B-type family protein 0.0159 0.0167 0.0304
Brugia malayi Fli-1 protein 0.0214 0.0236 0.0431
Echinococcus granulosus tyrosine protein kinase Lyn 0.0113 0.011 0.0185
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0049 0.003 0.0091
Brugia malayi hypothetical protein 0.014 0.0144 0.0261
Echinococcus multilocularis transfer RNA-Ala 0.003 0.0007 0.0009
Onchocerca volvulus 0.0045 0.0025 0.0426
Trypanosoma cruzi aminopeptidase, putative 0.0049 0.003 0.0091
Echinococcus granulosus tissue type plasminogen activator 0.0036 0.0014 0.0023
Echinococcus granulosus dro:myosuppressin receptor 0.0082 0.0071 0.0118
Brugia malayi G protein-coupled receptor F59B2.13 0.0082 0.0071 0.0127
Schistosoma mansoni maguk P55 subfamily member 26 0.004 0.0019 0.0018
Brugia malayi RNase H family protein 0.0047 0.0027 0.0048
Echinococcus multilocularis neuropeptides capa receptor 0.0082 0.0071 0.0116
Schistosoma mansoni hypothetical protein 0.0148 0.0153 0.0152
Schistosoma mansoni Dab2-interacting protein-like 0.003 0.0007 0.0006
Schistosoma mansoni hypothetical protein 0.0585 0.07 0.0699
Echinococcus granulosus NCK adaptor protein 0.0046 0.0027 0.0044
Schistosoma mansoni hypothetical protein 0.0082 0.0071 0.0069
Schistosoma mansoni inhibitor of apoptosis protein 0.0435 0.0512 0.0511
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.004 0.0019 0.0032
Loa Loa (eye worm) hypothetical protein 0.0754 0.0911 0.1667
Trypanosoma brucei Aminopeptidase M1, putative 0.014 0.0144 0.0532
Onchocerca volvulus 0.0082 0.0071 0.1234
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.014 0.0144 0.0532
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0046 0.0027 0.0025
Schistosoma mansoni MAGUK homolog 0.0049 0.003 0.0029
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0049 0.003 0.0029
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0047 0.0027 0.0656
Loa Loa (eye worm) hypothetical protein 0.0336 0.0388 0.0709
Onchocerca volvulus 0.0057 0.004 0.0688
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0082 0.0071 0.0116
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0082 0.0071 0.0116
Loa Loa (eye worm) hypothetical protein 0.0112 0.0108 0.0196
Onchocerca volvulus 0.0082 0.0071 0.1234
Loa Loa (eye worm) hypothetical protein 0.0205 0.0225 0.041
Echinococcus multilocularis nmda type glutamate receptor 0.0028 0.0004 0.0005
Echinococcus multilocularis slit robo rho gtpase activating protein 1 0.003 0.0007 0.0009
Mycobacterium tuberculosis Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) 0.006 0.0044 0.2132
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0057 0.004 0.0129
Schistosoma mansoni adapter molecule crk 0.0046 0.0027 0.0025
Echinococcus granulosus cathepsin b 0.0133 0.0135 0.0225
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Echinococcus granulosus tyrosine protein kinase HCK 0.0067 0.0053 0.0088
Plasmodium falciparum guanylate kinase 0.004 0.0019 0.0055
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.003 0.0007 0.0006
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0046 0.0027 0.0047
Echinococcus multilocularis rhodopsin orphan GPCR 0.0082 0.0071 0.0116
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0049 0.003 0.0051
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0112 0.0108 0.0196
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0082 0.0071 0.0127
Brugia malayi GnHR receptor homolog 0.0082 0.0071 0.0127
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.014 0.0144 0.0532
Echinococcus multilocularis breast cancer anti estrogen resistance protein 0.003 0.0007 0.0009
Toxoplasma gondii exonuclease III APE 0.0038 0.0017 0.0169
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.003 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0251 0.0283 0.0516
Schistosoma mansoni opsin-like receptor 0.0082 0.0071 0.0069
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0251 0.0283 0.0516
Echinococcus granulosus tyrosine protein kinase Src42A 0.0079 0.0067 0.0112
Loa Loa (eye worm) aspartic protease BmAsp-1 0.046 0.0543 0.0994
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.014 0.0144 0.0532
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0044 0.0023 0.0065
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0121 0.012 0.095
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0057 0.004 0.0129
Onchocerca volvulus 0.003 0.0007 0.0098
Loa Loa (eye worm) hypothetical protein 0.0069 0.0055 0.0098
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0113 0.011 0.0183
Brugia malayi Raf kinase 0.0042 0.0021 0.0037
Schistosoma mansoni sorbin 0.003 0.0007 0.0006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0024 0.0039
Loa Loa (eye worm) hypothetical protein 0.0091 0.0083 0.0149
Echinococcus multilocularis g-protein coupled receptor 0.0082 0.0071 0.0116
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0121 0.012 0.0438
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0082 0.0071 0.0116
Onchocerca volvulus 0.0082 0.0071 0.1234
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0121 0.012 0.1178
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.001
Echinococcus multilocularis G-protein coupled receptor, putative 0.0082 0.0071 0.0116
Echinococcus multilocularis peroxidasin 0.0067 0.0053 0.0087
Echinococcus granulosus tyrosine protein kinase Fyn 0.0113 0.011 0.0185
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0068 0.0053 0.0095
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0051 0.0032 0.0099
Echinococcus multilocularis integrin alpha ps 0.0066 0.0051 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.004 0.0279
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0648 0.0779 0.1425
Brugia malayi hypothetical protein 0.0082 0.0071 0.0127
Echinococcus granulosus integrin alpha 3 0.0113 0.011 0.0185
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0082 0.0071 0.0116
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0024 0.0023
Brugia malayi hypothetical protein 0.0082 0.0071 0.0127
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0151 0.0158 0.0157
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.4391 0.5457 1
Onchocerca volvulus 0.0162 0.0171 0.3027
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.0057 0.0093
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0205 0.0225 0.0375
Plasmodium vivax aspartyl proteinase, putative 0.0754 0.0911 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Echinococcus multilocularis neuropeptide receptor A26 0.0082 0.0071 0.0116
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.004 0.0019 0.0032
Loa Loa (eye worm) glutaminase 0.0266 0.0301 0.055
Echinococcus multilocularis MAGUK p55 subfamily 0.0049 0.003 0.0049
Brugia malayi SH3 domain containing protein 0.003 0.0007 0.001
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0133 0.0135 0.0133
Echinococcus multilocularis Kelch repeat type 1 0.0585 0.07 0.117
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0057 0.004 0.0129
Brugia malayi abnormal cell lineage protein 2 0.004 0.0019 0.0032
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.0198 0.0217 0.2367
Echinococcus multilocularis epidermal growth factor receptor kinase 0.003 0.0007 0.0009
Echinococcus granulosus tm gpcr rhodopsin 0.0082 0.0071 0.0118
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0133 0.0135 0.0133
Brugia malayi protein-tyrosine kinase 0.0083 0.0072 0.0131
Onchocerca volvulus 0.0082 0.0071 0.1234
Schistosoma mansoni growth factor receptor-bound protein 0.0046 0.0027 0.0025
Schistosoma mansoni phosphoglucomutase 0.0047 0.0027 0.0026
Echinococcus multilocularis Niemann Pick C1 protein 0.086 0.1044 0.1746
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.0167 0.0178 0.144
Loa Loa (eye worm) acetylcholinesterase 1 0.007 0.0056 0.01
Giardia lamblia Ribonuclease H 0.0047 0.0027 0.009
Echinococcus granulosus peripheral plasma membrane protein CASK 0.0049 0.003 0.0051
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0017 0.0038
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.0167 0.0178 1
Brugia malayi latrophilin 2 splice variant baaae 0.0443 0.0522 0.0955
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0082 0.0071 0.0127
Echinococcus multilocularis serotonin receptor 0.0082 0.0071 0.0116
Toxoplasma gondii cathepsin B 0.0044 0.0023 0.0244
Loa Loa (eye worm) variant SH3 domain-containing protein 0.003 0.0007 0.001
Schistosoma mansoni patched 1 0.086 0.1044 0.1043
Echinococcus multilocularis transfer RNA-Lys 0.0162 0.0171 0.0285
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0082 0.0071 0.0069
Brugia malayi ORL1-like opioid receptor 0.0082 0.0071 0.0127
Entamoeba histolytica guanylate kinase, putative 0.004 0.0019 0.0625
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0159 0.0167 0.9361
Echinococcus multilocularis neuropeptide receptor 0.0082 0.0071 0.0116
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0648 0.0779 0.1425
Loa Loa (eye worm) hypothetical protein 0.0067 0.0053 0.0095
Schistosoma mansoni hypothetical protein 0.0205 0.0225 0.0224
Brugia malayi Animal haem peroxidase family protein 0.0067 0.0053 0.0095
Echinococcus multilocularis protein patched 0.086 0.1044 0.1746
Loa Loa (eye worm) aminopeptidase N 0.014 0.0144 0.0261
Schistosoma mansoni aryl hydrocarbon receptor 0.0219 0.0243 0.0241
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0754 0.0911 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0082 0.0071 0.0127
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0024 0.0042
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0082 0.0071 0.0069
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.014 0.0144 0.0239
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0049 0.003 0.0091
Echinococcus granulosus G protein coupled receptor 139 0.0082 0.0071 0.0118
Mycobacterium leprae Probable guanylate kinase Gmk (GMP kinase). 0.004 0.0019 0.0661
Schistosoma mansoni neuropeptide receptor 0.0082 0.0071 0.0069
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0091 0.0082 0.0081
Loa Loa (eye worm) hypothetical protein 0.046 0.0543 0.0994
Loa Loa (eye worm) hypothetical protein 0.0067 0.0053 0.0095
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Loa Loa (eye worm) fli-1 protein 0.0214 0.0236 0.0431
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0057 0.004 0.1545
Brugia malayi Animal haem peroxidase family protein 0.0067 0.0053 0.0095
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Echinococcus granulosus high voltage activated calcium channel beta 0.004 0.0019 0.0031
Schistosoma mansoni transcription factor LCR-F1 0.0185 0.0199 0.0198
Echinococcus granulosus allatostatin A receptor 0.0082 0.0071 0.0118
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0057 0.004 0.0279
Echinococcus granulosus rhodopsin orphan GPCR 0.0082 0.0071 0.0118
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.0198 0.0217 1
Echinococcus granulosus neuropeptide receptor 0.0082 0.0071 0.0118
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.0198 0.0217 0.0815
Brugia malayi hypothetical protein 0.0082 0.0071 0.0127
Loa Loa (eye worm) hypothetical protein 0.0067 0.0053 0.0095
Loa Loa (eye worm) peptidase family M13 containing protein 0.0067 0.0053 0.0095
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.014 0.0144 0.0239
Schistosoma mansoni growth factor receptor-bound protein 0.0046 0.0027 0.0025
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0121 0.012 0.1301
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0057 0.004 0.0067
Onchocerca volvulus Peroxidasin homolog 0.0067 0.0053 0.0921
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0082 0.0071 0.0118
Brugia malayi hypothetical protein 0.0735 0.0887 0.1624
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0017 0.0026
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.0071 0.0069
Echinococcus granulosus c src tyrosine kinase 0.0051 0.0032 0.0054
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.086 0.1044 0.1911
Toxoplasma gondii guanylate kinase family protein 0.004 0.0019 0.0193
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Echinococcus multilocularis expressed protein 0.003 0.0007 0.0009
Loa Loa (eye worm) blistered cuticle protein 3 0.0067 0.0053 0.0095
Schistosoma mansoni apoptosis stimulating of P53 0.003 0.0007 0.0006
Echinococcus granulosus acetylcholinesterase 0.007 0.0056 0.0094
Echinococcus multilocularis hematopoietic lineage cell specific protein 0.003 0.0007 0.0009
Schistosoma mansoni hypothetical protein 0.003 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.001
Onchocerca volvulus 0.0082 0.0071 0.1234
Brugia malayi Angiotensin-converting enzyme family protein 0.4391 0.5457 1
Loa Loa (eye worm) TYRA-2 protein 0.0082 0.0071 0.0127
Brugia malayi hypothetical protein 0.0082 0.0071 0.0127
Brugia malayi Ets-domain containing protein 0.0071 0.0057 0.0102
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0057 0.004 0.0129
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0082 0.0071 0.0069
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0082 0.0071 0.0127
Loa Loa (eye worm) hypothetical protein 0.006 0.0044 0.0079
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0051 0.0032 0.0031
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.014 0.0144 0.1154
Schistosoma mansoni high voltage-activated calcium channel beta subunit 1 0.004 0.0019 0.0018
Onchocerca volvulus 0.0067 0.0053 0.0921
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.2089 0.258 1
Echinococcus granulosus kelch ECH associated protein 1 0.0584 0.0698 0.1169
Schistosoma mansoni neuropeptide receptor 0.0082 0.0071 0.0069
Echinococcus multilocularis cathepsin b 0.0133 0.0135 0.0223
Brugia malayi hypothetical protein 0.0082 0.0071 0.0127
Loa Loa (eye worm) hypothetical protein 0.0036 0.0014 0.0023
Loa Loa (eye worm) hypothetical protein 0.0067 0.0053 0.0095
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Loa Loa (eye worm) neuropeptide F receptor 0.0082 0.0071 0.0127
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.0198 0.0217 0.0395
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0083 0.0072 0.0121
Echinococcus multilocularis rhodopsin orphan GPCR 0.0082 0.0071 0.0116
Brugia malayi ZU5 domain containing protein 0.004 0.0019 0.0032
Loa Loa (eye worm) cathepsin B 0.0044 0.0023 0.0041
Leishmania major protein kinase, putative 0.0057 0.004 0.0129
Brugia malayi hypoxia-induced factor 1 0.0678 0.0816 0.1494
Onchocerca volvulus 0.0082 0.0071 0.1234
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0057 0.004 0.0071
Brugia malayi hypothetical protein 0.0082 0.0071 0.0127
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.001
Entamoeba histolytica hypothetical protein 0.0185 0.0199 1
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0049 0.003 0.0183
Onchocerca volvulus 0.0082 0.0071 0.1234
Onchocerca volvulus 0.003 0.0007 0.0098
Echinococcus multilocularis peripheral plasma membrane protein CASK 0.0049 0.003 0.0049
Loa Loa (eye worm) hypothetical protein 0.0067 0.0053 0.0095
Echinococcus granulosus peroxidasin 0.0067 0.0053 0.0089
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0079 0.0067 0.011
Loa Loa (eye worm) TK/ROR protein kinase 0.0041 0.0019 0.0033
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.004 0.0019 0.0018
Onchocerca volvulus 0.0207 0.0227 0.4014
Brugia malayi larval opioid receptor 0.0082 0.0071 0.0127
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.014 0.0144 0.0143
Schistosoma mansoni phosphoglucomutase 0.0047 0.0027 0.0026
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0082 0.0071 0.0127
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0082 0.0071 0.0127
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0082 0.0071 0.0116
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0017 0.0028
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.0071 0.0069
Loa Loa (eye worm) guanylate kinase 0.004 0.0019 0.0032
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.0198 0.0217 0.2367
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.098 0.1194 1
Giardia lamblia Cathepsin B precursor 0.0044 0.0023 0.0058
Echinococcus granulosus neuropeptide receptor A26 0.0082 0.0071 0.0118
Loa Loa (eye worm) G-protein coupled receptor 0.0082 0.0071 0.0127
Brugia malayi Serotonin receptor 0.0082 0.0071 0.0127
Echinococcus multilocularis tissue type plasminogen activator 0.0036 0.0014 0.0021
Brugia malayi Calcitonin receptor-like protein seb-1 0.0648 0.0779 0.1425
Echinococcus multilocularis neuropeptides capa receptor 0.0082 0.0071 0.0116
Echinococcus granulosus rhodopsin orphan GPCR 0.0082 0.0071 0.0118
Echinococcus granulosus neuropeptide FF receptor 2 0.0082 0.0071 0.0118
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Echinococcus granulosus src region 0.003 0.0007 0.0011
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0017 0.0028
Loa Loa (eye worm) hypothetical protein 0.0091 0.0082 0.0148
Echinococcus multilocularis growth factor receptor bound protein 2 0.0046 0.0027 0.0042
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0082 0.0071 0.0118
Schistosoma mansoni neprilysin-2 (M13 family) 0.0046 0.0026 0.0025
Loa Loa (eye worm) hypothetical protein 0.0443 0.0522 0.0955
Echinococcus granulosus tachykinin peptides receptor 99D 0.0082 0.0071 0.0118
Onchocerca volvulus 0.0263 0.0298 0.528
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.098 0.1194 1
Schistosoma mansoni slit-robo rho gtpase activating protein 0.003 0.0007 0.0006
Onchocerca volvulus Peroxidase homolog 0.0067 0.0053 0.0921
Brugia malayi Carboxylesterase family protein 0.007 0.0056 0.01
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0082 0.0071 0.0116
Toxoplasma gondii aminopeptidase N protein 0.0049 0.003 0.0319
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.014 0.0144 0.0239
Echinococcus granulosus MAGUK p55 subfamily 0.0049 0.003 0.0051
Brugia malayi hypothetical protein 0.0082 0.0071 0.0127
Echinococcus granulosus rhodopsin orphan GPCR 0.0082 0.0071 0.0118
Echinococcus granulosus neuropeptide s receptor 0.0082 0.0071 0.0118
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0082 0.0071 0.0069
Onchocerca volvulus 0.0082 0.0071 0.1234
Schistosoma mansoni opsin-like receptor 0.0082 0.0071 0.0069
Brugia malayi Myosin tail family protein 0.003 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0067 0.0053 0.0095
Brugia malayi Carboxylesterase family protein 0.007 0.0056 0.01
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.098 0.1194 1
Brugia malayi bHLH-PAS transcription factor 0.0162 0.0171 0.0312
Echinococcus multilocularis aryl hydrocarbon receptor 0.0057 0.004 0.0065
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Loa Loa (eye worm) thyroid receptor interactor 0.003 0.0007 0.001
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0057 0.004 0.0129
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Echinococcus multilocularis g protein coupled receptor 0.0082 0.0071 0.0116
Loa Loa (eye worm) hypothetical protein 0.0263 0.0298 0.0544
Brugia malayi proteasome subunit beta type 1 0.0121 0.012 0.0217
Loa Loa (eye worm) TATA binding protein associated factor 0.0049 0.003 0.0053
Wolbachia endosymbiont of Brugia malayi guanylate kinase 0.004 0.0019 0.0137
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0057 0.004 0.0065
Echinococcus multilocularis proteasome (prosome, macropain) 0.0159 0.0167 0.0277
Echinococcus granulosus 7tm_1 domain containing protein 0.0082 0.0071 0.0118
Loa Loa (eye worm) hypothetical protein 0.0049 0.003 0.0053
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.0198 0.0217 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0113 0.011 0.0185
Brugia malayi Tyrosine-protein kinase abl-1 0.0051 0.0032 0.0057
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.014 0.0144 0.0239
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0082 0.0071 0.0118
Brugia malayi Sex muscle abnormal protein 5 0.0046 0.0027 0.0047
Brugia malayi Spectrin alpha chain 0.003 0.0007 0.001
Brugia malayi SRC-1 0.0113 0.011 0.02
Echinococcus multilocularis kelch ECH associated protein 1 0.0584 0.0698 0.1167
Schistosoma mansoni C-fyn 0.003 0.0007 0.0006
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0049 0.003 0.0091
Loa Loa (eye worm) hypothetical protein 0.0067 0.0053 0.0095
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Trypanosoma brucei cysteine peptidase C (CPC) 0.0044 0.0023 0.0065
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0066 0.0051 0.0091
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Echinococcus granulosus g protein coupled receptor 0.0082 0.0071 0.0118
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0181 0.0195 0.0356
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.001
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0113 0.011 0.0183
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Schistosoma mansoni hypothetical protein 0.0036 0.0014 0.0013
Brugia malayi hypothetical protein 0.0049 0.003 0.0053
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0198 0.0217 0.0815
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0185 0.0199 0.0334
Trypanosoma brucei RNA helicase, putative 0.0175 0.0188 0.0704
Echinococcus multilocularis guanylate kinase 0.004 0.0019 0.0029
Echinococcus granulosus aminopeptidase N 0.0476 0.0563 0.0943
Schistosoma mansoni hypothetical protein 0.0185 0.0199 0.0198
Trichomonas vaginalis guanylate cyclase, putative 0.0057 0.004 0.0279
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0082 0.0071 0.0127
Brugia malayi hypothetical protein 0.0263 0.0298 0.0544
Onchocerca volvulus Peroxidase homolog 0.0067 0.0053 0.0921
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0017 0.0083
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0082 0.0071 0.0118
Loa Loa (eye worm) hypothetical protein 0.0034 0.0012 0.0019
Echinococcus granulosus neuropeptides capa receptor 0.0082 0.0071 0.0118
Brugia malayi hypothetical protein 0.046 0.0543 0.0994
Loa Loa (eye worm) hypothetical protein 0.0091 0.0082 0.0148
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0124 0.0124 0.0207
Echinococcus granulosus tyrosine protein kinase Blk 0.0083 0.0072 0.0121
Plasmodium falciparum plasmepsin IV 0.0754 0.0911 1
Schistosoma mansoni glutaminase 0.0266 0.0301 0.03
Echinococcus multilocularis sterol regulatory element binding protein 0.086 0.1044 0.1746
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0435 0.0512 0.0936
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.014 0.0144 0.0532
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.003 0.0007 0.0011
Brugia malayi POT family protein 0.0083 0.0072 0.013
Trichomonas vaginalis conserved hypothetical protein 0.086 0.1044 0.8736
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0113 0.011 0.0185
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0049 0.003 0.0091
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0017 0.0531
Mycobacterium ulcerans glutaminase 0.0266 0.0301 0.1142
Loa Loa (eye worm) hypothetical protein 0.0067 0.0053 0.0095
Echinococcus multilocularis serotonin receptor 0.0082 0.0071 0.0116
Loa Loa (eye worm) hypothetical protein 0.0426 0.0502 0.0917
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0124 0.0124 0.0205
Echinococcus granulosus fmrfamide receptor 0.0082 0.0071 0.0118
Onchocerca volvulus 0.0082 0.0071 0.1234
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0017 0.0083
Schistosoma mansoni biogenic amine (5HT) receptor 0.0082 0.0071 0.0069
Plasmodium vivax proteasome subunit beta type-1, putative 0.0121 0.012 0.1301
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.046 0.0543 0.0542
Schistosoma mansoni hypothetical protein 0.0435 0.0512 0.0511
Brugia malayi TATA binding protein associated factor 0.0049 0.003 0.0053
Loa Loa (eye worm) hypothetical protein 0.0107 0.0102 0.0185
Echinococcus granulosus 55 kDa erythrocyte membrane protein 0.0049 0.003 0.0051
Trichomonas vaginalis sap-102, putative 0.004 0.0019 0.0102
Echinococcus granulosus guanylate kinase 0.004 0.0019 0.0031
Schistosoma mansoni hypothetical protein 0.0205 0.0225 0.0224
Brugia malayi cathepsin B-like cysteine proteinase 0.0133 0.0135 0.0244
Onchocerca volvulus 0.003 0.0007 0.0098
Trypanosoma brucei hypothetical protein, conserved 0.0051 0.0032 0.0099
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.003 0.0007 0.0009
Echinococcus granulosus single minded 2 0.0162 0.0171 0.0287
Echinococcus granulosus Protein patched homolog 1 0.086 0.1044 0.1748
Schistosoma mansoni cell polarity protein 0.0071 0.0057 0.0056
Onchocerca volvulus 0.0082 0.0071 0.1234
Echinococcus multilocularis geminin 0.0148 0.0153 0.0255
Echinococcus multilocularis guanylate kinase 0.004 0.0019 0.0029
Echinococcus multilocularis disks large 1 0.004 0.0019 0.0029
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0049 0.003 0.0319
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.0071 0.0069
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0082 0.0071 0.0069
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0057 0.004 0.0279
Treponema pallidum ribonuclease H (rnhA) 0.0047 0.0027 0.0529
Echinococcus granulosus disks large 3 0.0148 0.0153 0.0256
Schistosoma mansoni single-minded 0.0219 0.0243 0.0241
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0049 0.003 0.0183
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0034 0.0012 0.0041
Leishmania major proteasome beta 5 subunit, putative 0.0159 0.0167 0.0622
Echinococcus multilocularis neuropeptide receptor 0.0082 0.0071 0.0116
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0113 0.011 0.0183
Onchocerca volvulus LIM and SH3 domain protein homolog 0.003 0.0007 0.0098
Schistosoma mansoni neuropeptide F-like receptor 0.0082 0.0071 0.0069
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0113 0.011 0.0183
Echinococcus granulosus raf serine:threonine protein kinase 0.0042 0.0021 0.0036
Echinococcus granulosus MAGUK p55 subfamily 0.0049 0.003 0.0051
Loa Loa (eye worm) hypothetical protein 0.0032 0.0008 0.0013
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Trichomonas vaginalis glutaminase, putative 0.0266 0.0301 0.2482
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0121 0.012 0.02
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Brugia malayi aspartic protease BmAsp-1, identical 0.046 0.0543 0.0994
Schistosoma mansoni hypothetical protein 0.0082 0.0071 0.0069
Brugia malayi Animal haem peroxidase family protein 0.0067 0.0053 0.0095
Loa Loa (eye worm) hypoxia-induced factor 1 0.0678 0.0816 0.1494
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.0198 0.0217 0.0361
Schistosoma mansoni run and tbc1 domain containing 0.003 0.0007 0.0006
Onchocerca volvulus 0.003 0.0007 0.0098
Echinococcus multilocularis orexin receptor type 2 0.0082 0.0071 0.0116
Mycobacterium tuberculosis Probable guanylate kinase Gmk 0.004 0.0019 0.0661
Schistosoma mansoni integrin alpha 0.0148 0.0153 0.0152
Plasmodium vivax guanylate kinase, putative 0.004 0.0019 0.0193
Loa Loa (eye worm) peptidase family M1 containing protein 0.0385 0.045 0.0822
Onchocerca volvulus 0.008 0.0068 0.1193
Mycobacterium ulcerans proteasome PrcB 0.0159 0.0167 0.0619
Onchocerca volvulus 0.046 0.0543 0.9648
Echinococcus multilocularis rhodopsin orphan GPCR 0.0082 0.0071 0.0116
Schistosoma mansoni neuropeptide receptor 0.0082 0.0071 0.0069
Loa Loa (eye worm) animal heme peroxidase 0.0067 0.0053 0.0095
Trypanosoma brucei proteasome beta 6 subunit 0.0121 0.012 0.0438
Plasmodium vivax aspartyl protease, putative 0.046 0.0543 0.5961
Schistosoma mansoni tyrosine kinase 0.0051 0.0032 0.0031
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0435 0.0512 0.0857
Schistosoma mansoni integrin alpha-ps 0.0066 0.0051 0.005
Echinococcus granulosus disks large 1 0.004 0.0019 0.0031
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0159 0.0167 0.0622
Echinococcus granulosus rhodopsin orphan GPCR 0.0082 0.0071 0.0118
Brugia malayi hypothetical protein 0.0067 0.0053 0.0095
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0024 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.004 0.0279
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.0167 0.0178 1
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0121 0.012 0.0438
Loa Loa (eye worm) hypothetical protein 0.0067 0.0053 0.0095
Echinococcus granulosus aryl hydrocarbon receptor 0.0057 0.004 0.0067
Schistosoma mansoni amine GPCR 0.0082 0.0071 0.0069
Loa Loa (eye worm) proteasome subunit beta type 1 0.0121 0.012 0.0217
Chlamydia trachomatis guanylate kinase 0.004 0.0019 0.0538
Trichomonas vaginalis discs large, putative 0.004 0.0019 0.0102
Loa Loa (eye worm) hypothetical protein 0.0049 0.003 0.0053
Brugia malayi AKH receptor 0.0082 0.0071 0.0127
Brugia malayi Guanylate kinase family protein 0.0049 0.003 0.0053
Brugia malayi Variant SH3 domain containing protein 0.0046 0.0027 0.0047
Echinococcus multilocularis integrin alpha ps 0.0032 0.0008 0.0012
Echinococcus multilocularis rhodopsin orphan GPCR 0.0082 0.0071 0.0116
Brugia malayi Peptidase family M1 containing protein 0.0476 0.0563 0.103
Brugia malayi RE15519p 0.0082 0.0071 0.0127
Echinococcus multilocularis allatostatin A receptor 0.0082 0.0071 0.0116
Schistosoma mansoni dynamin-associated protein 0.003 0.0007 0.0006
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.2089 0.258 0.4726
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.0071 0.0069
Schistosoma mansoni MAGUK homolog 0.0049 0.003 0.0029
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0159 0.0167 0.0622
Loa Loa (eye worm) peripheral plasma membrane protein CASK 0.0049 0.003 0.0053
Echinococcus multilocularis 0.0049 0.003 0.0049
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.098 0.1194 1
Loa Loa (eye worm) peptidase family M13 containing protein 0.0067 0.0053 0.0095
Onchocerca volvulus Dual oxidase homolog 0.0067 0.0053 0.0921
Onchocerca volvulus Deterin homolog 0.0435 0.0512 0.909
Brugia malayi Variant SH3 domain containing protein 0.003 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Schistosoma mansoni biogenic amine receptor 0.0082 0.0071 0.0069
Echinococcus granulosus tyrosine protein kinase Src42A 0.0113 0.011 0.0185
Onchocerca volvulus 0.0476 0.0563 1
Brugia malayi Variant SH3 domain containing protein 0.003 0.0007 0.001
Trichomonas vaginalis adenylate cyclase, putative 0.0057 0.004 0.0279
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0024 0.0023
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0083 0.0072 0.0119
Echinococcus multilocularis rhodopsin orphan GPCR 0.0082 0.0071 0.0116
Giardia lamblia Cathepsin B precursor 0.0044 0.0023 0.0058
Trypanosoma brucei unspecified product 0.0051 0.0032 0.0099
Schistosoma mansoni growth hormone secretagogue receptor 0.0082 0.0071 0.0069
Schistosoma mansoni sorting nexin 0.003 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0082 0.0071 0.0116
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0049 0.003 0.0091
Onchocerca volvulus 0.0082 0.0071 0.1234
Loa Loa (eye worm) SRC-1 0.0113 0.011 0.02
Onchocerca volvulus Ribonuclease H1 homolog 0.0047 0.0027 0.0462
Trypanosoma cruzi ribonuclease H1, putative 0.0047 0.0027 0.0079
Schistosoma mansoni neuropeptide f receptor 76f 0.0082 0.0071 0.0069
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0049 0.003 0.0053
Schistosoma mansoni thyroid hormone receptor 0.0144 0.0149 0.0148
Brugia malayi RNase H family protein 0.0047 0.0027 0.0048
Leishmania major protein kinase, putative 0.0057 0.004 0.0129
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Loa Loa (eye worm) animal heme peroxidase 0.0067 0.0053 0.0095
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0082 0.0071 0.0069
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0082 0.0071 0.0116
Schistosoma mansoni peroxidasin 0.0067 0.0053 0.0052
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0754 0.0911 0.1667
Loa Loa (eye worm) hypothetical protein 0.055 0.0656 0.1199
Brugia malayi Dopamine receptor protein 2 0.0082 0.0071 0.0127
Trichomonas vaginalis ribonuclease H1, putative 0.0047 0.0027 0.0172
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0046 0.0026 0.0025
Brugia malayi Peroxidasin 0.0067 0.0053 0.0095
Echinococcus multilocularis tyrosine protein kinase Blk 0.0083 0.0072 0.0119
Brugia malayi hypothetical protein 0.046 0.0543 0.0994
Schistosoma mansoni nck2/grb4 0.0046 0.0027 0.0025
Brugia malayi replication factor A 73 kDa subunit 0.0036 0.0014 0.0023
Schistosoma mansoni cathepsin D (A01 family) 0.1504 0.1849 0.1848
Brugia malayi follicle stimulating hormone receptor 0.0082 0.0071 0.0127
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.0071 0.0069
Schistosoma mansoni opsin-like receptor 0.0082 0.0071 0.0069
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0057 0.004 0.0279
Brugia malayi hypothetical protein 0.0082 0.0071 0.0127
Echinococcus granulosus tm gpcr rhodopsin 0.0082 0.0071 0.0118
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Schistosoma mansoni neuropeptide receptor 0.0082 0.0071 0.0069
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0082 0.0071 0.1234
Plasmodium vivax aspartyl protease, putative 0.046 0.0543 0.5961
Plasmodium vivax proteasome subunit beta type-5, putative 0.0159 0.0167 0.1821
Echinococcus granulosus hypothetical protein 0.0082 0.0071 0.0118
Echinococcus multilocularis high voltage activated calcium channel beta 0.004 0.0019 0.0029
Echinococcus granulosus tm gpcr rhodopsin 0.4803 0.5972 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0026 0.0001 0.0002
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.0032 0.0009 0.0141
Loa Loa (eye worm) hypothetical protein 0.0091 0.0083 0.0149
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0049 0.003 0.0319
Brugia malayi Melatonin receptor type 1A 0.0082 0.0071 0.0127
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0057 0.004 0.0129
Echinococcus multilocularis dro:myosuppressin receptor 0.0082 0.0071 0.0116
Echinococcus multilocularis inhibitor of apoptosis protein 0.0435 0.0512 0.0856
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0021 0.002
Loa Loa (eye worm) melatonin receptor type 1A 0.0082 0.0071 0.0127
Loa Loa (eye worm) POT family protein 0.0083 0.0072 0.013
Brugia malayi hypothetical protein 0.0082 0.0071 0.0127
Plasmodium falciparum plasmepsin I 0.0754 0.0911 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0113 0.011 0.0183
Schistosoma mansoni mannosidase endo-alpha 0.004 0.0019 0.0018
Schistosoma mansoni thyroid hormone receptor 0.0144 0.0149 0.0148
Echinococcus multilocularis neuropeptide Y receptor 0.0082 0.0071 0.0116
Brugia malayi guanylate kinase 0.004 0.0019 0.0032
Plasmodium falciparum plasmepsin VI 0.0754 0.0911 1
Entamoeba histolytica hypothetical protein 0.0185 0.0199 1
Brugia malayi Peripheral plasma membrane protein CASK 0.008 0.0068 0.0123
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Echinococcus granulosus neuropeptides capa receptor 0.0082 0.0071 0.0118
Schistosoma mansoni ATP-dependent RNA Helicase 0.0049 0.003 0.0029
Echinococcus granulosus MAGUK p55 subfamily 0.0049 0.003 0.0051
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0113 0.011 0.0183
Mycobacterium ulcerans putative regulatory protein 0.0162 0.0171 0.0637
Loa Loa (eye worm) hypothetical protein 0.0435 0.0512 0.0936
Trypanosoma brucei ingi protein (ORF1) 0.0051 0.0032 0.0099
Brugia malayi Latrophilin receptor protein 2 0.0205 0.0225 0.041
Loa Loa (eye worm) G-protein coupled receptor 0.0082 0.0071 0.0127
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0159 0.0167 0.8305
Echinococcus multilocularis g protein coupled receptor 0.0082 0.0071 0.0116
Trichomonas vaginalis guanylate kinase, putative 0.004 0.0019 0.0102
Loa Loa (eye worm) hypothetical protein 0.0067 0.0053 0.0095
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0046 0.0026 0.0025
Loa Loa (eye worm) neuropeptide F receptor 0.0082 0.0071 0.0127
Echinococcus granulosus kelch ECH associated protein 1 like 0.0584 0.0698 0.1169
Schistosoma mansoni replication factor A 1 rfa1 0.0036 0.0014 0.0013
Echinococcus granulosus puromycin sensitive aminopeptidase 0.014 0.0144 0.0241
Brugia malayi Tachykinin-like peptides receptor 99D 0.0082 0.0071 0.0127
Echinococcus granulosus serotonin receptor 0.0082 0.0071 0.0118
Schistosoma mansoni maguk P55 subfamily member 26 0.0049 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Mycobacterium ulcerans zinc metalloprotease 0.0091 0.0083 0.0292
Plasmodium falciparum plasmepsin X 0.046 0.0543 0.5904
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Plasmodium vivax plasmepsin V, putative 0.046 0.0543 0.5961
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.001
Leishmania major hypothetical protein, conserved 0.0036 0.0014 0.0028
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0113 0.011 0.0185
Schistosoma mansoni sh3-containing grb2-like protein 1 (endophilin II) 0.003 0.0007 0.0006
Brugia malayi G-protein coupled receptor 0.0082 0.0071 0.0127
Echinococcus granulosus biogenic amine 5HT receptor 0.0082 0.0071 0.0118
Echinococcus granulosus integrin alpha ps 0.0066 0.0051 0.0086
Loa Loa (eye worm) hypothetical protein 0.0069 0.0055 0.0098
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0014 0.0028
Schistosoma mansoni cathepsin D (A01 family) 0.1504 0.1849 0.1848
Echinococcus granulosus slit robo rho gtpase activating protein 1 0.003 0.0007 0.0011
Loa Loa (eye worm) hypothetical protein 0.0057 0.004 0.0071
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.0198 0.0217 0.0215
Loa Loa (eye worm) hypothetical protein 0.004 0.0019 0.0032
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0082 0.0071 0.0069
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0082 0.0071 0.0116
Toxoplasma gondii aspartyl protease ASP1 0.0754 0.0911 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0205 0.0225 0.041
Loa Loa (eye worm) hypothetical protein 0.004 0.0019 0.0032
Brugia malayi Ets-domain containing protein 0.0071 0.0057 0.0102
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0017 0.0038
Echinococcus granulosus puromycin sensitive aminopeptidase 0.014 0.0144 0.0241
Echinococcus multilocularis aminopeptidase N 0.0476 0.0563 0.0941
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Echinococcus granulosus ribonuclease H1 0.0047 0.0027 0.0045
Loa Loa (eye worm) animal heme peroxidase 0.0067 0.0053 0.0095
Echinococcus granulosus guanylate kinase 0.004 0.0019 0.0031
Onchocerca volvulus 0.046 0.0543 0.9648
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0082 0.0071 0.0069
Echinococcus granulosus expressed protein 0.003 0.0007 0.0011
Onchocerca volvulus 0.0082 0.0071 0.1234
Echinococcus granulosus hematopoietic lineage cell specific protein 0.003 0.0007 0.0011
Loa Loa (eye worm) TK protein kinase 0.0083 0.0072 0.0131
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.0071 0.0069
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0044 0.0023 0.0065
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.1354 0.1662 0.1661
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0082 0.0071 0.0127
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.2089 0.258 0.432
Toxoplasma gondii proteasome subunit beta type, putative 0.0159 0.0167 0.1821
Echinococcus granulosus sex peptide receptor 0.0082 0.0071 0.0118
Brugia malayi Variant SH3 domain containing protein 0.003 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0069 0.0055 0.0098
Trichomonas vaginalis set domain proteins, putative 0.0207 0.0227 0.1854
Schistosoma mansoni formin binding protein and related proteins 0.003 0.0007 0.0006
Schistosoma mansoni ap endonuclease 0.0038 0.0017 0.0015
Trichomonas vaginalis guanylate cyclase, putative 0.0057 0.004 0.0279
Echinococcus multilocularis high voltage activated calcium channel beta 0.004 0.0019 0.0029
Schistosoma mansoni dopamine-beta-monooxygenase 0.0133 0.0135 0.0134
Echinococcus multilocularis neuropeptide Y receptor 0.0082 0.0071 0.0116
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.014 0.0144 0.0239
Echinococcus multilocularis integrin alpha ps 0.0066 0.0051 0.0084
Echinococcus multilocularis g protein coupled receptor 0.0082 0.0071 0.0116
Brugia malayi G-protein coupled receptor 0.0082 0.0071 0.0127
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Trypanosoma cruzi Aminopeptidase M1, putative 0.014 0.0144 0.0532
Brugia malayi Peptidase family M13 containing protein 0.0091 0.0083 0.0149
Toxoplasma gondii ribonuclease HI protein 0.0047 0.0027 0.0285
Loa Loa (eye worm) hypothetical protein 0.0067 0.0053 0.0095
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.001
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0044 0.0023 0.0022
Schistosoma mansoni amine GPCR 0.0082 0.0071 0.0069
Mycobacterium ulcerans aminopeptidase N PepN 0.014 0.0144 0.0529
Brugia malayi Blistered cuticle protein 3 0.0067 0.0053 0.0095
Plasmodium vivax aspartyl proteinase, putative 0.046 0.0543 0.5961
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0047
Echinococcus multilocularis acetylcholinesterase 0.007 0.0056 0.0092
Echinococcus multilocularis Spectrin alpha actinin 0.003 0.0007 0.0009
Echinococcus multilocularis tyrosine protein kinase Srms 0.0083 0.0072 0.0119
Onchocerca volvulus 0.0067 0.0053 0.0921
Schistosoma mansoni tyrosine kinase 0.0051 0.0032 0.0031
Echinococcus granulosus tyrosine protein kinase Fyn 0.0113 0.011 0.0185
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0051 0.0032 0.0054
Schistosoma mansoni tyrosine kinase 0.0113 0.011 0.0109
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.046 0.0543 0.0542
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Schistosoma mansoni neuropeptide F-like receptor 0.0082 0.0071 0.0069
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0051 0.0032 0.0052
Schistosoma mansoni cell polarity protein 0.0148 0.0153 0.0152
Brugia malayi Variant SH3 domain containing protein 0.003 0.0007 0.001
Trypanosoma cruzi guanylate kinase, putative 0.004 0.0019 0.0047
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.0057 0.0095
Plasmodium falciparum proteasome subunit beta type-5 0.0159 0.0167 0.1705
Schistosoma mansoni hypothetical protein 0.0205 0.0225 0.0224
Toxoplasma gondii aspartyl protease ASP3 0.046 0.0543 0.5961
Echinococcus multilocularis rhodopsin orphan GPCR 0.0082 0.0071 0.0116
Brugia malayi Dopamine receptor protein 1 0.0082 0.0071 0.0127
Loa Loa (eye worm) hypothetical protein 0.0067 0.0053 0.0095
Brugia malayi aspartic protease BmAsp-2, identical 0.046 0.0543 0.0994
Echinococcus granulosus epidermal growth factor receptor kinase 0.003 0.0007 0.0011
Schistosoma mansoni guanylate kinase 0.004 0.0019 0.0018
Onchocerca volvulus Huntingtin homolog 0.0107 0.0102 0.1796
Echinococcus multilocularis kelch ECH associated protein 1 0.0584 0.0698 0.1167
Brugia malayi hypothetical protein 0.004 0.0019 0.0032
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Brugia malayi Kringle domain containing protein 0.0036 0.0014 0.0023
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0121 0.012 0.0438
Schistosoma mansoni alpha-1 adrenergic receptor 0.0082 0.0071 0.0069
Schistosoma mansoni eps8-related protein 0.003 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0107 0.0102 0.0185
Brugia malayi putative neuropeptide receptor 0.0082 0.0071 0.0127
Echinococcus granulosus nmda type glutamate receptor 0.0028 0.0004 0.0007
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0091 0.0083 0.0149
Onchocerca volvulus 0.0082 0.0071 0.1234
Brugia malayi glutaminase DH11.1 0.0266 0.0301 0.055
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.0057 0.0102
Echinococcus multilocularis 55 kDa erythrocyte membrane protein 0.0049 0.003 0.0049
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Schistosoma mansoni histamine h1 receptor 0.0082 0.0071 0.0069
Loa Loa (eye worm) guanylate kinase 0.0138 0.0141 0.0256
Echinococcus multilocularis sex peptide receptor 0.0082 0.0071 0.0116
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.046 0.0543 0.0542
Trypanosoma brucei guanylate kinase, putative 0.004 0.0019 0.0047
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0133 0.0135 0.0133
Brugia malayi neuropeptide F receptor 0.0082 0.0071 0.0127
Echinococcus multilocularis MAGUK p55 subfamily 0.0049 0.003 0.0049
Plasmodium vivax plasmepsin IV, putative 0.0754 0.0911 1
Loa Loa (eye worm) hypothetical protein 0.055 0.0656 0.1199
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0133 0.0135 0.0497
Echinococcus multilocularis NCK adaptor protein 0.0046 0.0027 0.0042
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.046 0.0543 0.5961
Echinococcus multilocularis tyrosine protein kinase Abl 0.0051 0.0032 0.0052
Mycobacterium ulcerans guanylate kinase 0.004 0.0019 0.0044
Echinococcus multilocularis tyrosine protein kinase HCK 0.0067 0.0053 0.0086
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0049 0.003 0.0029
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0159 0.0167 0.9361
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0017 0.0511
Schistosoma mansoni gabp alpha 0.0071 0.0057 0.0056
Trypanosoma cruzi aminopeptidase, putative 0.014 0.0144 0.0532
Plasmodium vivax aspartyl protease, putative 0.046 0.0543 0.5961
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0113 0.011 0.0183
Schistosoma mansoni biogenic amine (5HT) receptor 0.0082 0.0071 0.0069
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0082 0.0071 0.0069
Brugia malayi Variant SH3 domain containing protein 0.003 0.0007 0.001
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0082 0.0071 0.0116
Echinococcus granulosus GPCR family 2 0.0205 0.0225 0.0377
Trypanosoma cruzi guanylate kinase, putative 0.004 0.0019 0.0047
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0024 0.0041
Loa Loa (eye worm) hypothetical protein 0.007 0.0056 0.01
Toxoplasma gondii aspartyl protease 0.046 0.0543 0.5961
Loa Loa (eye worm) hypothetical protein 0.0091 0.0083 0.0149
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0082 0.0071 0.0116
Brugia malayi Pre-SET motif family protein 0.0181 0.0195 0.0356
Plasmodium falciparum plasmepsin III 0.046 0.0543 0.5904
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Trypanosoma cruzi ribonuclease H1, putative 0.0047 0.0027 0.0079
Onchocerca volvulus 0.0082 0.0071 0.1234
Brugia malayi Serotonin receptor 0.0082 0.0071 0.0127
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0159 0.0167 0.1349
Echinococcus granulosus sterol regulatory element binding protein 0.086 0.1044 0.1748
Trypanosoma brucei ribonuclease H1 0.0047 0.0027 0.0079
Loa Loa (eye worm) hypothetical protein 0.0067 0.0053 0.0095
Trichomonas vaginalis calcium/calmodulin-dependent serine protein kinase membrane-associated guanylate kinase, putative 0.004 0.0019 0.0102
Onchocerca volvulus Chorion peroxidase homolog 0.0067 0.0053 0.0921
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0091 0.0083 0.4417
Onchocerca volvulus 0.0067 0.0053 0.0921
Echinococcus granulosus integrin alpha ps 0.0032 0.0008 0.0014
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0133 0.0135 0.0246
Toxoplasma gondii kringle domain-containing protein 0.0036 0.0014 0.0139
Loa Loa (eye worm) guanylate kinase 0.0049 0.003 0.0053
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0435 0.0512 0.0856
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0754 0.0911 0.7618
Echinococcus granulosus proteasome prosome macropain 0.0159 0.0167 0.0279
Echinococcus granulosus peptide allatostatin:somatostatin 0.0082 0.0071 0.0118
Brugia malayi Fes/CIP4 homology domain containing protein 0.003 0.0007 0.001
Schistosoma mansoni ap endonuclease 0.0038 0.0017 0.0015
Brugia malayi Integrin alpha pat-2 precursor 0.0148 0.0153 0.0279
Echinococcus multilocularis rhodopsin orphan GPCR 0.0082 0.0071 0.0116
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.2089 0.258 0.4319
Loa Loa (eye worm) hypothetical protein 0.046 0.0543 0.0994
Echinococcus granulosus rhodopsin orphan GPCR 0.0082 0.0071 0.0118
Echinococcus multilocularis acetylcholinesterase 0.007 0.0056 0.0092
Echinococcus granulosus carboxylesterase 5A 0.007 0.0056 0.0094
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0251 0.0283 0.0471
Echinococcus granulosus rhodopsin orphan GPCR 0.0082 0.0071 0.0118
Brugia malayi hypothetical protein 0.0082 0.0071 0.0127
Schistosoma mansoni biogenic amine receptor 0.0082 0.0071 0.0069
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.046 0.0543 0.0542
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0017 0.0038
Brugia malayi Variant SH3 domain containing protein 0.003 0.0007 0.001
Schistosoma mansoni hypothetical protein 0.0124 0.0124 0.0122
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0082 0.0071 0.0069
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0046 0.0026 0.0025
Brugia malayi Src substrate cortactin 0.003 0.0007 0.001
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0159 0.0167 0.1276
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.2089 0.258 1
Schistosoma mansoni adenoreceptor 0.0082 0.0071 0.0069
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.001
Echinococcus granulosus cathepsin b 0.0133 0.0135 0.0225
Onchocerca volvulus Putative cortactin 0.003 0.0007 0.0098
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0049 0.003 0.0198
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.007 0.0056 0.0055
Echinococcus granulosus acetylcholinesterase 0.007 0.0056 0.0094
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0754 0.0911 0.1524
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0205 0.0225 0.041
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.0198 0.0217 0.0815
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0121 0.012 0.0118
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0159 0.0167 0.0166
Brugia malayi Animal haem peroxidase family protein 0.0067 0.0053 0.0095
Brugia malayi PAS domain containing protein 0.0219 0.0243 0.0442
Loa Loa (eye worm) hypothetical protein 0.0116 0.0114 0.0206
Mycobacterium leprae Possible regulatory protein 0.0057 0.004 0.1898
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.014 0.0144 0.1154
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0113 0.011 0.0183
Brugia malayi Guanylate kinase family protein 0.0178 0.0191 0.0348
Echinococcus multilocularis c src tyrosine kinase 0.0051 0.0032 0.0052
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0057 0.004 0.0279
Giardia lamblia Proteasome subunit beta type 1 0.0121 0.012 0.0875
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0082 0.0071 0.0116
Loa Loa (eye worm) protein-tyrosine kinase 0.003 0.0007 0.001
Brugia malayi hypothetical protein 0.0107 0.0102 0.0185
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0049 0.003 0.0091
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0012 0.0011
Echinococcus granulosus puromycin sensitive aminopeptidase 0.014 0.0144 0.0241
Mycobacterium leprae probable zinc metalloprotease 0.0091 0.0083 0.4417
Echinococcus multilocularis fmrfamide receptor 0.0082 0.0071 0.0116
Echinococcus granulosus puromycin sensitive aminopeptidase 0.014 0.0144 0.0241
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0159 0.0167 0.0622
Loa Loa (eye worm) hypothetical protein 0.0435 0.0512 0.0936
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.7449 0.928 0.928
Schistosoma mansoni hypothetical protein 0.0082 0.0071 0.0069
Schistosoma mansoni tyrosine kinase 0.0113 0.011 0.0109
Loa Loa (eye worm) hypothetical protein 0.0069 0.0055 0.0098
Onchocerca volvulus 0.0435 0.0512 0.909
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.0049 0.003 0.0029
Loa Loa (eye worm) carboxylesterase 0.007 0.0056 0.01
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0435 0.0512 0.0936
Loa Loa (eye worm) hypothetical protein 0.086 0.1044 0.1911
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0082 0.0071 0.0069
Echinococcus granulosus somatostatin receptor 0.0082 0.0071 0.0118
Onchocerca volvulus 0.0049 0.003 0.0516
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0046 0.0027 0.0047
Echinococcus multilocularis endothelin converting enzyme 1 0.0091 0.0083 0.0137
Leishmania major ribonuclease H1, putative 0.0047 0.0027 0.0079
Loa Loa (eye worm) hypothetical protein 0.007 0.0056 0.01
Loa Loa (eye worm) replication factor A 73 kDa subunit 0.0036 0.0014 0.0023
Brugia malayi Peptidase family M1 containing protein 0.014 0.0144 0.0261
Brugia malayi Guanylate kinase family protein 0.004 0.0019 0.0032
Echinococcus granulosus g-protein coupled receptor 0.0082 0.0071 0.0118
Echinococcus granulosus endophilin A3 0.003 0.0007 0.0011
Schistosoma mansoni dreadlocks/dock 0.003 0.0007 0.0006
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0435 0.0512 0.0511
Echinococcus multilocularis neuropeptide FF receptor 2 0.0082 0.0071 0.0116
Brugia malayi sulfakinin receptor protein 0.0082 0.0071 0.0127
Schistosoma mansoni amine GPCR 0.0082 0.0071 0.0069
Plasmodium falciparum plasmepsin VII 0.046 0.0543 0.5904
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0251 0.0283 0.0281
Schistosoma mansoni peroxidasin 0.0067 0.0053 0.0052
Entamoeba histolytica hypothetical protein 0.0185 0.0199 1
Echinococcus granulosus neuropeptide Y receptor 0.0082 0.0071 0.0118
Echinococcus granulosus g protein coupled receptor 0.0082 0.0071 0.0118
Loa Loa (eye worm) lethal(1)discs large-1 tumor suppressor 0.0139 0.0142 0.0258
Echinococcus granulosus Niemann Pick C1 protein 0.086 0.1044 0.1748
Brugia malayi putative neuropeptide receptor NPR1 0.0082 0.0071 0.0127
Giardia lamblia Guanylate kinase 0.004 0.0019 0.0019
Echinococcus granulosus geminin 0.0148 0.0153 0.0257
Schistosoma mansoni peptidylglycine monooxygenase 0.0133 0.0135 0.0134
Echinococcus multilocularis endophilin A3 0.003 0.0007 0.0009
Echinococcus multilocularis protein dispatched 1 0.086 0.1044 0.1746
Echinococcus granulosus neuropeptide Y receptor 0.0082 0.0071 0.0118
Brugia malayi hypothetical protein 0.0185 0.0199 0.0363
Loa Loa (eye worm) animal heme peroxidase 0.0067 0.0053 0.0095
Echinococcus multilocularis fmrfamide receptor 0.0082 0.0071 0.0116
Echinococcus granulosus inhibitor of apoptosis protein 0.0435 0.0512 0.0857
Trypanosoma brucei ingi protein (ORF1) 0.0051 0.0032 0.0099
Entamoeba histolytica hypothetical protein 0.0185 0.0199 1
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0121 0.012 0.5851
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Schistosoma mansoni signal transducing adapter molecule (stam) 0.003 0.0007 0.0006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.0071 0.0069
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0036 0.0014 0.006
Echinococcus multilocularis rho guanine nucleotide exchange factor 7 0.003 0.0007 0.0009
Echinococcus granulosus alpha 1A adrenergic receptor 0.0082 0.0071 0.0118
Schistosoma mansoni aminopeptidase A (M01 family) 0.0049 0.003 0.0029
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0082 0.0071 0.0127
Schistosoma mansoni integrin alpha-ps 0.0034 0.0012 0.0011
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.0198 0.0217 0.0363
Toxoplasma gondii peptidase family M13 protein 0.0091 0.0083 0.0896
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.0198 0.0217 0.0395
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.4803 0.5972 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0082 0.0071 0.1234
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.0071 0.0069
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.046 0.0543 0.0542
Echinococcus multilocularis raf serine:threonine protein kinase 0.0042 0.0021 0.0034
Onchocerca volvulus 0.0082 0.0071 0.1234
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0082 0.0071 0.0116
Schistosoma mansoni hypothetical protein 0.0148 0.0153 0.0152
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0082 0.0071 0.0069
Brugia malayi Variant SH3 domain containing protein 0.0046 0.0027 0.0047
Loa Loa (eye worm) hypothetical protein 0.0045 0.0025 0.0044
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0017 0.0035
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0024 0.0039
Loa Loa (eye worm) glutaminase 2 0.0266 0.0301 0.055
Onchocerca volvulus Peroxidasin homolog 0.0067 0.0053 0.0921
Brugia malayi Pepsin A precursor 0.046 0.0543 0.0994
Echinococcus granulosus kelch ECH associated protein 1 like 0.0584 0.0698 0.1169
Loa Loa (eye worm) hypothetical protein 0.0133 0.0135 0.0244
Brugia malayi Eukaryotic aspartyl protease family protein 0.046 0.0543 0.0994
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0017 0.0169
Schistosoma mansoni amine GPCR 0.0082 0.0071 0.0069
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0057 0.004 0.0129
Toxoplasma gondii aminopeptidase n, putative 0.0049 0.003 0.0319
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.046 0.0543 0.0542
Echinococcus multilocularis fch and double sh3 domains protein 2 0.003 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0069 0.0055 0.0098
Schistosoma mansoni maguk P55 subfamily member 35 0.0049 0.003 0.0029
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0017 0.0031
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0051 0.0033 0.0101
Echinococcus granulosus g protein coupled receptor 0.0082 0.0071 0.0118
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.0198 0.0217 0.226
Loa Loa (eye worm) hypothetical protein 0.0069 0.0055 0.0098
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0057 0.004 0.0279
Echinococcus multilocularis GPCR, family 2 0.0205 0.0225 0.0375
Plasmodium falciparum plasmepsin IX 0.046 0.0543 0.5904
Echinococcus multilocularis ribonuclease H1 0.0047 0.0027 0.0043
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.2089 0.258 0.2579
Echinococcus multilocularis MAGUK p55 subfamily 0.0049 0.003 0.0049
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0017 0.0028
Loa Loa (eye worm) hypothetical protein 0.0067 0.0053 0.0095
Echinococcus granulosus 7TM GPCR rhodopsin 0.0082 0.0071 0.0118
Brugia malayi CHE-14 protein 0.086 0.1044 0.1911
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.0127
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0205 0.0225 0.0375
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0082 0.0071 0.0118
Mycobacterium ulcerans aminopeptidase N PepN 0.0049 0.003 0.0088
Plasmodium falciparum plasmepsin V 0.046 0.0543 0.5904
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.2089 0.258 1
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.0167 0.0178 0.0661
Toxoplasma gondii aminopeptidase N, putative 0.0049 0.003 0.0319
Echinococcus granulosus leukotriene A 4 hydrolase 0.0049 0.003 0.0051
Loa Loa (eye worm) hypothetical protein 0.0735 0.0887 0.1624
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.004 0.0279
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.2089 0.258 1
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.0167 0.0178 1

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 4400 nM Binding affinity against neurotensin receptor. ChEMBL. 7830267

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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