Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.007 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.007 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.007 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.007 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.007 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.007 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.007 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.007 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.007 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.007 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.007 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.007 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.007 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.007 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.007 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.007 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.007 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.007 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.007 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.007 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.007 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.007 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.007 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.007 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.007 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.007 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.007 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.007 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.007 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.007 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.007 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.007 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.007 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.007 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.007 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.007 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.007 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.007 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.007 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.007 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.007 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.007 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.007 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.007 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.007 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.007 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.007 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.007 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.007 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.007 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.007 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.007 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.007 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.007 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.007 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.007 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.007 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.007 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.5 | 0.5 |
Onchocerca volvulus | 0.007 | 0.5 | 0.5 | |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.007 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.007 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.007 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 62 uM | 50% cell death in uninfected MT-4 cells was determined using MTS cytoprotection assay | ChEMBL. | 11262081 |
CC50 (ADMET) | = 62 uM | Cytotoxicity of compound was tested as concentration required for 50% reduction in cellular viability in MT-4 cells | ChEMBL. | 11086716 |
CC50 (functional) | > 200 uM | 50% cell death in uninfected CEM-SS cells was determined using MTS cytoprotection assay | ChEMBL. | 11262081 |
CC50 (ADMET) | > 200 uM | Cytotoxicity of compound was tested as concentration required for 50% reduction in cellular viability in CEM-SS cells | ChEMBL. | 11086716 |
EC50 (functional) | > 62 uM | In vitro inhibition of cytopathic effect was determined against HIV-1 IIIB in MT-4 cells using MTS cytoprotection assay | ChEMBL. | 11262081 |
EC50 (functional) | > 62 uM | In vitro inhibition of cytopathic effect was determined against HIV-2 ROD in MT-4 cells using MTS cytoprotection assay | ChEMBL. | 11262081 |
EC50 (functional) | > 62 uM | Tested for inhibition of cytopathic effect of HIV-1 IIIB in MT-4 cells | ChEMBL. | 11086716 |
EC50 (functional) | > 62 uM | Tested for inhibition of cytopathic effect of HIV-2ROD in MT-4 cells | ChEMBL. | 11086716 |
EC50 (functional) | > 200 uM | In vitro inhibition of cytopathic effect was determined against HIV-1 RF in CEM-SS cells using MTS cytoprotection assay | ChEMBL. | 11262081 |
EC50 (functional) | > 200 uM | Tested for inhibition of cytopathic effect of HIV-1RF in CEM-SS cells | ChEMBL. | 11086716 |
IC50 (functional) | 0 uM | Compound was evaluated for the inhibition of RANTES-induced migration of human monocytes; NA : not active | ChEMBL. | 11140734 |
IC50 (functional) | 0 uM | Compound was evaluated for the inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants; NT : not tested | ChEMBL. | 11140734 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.