TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 603.368 | Formula: C17H27N5O15P2
H donors: 10 H acceptors: 14 LogP: -6.41 Rotable bonds: 9
Rule of 5 violations (Lipinski): 4
SMILES: OCC1OC(OP(=O)(CP(=O)(OCC2OC(C(C2O)O)n2cnc3c2nc(N)nc3O)O)O)C(C(C1O)O)O
InChi: 1S/C17H27N5O15P2/c18-17-20-13-7(14(29)21-17)19-3-22(13)15-11(27)9(25)6(35-15)2-34-38(30,31)4-39(32,33)37-16-12(28)10(26)8(24)5(1-23)36-16/h3,5-6,8-12,15-16,23-28H,1-2,4H2,(H,30,31)(H,32,33)(H3,18,20,21,29)
InChiKey: UYLZCJJDYVHKOV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	FHA domain containing protein, putative	0.0061	0.0178	0.1642
Echinococcus granulosus	tm gpcr rhodopsin	0.0028	0.0043	0.0049
Trypanosoma cruzi	adenosine monophosphate deaminase, putative	0.0275	0.1049	1
Echinococcus granulosus	zinc finger protein	0.0019	0.001	0.0012
Leishmania major	4-coumarate:coa ligase-like protein	0.0121	0.0422	0.1236
Onchocerca volvulus		0.0028	0.0043	0.0041
Trypanosoma cruzi	hypothetical protein, conserved	0.0076	0.024	0.2239
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0075	0.0205
Brugia malayi	Patched family protein	0.0024	0.0029	0.0061
Schistosoma mansoni	biogenic amine receptor	0.0028	0.0043	0.0049
Onchocerca volvulus		0.0028	0.0043	0.0041
Leishmania major	AMP deaminase, putative,adenosine monophosphate deaminase-like protein	0.0275	0.1049	0.3106
Echinococcus multilocularis	Protein lozenge	0.0112	0.0387	0.0387
Onchocerca volvulus		0.0028	0.0043	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Echinococcus granulosus	histone acetyltransferase MYST2	0.0058	0.0169	0.0192
Schistosoma mansoni	opsin-like receptor	0.0028	0.0043	0.0049
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0043	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.0073
Echinococcus multilocularis	adenosine deaminase	0.0845	0.3362	0.3362
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0076	0.024	0.0274
Schistosoma mansoni	neuropeptide f receptor 76f	0.0028	0.0043	0.0049
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0051	0.0051
Echinococcus multilocularis	transcription factor Dp 1	0.0081	0.0259	0.0259
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.0073
Echinococcus multilocularis	sterol regulatory element binding protein	0.0169	0.0619	0.0619
Brugia malayi	Niemann-Pick C1 protein precursor	0.0394	0.1534	0.4295
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0219	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0088	0.0243
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0144	0.0515	0.143
Brugia malayi	sulfakinin receptor protein	0.0028	0.0043	0.0102
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0028	0.0043	0.0049
Echinococcus granulosus	adenosine deaminase	0.0845	0.3362	0.3836
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0194	0.0721	0.196
Mycobacterium tuberculosis	PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0031	0.0055	0.0144
Echinococcus granulosus	transcription factor Dp 1	0.0081	0.0259	0.0296
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0017	0.0093
Schistosoma mansoni	bromodomain containing protein	0.0063	0.0186	0.0212
Schistosoma mansoni	acetyl-CoA synthetase	0.0035	0.0075	0.0086
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0035	0.0075	0.0656
Leishmania major	AMP deaminase, putative	0.0275	0.1049	0.3106
Echinococcus granulosus	g-protein coupled receptor	0.0028	0.0043	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.0073
Echinococcus granulosus	neuropeptides capa receptor	0.0028	0.0043	0.0049
Schistosoma mansoni	chromobox protein	0.0069	0.0212	0.0241
Brugia malayi	hypothetical protein	0.0894	0.3561	1
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0035	0.0075	0.0075
Brugia malayi	RE15519p	0.0028	0.0043	0.0102
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0085	0.0278	0.0807
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0184	0.021
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0121	0.0422	0.1236
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.014	0.0498	0.4713
Schistosoma mansoni	hypothetical protein	0.0316	0.1214	0.1385
Schistosoma mansoni	opsin-like receptor	0.0028	0.0043	0.0049
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0035	0.0075	0.0205
Brugia malayi	PHD-finger family protein	0.0025	0.0032	0.0069
Onchocerca volvulus		0.0076	0.024	0.0599
Echinococcus multilocularis	neuropeptide receptor	0.0028	0.0043	0.0043
Brugia malayi	Pre-SET motif family protein	0.0206	0.0768	0.2142
Echinococcus multilocularis	fmrfamide receptor	0.0028	0.0043	0.0043
Trichomonas vaginalis	conserved hypothetical protein	0.0061	0.0178	0.051
Trypanosoma cruzi	AMP deaminase, putative	0.0275	0.1049	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0121	0.0422	0.1236
Loa Loa (eye worm)	hypothetical protein	0.009	0.0298	0.083
Loa Loa (eye worm)	AMP deaminase	0.0275	0.1049	0.2941
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0028	0.0043	0.0049
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0036	0.0076	0.0076
Loa Loa (eye worm)	neuropeptide F receptor	0.0028	0.0043	0.0114
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0184	0.021
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Brugia malayi	adenosine monophosphate deaminase	0.0275	0.1049	0.2932
Brugia malayi	Pax transcription activation domain interacting protein	0.0061	0.0178	0.0481
Schistosoma mansoni	hypothetical protein	0.0163	0.0594	0.0678
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0028	0.0043	0.0049
Schistosoma mansoni	amine GPCR	0.0028	0.0043	0.0049
Echinococcus granulosus	histone lysine methyltransferase setb	0.0046	0.012	0.0137
Treponema pallidum	DNA ligase (lig)	0.0061	0.0178	0.051
Schistosoma mansoni	topbp1	0.0061	0.0178	0.0203
Trichomonas vaginalis	antibiotic synthetase, putative	0.0035	0.0075	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0076	0.024	0.0668
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0043	0.0049
Mycobacterium ulcerans	acyl-CoA synthetase	0.0035	0.0075	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Trypanosoma cruzi	AMP deaminase, putative	0.0275	0.1049	1
Brugia malayi	Patched family protein	0.0024	0.0029	0.0061
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0017	0.004
Brugia malayi	Bromodomain containing protein	0.0074	0.0233	0.0636
Entamoeba histolytica	AMP deaminase, putative	0.0275	0.1049	0.3106
Echinococcus multilocularis	Niemann Pick C1 protein	0.0394	0.1534	0.1534
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0088	0.0242
Loa Loa (eye worm)	hypothetical protein	0.007	0.0216	0.0599
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0206	0.0768	0.0876
Leishmania major	acetyl-CoA synthetase, putative	0.0035	0.0075	0.0204
Mycobacterium ulcerans	acyl-CoA synthetase	0.0035	0.0075	0.0204
Trichomonas vaginalis	conserved hypothetical protein	0.0061	0.0178	0.051
Leishmania major	AMP deaminase, putative,amp deaminase-like protein	0.0275	0.1049	0.3106
Mycobacterium tuberculosis	Probable lipase LipD	0.0076	0.024	0.0695
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0028	0.0043	0.0049
Mycobacterium ulcerans	beta-lactamase	0.0076	0.024	0.0695
Brugia malayi	Patched family protein	0.0024	0.0029	0.0061
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0035	0.0075	0.0204
Onchocerca volvulus		0.0028	0.0043	0.0041
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0184	0.021
Entamoeba histolytica	hypothetical protein	0.0115	0.0399	0.1167
Loa Loa (eye worm)	hypothetical protein	0.0207	0.0774	0.2167
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0035	0.0075	0.0656
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0047	0.0054
Schistosoma mansoni	microtubule-associated protein tau	0.2175	0.8765	1
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0121	0.0422	0.1236
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0178	0.0494
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0028	0.0043	0.0043
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0028	0.0043	0.0043
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0121	0.0422	0.1236
Onchocerca volvulus		0.0028	0.0043	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.0073
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0035	0.0075	0.0204
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0076	0.024	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0028	0.0043	0.0049
Trypanosoma cruzi	AMP deaminase, putative	0.0275	0.1049	1
Echinococcus multilocularis	chromobox protein 1	0.0069	0.0212	0.0212
Leishmania major	adenosine monophosphate deaminase, putative,AMP deaminase, putative	0.0275	0.1049	0.3106
Schistosoma mansoni	AMP deaminase	0.0275	0.1049	0.1197
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0028	0.0043	0.0049
Onchocerca volvulus		0.0148	0.0532	0.1425
Schistosoma mansoni	ap endonuclease	0.0019	0.0007	0.0008
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0007	0.0008
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0025	0.0055
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0028	0.0043	0.0102
Plasmodium falciparum	lipid/sterol:H+ symporter	0.0024	0.0029	0.0064
Brugia malayi	Patched family protein	0.0024	0.0029	0.0061
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0206	0.0768	0.2152
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0035	0.0075	0.0086
Brugia malayi	Dopamine receptor protein 2	0.0028	0.0043	0.0102
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0033	0.0064	0.0074
Mycobacterium ulcerans	acyl-CoA synthetase	0.0121	0.0422	0.1236
Echinococcus granulosus	neuropeptide receptor	0.0028	0.0043	0.0049
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0028	0.0043	0.0041
Onchocerca volvulus		0.0121	0.0422	0.1113
Trichomonas vaginalis	adenosine deaminase, putative	0.0845	0.3362	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Brugia malayi	Serotonin receptor	0.0028	0.0043	0.0102
Schistosoma mansoni	hypothetical protein	0.0033	0.0064	0.0074
Toxoplasma gondii	Adenosine/AMP deaminase domain-containing protein	0.0845	0.3362	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.0073
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0025	0.0055
Trypanosoma brucei	AMP deaminase, putative	0.0275	0.1049	1
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0121	0.0422	0.1236
Echinococcus granulosus	neuropeptide Y receptor	0.0028	0.0043	0.0049
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0103	0.0352	0.0981
Mycobacterium ulcerans	adenosine deaminase	0.0845	0.3362	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Schistosoma mansoni	hypothetical protein	0.0305	0.1169	0.1334
Onchocerca volvulus		0.0102	0.0345	0.0895
Brugia malayi	Patched family protein	0.0024	0.0029	0.0061
Brugia malayi	Myosin head containing protein	0.0024	0.0029	0.0061
Echinococcus granulosus	AMP deaminase 2	0.0275	0.1049	0.1197
Loa Loa (eye worm)	hypothetical protein	0.0894	0.3561	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.0073
Trypanosoma cruzi	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.0061	0.0178	0.1642
Echinococcus granulosus	hypothetical protein	0.0028	0.0043	0.0049
Schistosoma mansoni	lozenge	0.0112	0.0387	0.0441
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0043	0.0106
Trichomonas vaginalis	replication factor C large subunit, putative	0.0061	0.0178	0.051
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0076	0.024	0.0695
Trichomonas vaginalis	conserved hypothetical protein	0.0061	0.0178	0.051
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.014	0.0498	0.1382
Onchocerca volvulus		0.0035	0.0075	0.0133
Echinococcus multilocularis	microtubule associated protein 2	0.2175	0.8765	0.8765
Brugia malayi	CHE-14 protein	0.0169	0.0619	0.1722
Plasmodium vivax	acyl-CoA synthetase, putative	0.009	0.0298	0.0867
Loa Loa (eye worm)	hypothetical protein	0.0076	0.024	0.0668
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0028	0.0043	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0178	0.0494
Leishmania major	hypothetical protein, conserved	0.0076	0.024	0.0695
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.0073
Trypanosoma brucei	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.0061	0.0178	0.1642
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0028	0.0043	0.0049
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0047	0.0387
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0035	0.0075	0.0204
Toxoplasma gondii	patched family protein	0.0024	0.0029	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0725	0.2876	0.8074
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.0073
Onchocerca volvulus	Glucosylceramidase homolog	0.0183	0.0673	0.1823
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0028	0.0043	0.0049
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0169	0.0619	0.1732
Brugia malayi	hypothetical protein	0.0028	0.0043	0.0102
Onchocerca volvulus		0.0061	0.0178	0.0423
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0076	0.024	0.024
Brugia malayi	follicle stimulating hormone receptor	0.0028	0.0043	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.0073
Loa Loa (eye worm)	MBCTL1	0.0058	0.0169	0.0467
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.0017	0.0029
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0028	0.0043	0.0049
Trichomonas vaginalis	glucosylceramidase, putative	0.0183	0.0673	0.1984
Mycobacterium ulcerans	acyl-CoA synthetase	0.0035	0.0075	0.0204
Brugia malayi	hypothetical protein	0.0028	0.0043	0.0102
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0144	0.0515	0.0515
Echinococcus multilocularis	AMP deaminase 2	0.0275	0.1049	0.1049
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0035	0.0075	0.0204
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0041	0.0097	0.0111
Trichomonas vaginalis	chromobox protein, putative	0.0069	0.0212	0.061
Trichomonas vaginalis	D-aminoacylase, putative	0.0076	0.024	0.0695
Mycobacterium tuberculosis	Conserved protein	0.0076	0.024	0.0695
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0035	0.0075	0.0204
Trichomonas vaginalis	adenosine deaminase, putative	0.0845	0.3362	1
Plasmodium falciparum	importin beta, putative	0.0029	0.0047	0.012
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Entamoeba histolytica	hypothetical protein	0.0115	0.0399	0.1167
Echinococcus granulosus	neuropeptides capa receptor	0.0028	0.0043	0.0049
Brugia malayi	Dopamine receptor	0.0028	0.0043	0.0102
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0028	0.0043	0.0043
Echinococcus granulosus	sterol regulatory element binding protein	0.0169	0.0619	0.0706
Schistosoma mansoni	transcription factor LCR-F1	0.0115	0.0399	0.0455
Loa Loa (eye worm)	hypothetical protein	0.057	0.2245	0.63
Onchocerca volvulus		0.003	0.0055	0.0073
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0043	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0169	0.0619	0.1732
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Brugia malayi	Melatonin receptor type 1A	0.0028	0.0043	0.0102
Schistosoma mansoni	adenosine deaminase	0.0845	0.3362	0.3836
Loa Loa (eye worm)	patched family protein	0.0024	0.0029	0.0073
Loa Loa (eye worm)	patched family protein	0.0024	0.0029	0.0073
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.009	0.0298	1
Plasmodium falciparum	AMP deaminase, putative	0.0275	0.1049	0.3106
Mycobacterium leprae	PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])	0.0061	0.0178	0.0312
Leishmania major	acetyl-CoA synthetase, putative	0.0035	0.0075	0.0204
Echinococcus multilocularis	fmrfamide receptor	0.0028	0.0043	0.0043
Brugia malayi	Patched family protein	0.0024	0.0029	0.0061
Onchocerca volvulus		0.0028	0.0043	0.0041
Echinococcus granulosus	g protein coupled receptor	0.0028	0.0043	0.0049
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0035	0.0075	0.0192
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0028	0.0043	0.0041
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0043	0.0049
Echinococcus granulosus	SAM and MBT domain containing protein	0.0051	0.014	0.016
Loa Loa (eye worm)	PHD-finger family protein	0.002	0.0014	0.0034
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0043	0.0049
Brugia malayi	AMP-binding enzyme family protein	0.0035	0.0075	0.0192
Onchocerca volvulus		0.0028	0.0043	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Toxoplasma gondii	patched family protein	0.0024	0.0029	0.0064
Brugia malayi	beta-lactamase	0.0076	0.024	0.0656
Trichomonas vaginalis	antibiotic synthetase, putative	0.0035	0.0075	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.0073
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0025	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.0073
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.0061	0.0178	0.051
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0043	0.0049
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0025	0.0055
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0022	0.0022	0.0022
Onchocerca volvulus		0.0275	0.1049	0.2889
Brugia malayi	chromobox protein homolog 3	0.0039	0.0088	0.0229
Echinococcus multilocularis	expressed conserved protein	0.0371	0.1436	0.1436
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0028	0.0043	0.0102
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0028	0.0043	0.0043
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0042	0.01	0.0203
Leishmania major	adenine aminohydrolase	0.0845	0.3362	1
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0017	0.0029
Trypanosoma brucei	adenosine monophosphate deaminase, putative	0.0275	0.1049	1
Onchocerca volvulus		0.0051	0.014	0.0315
Brugia malayi	hypothetical protein	0.0028	0.0043	0.0102
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0035	0.0075	0.0656
Schistosoma mansoni	neuropeptide receptor	0.0028	0.0043	0.0049
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0043	0.0043
Onchocerca volvulus		0.0028	0.0043	0.0041
Trichomonas vaginalis	chromobox protein, putative	0.0042	0.01	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0064	0.0174
Echinococcus granulosus	somatostatin receptor	0.0028	0.0043	0.0049
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0035	0.0075	0.0204
Mycobacterium ulcerans	peptide synthetase Nrp (peptide synthase)	0.0035	0.0075	0.0204
Echinococcus granulosus	microtubule associated protein 2	0.2175	0.8765	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0043	0.0043
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0085	0.0278	0.0807
Trypanosoma cruzi	adenosine monophosphate deaminase-like protein, putative	0.0275	0.1049	1
Mycobacterium ulcerans	bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase	0.0035	0.0075	0.0204
Trypanosoma brucei	AMP deaminase, putative	0.0275	0.1049	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0028	0.0043	0.0043
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0184	0.021
Onchocerca volvulus		0.0028	0.0043	0.0041
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0148	0.0532	0.1477
Loa Loa (eye worm)	patched family protein	0.0024	0.0029	0.0073
Brugia malayi	AMP-binding enzyme family protein	0.0121	0.0422	0.1167
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0305	0.1169	0.3278
Brugia malayi	G-protein coupled receptor	0.0028	0.0043	0.0102
Onchocerca volvulus		0.0028	0.0043	0.0041
Trichomonas vaginalis	glucosylceramidase, putative	0.0192	0.0713	0.2103
Trichomonas vaginalis	D-aminoacylase, putative	0.0076	0.024	0.0695
Echinococcus granulosus	fmrfamide receptor	0.0028	0.0043	0.0049
Schistosoma mansoni	hypothetical protein	0.0163	0.0594	0.0678
Trichomonas vaginalis	D-aminoacylase, putative	0.0076	0.024	0.0695
Schistosoma mansoni	opsin-like receptor	0.0028	0.0043	0.0049
Echinococcus granulosus	Protein patched homolog 1	0.0169	0.0619	0.0706
Echinococcus granulosus	neuropeptide Y receptor	0.0028	0.0043	0.0049
Echinococcus granulosus	tm gpcr rhodopsin	0.0028	0.0043	0.0049
Leishmania major	hypothetical protein, conserved	0.0275	0.1049	0.3106
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0184	0.021
Brugia malayi	G protein-coupled receptor	0.0028	0.0043	0.0102
Mycobacterium ulcerans	O-succinylbenzoic acid--CoA ligase	0.0035	0.0075	0.0204
Brugia malayi	hypothetical protein	0.0028	0.0043	0.0102
Schistosoma mansoni	hypothetical protein	0.0033	0.0064	0.0074
Plasmodium falciparum	acyl-CoA synthetase	0.009	0.0298	0.0867
Schistosoma mansoni	DNA ligase IV	0.0061	0.0178	0.0203
Mycobacterium ulcerans	acyl-CoA synthetase	0.0035	0.0075	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Schistosoma mansoni	neuropeptide receptor	0.0028	0.0043	0.0049
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0103	0.0352	0.097
Echinococcus granulosus	tar DNA binding protein	0.0062	0.0184	0.021
Echinococcus granulosus	biogenic amine 5HT receptor	0.0028	0.0043	0.0049
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0007	0.0007
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0046	0.012	0.012
Onchocerca volvulus	AMP deaminase 2 homolog	0.0275	0.1049	0.2889
Onchocerca volvulus		0.0028	0.0043	0.0041
Entamoeba histolytica	hypothetical protein	0.0023	0.0025	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.0073
Loa Loa (eye worm)	patched family protein	0.0024	0.0029	0.0073
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0035	0.0075	0.0656
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.0073
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0035	0.0075	0.0656
Entamoeba histolytica	adenosine deaminase, putative	0.0845	0.3362	1
Echinococcus multilocularis	g-protein coupled receptor	0.0028	0.0043	0.0043
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0401	0.1558	0.1778
Loa Loa (eye worm)	G-protein coupled receptor	0.0028	0.0043	0.0114
Loa Loa (eye worm)	oxidoreductase	0.0035	0.0075	0.0205
Mycobacterium ulcerans	acyl-CoA synthetase	0.0121	0.0422	0.1236
Echinococcus granulosus	tm gpcr rhodopsin	0.0028	0.0043	0.0049
Mycobacterium tuberculosis	Probable adenosine deaminase Add (adenosine aminohydrolase)	0.0845	0.3362	1
Brugia malayi	hypothetical protein	0.0028	0.0043	0.0102
Brugia malayi	AMP-binding enzyme family protein	0.0035	0.0075	0.0192
Schistosoma mansoni	neuropeptide receptor	0.0028	0.0043	0.0049
Trichomonas vaginalis	glucosylceramidase, putative	0.0192	0.0713	0.2103
Schistosoma mansoni	neuropeptide F-like receptor	0.0028	0.0043	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.0073
Echinococcus multilocularis	G protein coupled receptor 139	0.0028	0.0043	0.0043
Toxoplasma gondii	AMP deaminase	0.0275	0.1049	0.3106
Loa Loa (eye worm)	hypothetical protein	0.0076	0.024	0.0668
Echinococcus granulosus	7tm_1 domain containing protein	0.0028	0.0043	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0422	0.1178
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0085	0.0278	0.0807
Brugia malayi	Adenosine/AMP deaminase family protein	0.0845	0.3362	0.944
Entamoeba histolytica	adenosine deaminase, putative	0.0845	0.3362	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0028	0.0043	0.0114
Mycobacterium ulcerans	acyl-CoA synthetase	0.0035	0.0075	0.0204
Echinococcus multilocularis	polycomb protein SCMH1	0.0051	0.014	0.014
Echinococcus granulosus	dro:myosuppressin receptor	0.0028	0.0043	0.0049
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.014	0.0498	0.4713
Brugia malayi	neuropeptide F receptor	0.0028	0.0043	0.0102
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0035	0.0075	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0076	0.024	0.0668
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0028	0.0043	0.0043
Brugia malayi	latrophilin 2 splice variant baaae	0.0071	0.0219	0.0596
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Loa Loa (eye worm)	mbt repeat family protein	0.0051	0.014	0.0386
Onchocerca volvulus		0.0028	0.0043	0.0041
Brugia malayi	GnHR receptor homolog	0.0028	0.0043	0.0102
Toxoplasma gondii	patched family protein	0.0024	0.0029	0.0064
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.0061	0.0178	0.051
Mycobacterium leprae	Probable lipase LipE	0.0076	0.024	0.0502
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0028	0.0043	0.0114
Brugia malayi	topoisomerase	0.0061	0.0178	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Schistosoma mansoni	sex comb on midleg homolog	0.0051	0.014	0.016
Echinococcus granulosus	G protein coupled receptor 139	0.0028	0.0043	0.0049
Brugia malayi	G protein-coupled receptor F59B2.13	0.0028	0.0043	0.0102
Trichomonas vaginalis	ran, putative	0.0021	0.0017	0.0029
Brugia malayi	G-protein coupled receptor	0.0028	0.0043	0.0102
Echinococcus granulosus	beta LACTamase domain containing family member	0.0076	0.024	0.0274
Onchocerca volvulus		0.0035	0.0075	0.0133
Trypanosoma cruzi	AMP deaminase, putative	0.0275	0.1049	1
Schistosoma mansoni	patched 1	0.0169	0.0619	0.0706
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Loa Loa (eye worm)	TYRA-2 protein	0.0028	0.0043	0.0114
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	0.0035	0.0075	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.0073
Entamoeba histolytica	hypothetical protein	0.0061	0.0178	0.051
Echinococcus granulosus	replication factor c subunit 1	0.0061	0.0178	0.0203
Loa Loa (eye worm)	hypothetical protein	0.057	0.2245	0.63
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0046	0.012	0.0137
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0028	0.0043	0.0043
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0051	0.014	0.014
Echinococcus multilocularis	Niemann Pick C1 protein	0.0564	0.2221	0.2221
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0115	0.0399	0.0399
Schistosoma mansoni	amine GPCR	0.0028	0.0043	0.0049
Brugia malayi	beta-lactamase family protein	0.0076	0.024	0.0656
Giardia lamblia	Replication factor C, subunit 1	0.0061	0.0178	1
Brugia malayi	Patched family protein	0.0024	0.0029	0.0061
Brugia malayi	protein C24B5.3	0.0024	0.0029	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0047	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Echinococcus granulosus	g protein coupled receptor	0.0028	0.0043	0.0049
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0028	0.0043	0.0043
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.014	0.0498	0.1393
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Trichomonas vaginalis	conserved hypothetical protein	0.0169	0.0619	0.1824
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.009	0.0298	0.0867
Echinococcus granulosus	GPCR family 2	0.0033	0.0064	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0086	0.0234
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0076	0.024	0.0656
Echinococcus multilocularis	orexin receptor type 2	0.0028	0.0043	0.0043
Trichomonas vaginalis	glucosylceramidase, putative	0.0278	0.1061	0.3141
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0017	0.0019
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0028	0.0043	0.0049
Brugia malayi	RNA, U transporter 1	0.0081	0.0261	0.0715
Echinococcus multilocularis	serotonin receptor	0.0028	0.0043	0.0043
Trypanosoma cruzi	AMP deaminase, putative	0.0275	0.1049	1
Plasmodium vivax	adenosine/AMP deaminase, putative	0.0275	0.1049	0.3106
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0028	0.0043	0.0043
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0059	0.0171	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Brugia malayi	Pre-SET motif family protein	0.003	0.0051	0.0125
Echinococcus granulosus	neuropeptide receptor A26	0.0028	0.0043	0.0049
Schistosoma mansoni	sex comb on midleg homolog	0.0051	0.014	0.016
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.0061	0.0178	0.051
Mycobacterium tuberculosis	Conserved protein	0.0076	0.024	0.0695
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0028	0.0043	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0028	0.0043	0.0043
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0035	0.0075	0.0205
Leishmania major	long-chain-fatty-acid-CoA ligase, putative	0.0035	0.0075	0.0204
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0278	0.1061	0.2975
Toxoplasma gondii	Adenosine/AMP deaminase domain-containing protein	0.0845	0.3362	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Mycobacterium ulcerans	hypothetical protein	0.0121	0.0422	0.1236
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0028	0.0043	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Brugia malayi	AKH receptor	0.0028	0.0043	0.0102
Brugia malayi	mbt repeat family protein	0.0051	0.014	0.0374
Brugia malayi	Heterochromatin protein 1	0.0069	0.0212	0.0575
Echinococcus granulosus	polycomb protein SCMH1	0.0051	0.014	0.016
Schistosoma mansoni	biogenic amine receptor	0.0028	0.0043	0.0049
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0028	0.0043	0.0049
Echinococcus granulosus	snurportin 1	0.0305	0.1169	0.1334
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Schistosoma mansoni	amine GPCR	0.0028	0.0043	0.0049
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0058	0.0169	0.0192
Plasmodium vivax	patched family protein, putative	0.0024	0.0029	0.0064
Mycobacterium ulcerans	esterase/lipase LipP	0.0076	0.024	0.0695
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0039	0.0088	0.0169
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.014	0.0498	0.4713
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0028	0.0043	0.0049
Brugia malayi	neuropeptide F receptor	0.0028	0.0043	0.0102
Brugia malayi	hypothetical protein	0.0028	0.0043	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.0073
Entamoeba histolytica	hypothetical protein	0.0115	0.0399	0.1167
Echinococcus granulosus	7TM GPCR rhodopsin	0.0028	0.0043	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.0073
Entamoeba histolytica	acyl-coA synthetase, putative	0.0121	0.0422	0.1236
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0035	0.0075	0.0204
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0043	0.0043
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0043	0.0043
Echinococcus multilocularis	neuropeptide receptor A26	0.0028	0.0043	0.0043
Echinococcus multilocularis	neuropeptides capa receptor	0.0028	0.0043	0.0043
Toxoplasma gondii	HEAT repeat-containing protein	0.0029	0.0047	0.012
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Echinococcus multilocularis	allatostatin A receptor	0.0028	0.0043	0.0043
Trichomonas vaginalis	glucosylceramidase, putative	0.0278	0.1061	0.3141
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0035	0.0075	0.0204
Onchocerca volvulus		0.0028	0.0043	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0845	0.3362	0.9441
Echinococcus granulosus	nibrin	0.0061	0.0178	0.0203
Onchocerca volvulus		0.0041	0.0097	0.0195
Plasmodium vivax	hypothetical protein, conserved	0.0076	0.024	0.0695
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.014	0.0498	0.1464
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0486	0.1905	0.5657
Loa Loa (eye worm)	hypothetical protein	0.057	0.2245	0.63
Echinococcus multilocularis	somatostatin receptor	0.0028	0.0043	0.0043
Echinococcus multilocularis	protein dispatched 1	0.0193	0.0716	0.0716
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0028	0.0043	0.0049
Plasmodium falciparum	replication factor C subunit 1, putative	0.0061	0.0178	0.051
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0075	0.0205
Echinococcus multilocularis	neuropeptide s receptor	0.0028	0.0043	0.0043
Brugia malayi	hypothetical protein	0.0024	0.0029	0.0061
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0076	0.024	0.0695
Mycobacterium ulcerans	acetyl-CoA synthetase	0.0035	0.0075	0.0204
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0017	0.0017
Schistosoma mansoni	hypothetical protein	0.0115	0.0399	0.0455
Echinococcus granulosus	orexin receptor type 2	0.0028	0.0043	0.0049
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0028	0.0043	0.0102
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0043	0.0043
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.014	0.0498	0.0498
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0022	0.0022	0.0025
Toxoplasma gondii	ABC1 family protein	0.0076	0.024	0.0695
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0035	0.0075	0.0204
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0043	0.0049
Schistosoma mansoni	importin beta-1	0.0029	0.0047	0.0054
Schistosoma mansoni	amine GPCR	0.0028	0.0043	0.0049
Brugia malayi	AMP-binding enzyme family protein	0.0121	0.0422	0.1167
Leishmania major	4-coumarate:coa ligase-like protein	0.0121	0.0422	0.1236
Plasmodium vivax	importin-beta 2, putative	0.0029	0.0047	0.012
Schistosoma mansoni	hypothetical protein	0.0033	0.0064	0.0074
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0028	0.0043	0.0049
Brugia malayi	hypothetical protein	0.0725	0.2876	0.8071
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0028	0.0043	0.0049
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0035	0.0075	0.0204
Echinococcus multilocularis	snurportin 1	0.0305	0.1169	0.1169
Loa Loa (eye worm)	hypothetical protein	0.003	0.0055	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Brugia malayi	RNA binding protein	0.0062	0.0184	0.0497
Echinococcus granulosus	sex peptide receptor	0.0028	0.0043	0.0049
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0028	0.0043	0.0049
Onchocerca volvulus		0.0028	0.0043	0.0041
Schistosoma mansoni	hypothetical protein	0.0028	0.0043	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Echinococcus granulosus	g protein coupled receptor	0.0028	0.0043	0.0049
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0088	0.0243
Onchocerca volvulus		0.0028	0.0043	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0894	0.3561	1
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0352	0.0981
Entamoeba histolytica	hypothetical protein	0.0115	0.0399	0.1167
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0121	0.0422	0.1236
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtE	0.0035	0.0075	0.0204
Echinococcus multilocularis	GPCR, family 2	0.0033	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0144	0.0515	0.0515
Trichomonas vaginalis	chromobox protein, putative	0.0042	0.01	0.0278
Loa Loa (eye worm)	G-protein coupled receptor	0.0028	0.0043	0.0114
Entamoeba histolytica	AMP deaminase, putative	0.0275	0.1049	0.3106
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0115	0.0399	0.0455
Mycobacterium leprae	conserved hypothetical protein	0.0076	0.024	0.0502
Trichomonas vaginalis	glucosylceramidase, putative	0.0183	0.0673	0.1984
Schistosoma mansoni	hypothetical protein	0.0163	0.0594	0.0678
Echinococcus multilocularis	tumor protein p63	0.0695	0.2756	0.2756
Loa Loa (eye worm)	hypothetical protein	0.057	0.2245	0.63
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0058	0.0169	0.0455
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.0184	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0178	0.0494
Trypanosoma brucei	AMP deaminase, putative	0.0275	0.1049	1
Loa Loa (eye worm)	RNA binding protein	0.0062	0.0184	0.051
Echinococcus multilocularis	protein patched	0.0169	0.0619	0.0619
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0028	0.0043	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Schistosoma mansoni	survival motor neuron protein	0.0148	0.0532	0.0607
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0061	0.0178	0.051
Brugia malayi	hypothetical protein	0.0024	0.0029	0.0061
Echinococcus granulosus	survival motor neuron protein 1	0.0725	0.2876	0.3281
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0169	0.0467
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.0061	0.0178	0.0481
Brugia malayi	Patched family protein	0.0024	0.0029	0.0061
Trichomonas vaginalis	set domain proteins, putative	0.0235	0.0884	0.2613
Trichomonas vaginalis	glucosylceramidase, putative	0.0183	0.0673	0.1984
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.0184	0.051
Mycobacterium ulcerans	acyl-CoA synthetase	0.0035	0.0075	0.0204
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0043	0.0049
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0033	0.0064	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Schistosoma mansoni	hypothetical protein	0.0071	0.0219	0.025
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0121	0.0422	0.1236
Loa Loa (eye worm)	patched family protein	0.0024	0.0029	0.0073
Echinococcus granulosus	biogenic amine 5HT receptor	0.0028	0.0043	0.0049
Brugia malayi	AMP-binding enzyme family protein	0.0035	0.0075	0.0192
Mycobacterium ulcerans	long-chain-acyl-CoA synthetase	0.0035	0.0075	0.0204
Brugia malayi	Patched family protein	0.0024	0.0029	0.0061
Trypanosoma cruzi	hypothetical protein, conserved	0.0076	0.024	0.2239
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0043	0.0049
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0028	0.0043	0.0049
Echinococcus multilocularis	survival motor neuron protein 1	0.0725	0.2876	0.2876
Loa Loa (eye worm)	hypothetical protein	0.009	0.0298	0.083
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0035	0.0075	0.0204
Toxoplasma gondii	ATPase, AAA family protein	0.0061	0.0178	0.051
Schistosoma mansoni	myosin xvIII	0.0028	0.0043	0.0049
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0061	0.0178	0.051
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.009	0.0298	0.0867
Brugia malayi	Patched related family protein 10	0.0024	0.0029	0.0061
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.014	0.0498	0.0568
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.0073
Trichomonas vaginalis	penicillin-binding protein, putative	0.0076	0.024	0.0695
Schistosoma mansoni	hypothetical protein	0.0033	0.0064	0.0074
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0144	0.0515	0.1441
Trichomonas vaginalis	glucosylceramidase, putative	0.0183	0.0673	0.1984
Schistosoma mansoni	ran	0.0021	0.0017	0.0019
Brugia malayi	Latrophilin receptor protein 2	0.0033	0.0064	0.0161
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0028	0.0043	0.0043
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0017	0.0029
Loa Loa (eye worm)	hypothetical protein	0.004	0.0095	0.0261
Echinococcus multilocularis	g protein coupled receptor	0.0028	0.0043	0.0043
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0076	0.024	0.0695
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.0073
Brugia malayi	Patched family protein	0.0024	0.0029	0.0061
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0028	0.0043	0.0049
Plasmodium vivax	adenosine deaminase, putative	0.0845	0.3362	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0144	0.0515	0.0588
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Onchocerca volvulus		0.0028	0.0043	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Echinococcus granulosus	allatostatin A receptor	0.0028	0.0043	0.0049
Loa Loa (eye worm)	hypothetical protein	0.009	0.0298	0.083
Onchocerca volvulus	Adenosine deaminase homolog	0.0845	0.3362	0.9436
Schistosoma mansoni	hypothetical protein	0.0028	0.0043	0.0049
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0043	0.0049
Brugia malayi	Importin beta-1 subunit	0.0029	0.0047	0.0113
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0033	0.0064	0.0064
Onchocerca volvulus		0.0035	0.0075	0.0133
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0035	0.0075	0.0204
Schistosoma mansoni	neuropeptide F-like receptor	0.0028	0.0043	0.0049
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0076	0.024	0.0695
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0043	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.0073
Brugia malayi	TAR-binding protein	0.0062	0.0184	0.0497
Echinococcus granulosus	fetal alzheimer antigen falz	0.0022	0.0022	0.0025
Mycobacterium ulcerans	lipase LipD	0.0076	0.024	0.0695
Mycobacterium ulcerans	phenyloxazoline synthase MbtB	0.0035	0.0075	0.0204
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0043	0.0049
Trypanosoma cruzi	hypothetical protein, conserved	0.0061	0.0178	0.1642
Echinococcus multilocularis	neuropeptide Y receptor	0.0028	0.0043	0.0043
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0121	0.0422	0.1054
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.0073
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0033	0.0064	0.0174
Echinococcus multilocularis	sex peptide receptor	0.0028	0.0043	0.0043
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0043	0.0049
Echinococcus multilocularis	dro:myosuppressin receptor	0.0028	0.0043	0.0043
Brugia malayi	Dopamine receptor protein 1	0.0028	0.0043	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0275	0.1049	0.2941
Echinococcus multilocularis	replication factor c subunit 1	0.0061	0.0178	0.0178
Echinococcus multilocularis	nibrin	0.0061	0.0178	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Loa Loa (eye worm)	runx1	0.0112	0.0387	0.108
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0033	0.0064	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.0073
Trichomonas vaginalis	glucosylceramidase, putative	0.0183	0.0673	0.1984
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0178	0.0494
Echinococcus multilocularis	neuropeptides capa receptor	0.0028	0.0043	0.0043
Echinococcus granulosus	neuropeptide receptor	0.0028	0.0043	0.0049
Echinococcus granulosus	importin subunit beta 1	0.0029	0.0047	0.0054
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0033	0.0064	0.0064
Schistosoma mansoni	growth hormone secretagogue receptor	0.0028	0.0043	0.0049
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0144	0.0515	0.0588
Onchocerca volvulus		0.0035	0.0075	0.0133
Mycobacterium leprae	Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE)	0.0845	0.3362	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0178	0.0494
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0043	0.0049
Brugia malayi	hypothetical protein	0.0028	0.0043	0.0102
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0051	0.0059
Echinococcus granulosus	Niemann Pick C1 protein	0.0564	0.2221	0.2534
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.0061	0.0178	0.051
Brugia malayi	Patched related family protein 12	0.0024	0.0029	0.0061
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0028	0.0043	0.0049
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0035	0.0075	0.0192
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0058	0.0169	0.0169
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0028	0.0043	0.0043
Plasmodium falciparum	adenosine deaminase	0.0845	0.3362	1
Mycobacterium tuberculosis	Probable hydrolase	0.0076	0.024	0.0695
Mycobacterium ulcerans	NAD-dependent DNA ligase LigA	0.0061	0.0178	0.051
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0121	0.0422	0.1236
Mycobacterium tuberculosis	Probable esterase LipL	0.0076	0.024	0.0695
Echinococcus multilocularis	chromobox protein 1	0.0069	0.0212	0.0212
Schistosoma mansoni	hypothetical protein	0.002	0.0014	0.0016
Brugia malayi	hypothetical protein	0.0024	0.0029	0.0061
Trichomonas vaginalis	penicillin-binding protein, putative	0.0076	0.024	0.0695
Echinococcus multilocularis	serotonin receptor	0.0028	0.0043	0.0043
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.014	0.0498	0.1464
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0085	0.0278	0.0807
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Schistosoma mansoni	amine GPCR	0.0028	0.0043	0.0049
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0103	0.0352	0.097
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0035	0.0075	0.0656
Leishmania major	GTP-binding protein, putative	0.0021	0.0017	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.0073
Schistosoma mansoni	ap endonuclease	0.0019	0.0007	0.0008
Brugia malayi	beta-lactamase family protein	0.0076	0.024	0.0656
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.0073
Trichomonas vaginalis	conserved hypothetical protein	0.0061	0.0178	0.051
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0103	0.0282
Plasmodium vivax	SET domain protein, putative	0.003	0.0051	0.0132
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0021	0.0017	0.0568
Loa Loa (eye worm)	hypothetical protein	0.0076	0.024	0.0668
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0278	0.1061	0.2966
Toxoplasma gondii	hypothetical protein	0.0024	0.0029	0.0064
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0028	0.0043	0.0049
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtF	0.0035	0.0075	0.0204
Brugia malayi	Serotonin receptor	0.0028	0.0043	0.0102
Echinococcus multilocularis	g protein coupled receptor	0.0028	0.0043	0.0043
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.0073
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0028	0.0043	0.0043
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0035	0.0075	0.0204
Trichomonas vaginalis	glucosylceramidase, putative	0.0278	0.1061	0.3141
Brugia malayi	Patched related family protein 4	0.0024	0.0029	0.0061
Brugia malayi	Bromodomain containing protein	0.0038	0.0085	0.0221
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0028	0.0043	0.0043
Brugia malayi	N-terminal motif family protein	0.0194	0.0721	0.2009
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0178	0.0494
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.0073
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0144	0.0515	0.0588
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0028	0.0043	0.0102
Toxoplasma gondii	propionate-CoA ligase	0.0035	0.0075	0.0204
Mycobacterium tuberculosis	Probable lipase LipE	0.0076	0.024	0.0695
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0028	0.0043	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0051	0.014	0.0386
Schistosoma mansoni	topbp1	0.0061	0.0178	0.0203
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0121	0.0422	0.1054
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0121	0.0422	0.1236
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0058	0.0169	0.0192
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0043	0.0043
Treponema pallidum	adenosine deaminase	0.0845	0.3362	1
Onchocerca volvulus		0.0235	0.0884	0.2421
Brugia malayi	ORL1-like opioid receptor	0.0028	0.0043	0.0102
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0047	0.0387
Brugia malayi	Patched protein homolog 1	0.0024	0.0029	0.0061
Wolbachia endosymbiont of Brugia malayi	NAD-dependent DNA ligase, Lig	0.0061	0.0178	1
Echinococcus multilocularis	g protein coupled receptor	0.0028	0.0043	0.0043
Brugia malayi	Patched family protein	0.0024	0.0029	0.0061
Brugia malayi	AMP-binding enzyme family protein	0.0035	0.0075	0.0192
Trypanosoma cruzi	hypothetical protein, conserved	0.0061	0.0178	0.1642
Brugia malayi	hypothetical protein	0.0115	0.0399	0.1102
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.014	0.0498	0.0568
Brugia malayi	hypothetical protein	0.0024	0.0029	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0046	0.012	0.033
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0394	0.1534	0.455
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.0073
Onchocerca volvulus		0.0076	0.024	0.0599
Trypanosoma cruzi	AMP deaminase 2, putative	0.0275	0.1049	1
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0206	0.0768	0.0768
Loa Loa (eye worm)	hypothetical protein	0.0076	0.024	0.0668
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0076	0.024	0.0668
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0007	0.0013
Schistosoma mansoni	chromobox protein	0.0069	0.0212	0.0241
Trichomonas vaginalis	chromobox protein, putative	0.0069	0.0212	0.061
Schistosoma mansoni	ran	0.0021	0.0017	0.0019
Echinococcus granulosus	Niemann Pick C1 protein	0.0394	0.1534	0.175
Brugia malayi	putative neuropeptide receptor	0.0028	0.0043	0.0102
Schistosoma mansoni	hypothetical protein	0.0028	0.0043	0.0049
Onchocerca volvulus		0.0028	0.0043	0.0041
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.0184	0.0497
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0043	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.0184	0.051
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0043	0.0049
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0046	0.012	0.0137
Trichomonas vaginalis	glucosylceramidase, putative	0.0278	0.1061	0.3141
Echinococcus granulosus	serotonin receptor	0.0028	0.0043	0.0049
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0028	0.0043	0.0049
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0043	0.0106
Brugia malayi	hypothetical protein	0.0028	0.0043	0.0102
Brugia malayi	hypothetical protein	0.0061	0.0178	0.0481
Loa Loa (eye worm)	neuropeptide F receptor	0.0028	0.0043	0.0114
Loa Loa (eye worm)	hypothetical protein	0.009	0.0298	0.083
Brugia malayi	AMP-binding enzyme family protein	0.0121	0.0422	0.1167
Schistosoma mansoni	histamine h1 receptor	0.0028	0.0043	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0394	0.1534	0.4302
Onchocerca volvulus		0.0894	0.3561	1
Onchocerca volvulus		0.0076	0.024	0.0599
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0035	0.0075	0.0204
Echinococcus multilocularis	zinc finger protein	0.0019	0.001	0.001
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0043	0.0043
Brugia malayi	hypothetical protein	0.0061	0.0178	0.0481
Loa Loa (eye worm)	melatonin receptor type 1A	0.0028	0.0043	0.0114
Echinococcus granulosus	chromobox protein 1	0.0069	0.0212	0.0241
Trichomonas vaginalis	glucosylceramidase, putative	0.0278	0.1061	0.3141
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0029	0.0073
Schistosoma mansoni	hypothetical protein	0.0148	0.0532	0.0607
Schistosoma mansoni	biogenic amine receptor	0.0028	0.0043	0.0049
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0028	0.0043	0.0043
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0058	0.0169	0.0169
Loa Loa (eye worm)	heterochromatin protein 1	0.0069	0.0212	0.0588
Mycobacterium ulcerans	acyl-CoA synthetase	0.0121	0.0422	0.1236
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0051	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0345	0.0962
Brugia malayi	Patched family protein	0.0024	0.0029	0.0061
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0025	0.0055
Brugia malayi	hypothetical protein	0.0028	0.0043	0.0102
Schistosoma mansoni	cellular tumor antigen P53	0.0102	0.0345	0.0393
Echinococcus granulosus	tumor protein p63	0.0695	0.2756	0.3144
Toxoplasma gondii	patched family protein	0.0024	0.0029	0.0064
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0017	0.0093
Echinococcus granulosus	neuropeptide s receptor	0.0028	0.0043	0.0049
Mycobacterium ulcerans	acyl-CoA synthetase	0.0035	0.0075	0.0204
Loa Loa (eye worm)	hypothetical protein	0.009	0.0298	0.083
Schistosoma mansoni	adenosine deaminase-related	0.0845	0.3362	0.3836
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0051	0.014	0.016
Trichomonas vaginalis	glucosylceramidase, putative	0.0183	0.0673	0.1984
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0028	0.0043	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0422	0.1178
Brugia malayi	putative neuropeptide receptor NPR1	0.0028	0.0043	0.0102
Trichomonas vaginalis	glucosylceramidase, putative	0.0278	0.1061	0.3141
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Echinococcus multilocularis	neuropeptide receptor	0.0028	0.0043	0.0043
Trichomonas vaginalis	esterase, putative	0.0076	0.024	0.0695
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0051	0.014	0.0315
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0028	0.0043	0.0049
Mycobacterium ulcerans	hypothetical protein	0.0076	0.024	0.0695
Echinococcus granulosus	expressed conserved protein	0.0371	0.1436	0.1639
Trichomonas vaginalis	glucosylceramidase, putative	0.0183	0.0673	0.1984
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0035	0.0075	0.0204
Schistosoma mansoni	hypothetical protein	0.0163	0.0594	0.0678
Brugia malayi	Patched family protein	0.0024	0.0029	0.0061
Brugia malayi	Patched family protein	0.0024	0.0029	0.0061
Brugia malayi	Patched family protein	0.0024	0.0029	0.0061
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0017	0.0027
Mycobacterium tuberculosis	Conserved protein	0.0076	0.024	0.0695
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0028	0.0043	0.0114
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0028	0.0043	0.0114
Schistosoma mansoni	adenoreceptor	0.0028	0.0043	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0422	0.1178
Trichomonas vaginalis	conserved hypothetical protein	0.0061	0.0178	0.051
Schistosoma mansoni	neuropeptide receptor	0.0028	0.0043	0.0049
Echinococcus granulosus	neuropeptide FF receptor 2	0.0028	0.0043	0.0049
Schistosoma mansoni	hypothetical protein	0.0028	0.0043	0.0049
Echinococcus granulosus	chromobox protein 1	0.0069	0.0212	0.0241
Echinococcus multilocularis	neuropeptide Y receptor	0.0028	0.0043	0.0043
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0017	0.0093
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0036	0.0076	0.0087
Trypanosoma brucei	hypothetical protein, conserved	0.0076	0.024	0.2239
Brugia malayi	mbt repeat family protein	0.0051	0.014	0.0374
Brugia malayi	protein C24B5.3	0.0024	0.0029	0.0061
Brugia malayi	DKFZp564C0469 protein	0.0061	0.0178	0.0481
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0043	0.0049
Entamoeba histolytica	Ran family GTPase	0.0021	0.0017	0.0029
Brugia malayi	hypothetical protein	0.0028	0.0043	0.0102
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0028	0.0043	0.0049
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0144	0.0515	0.0588
Mycobacterium ulcerans	acyl-CoA synthetase	0.0035	0.0075	0.0204
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0144	0.0515	0.0588
Schistosoma mansoni	chromosome transmission fidelity factor	0.0061	0.0178	0.0203
Brugia malayi	larval opioid receptor	0.0028	0.0043	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0043	0.0114
Plasmodium vivax	replication factor C subunit 1, putative	0.0061	0.0178	0.051
Loa Loa (eye worm)	beta-lactamase	0.0076	0.024	0.0668
Loa Loa (eye worm)	hypothetical protein	0.0194	0.0721	0.2019
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0059	0.0171	0.0171
Schistosoma mansoni	zinc finger protein	0.0019	0.001	0.0012

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	NA 0	In vitro antiviral activity of the compound was evaluated against vero cell lines infected with herpes simplex virus type-2; non toxic at concentrations as high as 50000 microM	ChEMBL.	3475472
Activity (functional)	NA 0	In vitro antiviral activity of the compound was evaluated against vero cell lines infected with Parainfluenza virus type 3; non toxic at concentrations as high as 50000 microM	ChEMBL.	3475472
Activity (functional)	NA 0	In vitro antiviral activity of the compound was evaluated against vero cell lines infected with adenovirus type 2; non toxic at concentrations as high as 50000 microM	ChEMBL.	3475472
Activity (functional)	NA 0	In vitro antiviral activity of the compound was evaluated against vero cell lines infected with rhino virus; non toxic at concentrations as high as 50000 microM	ChEMBL.	3475472
Activity (functional)	NA 0	In vitro antiviral activity of the compound was evaluated against vero cell lines infected with influenza virus; non toxic at concentrations as high as 50000 microM	ChEMBL.	3475472
Activity (functional)	NA 0	In vitro antiviral activity of the compound was evaluated against vero cell lines infected with visna virus; non toxic at concentrations as high as 50000 microM	ChEMBL.	3475472
Cytotoxiciy (functional)	None 0	In vitro antitumor activity of the compound was evaluated against L1210 leukemia cell lines; None = no activity	ChEMBL.	3475472
Cytotoxiciy (functional)	None 0	In vitro antitumor activity of the compound was evaluated against human B-lymphoblastic leukemia cell lines; None = no activity	ChEMBL.	3475472
Cytotoxiciy (functional)	None 0	In vitro antitumor activity of the compound was evaluated against human T-lymphoblastic leukemia cell lines; None = no activity	ChEMBL.	3475472
Km (binding)	Without significant activity 0 uM	Glycosyltransferase inhibitory activity of the compound was determined up to a concentration of 50 microg/mL; Without significant activity	ChEMBL.	3475472

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: 141650

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 40099