Detailed information for compound 401154

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1020.19 | Formula: C52H69N13O9
  • H donors: 12 H acceptors: 9 LogP: 1.38 Rotable bonds: 18
    Rule of 5 violations (Lipinski): 3
  • SMILES: CCCC[C@H](C(=O)N[C@@H]1CC(=O)NCCCC[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1ccccc1)Cc1ccccc1)CCCN=C(N)N)c1c[nH]c2c1cccc2)C(=O)N)NC(=O)C
  • InChi: 1S/C52H69N13O9/c1-3-4-21-38(59-31(2)66)46(69)64-42-29-43(67)56-25-14-13-23-37(45(53)68)60-51(74)44(35-30-58-36-22-12-11-20-34(35)36)65-47(70)39(24-15-26-57-52(54)55)61-48(71)40(27-32-16-7-5-8-17-32)62-49(72)41(63-50(42)73)28-33-18-9-6-10-19-33/h5-12,16-20,22,30,37-42,44,58H,3-4,13-15,21,23-29H2,1-2H3,(H2,53,68)(H,56,67)(H,59,66)(H,60,74)(H,61,71)(H,62,72)(H,63,73)(H,64,69)(H,65,70)(H4,54,55,57)/t37-,38-,39+,40-,41+,42+,44-/m0/s1
  • InChiKey: FKUIDHXQHASFMB-QVKYSVLBSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0305 0.0322
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Echinococcus granulosus neuropeptide receptor 0.012 0.2775 0.3302
Schistosoma mansoni biogenic amine receptor 0.012 0.2775 0.3536
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.012 0.2775 0.2747
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0014 0.0038 0.0067
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Echinococcus multilocularis expressed conserved protein 0.0046 0.0866 0.0831
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Schistosoma mansoni amine GPCR 0.012 0.2775 0.3536
Onchocerca volvulus 0.012 0.2775 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0037 0.0644 0.1568
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.012 0.2769 0.6745
Echinococcus granulosus Niemann Pick C1 protein 0.007 0.1479 0.1738
Loa Loa (eye worm) hypothetical protein 0.0057 0.1143 0.1994
Echinococcus multilocularis sex peptide receptor 0.012 0.2775 0.2747
Echinococcus multilocularis rhodopsin orphan GPCR 0.012 0.2775 0.2747
Schistosoma mansoni biogenic amine (dopamine) receptor 0.012 0.2775 0.3536
Schistosoma mansoni hypothetical protein 0.0162 0.3855 0.4911
Onchocerca volvulus 0.0048 0.0923 0.3232
Brugia malayi Serotonin receptor 0.012 0.2775 0.4805
Echinococcus multilocularis neuropeptide receptor A26 0.012 0.2775 0.2747
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0024 0.0305 0.0268
Echinococcus multilocularis rhodopsin orphan GPCR 0.012 0.2775 0.2747
Schistosoma mansoni hypothetical protein 0.0048 0.0923 0.1176
Schistosoma mansoni biogenic amine (dopamine) receptor 0.012 0.2775 0.3536
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0954 0.1216
Echinococcus multilocularis neuropeptide receptor 0.012 0.2775 0.2747
Schistosoma mansoni aryl hydrocarbon receptor 0.0026 0.0356 0.0454
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0079 0.1707 0.3816
Echinococcus granulosus lamin 0.0014 0.0059 0.0026
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.012 0.2769 0.6745
Echinococcus multilocularis rhodopsin orphan GPCR 0.012 0.2775 0.2747
Onchocerca volvulus 0.012 0.2775 1
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.012 0.2775 0.3536
Trichomonas vaginalis conserved hypothetical protein 0.0172 0.4105 1
Brugia malayi putative neuropeptide receptor NPR1 0.012 0.2775 0.4805
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.012 0.2775 0.484
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0105 0.2387 0.8419
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.012 0.2775 0.4805
Echinococcus granulosus biogenic amine 5HT receptor 0.012 0.2775 0.3302
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.012 0.2769 0.4431
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0079 0.1707 0.1675
Schistosoma mansoni adenoreceptor 0.012 0.2775 0.3536
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0024 0.0305 0.0201
Onchocerca volvulus Neuropeptide F receptor homolog 0.012 0.2775 1
Echinococcus multilocularis lamin dm0 0.0014 0.0059 0.0021
Brugia malayi larval opioid receptor 0.012 0.2775 0.4805
Loa Loa (eye worm) hypothetical protein 0.0014 0.0038 0.0067
Brugia malayi Pax transcription factor protein 2 0.0119 0.275 0.4761
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0021 0.0228 0.0397
Onchocerca volvulus 0.012 0.2775 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.012 0.2775 0.3536
Brugia malayi Serotonin receptor 0.012 0.2775 0.4805
Schistosoma mansoni hypothetical protein 0.0024 0.0304 0.0387
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0021 0.0228 0.0228
Brugia malayi hypothetical protein 0.012 0.2775 0.4805
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Schistosoma mansoni steroid hormone receptor ad4bp 0.0014 0.0038 0.0049
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.012 0.2775 0.3302
Onchocerca volvulus 0.012 0.2775 1
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.012 0.2769 0.2741
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0021 0.0228 0.0555
Echinococcus granulosus g protein coupled receptor 0.012 0.2775 0.3302
Echinococcus multilocularis fmrfamide receptor 0.012 0.2775 0.2747
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Echinococcus granulosus intermediate filament protein 0.0014 0.0059 0.0026
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.012 0.2769 0.6554
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0014 0.0038 0.0049
Loa Loa (eye worm) hypoxia-induced factor 1 0.008 0.1752 0.3056
Loa Loa (eye worm) transcription factor SMAD2 0.0059 0.1208 0.2107
Echinococcus multilocularis leucyl aminopeptidase 0.0021 0.0228 0.019
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.012 0.2769 0.3528
Loa Loa (eye worm) G-protein coupled receptor 0.012 0.2775 0.484
Schistosoma mansoni transcription factor LCR-F1 0.0018 0.0148 0.0188
Schistosoma mansoni biogenic amine (5HT) receptor 0.012 0.2775 0.3536
Schistosoma mansoni hypothetical protein 0.002 0.0208 0.0265
Schistosoma mansoni coup transcription factor 0.0014 0.0038 0.0049
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Echinococcus granulosus 7TM GPCR rhodopsin 0.012 0.2775 0.3302
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.012 0.2769 0.3528
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Echinococcus multilocularis alpha 1A adrenergic receptor 0.012 0.2775 0.2747
Loa Loa (eye worm) neuropeptide F receptor 0.012 0.2775 0.484
Echinococcus granulosus 7tm_1 domain containing protein 0.012 0.2775 0.3302
Echinococcus granulosus sterol regulatory element binding protein 0.0021 0.0227 0.0228
Schistosoma mansoni rhodopsin-like orphan GPCR 0.012 0.2775 0.3536
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0049 0.0942 0.2007
Loa Loa (eye worm) hypothetical protein 0.0079 0.1707 0.2977
Brugia malayi gonadotropin-releasing hormone receptor 2 0.012 0.2775 0.4805
Brugia malayi Peptidase family M1 containing protein 0.0019 0.0168 0.0228
Onchocerca volvulus Huntingtin homolog 0.0057 0.1143 0.4038
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.012 0.2769 0.5
Trypanosoma cruzi Aminopeptidase M1, putative 0.0019 0.0168 0.0409
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.0305 0.0268
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.012 0.2769 1
Onchocerca volvulus 0.012 0.2775 1
Echinococcus granulosus leucine aminopeptidase protein 0.0105 0.2387 0.2834
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.012 0.2769 0.6745
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0024 0.0305 0.0389
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Schistosoma mansoni hypothetical protein 0.012 0.2775 0.3536
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0021 0.0228 0.0151
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Brugia malayi CHE-14 protein 0.0021 0.0227 0.0332
Echinococcus multilocularis transfer RNA-Lys 0.0019 0.0183 0.0145
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0024 0.0305 0.0178
Schistosoma mansoni rhodopsin-like orphan GPCR 0.012 0.2775 0.3536
Echinococcus multilocularis tumor protein p63 0.0336 0.8327 0.832
Schistosoma mansoni growth hormone secretagogue receptor 0.012 0.2775 0.3536
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.0305 0.0268
Schistosoma mansoni hypothetical protein 0.002 0.0208 0.0265
Schistosoma mansoni lamin 0.0014 0.0059 0.0076
Echinococcus multilocularis rhodopsin orphan GPCR 0.012 0.2775 0.2747
Schistosoma mansoni neuropeptide receptor 0.012 0.2775 0.3536
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0079 0.1707 0.2977
Schistosoma mansoni opsin-like receptor 0.012 0.2775 0.3536
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.012 0.2775 0.2747
Schistosoma mansoni amine GPCR 0.012 0.2775 0.3536
Brugia malayi Dopamine receptor 0.012 0.2775 0.4805
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0014 0.0038 0.0049
Loa Loa (eye worm) hypothetical protein 0.0014 0.0038 0.0067
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.012 0.2775 0.3536
Echinococcus multilocularis g-protein coupled receptor 0.012 0.2775 0.2747
Echinococcus granulosus sex peptide receptor 0.012 0.2775 0.3302
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0037 0.0644 0.1568
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.012 0.2775 0.3536
Entamoeba histolytica hypothetical protein, conserved 0.0172 0.4105 1
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0172 0.4105 1
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.012 0.2769 0.3294
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0105 0.2387 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.012 0.2775 0.4805
Brugia malayi hypothetical protein 0.0019 0.0168 0.0228
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.012 0.2775 0.484
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.012 0.2775 0.4805
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0014 0.0038 0.0049
Echinococcus granulosus serotonin receptor 0.012 0.2775 0.3302
Schistosoma mansoni hypothetical protein 0.012 0.2775 0.3536
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0014 0.0059 0.0104
Loa Loa (eye worm) neuropeptide F receptor 0.012 0.2775 0.484
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0014 0.0038 0.0067
Loa Loa (eye worm) pax transcription factor protein 2 0.0119 0.275 0.4796
Brugia malayi hypothetical protein 0.012 0.2775 0.4805
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0041 0.0752 0.1253
Schistosoma mansoni neuropeptide f receptor 76f 0.012 0.2775 0.3536
Loa Loa (eye worm) melatonin receptor type 1A 0.012 0.2775 0.484
Brugia malayi hypothetical protein 0.0017 0.012 0.0143
Schistosoma mansoni hypothetical protein 0.012 0.2775 0.3536
Schistosoma mansoni rhodopsin-like orphan GPCR 0.012 0.2775 0.3536
Onchocerca volvulus 0.012 0.2775 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.012 0.2775 0.3536
Echinococcus multilocularis leucine aminopeptidase protein 0.0105 0.2387 0.2358
Schistosoma mansoni hypothetical protein 0.0162 0.3855 0.4911
Echinococcus granulosus dro:myosuppressin receptor 0.012 0.2775 0.3302
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0105 0.2387 0.289
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.012 0.2769 0.6554
Schistosoma mansoni opsin-like receptor 0.012 0.2775 0.3536
Echinococcus multilocularis sterol regulatory element binding protein 0.0021 0.0227 0.019
Echinococcus multilocularis rhodopsin orphan GPCR 0.012 0.2775 0.2747
Giardia lamblia Rrm3p helicase 0.0172 0.4105 1
Echinococcus multilocularis allatostatin A receptor 0.012 0.2775 0.2747
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0014 0.0038 0.0067
Onchocerca volvulus 0.0019 0.0183 0.053
Loa Loa (eye worm) hypothetical protein 0.0014 0.0038 0.0067
Echinococcus granulosus neuropeptide receptor A26 0.012 0.2775 0.3302
Schistosoma mansoni hypothetical protein 0.002 0.0208 0.0265
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.012 0.2769 0.3386
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0037 0.0644 0.1568
Brugia malayi hypothetical protein 0.0057 0.1143 0.194
Schistosoma mansoni alpha-1 adrenergic receptor 0.012 0.2775 0.3536
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0172 0.4105 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.012 0.2775 0.3536
Echinococcus granulosus neuropeptide Y receptor 0.012 0.2775 0.3302
Schistosoma mansoni retinoic acid receptor RXR 0.0014 0.0038 0.0049
Toxoplasma gondii leucyl aminopeptidase LAP 0.0105 0.2387 0.8419
Echinococcus granulosus leucyl aminopeptidase 0.0021 0.0228 0.0228
Loa Loa (eye worm) MH2 domain-containing protein 0.0059 0.1208 0.2107
Echinococcus multilocularis aminopeptidase N 0.0019 0.0168 0.013
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.012 0.2769 0.6623
Echinococcus granulosus aminopeptidase N 0.0019 0.0168 0.0156
Brugia malayi bHLH-PAS transcription factor 0.0019 0.0183 0.0254
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0014 0.0038 0.0049
Plasmodium falciparum M17 leucyl aminopeptidase 0.0105 0.2387 0.8419
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0078 0.1706 0.3905
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0105 0.2387 0.5637
Loa Loa (eye worm) hypothetical protein 0.0014 0.0053 0.0092
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0019 0.0168 0.0214
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0172 0.4105 1
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0172 0.4105 0.4083
Echinococcus granulosus fmrfamide receptor 0.012 0.2775 0.3302
Onchocerca volvulus 0.0019 0.0168 0.0474
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.5734 0.6872
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.012 0.2769 1
Brugia malayi hypoxia-induced factor 1 0.008 0.1752 0.3009
Echinococcus multilocularis neuropeptide Y receptor 0.012 0.2775 0.2747
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.012 0.2769 0.6745
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.012 0.2769 0.6745
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Schistosoma mansoni thyroid hormone receptor 0.0014 0.0038 0.0049
Schistosoma mansoni neuropeptide receptor 0.012 0.2775 0.3536
Echinococcus granulosus neuropeptide Y receptor 0.012 0.2775 0.3302
Loa Loa (eye worm) hypothetical protein 0.0014 0.0038 0.0067
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0078 0.1706 0.2002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0356 0.0621
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0079 0.1707 0.2014
Echinococcus multilocularis Niemann Pick C1 protein 0.0049 0.0942 0.0907
Onchocerca volvulus 0.012 0.2775 1
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0021 0.0228 0.0078
Schistosoma mansoni rhodopsin-like orphan GPCR 0.012 0.2775 0.3536
Brugia malayi cytosol aminopeptidase 0.0021 0.0228 0.0332
Brugia malayi hypothetical protein 0.012 0.2775 0.4805
Loa Loa (eye worm) hypothetical protein 0.0235 0.5734 1
Brugia malayi hypothetical protein 0.0018 0.0148 0.0192
Echinococcus granulosus neuropeptide FF receptor 2 0.012 0.2775 0.3302
Loa Loa (eye worm) TYRA-2 protein 0.012 0.2775 0.484
Schistosoma mansoni hypothetical protein 0.0018 0.0148 0.0188
Entamoeba histolytica aminopeptidase, putative 0.0024 0.0305 0.0398
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0172 0.4105 1
Echinococcus multilocularis g protein coupled receptor 0.012 0.2775 0.2747
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.012 0.2775 0.2747
Brugia malayi hypothetical protein 0.012 0.2775 0.4805
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.012 0.2775 0.484
Echinococcus multilocularis dro:myosuppressin receptor 0.012 0.2775 0.2747
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.5734 0.5718
Echinococcus multilocularis leucyl aminopeptidase 0.0021 0.0228 0.019
Echinococcus multilocularis fmrfamide receptor 0.012 0.2775 0.2747
Onchocerca volvulus 0.012 0.2775 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.012 0.2775 0.2747
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.012 0.2775 0.2747
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0083 0.1815 0.3165
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0018 0.0148 0.011
Loa Loa (eye worm) intermediate filament protein 0.0014 0.0059 0.0104
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.012 0.2775 0.3302
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0041 0.0752 0.1352
Onchocerca volvulus 0.0014 0.0059 0.0077
Echinococcus granulosus expressed conserved protein 0.0046 0.0866 0.0998
Brugia malayi GnHR receptor homolog 0.012 0.2775 0.4805
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Echinococcus granulosus g-protein coupled receptor 0.012 0.2775 0.3302
Echinococcus granulosus geminin 0.0162 0.3855 0.4604
Brugia malayi Dopamine receptor protein 2 0.012 0.2775 0.4805
Echinococcus multilocularis lamin 0.0014 0.0059 0.0021
Onchocerca volvulus 0.012 0.2775 1
Echinococcus granulosus tm gpcr rhodopsin 0.012 0.2775 0.3302
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0079 0.1707 0.3816
Loa Loa (eye worm) hypothetical protein 0.0057 0.1143 0.1994
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Loa Loa (eye worm) hypothetical protein 0.0087 0.1926 0.3358
Brugia malayi Intermediate filament tail domain containing protein 0.0014 0.0059 0.0037
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Schistosoma mansoni intermediate filament proteins 0.0014 0.0059 0.0076
Echinococcus granulosus somatostatin receptor 0.012 0.2775 0.3302
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0172 0.4105 0.5126
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0037 0.0644 0.1063
Loa Loa (eye worm) hypothetical protein 0.0014 0.0038 0.0067
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0172 0.4105 0.4907
Loa Loa (eye worm) hypothetical protein 0.0014 0.0038 0.0067
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0014 0.0038 0.0067
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.012 0.2769 0.6606
Echinococcus multilocularis neuropeptide receptor 0.012 0.2775 0.2747
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0021 0.0228 0.0151
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.012 0.2769 0.6623
Brugia malayi Serotonin/octopamine receptor family protein 7 0.012 0.2775 0.4805
Echinococcus granulosus neuropeptide s receptor 0.012 0.2775 0.3302
Echinococcus granulosus leucyl aminopeptidase 0.0021 0.0228 0.0228
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.012 0.2769 1
Brugia malayi AKH receptor 0.012 0.2775 0.4805
Echinococcus multilocularis neuropeptide s receptor 0.012 0.2775 0.2747
Echinococcus multilocularis somatostatin receptor 0.012 0.2775 0.2747
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0305 0.0322
Schistosoma mansoni hypothetical protein 0.0172 0.4105 0.523
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Trypanosoma cruzi aminopeptidase, putative 0.0024 0.0305 0.0743
Brugia malayi hypothetical protein 0.012 0.2775 0.4805
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Echinococcus granulosus lamin dm0 0.0014 0.0059 0.0026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0014 0.0038 0.0067
Echinococcus granulosus Niemann Pick C1 protein 0.0049 0.0942 0.109
Echinococcus multilocularis protein dispatched 1 0.0024 0.0303 0.0266
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0014 0.0038 0.0067
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.012 0.2769 0.3528
Echinococcus multilocularis G protein coupled receptor 139 0.012 0.2775 0.2747
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.012 0.2769 0.6554
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0305 0.0322
Brugia malayi hypothetical protein 0.012 0.2775 0.4805
Brugia malayi follicle stimulating hormone receptor 0.012 0.2775 0.4805
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.0305 0.0268
Onchocerca volvulus 0.0119 0.275 0.9908
Schistosoma mansoni neuropeptide receptor 0.012 0.2775 0.3536
Loa Loa (eye worm) steroid hormone receptor 0.0014 0.0038 0.0067
Schistosoma mansoni lamin 0.0014 0.0059 0.0076
Echinococcus granulosus thyrotropin releasing hormone receptor 0.012 0.2775 0.3302
Echinococcus granulosus G protein coupled receptor 139 0.012 0.2775 0.3302
Mycobacterium ulcerans aminopeptidase N PepN 0.0024 0.0305 0.0471
Echinococcus granulosus rhodopsin orphan GPCR 0.012 0.2775 0.3302
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.012 0.2775 0.2747
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Echinococcus granulosus rhodopsin orphan GPCR 0.012 0.2775 0.3302
Brugia malayi Melatonin receptor type 1A 0.012 0.2775 0.4805
Schistosoma mansoni rhodopsin-like orphan GPCR 0.012 0.2775 0.3536
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0038 0.0049
Onchocerca volvulus 0.012 0.2775 1
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0356 0.0244
Onchocerca volvulus 0.012 0.2775 1
Onchocerca volvulus 0.0019 0.0168 0.0474
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0021 0.0228 0.0332
Brugia malayi hypothetical protein 0.012 0.2775 0.4805
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.012 0.2769 1
Schistosoma mansoni amine GPCR 0.012 0.2775 0.3536
Echinococcus granulosus g protein coupled receptor 0.012 0.2775 0.3302
Schistosoma mansoni opsin-like receptor 0.012 0.2775 0.3536
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0105 0.2387 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.012 0.2775 0.2747
Loa Loa (eye worm) aminopeptidase N 0.0024 0.0305 0.0532
Onchocerca volvulus 0.012 0.2775 1
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.012 0.2769 0.3528
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0018 0.0148 0.0132
Schistosoma mansoni biogenic amine (dopamine) receptor 0.012 0.2775 0.3536
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.012 0.2769 1
Brugia malayi hypothetical protein 0.012 0.2775 0.4805
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.012 0.2769 0.3294
Echinococcus multilocularis leucyl aminopeptidase 0.0021 0.0228 0.019
Onchocerca volvulus 0.0014 0.0059 0.0077
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Onchocerca volvulus 0.012 0.2775 1
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.012 0.2775 0.3536
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0923 0.1553
Onchocerca volvulus Huntingtin homolog 0.0057 0.1143 0.4038
Echinococcus multilocularis rhodopsin orphan GPCR 0.012 0.2775 0.2747
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0024 0.0305 0.0201
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.012 0.2775 0.2747
Echinococcus multilocularis musashi 0.0014 0.0059 0.0021
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.012 0.2775 0.3302
Leishmania major hypothetical protein, conserved 0.0026 0.0356 0.0477
Echinococcus granulosus tachykinin peptides receptor 99D 0.012 0.2775 0.3302
Trypanosoma brucei RNA helicase, putative 0.0318 0.7849 1
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Schistosoma mansoni hypothetical protein 0.012 0.2775 0.3536
Echinococcus granulosus neuropeptide receptor 0.012 0.2775 0.3302
Brugia malayi Niemann-Pick C1 protein precursor 0.0049 0.0942 0.1586
Schistosoma mansoni hypothetical protein 0.0318 0.7849 1
Schistosoma mansoni hypothetical protein 0.002 0.0208 0.0265
Schistosoma mansoni neuropeptide receptor 0.012 0.2775 0.3536
Onchocerca volvulus 0.012 0.2775 1
Echinococcus granulosus rhodopsin orphan GPCR 0.012 0.2775 0.3302
Brugia malayi G protein-coupled receptor 0.012 0.2775 0.4805
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.012 0.2769 0.3386
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0021 0.0228 0.029
Echinococcus granulosus tm gpcr rhodopsin 0.012 0.2775 0.3302
Schistosoma mansoni amine GPCR 0.012 0.2775 0.3536
Echinococcus granulosus rhodopsin orphan GPCR 0.012 0.2775 0.3302
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0037 0.0644 0.1568
Schistosoma mansoni patched 1 0.0021 0.0227 0.029
Brugia malayi hypothetical protein 0.012 0.2775 0.4805
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0037 0.0644 0.1568
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0021 0.0228 0.0332
Echinococcus granulosus orexin receptor type 2 0.012 0.2775 0.3302
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.012 0.2775 0.2747
Echinococcus multilocularis neuropeptide FF receptor 2 0.012 0.2775 0.2747
Onchocerca volvulus 0.012 0.2775 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.012 0.2775 0.2747
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0172 0.4105 1
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.012 0.2769 0.6606
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0014 0.0038 0.0049
Echinococcus multilocularis serotonin receptor 0.012 0.2775 0.2747
Echinococcus multilocularis protein patched 0.0021 0.0227 0.019
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0356 0.0867
Schistosoma mansoni rhodopsin-like orphan GPCR 0.012 0.2775 0.3536
Brugia malayi G protein-coupled receptor F59B2.13 0.012 0.2775 0.4805
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.012 0.2775 0.484
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0083 0.1815 0.3165
Echinococcus multilocularis g protein coupled receptor 0.012 0.2775 0.2747
Loa Loa (eye worm) hypothetical protein 0.0026 0.0348 0.0607
Echinococcus multilocularis biogenic amine (5HT) receptor 0.012 0.2775 0.2747
Brugia malayi hypothetical protein 0.012 0.2775 0.4805
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.012 0.2769 0.6745
Echinococcus granulosus g protein coupled receptor 0.012 0.2775 0.3302
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.012 0.2775 1
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0172 0.4105 0.5126
Loa Loa (eye worm) hypothetical protein 0.0014 0.0038 0.0067
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0014 0.0038 0.0067
Brugia malayi hypothetical protein 0.0235 0.5734 1
Brugia malayi RE15519p 0.012 0.2775 0.4805
Schistosoma mansoni amine GPCR 0.012 0.2775 0.3536
Schistosoma mansoni survival motor neuron protein 0.0048 0.0923 0.1176
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.012 0.2769 0.6554
Echinococcus multilocularis neuropeptides capa receptor 0.012 0.2775 0.2747
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.012 0.2775 0.2747
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Brugia malayi G-protein coupled receptor 0.012 0.2775 0.4805
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Brugia malayi MH2 domain containing protein 0.0059 0.1208 0.2053
Brugia malayi neuropeptide F receptor 0.012 0.2775 0.4805
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0078 0.1706 0.4154
Echinococcus multilocularis geminin 0.0162 0.3855 0.3831
Echinococcus multilocularis Niemann Pick C1 protein 0.007 0.1479 0.1446
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.0305 0.0268
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0078 0.1706 0.4154
Schistosoma mansoni biogenic amine receptor 0.012 0.2775 0.3536
Onchocerca volvulus 0.0049 0.0954 0.3346
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0021 0.0228 0.0078
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0021 0.0228 0.0397
Brugia malayi PAS domain containing protein 0.0026 0.0356 0.0558
Brugia malayi hypothetical protein 0.0087 0.1926 0.3313
Entamoeba histolytica DNA repair and recombination protein, putative 0.0172 0.4105 1
Brugia malayi ORL1-like opioid receptor 0.012 0.2775 0.4805
Echinococcus multilocularis G-protein coupled receptor, putative 0.012 0.2775 0.2747
Brugia malayi putative neuropeptide receptor 0.012 0.2775 0.4805
Echinococcus granulosus rhodopsin orphan GPCR 0.012 0.2775 0.3302
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.0305 0.0268
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0024 0.0305 0.0743
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.012 0.2769 0.6745
Echinococcus granulosus tm gpcr rhodopsin 0.012 0.2775 0.3302
Echinococcus multilocularis rhodopsin orphan GPCR 0.012 0.2775 0.2747
Echinococcus granulosus rhodopsin orphan GPCR 0.012 0.2775 0.3302
Onchocerca volvulus 0.012 0.2775 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0305 0.0322
Echinococcus granulosus neuropeptides capa receptor 0.012 0.2775 0.3302
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0021 0.0227 0.0396
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.012 0.2769 0.2741
Loa Loa (eye worm) G-protein coupled receptor 0.012 0.2775 0.484
Schistosoma mansoni RAR-like nuclear receptor 0.0014 0.0038 0.0049
Echinococcus multilocularis serotonin receptor 0.012 0.2775 0.2747
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0356 0.0867
Brugia malayi hypothetical protein 0.0026 0.0356 0.0557
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.012 0.2775 0.3536
Loa Loa (eye worm) follicle stimulating hormone receptor 0.012 0.2775 0.484
Schistosoma mansoni histamine h1 receptor 0.012 0.2775 0.3536
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.012 0.2775 0.3536
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0105 0.2387 0.5816
Trypanosoma brucei aminopeptidase, putative 0.0021 0.0228 0.0078
Schistosoma mansoni rhodopsin-like orphan GPCR 0.012 0.2775 0.3536
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0079 0.1707 0.2977
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0024 0.0305 0.0348
Schistosoma mansoni thyroid hormone receptor 0.0014 0.0038 0.0049
Brugia malayi sulfakinin receptor protein 0.012 0.2775 0.4805
Brugia malayi G-protein coupled receptor 0.012 0.2775 0.4805
Schistosoma mansoni biogenic amine receptor 0.012 0.2775 0.3536
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Echinococcus granulosus neuropeptides capa receptor 0.012 0.2775 0.3302
Echinococcus granulosus biogenic amine 5HT receptor 0.012 0.2775 0.3302
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.012 0.2775 0.3536
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0017 0.0137 0.0099
Echinococcus granulosus Protein patched homolog 1 0.0021 0.0227 0.0228
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.012 0.2775 0.2747
Brugia malayi Dopamine receptor protein 1 0.012 0.2775 0.4805
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.012 0.2775 0.3536
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0049 0.0961 0.1225
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.012 0.2775 0.3302
Onchocerca volvulus 0.012 0.2775 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0942 0.1642
Schistosoma mansoni neuropeptide F-like receptor 0.012 0.2775 0.3536
Echinococcus granulosus rhodopsin orphan GPCR 0.012 0.2775 0.3302
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0021 0.0228 0.0555
Echinococcus granulosus tumor protein p63 0.0336 0.8327 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.012 0.2775 0.3302
Echinococcus granulosus hypothetical protein 0.012 0.2775 0.3302
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Brugia malayi Peptidase family M1 containing protein 0.0024 0.0305 0.0468
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.012 0.2769 0.4794
Echinococcus granulosus allatostatin A receptor 0.012 0.2775 0.3302
Echinococcus multilocularis g protein coupled receptor 0.012 0.2775 0.2747
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.012 0.2769 1
Schistosoma mansoni neuropeptide F-like receptor 0.012 0.2775 0.3536
Brugia malayi intermediate filament protein 0.0014 0.0059 0.0037
Echinococcus multilocularis orexin receptor type 2 0.012 0.2775 0.2747
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0105 0.2387 0.5816
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Loa Loa (eye worm) hypothetical protein 0.0049 0.0954 0.1664
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.012 0.2775 0.3302
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0021 0.0228 0.0151
Echinococcus granulosus single minded 2 0.0019 0.0183 0.0175
Echinococcus multilocularis neuropeptides capa receptor 0.012 0.2775 0.2747
Mycobacterium ulcerans leucyl aminopeptidase 0.0105 0.2387 0.8525
Brugia malayi neuropeptide F receptor 0.012 0.2775 0.4805
Brugia malayi Tachykinin-like peptides receptor 99D 0.012 0.2775 0.4805
Schistosoma mansoni leucine aminopeptidase 0.0021 0.0228 0.029
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.012 0.2769 0.6623
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0014 0.0038 0.0049
Echinococcus multilocularis neuropeptide Y receptor 0.012 0.2775 0.2747
Loa Loa (eye worm) hypothetical protein 0.0014 0.0059 0.0104
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.012 0.2769 0.3386
Echinococcus granulosus alpha 1A adrenergic receptor 0.012 0.2775 0.3302
Loa Loa (eye worm) hypothetical protein 0.012 0.2775 0.484
Schistosoma mansoni myosin xvIII 0.012 0.2775 0.3536
Schistosoma mansoni rhodopsin-like orphan GPCR 0.012 0.2775 0.3536
Schistosoma mansoni single-minded 0.0026 0.0356 0.0454
Loa Loa (eye worm) hypothetical protein 0.0014 0.0038 0.0067
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.012 0.2769 1
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0021 0.0228 0.0332
Schistosoma mansoni biogenic amine (5HT) receptor 0.012 0.2775 0.3536
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.012 0.2775 0.2747
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.012 0.2769 0.6554
Loa Loa (eye worm) hypothetical protein 0.0021 0.0227 0.0396

Activities

Activity type Activity value Assay description Source Reference
Relative potency (functional) = 0.8 Melanotropic potency against Rana pipiens using frog skin bioassay; effect continued after the removal of the compound ChEMBL. 2555512
Relative potency (functional) = 1 Melanotropic potency against Rana pipiens using frog skin bioassay; effect did not continue after the removal of the compound ChEMBL. 2555512
Relative potency (functional) = 20 Melanotropic potency against Anolis carolinensis using lizard skin bioassay; effect did not continue after the removal of the compound ChEMBL. 2555512
Relative potency (functional) = 90 Melanotropic potency against Anolis carolinensis using lizard skin bioassay; effect continued after the removal of the compound ChEMBL. 2555512

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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