Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0061 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 11 uM | Concentration required to protect human T-lymphocytic cells against the cytopathogenicity of HIV-2 | ChEMBL. | 12801238 |
EC50 (functional) | = 17 uM | Effective concentration of compound required to protect human T-lymphocytic cells against the cytopathogenicity of HIV-1 | ChEMBL. | 12801238 |
EC50 (functional) | = 26 uM | Effective concentration of compound required to protect C3H/3T3 embryo murine fibroblasts against the MSV induced transformation | ChEMBL. | 12801238 |
EC50 (functional) | = 26 uM | Effective concentration of compound required to protect C3H/3T3 embryo murine fibroblasts against the MSV induced transformation | ChEMBL. | 12801238 |
IC50 (functional) | = 95 uM | Inhibitory concentration of compound against proliferation of murine lukemia cells L1210 was determined | ChEMBL. | 12801238 |
IC50 (functional) | = 95 uM | Inhibitory concentration of compound against proliferation of murine lukemia cells L1210 was determined | ChEMBL. | 12801238 |
IC50 (functional) | = 122 uM | Inhibitory concentration of compound against proliferation of human T-lymphocytic cells MOLT-4/C8 was determined | ChEMBL. | 12801238 |
IC50 (functional) | = 122 uM | Inhibitory concentration of compound against proliferation of human T-lymphocytic cells MOLT-4/C8 was determined | ChEMBL. | 12801238 |
IC50 (functional) | = 240 uM | Inhibitory concentration against proliferation of human T-lymphocytic (CEM) cells | ChEMBL. | 12801238 |
IC50 (functional) | = 240 uM | Inhibitory concentration against proliferation of human T-lymphocytic (CEM) cells | ChEMBL. | 12801238 |
MIC (functional) | > 100 uM | Minimal inhibitory concentration required to cause a microscopic detectable alteration of C3H/3T3 embryo murine fibroblast cell morphology | ChEMBL. | 12801238 |
MIC (functional) | > 100 uM | Minimal inhibitory concentration required to cause a microscopic detectable alteration of C3H/3T3 embryo murine fibroblast cell morphology | ChEMBL. | 12801238 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.