Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cathepsin L-like precursor | 0.0141 | 1 | 1 |
Onchocerca volvulus | 0.0141 | 1 | 1 | |
Leishmania major | cathepsin L-like protease | 0.0141 | 1 | 0.5 |
Toxoplasma gondii | cathepsin CPL | 0.0141 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0141 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0094 | 0.5061 | 0.3182 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0141 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0073 | 0.2757 | 0.2757 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0141 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0141 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.1606 | 0.1606 |
Loa Loa (eye worm) | fibroinase | 0.0141 | 1 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0073 | 0.2757 | 0.2757 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0141 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0141 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0141 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0141 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0141 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0141 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0141 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0141 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0141 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.5061 | 0.5061 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0141 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0141 | 1 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0141 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0141 | 1 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0141 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0141 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0141 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.5061 | 0.5061 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0141 | 1 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0141 | 1 | 0.5 |
Loa Loa (eye worm) | ctsf protein | 0.0141 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0141 | 1 | 1 |
Onchocerca volvulus | 0.0141 | 1 | 1 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.1606 | 0.1606 |
Onchocerca volvulus | 0.0141 | 1 | 1 | |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.7396 | 0.7396 |
Plasmodium vivax | vivapain-1 | 0.0073 | 0.2757 | 0.2757 |
Leishmania major | cathepsin L-like protease | 0.0141 | 1 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.0141 | 1 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0094 | 0.5061 | 0.5061 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0073 | 0.2757 | 0.2757 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0141 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.5061 | 0.5061 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0073 | 0.2757 | 0.2757 |
Echinococcus multilocularis | cysteine protease | 0.0141 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.7396 | 0.7396 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0141 | 1 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0141 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0141 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0141 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0141 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0141 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0141 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0141 | 1 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0094 | 0.5061 | 0.5061 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0141 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0141 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0141 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0141 | 1 | 0.5 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0094 | 0.5061 | 0.5061 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.7396 | 0.7396 |
Brugia malayi | Cathepsin L-like precursor | 0.0094 | 0.5061 | 0.5061 |
Brugia malayi | Cathepsin L-like precursor | 0.0141 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0141 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0141 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0062 | 0.1606 | 0.1606 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0141 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0141 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0141 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0141 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0141 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0141 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.1606 | 0.1606 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0141 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.1606 | 0.1606 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.1606 | 0.1606 |
Trypanosoma cruzi | cysteine protease, putative | 0.0073 | 0.2757 | 0.2757 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0141 | 1 | 1 |
Plasmodium vivax | unspecified product | 0.0073 | 0.2757 | 0.2757 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0141 | 1 | 1 |
Onchocerca volvulus | 0.0141 | 1 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0141 | 1 | 1 |
Onchocerca volvulus | 0.0141 | 1 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0141 | 1 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0141 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0073 | 0.2757 | 0.2757 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0141 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0141 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0094 | 0.5061 | 0.4116 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0141 | 1 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0073 | 0.2757 | 0.2757 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0141 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 1 | 1 |
Onchocerca volvulus | 0.0141 | 1 | 1 | |
Leishmania major | cathepsin L-like protease | 0.0141 | 1 | 0.5 |
Plasmodium vivax | vivapain-2 | 0.0141 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0141 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0141 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0141 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0141 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0141 | 1 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0094 | 0.5061 | 0.5061 |
Leishmania major | cathepsin L-like protease | 0.0141 | 1 | 0.5 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0141 | 1 | 1 |
Echinococcus granulosus | cysteine protease | 0.0073 | 0.2757 | 0.1371 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0073 | 0.2757 | 0.2757 |
Onchocerca volvulus | Cathepsin L homolog | 0.0141 | 1 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0141 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.1606 | 0.1606 |
Plasmodium vivax | vivapain-3 | 0.0073 | 0.2757 | 0.2757 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0141 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0094 | 0.5061 | 0.3182 |
Echinococcus granulosus | cathepsin L | 0.0073 | 0.2757 | 0.1371 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.1606 | 0.1606 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0141 | 1 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0141 | 1 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0073 | 0.2757 | 0.2757 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0094 | 0.5061 | 0.5061 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0141 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.1606 | 0.1606 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.1606 | 0.1606 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.1606 | 0.1606 |
Leishmania major | cathepsin L-like protease | 0.0141 | 1 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0141 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0141 | 1 | 1 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0073 | 0.2757 | 0.1371 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0073 | 0.2757 | 0.2757 |
Echinococcus multilocularis | cathepsin L | 0.0073 | 0.2757 | 0.1371 |
Onchocerca volvulus | 0.0141 | 1 | 1 | |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0141 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0141 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0141 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0094 | 0.5061 | 0.3182 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Relative potency (functional) | = 0.5 | Melanotropic potency against Rana pipiens using frog skin bioassay; effect continued after the removal of the compound | ChEMBL. | 2555512 |
Relative potency (functional) | = 9 | Melanotropic potency against Anolis carolinensis using lizard skin bioassay; effect continued after the removal of the compound | ChEMBL. | 2555512 |
Relative potency (functional) | = 0.5 | Melanotropic potency against Rana pipiens using frog skin bioassay; effect continued after the removal of the compound | ChEMBL. | 2555512 |
Relative potency (functional) | = 9 | Melanotropic potency against Anolis carolinensis using lizard skin bioassay; effect continued after the removal of the compound | ChEMBL. | 2555512 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.