Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0272 | 0.4834 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0257 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0288 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0287 | 0.9551 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0288 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Retention time | = 51.9 min | Lipophilicity of compound evaluated by HPLC retention time on reverse phase C18 column | ChEMBL. | 9873647 |
T1/2 (ADMET) | = 3 hr | Half-life of the compound in the presence of total cell extract(TCE) was evaluated. | ChEMBL. | 9873647 |
T1/2 (ADMET) | 0 min | Half-life of the compound in the presence of pig liver esterase(PLE) was evaluated; Stable | ChEMBL. | 9873647 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.