Detailed information for compound 40134

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 445.391 | Formula: C22H18F3N3O4
  • H donors: 1 H acceptors: 3 LogP: 4 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CON=C1CCN(CC1)c1cc2c(cc1F)c(=O)c(cn2c1ccc(cc1F)F)C(=O)O
  • InChi: 1S/C22H18F3N3O4/c1-32-26-13-4-6-27(7-5-13)20-10-19-14(9-17(20)25)21(29)15(22(30)31)11-28(19)18-3-2-12(23)8-16(18)24/h2-3,8-11H,4-7H2,1H3,(H,30,31)
  • InChiKey: IPHPAMMGXDZTLF-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0032 0.001 0.0011
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0029 0.0001 0.0001
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0055 0.0073 0.0149
Echinococcus multilocularis neuropeptide receptor A26 0.0575 0.1526 0.1819
Loa Loa (eye worm) hypothetical protein 0.0129 0.028 0.0823
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.006 0.0088 0.0256
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0048 0.0054 0.0048
Plasmodium vivax ferrodoxin reductase, putative 0.0264 0.0657 0.1932
Echinococcus multilocularis acetylcholinesterase 0.0357 0.0916 0.1092
Brugia malayi M-phase phosphoprotein, mpp8 0.0098 0.0194 0.0569
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0041 0.0033 0.0087
Schistosoma mansoni serine/threonine protein kinase 0.0119 0.0253 0.0301
Echinococcus granulosus single minded 2 0.0123 0.0263 0.0313
Trichomonas vaginalis glucosylceramidase, putative 0.036 0.0926 0.3407
Loa Loa (eye worm) hypothetical protein 0.007 0.0115 0.0337
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0055 0.0073 0.0213
Toxoplasma gondii hypothetical protein 0.0055 0.0073 0.0213
Trypanosoma cruzi hypothetical protein, conserved 0.0264 0.0657 0.0652
Echinococcus granulosus dro:myosuppressin receptor 0.0129 0.028 0.0333
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0035 0.0016 0.0019
Echinococcus multilocularis glutamate synthase 0.0264 0.0657 0.0783
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.006 0.0088 0.0104
Brugia malayi hypothetical protein 0.0129 0.028 0.0822
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0264 0.0657 0.0652
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.0031 0.0006 0.0015
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.006 0.0088 0.0082
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.0316 0.0311
Onchocerca volvulus 0.0029 0.0001 0.0004
Brugia malayi hypothetical protein 0.0294 0.0741 0.2177
Schistosoma mansoni rab6-interacting 0.007 0.0115 0.0136
Entamoeba histolytica hypothetical protein 0.0041 0.0034 0.044
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0264 0.0657 0.2181
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0029 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0033 0.0011 0.0013
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0129 0.028 0.0333
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0087 0.0163 0.0194
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0029 0.0001 0.0003
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0264 0.0657 0.1932
Schistosoma mansoni hypothetical protein 0.0033 0.0012 0.0014
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0055 0.0073 0.0213
Echinococcus granulosus netrin receptor unc 5 0.0033 0.0012 0.0014
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.2648 0.7319 0.7318
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0139 0.0309 0.0368
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0129 0.028 0.0333
Echinococcus granulosus death domain containing protein 0.0033 0.0012 0.0014
Mycobacterium ulcerans hypothetical protein 0.0158 0.0361 0.132
Plasmodium falciparum ferrodoxin reductase-like protein 0.0264 0.0657 0.1932
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0033 0.0013 0.0014
Plasmodium falciparum thioredoxin reductase 0.1246 0.3401 1
Schistosoma mansoni opsin-like receptor 0.0129 0.028 0.0333
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0084 0.0091
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0084 0.01
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0055 0.0073 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0064 0.0203
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0264 0.0657 0.0783
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.006 0.0088 0.0323
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0264 0.0657 0.0783
Loa Loa (eye worm) hypothetical protein 0.0029 0.0001 0.0003
Echinococcus multilocularis lamin dm0 0.0062 0.0093 0.011
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0055 0.0073 0.0086
Echinococcus granulosus hyperpolarization activated cyclic 0.0035 0.0016 0.0019
Echinococcus multilocularis sex peptide receptor 0.0129 0.028 0.0333
Schistosoma mansoni biogenic amine (5HT) receptor 0.0389 0.1008 0.1201
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0029 0.0001 0.0001
Loa Loa (eye worm) neuropeptide F receptor 0.0129 0.028 0.0823
Loa Loa (eye worm) cytochrome P450 family protein 0.0066 0.0104 0.0307
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0119 0.0408
Loa Loa (eye worm) hypothetical protein 0.0079 0.014 0.0412
Loa Loa (eye worm) hypothetical protein 0.0062 0.0093 0.0273
Mycobacterium tuberculosis Carboxylesterase LipT 0.006 0.0088 0.0102
Onchocerca volvulus Netrin receptor homolog 0.0033 0.0012 0.0085
Echinococcus granulosus Polycystic kidney disease protein 0.007 0.0115 0.0136
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0048 0.0054 0.0179
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0079 0.0139 0.0165
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0029 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.006 0.0088 0.0259
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0033 0.0087
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0995 0.2699 0.3219
Onchocerca volvulus 0.0055 0.0073 0.0542
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0055 0.0065
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0018 0.002
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0035 0.0016 0.0019
Schistosoma mansoni inositol monophosphatase 0.0157 0.0358 0.0426
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.0758 0.0753
Echinococcus granulosus G protein coupled receptor 139 0.0129 0.028 0.0333
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0016 0.0025
Onchocerca volvulus 0.007 0.0115 0.0854
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0264 0.0657 0.1804
Trypanosoma cruzi trypanothione reductase, putative 0.1246 0.3401 0.3397
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0133 0.0459
Echinococcus multilocularis rhodopsin orphan GPCR 0.0129 0.028 0.0333
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0121 0.0144
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0048 0.0054 0.0179
Brugia malayi Steroid receptor seven-up type 2 0.0029 0.0001 0.0002
Onchocerca volvulus 0.0429 0.1119 0.8377
Loa Loa (eye worm) hypothetical protein 0.0029 0.0001 0.0003
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0142 0.0316 0.0311
Schistosoma mansoni jumonji domain containing protein 0.0075 0.013 0.0155
Echinococcus granulosus jumonji domain containing protein 0.004 0.0032 0.0038
Loa Loa (eye worm) hypothetical protein 0.0104 0.021 0.0617
Echinococcus granulosus lipoxygenase domain containing protein 0.007 0.0115 0.0136
Leishmania major hypothetical protein, conserved 0.0264 0.0657 0.0652
Schistosoma mansoni lamin 0.0062 0.0093 0.011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0129 0.028 0.0333
Trichomonas vaginalis glucosylceramidase, putative 0.0549 0.1454 0.5368
Schistosoma mansoni neuropeptide receptor 0.0129 0.028 0.0333
Trypanosoma cruzi NADH dehydrogenase, putative 0.0264 0.0657 0.0652
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.027 0.0674 0.0803
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0133 0.0459
Leishmania major cytochrome p450-like protein 0.0048 0.0054 0.0048
Onchocerca volvulus 0.0264 0.0657 0.4919
Onchocerca volvulus 0.0129 0.028 0.2093
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0011 0.0013
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0048 0.0054 0.0048
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0502 0.1322 0.3788
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0029 0.0001 0.0003
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.0185 0.022
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0001 0.0002
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0157 0.0358 0.1295
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0264 0.0657 0.1932
Echinococcus granulosus voltage gated potassium channel 0.0042 0.0036 0.0043
Schistosoma mansoni BC026374 protein (S09 family) 0.006 0.0088 0.0104
Trypanosoma brucei NADH dehydrogenase 0.0264 0.0657 0.0652
Schistosoma mansoni biogenic amine receptor 0.0129 0.028 0.0333
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0035 0.0016 0.0048
Echinococcus multilocularis sodium channel protein 0.025 0.0617 0.0735
Schistosoma mansoni loxhd1 0.007 0.0115 0.0136
Loa Loa (eye worm) intermediate filament protein 0.0062 0.0093 0.0273
Echinococcus granulosus glutamate synthase 0.0264 0.0657 0.0783
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0048 0.0054 0.0179
Echinococcus granulosus family S9 non peptidase ue S09 family 0.006 0.0088 0.0104
Onchocerca volvulus 0.0116 0.0243 0.1814
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.0185 0.022
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0264 0.0657 0.0652
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0156 0.0354 0.0422
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0156 0.0354 0.0422
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.3033 0.8394 0.8393
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0264 0.0657 0.1804
Schistosoma mansoni steroid hormone receptor ad4bp 0.0029 0.0001 0.0001
Onchocerca volvulus Glucosylceramidase homolog 0.036 0.0926 0.6931
Loa Loa (eye worm) hypothetical protein 0.0129 0.028 0.0823
Echinococcus multilocularis dro:myosuppressin receptor 0.0129 0.028 0.0333
Brugia malayi glutathione reductase 0.1246 0.3401 1
Onchocerca volvulus 0.0041 0.0033 0.0244
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0129 0.028 0.0333
Loa Loa (eye worm) hypothetical protein 0.0129 0.028 0.0823
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0065 0.0204
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0033 0.0012 0.0035
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0079 0.0139 0.0134
Mycobacterium tuberculosis Probable dehydrogenase 0.0502 0.1322 0.3788
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0048 0.0054 0.0179
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0055 0.0073 0.0086
Loa Loa (eye worm) hypothetical protein 0.0323 0.0823 0.2419
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0001 0.0001
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0129 0.028 0.0333
Echinococcus multilocularis g-protein coupled receptor 0.0129 0.028 0.0333
Schistosoma mansoni sulfide quinone reductase 0.0264 0.0657 0.0783
Schistosoma mansoni ap endonuclease 0.006 0.0088 0.0104
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0129 0.028 0.0333
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0157 0.0358 0.5407
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0264 0.0657 0.0652
Loa Loa (eye worm) glutathione reductase 0.1246 0.3401 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0096 0.0188 0.0664
Loa Loa (eye worm) hypothetical protein 0.0129 0.028 0.0823
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0264 0.0657 0.0783
Trypanosoma brucei trypanothione reductase 0.1246 0.3401 0.3397
Echinococcus granulosus mitogen activated protein kinase 3 0.0119 0.0253 0.0301
Echinococcus multilocularis rhodopsin orphan GPCR 0.0129 0.028 0.0333
Echinococcus multilocularis aryl hydrocarbon receptor 0.0041 0.0033 0.0039
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0129 0.028 0.0333
Onchocerca volvulus 0.0129 0.028 0.2093
Echinococcus multilocularis tar DNA binding protein 0.0072 0.0121 0.0144
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0374 0.0965 0.1151
Toxoplasma gondii NADPH-glutathione reductase 0.0995 0.2699 0.7936
Loa Loa (eye worm) solute carrier family 6 member 4 0.0323 0.0823 0.2419
Plasmodium falciparum LCCL domain-containing protein 0.007 0.0115 0.0335
Trichomonas vaginalis guanylate cyclase, putative 0.0041 0.0033 0.0087
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0502 0.1322 0.3788
Echinococcus granulosus ATP binding cassette sub family G 0.0031 0.0006 0.0006
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0264 0.0657 0.1875
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0133 0.0459
Trichomonas vaginalis glucosylceramidase, putative 0.038 0.098 0.3609
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0129 0.028 0.2093
Schistosoma mansoni aryl hydrocarbon receptor 0.0156 0.0356 0.0424
Echinococcus granulosus RUN 0.007 0.0115 0.0136
Echinococcus multilocularis GPCR, family 2 0.0033 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0389 0.1008 0.2963
Brugia malayi Serotonin receptor 0.1113 0.3029 0.8906
Loa Loa (eye worm) TYRA-2 protein 0.0129 0.028 0.0823
Trichomonas vaginalis adenylate cyclase, putative 0.0041 0.0033 0.0087
Plasmodium falciparum glutathione reductase 0.0995 0.2699 0.7936
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0018 0.002
Onchocerca volvulus Dual oxidase homolog 0.007 0.0116 0.0867
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0129 0.028 0.0333
Echinococcus granulosus sodium and chloride dependent glycine 0.0055 0.0073 0.0086
Echinococcus granulosus FTZ F1 alpha 0.0029 0.0001 0.0001
Plasmodium vivax multidomain scavenger receptor, putative 0.007 0.0115 0.0335
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0157 0.0358 0.1295
Treponema pallidum oxidoreductase 0.0264 0.0657 0.2181
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.2648 0.7319 0.7318
Treponema pallidum sodium- and chloride- dependent transporter 0.0323 0.0823 0.2814
Onchocerca volvulus 0.006 0.0088 0.0655
Loa Loa (eye worm) hypothetical protein 0.0129 0.028 0.0823
Trichomonas vaginalis glucosylceramidase, putative 0.036 0.0926 0.3407
Schistosoma mansoni hypothetical protein 0.0035 0.0019 0.0021
Echinococcus granulosus nuclear factor of activated T cells 5 0.0169 0.0392 0.0467
Schistosoma mansoni acetylcholinesterase 0.006 0.0088 0.0104
Brugia malayi neuropeptide F receptor 0.0129 0.028 0.0822
Loa Loa (eye worm) hypothetical protein 0.0029 0.0001 0.0003
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0045 0.0047 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0033 0.0087
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0264 0.0657 0.1875
Trypanosoma cruzi hypothetical protein, conserved 0.0264 0.0657 0.0652
Brugia malayi Pre-SET motif family protein 0.0064 0.0098 0.0287
Echinococcus granulosus hyperpolarization activated cyclic 0.0035 0.0016 0.0019
Schistosoma mansoni hypothetical protein 0.0159 0.0364 0.0434
Echinococcus granulosus geminin 0.0706 0.1893 0.2258
Echinococcus granulosus fmrfamide receptor 0.0129 0.028 0.0333
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0264 0.0657 0.1932
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.006 0.0088 0.0104
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0129 0.028 0.0333
Leishmania major hypothetical protein, conserved 0.0264 0.0657 0.0652
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0029 0.0001 0.0002
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0097 0.0191 0.056
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0264 0.0657 0.0652
Echinococcus multilocularis voltage gated potassium channel 0.0042 0.0036 0.0043
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0139 0.0309 0.1125
Loa Loa (eye worm) hypothetical protein 0.0029 0.0001 0.0003
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0001 0.0002
Brugia malayi Augmenter of liver regeneration 0.0072 0.0122 0.0357
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.004 0.0031 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.01 0.0335
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0042 0.0036 0.0043
Echinococcus granulosus rhodopsin orphan GPCR 0.0129 0.028 0.0333
Loa Loa (eye worm) carboxylesterase 0.0357 0.0916 0.2694
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0079 0.0256
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0129 0.028 0.0333
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.1233 0.3363 0.9888
Schistosoma mansoni biogenic amine (5HT) receptor 0.0129 0.028 0.0333
Trypanosoma brucei mitochondrial DNA polymerase beta 0.03 0.0758 0.0753
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0055 0.0073 0.0086
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0036 0.0043
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0264 0.0657 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0264 0.0657 0.0783
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0032 0.001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0129 0.028 0.0823
Echinococcus granulosus rhodopsin orphan GPCR 0.0129 0.028 0.0333
Loa Loa (eye worm) hypothetical protein 0.0129 0.028 0.0823
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.0031 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0029 0.0001 0.0003
Schistosoma mansoni thyroid hormone receptor 0.0029 0.0001 0.0001
Plasmodium vivax thioredoxin reductase, putative 0.1246 0.3401 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.006 0.0088 0.0104
Brugia malayi Serotonin receptor 0.0129 0.028 0.0822
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0264 0.0657 0.0783
Loa Loa (eye worm) cytochrome P450 family protein 0.0066 0.0104 0.0307
Echinococcus granulosus BC026374 protein S09 family 0.006 0.0088 0.0104
Onchocerca volvulus 0.0129 0.028 0.2093
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0129 0.028 0.0333
Echinococcus granulosus neuropeptide Y receptor 0.0129 0.028 0.0333
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.3033 0.8394 0.8393
Trichomonas vaginalis glucosylceramidase, putative 0.0549 0.1454 0.5368
Schistosoma mansoni lamin 0.0062 0.0093 0.011
Onchocerca volvulus 0.0323 0.0823 0.6157
Loa Loa (eye worm) hypothetical protein 0.078 0.21 0.6175
Schistosoma mansoni hypothetical protein 0.0129 0.028 0.0333
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0157 0.0358 0.0353
Schistosoma mansoni lipoxygenase 0.0144 0.0323 0.0385
Loa Loa (eye worm) hypothetical protein 0.0071 0.0118 0.0347
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0048 0.0054 0.0179
Schistosoma mansoni hypothetical protein 0.0033 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0087 0.0162 0.0477
Trypanosoma cruzi target of rapamycin kinase 3 0.0077 0.0133 0.0128
Schistosoma mansoni gliotactin 0.006 0.0088 0.0104
Schistosoma mansoni hypothetical protein 0.0033 0.0011 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0119 0.0408
Brugia malayi bHLH-PAS transcription factor 0.0116 0.0243 0.0712
Schistosoma mansoni hypothetical protein 0.0048 0.0054 0.0063
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0048 0.0054 0.0179
Trichomonas vaginalis mercuric reductase, putative 0.0995 0.2699 1
Onchocerca volvulus 0.0055 0.0073 0.0542
Schistosoma mansoni ankyrin 23/unc44 0.0033 0.0012 0.0014
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0129 0.028 0.0333
Echinococcus granulosus 7TM GPCR rhodopsin 0.0129 0.028 0.0333
Echinococcus granulosus tm gpcr rhodopsin 0.0129 0.028 0.0333
Loa Loa (eye worm) hypothetical protein 0.0403 0.1044 0.307
Onchocerca volvulus 0.0098 0.0194 0.1448
Loa Loa (eye worm) hypothetical protein 0.0129 0.028 0.0823
Loa Loa (eye worm) cytochrome P450 0.0048 0.0054 0.0158
Echinococcus multilocularis sodium and chloride dependent glycine 0.0055 0.0073 0.0086
Mycobacterium ulcerans monoxygenase 0.0264 0.0657 0.242
Echinococcus granulosus neuroligin 0.006 0.0088 0.0104
Echinococcus granulosus GPCR family 2 0.0033 0.0011 0.0013
Echinococcus multilocularis sodium and chloride dependent glycine 0.0055 0.0073 0.0086
Loa Loa (eye worm) hypothetical protein 0.0129 0.028 0.0823
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0032 0.001 0.0011
Echinococcus granulosus allatostatin A receptor 0.0129 0.028 0.0333
Brugia malayi hypothetical protein 0.0129 0.028 0.0822
Onchocerca volvulus 0.0129 0.028 0.2093
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0019 0.0021
Loa Loa (eye worm) inositol-1 0.0157 0.0358 0.1053
Brugia malayi G-protein coupled receptor 0.0129 0.028 0.0822
Loa Loa (eye worm) hepatopoietin HPO2 0.0072 0.0122 0.0358
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0157 0.0358 0.1309
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0129 0.028 0.0333
Trichomonas vaginalis CMGC family protein kinase 0.0119 0.0253 0.0904
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0087 0.0163 0.0194
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0011 0.0032
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0264 0.0657 1
Toxoplasma gondii selenide, water dikinase 0.0264 0.0657 0.1932
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.0094 0.0313
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0129 0.028 0.0333
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0035 0.0016 0.0019
Echinococcus granulosus neuropeptide receptor 0.0129 0.028 0.0333
Schistosoma mansoni sodium/chloride dependent transporter 0.0323 0.0823 0.098
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.006 0.0088 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.008 0.0262
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0016 0.0025
Onchocerca volvulus 0.0129 0.028 0.2093
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.006 0.0088 0.0256
Loa Loa (eye worm) RNA binding protein 0.0072 0.0121 0.0357
Echinococcus multilocularis FTZ F1 alpha 0.0029 0.0001 0.0001
Brugia malayi exodeoxyribonuclease III family protein 0.006 0.0088 0.0256
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0032 0.001 0.0027
Brugia malayi Pre-SET motif family protein 0.0445 0.1163 0.3419
Echinococcus granulosus rhodopsin orphan GPCR 0.0129 0.028 0.0333
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0064 0.0203
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0079 0.0139 0.0134
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0264 0.0657 0.1875
Brugia malayi follicle stimulating hormone receptor 0.059 0.1567 0.4607
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0032 0.0038
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0033 0.0012 0.0036
Loa Loa (eye worm) hypothetical protein 0.0524 0.1385 0.4071
Brugia malayi hypothetical protein 0.078 0.21 0.6175
Loa Loa (eye worm) hypothetical protein 0.0129 0.028 0.0823
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0502 0.1322 0.3869
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0995 0.2699 0.2695
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0264 0.0657 0.0652
Loa Loa (eye worm) serotonin transporter b 0.0323 0.0823 0.2419
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0264 0.0657 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0264 0.0657 0.2408
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0029 0.0001 0.0001
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0041 0.0033 0.0097
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0096 0.0188 0.0183
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0995 0.2699 0.7936
Echinococcus multilocularis lipoxygenase domain containing protein 0.007 0.0115 0.0136
Loa Loa (eye worm) norepinephrine transporter 0.0323 0.0823 0.2419
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0032 0.001 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0129 0.028 0.0333
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0048 0.0054 0.0179
Loa Loa (eye worm) programmed cell death 8 0.0264 0.0657 0.1933
Leishmania major mitochondrial DNA polymerase beta 0.03 0.0758 0.0753
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.1233 0.3363 1
Plasmodium falciparum thioredoxin reductase 0.0995 0.2699 0.7936
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0001 0.0002
Loa Loa (eye worm) steroid hormone receptor 0.0029 0.0001 0.0003
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0264 0.0657 0.0652
Onchocerca volvulus 0.0129 0.028 0.2093
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0055 0.0073 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0065 0.0204
Loa Loa (eye worm) hypothetical protein 0.0098 0.0195 0.0572
Echinococcus granulosus biogenic amine 5HT receptor 0.0389 0.1008 0.1201
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0264 0.0657 1
Entamoeba histolytica hypothetical protein 0.0041 0.0034 0.044
Loa Loa (eye worm) hypothetical protein 0.0323 0.0823 0.2419
Echinococcus granulosus thioredoxin glutathione reductase 0.1246 0.3401 0.4056
Loa Loa (eye worm) hypothetical protein 0.0129 0.028 0.0823
Loa Loa (eye worm) hypothetical protein 0.0129 0.028 0.0823
Schistosoma mansoni glutamate synthase 0.0264 0.0657 0.0783
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0264 0.0657 0.0652
Brugia malayi Cytochrome P450 family protein 0.0048 0.0054 0.0156
Loa Loa (eye worm) hypothetical protein 0.0429 0.1119 0.3291
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.021 0.0617
Loa Loa (eye worm) hypothetical protein 0.005 0.0058 0.0172
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.006 0.0088 0.0305
Echinococcus granulosus neuropeptides capa receptor 0.0129 0.028 0.0333
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0029 0.0001 0.0001
Mycobacterium ulcerans hypothetical protein 0.0264 0.0657 0.242
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0063 0.0058
Loa Loa (eye worm) hypothetical protein 0.0264 0.0657 0.1933
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0264 0.0657 0.0783
Schistosoma mansoni hypothetical protein 0.0033 0.0011 0.0013
Brugia malayi nuclear hormone receptor 0.0029 0.0001 0.0002
Trypanosoma brucei hypothetical protein, conserved 0.0264 0.0657 0.0652
Trypanosoma brucei PAB1-binding protein , putative 0.0079 0.014 0.0135
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0264 0.0657 0.242
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0048 0.0054 0.0179
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0055 0.0073 0.0213
Loa Loa (eye worm) hypothetical protein 0.0033 0.0012 0.0035
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0035 0.0016 0.0019
Onchocerca volvulus 0.006 0.0088 0.0655
Echinococcus granulosus peptide allatostatin:somatostatin 0.0129 0.028 0.0333
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0029 0.0001 0.0001
Echinococcus granulosus g protein coupled receptor 0.0129 0.028 0.0333
Onchocerca volvulus 0.006 0.0088 0.0655
Onchocerca volvulus 0.0062 0.0093 0.069
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0034 0.004
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0119 0.0253 0.0247
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0029 0.0001 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0001 0.0002
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0264 0.0657 0.1932
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0079 0.0139 0.2051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0029 0.0001 0.0003
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0041 0.0033 0.0039
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0048 0.0054 0.0179
Echinococcus granulosus jun protein 0.0374 0.0965 0.1151
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0062 0.0093 0.0273
Schistosoma mansoni lozenge 0.0054 0.007 0.0083
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0084 0.0291
Loa Loa (eye worm) hypothetical protein 0.0129 0.028 0.0823
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0096 0.0188 0.0224
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0264 0.0657 0.2434
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0048 0.0054 0.0048
Loa Loa (eye worm) hypothetical protein 0.0033 0.0011 0.0034
Brugia malayi photoreceptor-specific nuclear receptor 0.0029 0.0001 0.0002
Leishmania major C-8 sterol isomerase-like protein 0.0788 0.212 0.2116
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0035 0.0016 0.0019
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0129 0.028 0.0333
Trichomonas vaginalis glucosylceramidase, putative 0.036 0.0926 0.3407
Echinococcus multilocularis ATP binding cassette sub family G 0.0031 0.0006 0.0006
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0048 0.0054 0.0179
Loa Loa (eye worm) blistered cuticle protein 3 0.007 0.0116 0.0342
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0029 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.006 0.0088 0.0259
Echinococcus multilocularis transfer RNA-Lys 0.0116 0.0243 0.0289
Schistosoma mansoni amine GPCR 0.0129 0.028 0.0333
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0048 0.0054 0.0179
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.3608 1 1
Brugia malayi hypothetical protein 0.0129 0.028 0.0822
Loa Loa (eye worm) hypothetical protein 0.0129 0.028 0.0823
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0096 0.0188 0.0224
Trypanosoma cruzi PAB1-binding protein , putative 0.0079 0.014 0.0135
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0159 0.0364 0.107
Brugia malayi Carboxylesterase family protein 0.006 0.0088 0.0257
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.021 0.0616
Echinococcus multilocularis neuropeptide receptor 0.0129 0.028 0.0333
Echinococcus multilocularis serotonin transporter 0.0323 0.0823 0.098
Brugia malayi Inositol-1 0.0157 0.0358 0.1051
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0156 0.0354 0.104
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0055 0.0073 0.0213
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.006 0.0088 0.0258
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0042 0.0037 0.0032
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.006 0.0088 0.0082
Schistosoma mansoni neuropeptide f receptor 76f 0.0129 0.028 0.0333
Echinococcus granulosus g protein coupled receptor 0.0129 0.028 0.0333
Brugia malayi intermediate filament protein 0.0062 0.0093 0.0271
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0041 0.0033 0.0028
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0129 0.028 0.0823
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0264 0.0657 0.1875
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0788 0.212 0.2116
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0129 0.028 0.0333
Mycobacterium ulcerans glutamate synthase subunit beta 0.0264 0.0657 0.242
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0041 0.0033 0.0028
Brugia malayi putative neuropeptide receptor NPR1 0.0129 0.028 0.0822
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.006 0.0088 0.0102
Echinococcus multilocularis neuropeptide s receptor 0.0575 0.1526 0.1819
Brugia malayi jmjC domain containing protein 0.0095 0.0185 0.0542
Schistosoma mansoni hypothetical protein 0.0706 0.1893 0.2258
Loa Loa (eye worm) hypothetical protein 0.006 0.0088 0.0259
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0073 0.0123 0.042
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0047 0.0055
Echinococcus multilocularis para nitrobenzyl esterase 0.006 0.0088 0.0104
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0072 0.0122 0.0357
Brugia malayi hypoxia-induced factor 1 0.0484 0.1271 0.3737
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0034 0.004
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0034 0.004
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0156 0.0354 0.1042
Brugia malayi ecdysteroid receptor 0.0029 0.0001 0.0002
Echinococcus multilocularis microtubule associated protein 2 0.303 0.8385 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0129 0.028 0.0333
Echinococcus multilocularis g protein coupled receptor 0.0129 0.028 0.0333
Loa Loa (eye worm) phosphatidylinositol 3 0.0096 0.0188 0.0553
Toxoplasma gondii thioredoxin reductase 0.1246 0.3401 1
Brugia malayi hypothetical protein 0.0129 0.028 0.0822
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0157 0.0358 0.1035
Brugia malayi sulfakinin receptor protein 0.0129 0.028 0.0822
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0096 0.0188 0.2801
Brugia malayi nuclear receptor NHR-88 0.0029 0.0001 0.0002
Echinococcus multilocularis musashi 0.0062 0.0093 0.011
Mycobacterium ulcerans dehydrogenase 0.0264 0.0657 0.242
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0119 0.0408
Loa Loa (eye worm) hypothetical protein 0.0129 0.028 0.0823
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0055 0.0073 0.0214
Schistosoma mansoni neuropeptide receptor 0.0129 0.028 0.0333
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0098 0.0116
Echinococcus granulosus neuropeptide FF receptor 2 0.0129 0.028 0.0333
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0079 0.0139 0.0165
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0087 0.0163 0.0194
Schistosoma mansoni neuropeptide F-like receptor 0.0129 0.028 0.0333
Schistosoma mansoni voltage-gated potassium channel 0.0104 0.0211 0.0251
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0072 0.0122 0.0357
Brugia malayi hypothetical protein 0.0129 0.028 0.0822
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0129 0.028 0.0333
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0035 0.0016 0.0019
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0055 0.0073 0.0213
Toxoplasma gondii hypothetical protein 0.0048 0.0055 0.016
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0035 0.0016 0.0019
Onchocerca volvulus 0.0129 0.028 0.2093
Loa Loa (eye worm) hypothetical protein 0.0098 0.0194 0.057
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.006 0.0088 0.0102
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0731 0.1961 0.5766
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0048 0.0054 0.0179
Schistosoma mansoni opsin-like receptor 0.0129 0.028 0.0333
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.006 0.0088 0.0102
Giardia lamblia NADH oxidase lateral transfer candidate 0.0995 0.2699 1
Echinococcus granulosus acetylcholinesterase 0.0357 0.0916 0.1092
Trichomonas vaginalis glutathione reductase, putative 0.0995 0.2699 1
Toxoplasma gondii Erv1 / Alr family protein 0.0072 0.0122 0.0357
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0264 0.0657 0.1932
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0129 0.028 0.0823
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0129 0.028 0.0333
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0129 0.028 0.0333
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0129 0.028 0.0333
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.021 0.0616
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0264 0.0657 0.242
Loa Loa (eye worm) hypothetical protein 0.0389 0.1008 0.2963
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0055 0.0073 0.0086
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0156 0.0354 0.1042
Echinococcus multilocularis rhodopsin orphan GPCR 0.0129 0.028 0.0333
Echinococcus multilocularis RUN 0.007 0.0115 0.0136
Trypanosoma brucei ferric reductase transmembrane protein, putative 0.0033 0.0012 0.0006
Echinococcus multilocularis netrin receptor unc 5 0.0033 0.0012 0.0014
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0129 0.028 0.0333
Echinococcus multilocularis neuropeptide Y receptor 0.0129 0.028 0.0333
Brugia malayi Dopamine receptor 0.0129 0.028 0.0822
Echinococcus multilocularis neuropeptide FF receptor 2 0.0129 0.028 0.0333
Loa Loa (eye worm) hypothetical protein 0.0055 0.0073 0.0214
Echinococcus granulosus g protein coupled receptor 0.0129 0.028 0.0333
Schistosoma mansoni survival motor neuron protein 0.0159 0.0364 0.0434
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0048 0.0054 0.0179
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0129 0.028 0.0333
Echinococcus multilocularis fmrfamide receptor 0.0129 0.028 0.0333
Echinococcus multilocularis mitogen activated protein kinase 0.0119 0.0253 0.0301
Loa Loa (eye worm) hypothetical protein 0.0129 0.028 0.0823
Trichomonas vaginalis glucosylceramidase, putative 0.036 0.0926 0.3407
Brugia malayi hypothetical protein 0.0129 0.028 0.0822
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0119 0.0408
Trichomonas vaginalis glucosylceramidase, putative 0.036 0.0926 0.3407
Echinococcus multilocularis orexin receptor type 2 0.0129 0.028 0.0333
Trichomonas vaginalis glucosylceramidase, putative 0.0549 0.1454 0.5368
Leishmania major hypothetical protein, conserved 0.0079 0.014 0.0135
Echinococcus multilocularis BC026374 protein (S09 family) 0.006 0.0088 0.0104
Brugia malayi hypothetical protein 0.0129 0.028 0.0822
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0129 0.028 0.0333
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0001 0.0001
Schistosoma mansoni sodium/chloride dependent transporter 0.0055 0.0073 0.0086
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0995 0.2699 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0119 0.0253 0.0247
Mycobacterium leprae putative cytochrome p450 0.0048 0.0054 0.0062
Loa Loa (eye worm) hypothetical protein 0.006 0.0088 0.0259
Loa Loa (eye worm) follicle stimulating hormone receptor 0.059 0.1567 0.4608
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0264 0.0657 0.2408
Echinococcus multilocularis geminin 0.0706 0.1893 0.2258
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0041 0.0033 0.0087
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0264 0.0657 0.1804
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0129 0.028 0.0333
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0995 0.2699 0.3219
Brugia malayi MAP kinase sur-1 0.0119 0.0253 0.0742
Echinococcus granulosus Ankyrin 0.0033 0.0013 0.0014
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0788 0.212 0.6233
Brugia malayi Tachykinin-like peptides receptor 99D 0.0129 0.028 0.0822
Loa Loa (eye worm) cytochrome P450 family protein 0.0106 0.0216 0.0635
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0264 0.0657 0.1804
Schistosoma mansoni hypothetical protein 0.0264 0.0657 0.0783
Trypanosoma cruzi ferric reductase transmembrane protein, putative 0.0033 0.0012 0.0006
Schistosoma mansoni sodium-dependent amino acid transporter 0.0055 0.0073 0.0086
Schistosoma mansoni intermediate filament proteins 0.0062 0.0093 0.011
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0119 0.0253 0.0247
Echinococcus granulosus neuropeptide receptor A26 0.0575 0.1526 0.1819
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0264 0.0657 0.242
Echinococcus granulosus neuropeptides capa receptor 0.0129 0.028 0.0333
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0129 0.028 0.0333
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0129 0.028 0.0333
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0087 0.0255
Schistosoma mansoni glutamate synthase 0.0264 0.0657 0.0783
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0264 0.0657 0.0652
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0011 0.0013
Schistosoma mansoni hypothetical protein 0.0129 0.028 0.0333
Schistosoma mansoni polycystin 1-related 0.007 0.0115 0.0136
Echinococcus multilocularis G protein coupled receptor 139 0.0129 0.028 0.0333
Schistosoma mansoni disulfide oxidoreductase 0.0264 0.0657 0.0783
Schistosoma mansoni glutamate synthase 0.0264 0.0657 0.0783
Echinococcus granulosus para nitrobenzyl esterase 0.006 0.0088 0.0104
Brugia malayi Death domain containing protein 0.0033 0.0012 0.0033
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0072 0.0122 0.0145
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0119 0.0253 0.0743
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.014 0.0312 0.0838
Loa Loa (eye worm) hypothetical protein 0.0323 0.0823 0.2419
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0995 0.2699 1
Leishmania major cytochrome p450-like protein 0.0066 0.0104 0.0099
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0264 0.0657 0.242
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0264 0.0657 0.1932
Echinococcus granulosus carboxylesterase 5A 0.0357 0.0916 0.1092
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0048 0.0054 0.0179
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.006 0.0088 0.0291
Brugia malayi G protein-coupled receptor F59B2.13 0.0129 0.028 0.0822
Echinococcus granulosus tachykinin peptides receptor 99D 0.0129 0.028 0.0333
Brugia malayi ORL1-like opioid receptor 0.0129 0.028 0.0822
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0035 0.0016 0.0019
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0995 0.2699 0.7936
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0096 0.0188 0.0183
Mycobacterium leprae Conserved hypothetical protein 0.0048 0.0054 0.0062
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.0016 0.0019
Echinococcus granulosus orexin receptor type 2 0.0129 0.028 0.0333
Loa Loa (eye worm) hypothetical protein 0.0129 0.028 0.0823
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.006 0.0088 0.0104
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0129 0.028 0.0822
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0129 0.028 0.0333
Brugia malayi putative neuropeptide receptor 0.0129 0.028 0.0822
Trichomonas vaginalis CMGC family protein kinase 0.0119 0.0253 0.0904
Loa Loa (eye worm) hypothetical protein 0.0055 0.0073 0.0214
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0121 0.0144
Onchocerca volvulus 0.0294 0.0741 0.5544
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0038 0.0032
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0097 0.0191 0.0561
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0264 0.0657 0.2408
Echinococcus multilocularis rhodopsin orphan GPCR 0.0129 0.028 0.0333
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0018 0.002
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0118 0.0345
Loa Loa (eye worm) CYP4Cod1 0.0066 0.0104 0.0307
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0264 0.0657 0.2408
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0077 0.0133 0.0128
Echinococcus granulosus survival motor neuron protein 1 0.078 0.21 0.2504
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0001 0.0002
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0048 0.0054 0.0179
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0264 0.0657 0.1804
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0264 0.0657 0.1932
Brugia malayi GnHR receptor homolog 0.0129 0.028 0.0822
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0264 0.0657 0.2181
Loa Loa (eye worm) hypothetical protein 0.0129 0.028 0.0823
Trypanosoma cruzi ferric reductase transmembrane protein, putative 0.0033 0.0012 0.0006
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.3033 0.8394 0.8393
Loa Loa (eye worm) hypothetical protein 0.0129 0.028 0.0823
Onchocerca volvulus 0.0129 0.028 0.2093
Loa Loa (eye worm) hypothetical protein 0.0129 0.028 0.0823
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.008 0.0262
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0029 0.0001 0.0001
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0119 0.0253 0.0247
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0048 0.0054 0.0048
Echinococcus multilocularis neuroligin 0.006 0.0088 0.0104
Echinococcus multilocularis ATP binding cassette sub family G 0.0031 0.0006 0.0006
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0032 0.001 0.0011
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0264 0.0657 0.1932
Schistosoma mansoni biogenic amine receptor 0.0129 0.028 0.0333
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0055 0.0073 0.0086
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0032 0.001 0.0004
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0264 0.0657 0.2408
Trichomonas vaginalis PIKK family atypical protein kinase 0.0082 0.0149 0.0518
Echinococcus multilocularis neuropeptides capa receptor 0.0129 0.028 0.0333
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0264 0.0657 0.0783
Echinococcus granulosus g-protein coupled receptor 0.0129 0.028 0.0333
Echinococcus multilocularis thyroid hormone receptor alpha 0.0029 0.0001 0.0001
Loa Loa (eye worm) carboxylesterase 0.006 0.0088 0.0259
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0129 0.028 0.0333
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0035 0.0016 0.0019
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0001 0.0002
Schistosoma mansoni jun-related protein 0.0304 0.0769 0.0917
Loa Loa (eye worm) hypothetical protein 0.0042 0.0036 0.0107
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0077 0.0133 0.0128
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0157 0.0358 0.0353
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0121 0.0144
Echinococcus granulosus neuropeptide s receptor 0.0575 0.1526 0.1819
Echinococcus multilocularis fmrfamide receptor 0.0129 0.028 0.0333
Echinococcus granulosus somatostatin receptor 0.0129 0.028 0.0333
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0323 0.0823 0.2418
Echinococcus multilocularis mitogen activated protein kinase 3 0.0119 0.0253 0.0301
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0065 0.0204
Brugia malayi Cytochrome P450 family protein 0.0106 0.0216 0.0633
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0264 0.0657 0.242
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0072 0.0122 0.0145
Onchocerca volvulus 0.0129 0.028 0.2093
Brugia malayi Intermediate filament tail domain containing protein 0.0062 0.0093 0.0271
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0995 0.2699 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0264 0.0657 0.2408
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0048 0.0054 0.0179
Loa Loa (eye worm) hypothetical protein 0.0129 0.028 0.0823
Onchocerca volvulus 0.007 0.0115 0.0854
Schistosoma mansoni lipoxygenase 0.027 0.0674 0.0803
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0001 0.0001
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0995 0.2699 0.2695
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0097 0.0191 0.0227
Echinococcus granulosus hypothetical protein 0.1605 0.4404 0.5251
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0995 0.2699 0.7936
Loa Loa (eye worm) hypothetical protein 0.0129 0.028 0.0823
Schistosoma mansoni sulfide quinone reductase 0.0264 0.0657 0.0783
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0055 0.0073 0.0086
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0079 0.0139 0.0408
Brugia malayi Carboxylesterase family protein 0.0357 0.0916 0.2693
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0035 0.0016 0.0019
Schistosoma mansoni myosin xvIII 0.0129 0.028 0.0333
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0029 0.0001 0.0002
Echinococcus multilocularis ATP binding cassette sub family G 0.0031 0.0006 0.0006
Mycobacterium ulcerans NADH dehydrogenase 0.0264 0.0657 0.242
Schistosoma mansoni hypothetical protein 0.0304 0.0769 0.0917
Loa Loa (eye worm) hypothetical protein 0.006 0.0088 0.0259
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.3033 0.8394 0.8393
Echinococcus multilocularis lamin 0.0062 0.0093 0.011
Echinococcus multilocularis Protein lozenge 0.0054 0.007 0.0083
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0098 0.0116
Giardia lamblia ABC transporter 0.003 0.0005 0.0015
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0121 0.0144
Loa Loa (eye worm) hypothetical protein 0.0129 0.028 0.0823
Schistosoma mansoni neuropeptide F-like receptor 0.0129 0.028 0.0333
Loa Loa (eye worm) hypothetical protein 0.0129 0.028 0.0823
Mycobacterium ulcerans putative regulatory protein 0.0116 0.0243 0.0881
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0048 0.0054 0.0179
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0139 0.0309 0.0906
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0264 0.0657 0.1932
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0011 0.0013
Echinococcus granulosus rhodopsin orphan GPCR 0.0129 0.028 0.0333
Loa Loa (eye worm) hypothetical protein 0.0129 0.028 0.0823
Trichomonas vaginalis CMGC family protein kinase 0.0119 0.0253 0.0904
Trichomonas vaginalis glucosylceramidase, putative 0.036 0.0926 0.3407
Echinococcus granulosus neuropeptide receptor 0.0129 0.028 0.0333
Chlamydia trachomatis thioredoxin reductase 0.0264 0.0657 0.2342
Toxoplasma gondii exonuclease III APE 0.006 0.0088 0.0256
Entamoeba histolytica exodeoxyribonuclease III, putative 0.006 0.0088 0.1261
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0264 0.0657 0.0783
Onchocerca volvulus 0.0129 0.028 0.2093
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0129 0.028 0.0823
Brugia malayi hypothetical protein 0.0129 0.028 0.0822
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0065 0.0204
Brugia malayi Immunoglobulin I-set domain containing protein 0.0033 0.0012 0.0033
Schistosoma mansoni microtubule-associated protein tau 0.303 0.8385 1
Trypanosoma cruzi NADH dehydrogenase, putative 0.0264 0.0657 0.0652
Echinococcus multilocularis ecdysone induced protein 78C 0.0029 0.0001 0.0001
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0055 0.0073 0.0086
Trichomonas vaginalis ap endonuclease, putative 0.006 0.0088 0.029
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0041 0.0033 0.0039
Echinococcus multilocularis thioredoxin glutathione reductase 0.1246 0.3401 0.4056
Mycobacterium tuberculosis Conserved hypothetical protein 0.0158 0.0361 0.0919
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0035 0.0016 0.0048
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0055 0.0073 0.0086
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.2648 0.7319 0.7318
Echinococcus granulosus tumor protein p63 0.0332 0.0847 0.1009
Loa Loa (eye worm) hypothetical protein 0.0129 0.028 0.0823
Giardia lamblia Kinase, CMGC MAPK 0.0119 0.0253 0.0935
Loa Loa (eye worm) hypothetical protein 0.0055 0.0073 0.0214
Loa Loa (eye worm) melatonin receptor type 1A 0.0129 0.028 0.0823
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0029 0.0001 0.0002
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0264 0.0657 0.2408
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0549 0.1454 0.4274
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0042 0.0037 0.0032
Leishmania major acetoin dehydrogenase e3 component-like protein 0.2648 0.7319 0.7318
Schistosoma mansoni hypothetical protein 0.0165 0.0381 0.0453
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0129 0.028 0.0333
Schistosoma mansoni RAR-like nuclear receptor 0.0029 0.0001 0.0001
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0156 0.0354 0.2649
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0001 0.0001
Onchocerca volvulus 0.0062 0.0093 0.069
Onchocerca volvulus Protein ultraspiracle homolog 0.0029 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0129 0.028 0.0823
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0033 0.0012 0.0014
Schistosoma mansoni cytochrome P450 0.0048 0.0054 0.0063
Echinococcus granulosus ecdysone induced protein 78C 0.0029 0.0001 0.0001
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0033 0.0012 0.0014
Brugia malayi RNA binding protein 0.0072 0.0121 0.0356
Onchocerca volvulus 0.0507 0.1336 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0129 0.028 0.0822
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0091 0.0108
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0119 0.0253 0.0247
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0084 0.01
Echinococcus granulosus alpha 1A adrenergic receptor 0.0129 0.028 0.0333
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0038 0.0032
Trypanosoma cruzi cytochrome P450, putative 0.0066 0.0104 0.0099
Loa Loa (eye worm) hypothetical protein 0.0037 0.0024 0.0071
Loa Loa (eye worm) hypothetical protein 0.0429 0.1119 0.3291
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0139 0.0309 0.0762
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0066 0.0104 0.0367
Loa Loa (eye worm) hypothetical protein 0.0029 0.0001 0.0002
Echinococcus granulosus tm gpcr rhodopsin 0.19 0.5228 0.6235
Echinococcus multilocularis rhodopsin orphan GPCR 0.0129 0.028 0.0333
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0121 0.0144
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0264 0.0657 0.2408
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0139 0.0309 0.0303
Loa Loa (eye worm) hypothetical protein 0.0049 0.0055 0.0163
Schistosoma mansoni 60S ribosomal protein L21 0.0032 0.0008 0.0009
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0042 0.0036 0.0043
Echinococcus granulosus serotonin receptor 0.0129 0.028 0.0333
Giardia lamblia Glutamate synthase 0.0264 0.0657 0.2434
Leishmania major protein kinase, putative 0.0052 0.0066 0.0061
Loa Loa (eye worm) hypothetical protein 0.0029 0.0001 0.0003
Brugia malayi hypothetical protein 0.0051 0.0062 0.0181
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0264 0.0657 0.1932
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0129 0.028 0.0333
Entamoeba histolytica hypothetical protein 0.0041 0.0034 0.044
Loa Loa (eye worm) hypothetical protein 0.0129 0.028 0.0823
Trichomonas vaginalis ap endonuclease, putative 0.006 0.0088 0.029
Brugia malayi hypothetical protein 0.0098 0.0195 0.0571
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0079 0.0139 0.0165
Loa Loa (eye worm) hypothetical protein 0.0055 0.0073 0.0214
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0264 0.0657 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0119 0.0253 0.0247
Onchocerca volvulus Neuropeptide F receptor homolog 0.0129 0.028 0.2093
Echinococcus granulosus lipoxygenase domain containing protein 0.007 0.0115 0.0136
Echinococcus granulosus inositol monophosphatase 1 0.0157 0.0358 0.0426
Brugia malayi Melatonin receptor type 1A 0.0129 0.028 0.0822
Echinococcus multilocularis jun protein 0.0374 0.0965 0.1151
Loa Loa (eye worm) TAR-binding protein 0.0072 0.0121 0.0357
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0096 0.0188 0.0552
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0029 0.0001 0.0001
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0072 0.0122 0.0116
Echinococcus granulosus serotonin transporter 0.0323 0.0823 0.098
Onchocerca volvulus 0.0129 0.028 0.2093
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0129 0.028 0.0333
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0055 0.0073 0.0086
Brugia malayi Blistered cuticle protein 3 0.007 0.0116 0.0341
Schistosoma mansoni hypothetical protein 0.0129 0.028 0.0333
Brugia malayi hypothetical protein 0.0129 0.028 0.0822
Mycobacterium ulcerans carboxylesterase, LipT 0.006 0.0088 0.0306
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0157 0.0358 0.1051
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0098 0.0116
Echinococcus multilocularis g protein coupled receptor 0.0129 0.028 0.0333
Echinococcus granulosus cytochrome P450 2K1 0.0048 0.0054 0.0063
Toxoplasma gondii Erv1 / Alr family protein 0.0072 0.0122 0.0357
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0032 0.001 0.0004
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0139 0.0309 0.1125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.008 0.0262
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0084 0.0291
Brugia malayi hypothetical protein 0.007 0.0115 0.0335
Plasmodium vivax SET domain protein, putative 0.0064 0.0098 0.0287
Schistosoma mansoni neuropeptide receptor 0.0129 0.028 0.0333
Echinococcus granulosus cytoplasmic intermediate filament protein 0.003 0.0003 0.0003
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0072 0.0122 0.0116
Leishmania major trypanothione reductase 0.1246 0.3401 0.3397
Onchocerca volvulus 0.0129 0.028 0.2093
Leishmania major calcium channel protein, putative,ion transporter, putative 0.025 0.0617 0.0612
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0264 0.0657 0.0652
Trichomonas vaginalis PIKK family atypical protein kinase 0.0096 0.0188 0.0664
Echinococcus multilocularis serotonin receptor 0.0389 0.1008 0.1201
Brugia malayi larval opioid receptor 0.0129 0.028 0.0822
Brugia malayi hypothetical protein 0.0524 0.1385 0.407
Loa Loa (eye worm) doublecortin family protein 0.007 0.0115 0.0337
Giardia lamblia Thioredoxin reductase 0.0264 0.0657 0.2434
Schistosoma mansoni neuropeptide receptor 0.0129 0.028 0.0333
Echinococcus granulosus rhodopsin orphan GPCR 0.0129 0.028 0.0333
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.3608 1 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0035 0.0016 0.0019
Loa Loa (eye worm) hypothetical protein 0.0312 0.079 0.2323
Loa Loa (eye worm) hypothetical protein 0.0061 0.009 0.0263
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0047 0.0055
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0129 0.028 0.0333
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0041 0.0033 0.0028
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0264 0.0657 0.242
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.0758 0.0753
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.006 0.0088 0.0082
Entamoeba histolytica disulphide oxidoreductase, putative 0.0264 0.0657 1
Echinococcus multilocularis inositol monophosphatase 1 0.0157 0.0358 0.0426
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0048 0.0054 0.0179
Schistosoma mansoni biogenic amine receptor 0.0129 0.028 0.0333
Toxoplasma gondii target of rapamycin (TOR), putative 0.0071 0.0119 0.0349
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0264 0.0657 0.1932
Echinococcus multilocularis neuropeptide Y receptor 0.0129 0.028 0.0333
Echinococcus granulosus 7tm_1 domain containing protein 0.0129 0.028 0.0333
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0029 0.0001 0.0004
Echinococcus granulosus mitogen activated protein kinase 0.0119 0.0253 0.0301
Loa Loa (eye worm) hypothetical protein 0.0129 0.028 0.0823
Brugia malayi G-protein coupled receptor 0.0129 0.028 0.0822
Loa Loa (eye worm) G-protein coupled receptor 0.0129 0.028 0.0823
Loa Loa (eye worm) hypothetical protein 0.0129 0.028 0.0823
Echinococcus multilocularis hyperpolarization activated cyclic 0.0035 0.0016 0.0019
Brugia malayi G protein-coupled receptor 0.0129 0.028 0.0822
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0029 0.0001 0.0003
Echinococcus granulosus aryl hydrocarbon receptor 0.0041 0.0033 0.0039
Loa Loa (eye worm) phosphatidylinositol 3 0.0032 0.001 0.0029
Schistosoma mansoni hypothetical protein 0.0041 0.0034 0.004
Brugia malayi Carboxylesterase family protein 0.006 0.0088 0.0257
Trichomonas vaginalis glutamate synthase, putative 0.0264 0.0657 0.2408
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0374 0.0965 0.1151
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0084 0.01
Echinococcus multilocularis serotonin receptor 0.0389 0.1008 0.1201
Brugia malayi bZIP transcription factor family protein 0.0374 0.0965 0.2837
Loa Loa (eye worm) neuropeptide F receptor 0.0129 0.028 0.0823
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0041 0.0033 0.0087
Trichomonas vaginalis guanylate cyclase, putative 0.0041 0.0033 0.0087
Echinococcus granulosus ATP binding cassette sub family G 0.0031 0.0006 0.0006
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0029 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0029 0.0001 0.0003
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0126 0.0271 0.0796
Echinococcus granulosus tar DNA binding protein 0.0072 0.0121 0.0144
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0055 0.0073 0.0086
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0029 0.0001 0.0001
Trypanosoma cruzi PAB1-binding protein , putative 0.0079 0.014 0.0135
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.3608 1 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0042 0.0037 0.0032
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0502 0.1322 0.3788
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.006 0.0088 0.0104
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0264 0.0657 0.0783
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0097 0.0191 0.0227
Loa Loa (eye worm) G-protein coupled receptor 0.0129 0.028 0.0823
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0129 0.028 0.0333
Echinococcus multilocularis Polycystic kidney disease protein 0.007 0.0115 0.0136
Echinococcus multilocularis Ankyrin 0.0033 0.0013 0.0014
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0264 0.0657 0.2408
Brugia malayi Protein kinase domain containing protein 0.0156 0.0354 0.104
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0072 0.0122 0.0116
Leishmania major hypothetical protein, conserved 0.0264 0.0657 0.0652
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0323 0.0823 0.098
Trichomonas vaginalis spcc417.12 protein, putative 0.006 0.0088 0.0291
Schistosoma mansoni serine/threonine protein kinase 0.0156 0.0354 0.0422
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0055 0.0073 0.0214
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0264 0.0657 0.242
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0788 0.212 0.6233
Echinococcus multilocularis carboxylesterase 5A 0.0357 0.0916 0.1092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0064 0.0203
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0072 0.0122 0.0116
Trichomonas vaginalis inositol monophosphatase, putative 0.0157 0.0358 0.1295
Brugia malayi hypothetical protein 0.0129 0.028 0.0822
Echinococcus granulosus lamin 0.0062 0.0093 0.011
Loa Loa (eye worm) hypothetical protein 0.003 0.0003 0.0009
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.003 0.0003 0.0003
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.025 0.0617 0.0735
Brugia malayi hypothetical protein 0.0041 0.0034 0.0099
Loa Loa (eye worm) hypothetical protein 0.0129 0.028 0.0823
Trypanosoma brucei protein kinase, putative 0.0119 0.0253 0.0247
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0029 0.0001 0.0003
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0129 0.028 0.0823
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0079 0.0139 0.0134
Brugia malayi hypothetical protein 0.0055 0.0073 0.0213
Brugia malayi Protein kinase domain containing protein 0.0035 0.0016 0.0046
Schistosoma mansoni inositol monophosphatase 0.0157 0.0358 0.0426
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0157 0.0358 0.0353
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0731 0.1961 0.5766
Schistosoma mansoni hypothetical protein 0.0071 0.0118 0.014
Brugia malayi Cyclic-nucleotide gated cation channel 0.0035 0.0016 0.0047
Trichomonas vaginalis glucosylceramidase, putative 0.038 0.098 0.3609
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0264 0.0657 0.2181
Mycobacterium tuberculosis Probable oxidoreductase 0.1233 0.3363 0.9888
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0073 0.0123 0.042
Schistosoma mansoni rab6-interacting 0.007 0.0115 0.0136
Echinococcus multilocularis conserved hypothetical protein 0.1476 0.4043 0.4822
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0055 0.0073 0.0086
Brugia malayi RNA recognition motif domain containing protein 0.0072 0.0121 0.0356
Trichomonas vaginalis glucosylceramidase, putative 0.0549 0.1454 0.5368
Plasmodium vivax hypothetical protein, conserved 0.0055 0.0073 0.0213
Schistosoma mansoni voltage-gated potassium channel 0.0104 0.0211 0.0251
Leishmania major NADH dehydrogenase, putative 0.0264 0.0657 0.0652
Brugia malayi hypothetical protein 0.006 0.0088 0.0257
Plasmodium vivax glutathione reductase, putative 0.1246 0.3401 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0129 0.028 0.0333
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0048 0.0054 0.0179
Schistosoma mansoni amine GPCR 0.0129 0.028 0.0333
Echinococcus multilocularis lipoxygenase domain containing protein 0.007 0.0115 0.0136
Echinococcus granulosus biogenic amine 5HT receptor 0.0129 0.028 0.0333
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0995 0.2699 0.7903
Brugia malayi hypothetical protein 0.007 0.0115 0.0335
Mycobacterium ulcerans ferredoxin reductase 0.0264 0.0657 0.242
Echinococcus granulosus ATP binding cassette sub family G 0.0031 0.0006 0.0006
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0035 0.0016 0.0019
Loa Loa (eye worm) hypothetical protein 0.0064 0.0098 0.0288
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0264 0.0657 0.1804
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.1246 0.3401 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.027 0.0674 0.0803
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0129 0.028 0.0822
Brugia malayi Dopamine receptor protein 1 0.0129 0.028 0.0822
Brugia malayi AKH receptor 0.0129 0.028 0.0822
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0084 0.0291
Loa Loa (eye worm) hypothetical protein 0.0041 0.0033 0.0097
Onchocerca volvulus 0.006 0.0088 0.0655
Schistosoma mansoni hypothetical protein 0.0706 0.1893 0.2258
Schistosoma mansoni alpha-1 adrenergic receptor 0.0129 0.028 0.0333
Plasmodium falciparum amino acid transporter, putative 0.0055 0.0073 0.0213
Echinococcus multilocularis 0.0048 0.0054 0.0063
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0055 0.0073 0.0086
Echinococcus granulosus rhodopsin orphan GPCR 0.0129 0.028 0.0333
Plasmodium falciparum glutathione reductase 0.1246 0.3401 1
Onchocerca volvulus 0.0129 0.028 0.2093
Leishmania major phosphatidylinositol 3-kinase, putative 0.0032 0.001 0.0004
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0055 0.0073 0.0213
Loa Loa (eye worm) hypothetical protein 0.0129 0.028 0.0823
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0036 0.0043
Brugia malayi hypothetical protein 0.0429 0.1119 0.3289
Echinococcus granulosus sodium and chloride dependent glycine 0.0055 0.0073 0.0086
Onchocerca volvulus 0.0098 0.0194 0.1448
Loa Loa (eye worm) hypothetical protein 0.0129 0.028 0.0823
Onchocerca volvulus 0.0129 0.028 0.2093
Treponema pallidum thioredoxin reductase (trxB) 0.0264 0.0657 0.2181
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0029 0.0001 0.0001
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0995 0.2699 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0264 0.0657 0.0783
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0995 0.2699 0.7936
Echinococcus multilocularis allatostatin A receptor 0.0129 0.028 0.0333
Loa Loa (eye worm) hypothetical protein 0.0129 0.028 0.0823
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0079 0.0139 0.0409
Onchocerca volvulus 0.0055 0.0073 0.0542
Echinococcus granulosus neuropeptide Y receptor 0.0129 0.028 0.0333
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0096 0.0188 0.2801
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0264 0.0657 0.0783
Loa Loa (eye worm) runx1 0.0054 0.007 0.0206
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0264 0.0657 0.0652
Brugia malayi PAS domain containing protein 0.0156 0.0356 0.1046
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0129 0.028 0.0333
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0098 0.0287
Trichomonas vaginalis CMGC family protein kinase 0.0119 0.0253 0.0904
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0038 0.0032
Loa Loa (eye worm) hypothetical protein 0.0129 0.028 0.0823
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0011 0.0034
Brugia malayi jmjC domain containing protein 0.0035 0.0018 0.005
Plasmodium vivax ABC transporter G family member 2, putative 0.0031 0.0006 0.0015
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0079 0.0139 0.0134
Trichomonas vaginalis glucosylceramidase, putative 0.0549 0.1454 0.5368
Loa Loa (eye worm) thioredoxin reductase 0.1246 0.3401 1
Brugia malayi steroid hormone receptor 0.0029 0.0001 0.0002
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0139 0.0309 0.0368
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0029 0.0001 0.0001
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0038 0.0032
Schistosoma mansoni amine GPCR 0.0129 0.028 0.0333
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0129 0.028 0.0823
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.014 0.0312 0.0772
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0087 0.0163 0.0194
Toxoplasma gondii hypothetical protein 0.0055 0.0073 0.0213
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.19 0.5228 0.6235
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0029 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0055 0.0073 0.0214
Loa Loa (eye worm) hypothetical protein 0.0035 0.0016 0.0048
Onchocerca volvulus 0.0075 0.0129 0.0961
Echinococcus granulosus intermediate filament protein 0.0062 0.0093 0.011
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0032 0.001 0.0004
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0129 0.028 0.0823
Leishmania major ferric reductase, putative 0.0033 0.0012 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0029 0.0001 0.0003
Trypanosoma brucei cytochrome P450, putative 0.0066 0.0104 0.0099
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0075 0.0129 0.0153
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0995 0.2699 0.2695
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0129 0.028 0.0333
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0995 0.2699 1
Loa Loa (eye worm) carboxylesterase 0.006 0.0088 0.0259
Schistosoma mansoni retinoic acid receptor RXR 0.0029 0.0001 0.0001
Onchocerca volvulus 0.0129 0.028 0.2093
Brugia malayi neuropeptide F receptor 0.0129 0.028 0.0822
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0033 0.0087
Brugia malayi Dopamine receptor protein 2 0.0129 0.028 0.0822
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0119 0.0408
Giardia lamblia GTOR 0.0096 0.0188 0.0695
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0139 0.0309 0.0368
Trypanosoma brucei C-8 sterol isomerase, putative 0.0788 0.212 0.2116
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0084 0.0079
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0055 0.0073 0.0086
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0129 0.028 0.0333
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0157 0.0358 0.0353
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0019 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0029 0.0001 0.0002
Onchocerca volvulus 0.0049 0.0055 0.041
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0011 0.0032
Onchocerca volvulus 0.006 0.0088 0.0655
Schistosoma mansoni amine GPCR 0.0129 0.028 0.0333
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0129 0.028 0.0333
Schistosoma mansoni adenoreceptor 0.0129 0.028 0.0333
Loa Loa (eye worm) hypothetical protein 0.0029 0.0001 0.0003
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.006 0.0088 0.0104
Echinococcus multilocularis rhodopsin orphan GPCR 0.0129 0.028 0.0333
Loa Loa (eye worm) hypothetical protein 0.0357 0.0916 0.2694
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0357 0.0916 0.1092
Echinococcus granulosus lamin dm0 0.0062 0.0093 0.011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0029 0.0001 0.0003
Plasmodium falciparum ataxin-2 like protein, putative 0.0079 0.014 0.0411
Brugia malayi cytoplasmic intermediate filament protein 0.0033 0.0012 0.0035
Loa Loa (eye worm) hypothetical protein 0.1015 0.2754 0.8098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0079 0.0256
Brugia malayi RE15519p 0.0129 0.028 0.0822
Plasmodium vivax ataxin-2 like protein, putative 0.0079 0.014 0.0411
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0129 0.028 0.0822
Brugia malayi Carboxylesterase family protein 0.006 0.0088 0.0257
Echinococcus multilocularis rhodopsin orphan GPCR 0.0129 0.028 0.0333
Loa Loa (eye worm) hypoxia-induced factor 1 0.0484 0.1271 0.3738
Entamoeba histolytica hypothetical protein 0.0041 0.0034 0.044
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0169 0.0392 0.0467
Loa Loa (eye worm) hypothetical protein 0.0033 0.0013 0.0037
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0264 0.0657 0.2408
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0035 0.0016 0.0019
Echinococcus multilocularis survival motor neuron protein 1 0.078 0.21 0.2504
Onchocerca volvulus 0.0129 0.028 0.2093
Echinococcus multilocularis g protein coupled receptor 0.0129 0.028 0.0333
Schistosoma mansoni neuroligin 3 (S09 family) 0.006 0.0088 0.0104
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0084 0.01
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0018 0.0052
Loa Loa (eye worm) acetylcholinesterase 1 0.0357 0.0916 0.2694
Schistosoma mansoni growth hormone secretagogue receptor 0.0129 0.028 0.0333
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0995 0.2699 0.7936
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0011 0.0013
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0119 0.0253 0.0247
Echinococcus granulosus acetylcholinesterase 0.0357 0.0916 0.1092
Brugia malayi glutamate synthase 0.0264 0.0657 0.1932
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0072 0.0121 0.0357
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0264 0.0657 0.0652
Trichomonas vaginalis glutamate synthase, putative 0.0264 0.0657 0.2408
Schistosoma mansoni amine GPCR 0.1192 0.3249 0.3874
Toxoplasma gondii cytochrome p450 superfamily protein 0.0048 0.0054 0.0156
Loa Loa (eye worm) hypothetical protein 0.0357 0.0916 0.2694
Loa Loa (eye worm) hypothetical protein 0.1015 0.2754 0.8098
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0445 0.1163 0.342
Echinococcus granulosus sodium channel protein 0.025 0.0617 0.0735
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0995 0.2699 0.3219
Loa Loa (eye worm) hypothetical protein 0.0129 0.028 0.0823
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0048 0.0054 0.0179
Loa Loa (eye worm) hypothetical protein 0.0055 0.0073 0.0214
Brugia malayi Cytochrome P450 family protein 0.0066 0.0104 0.0306
Brugia malayi Thioredoxin reductase 0.1246 0.3401 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0088 0.0259
Echinococcus multilocularis somatostatin receptor 0.0129 0.028 0.0333
Trypanosoma cruzi cytochrome P450, putative 0.0066 0.0104 0.0099
Trichomonas vaginalis set domain proteins, putative 0.0507 0.1335 0.4928
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0129 0.028 0.0822
Echinococcus multilocularis acetylcholinesterase 0.0357 0.0916 0.1092
Loa Loa (eye worm) hypothetical protein 0.0129 0.028 0.0823
Echinococcus granulosus microtubule associated protein 2 0.303 0.8385 1
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0042 0.0037 0.0032
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.1233 0.3363 0.9888
Trypanosoma cruzi trypanothione reductase, putative 0.0995 0.2699 0.2695
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0129 0.028 0.0333
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0549 0.1454 0.4273
Brugia malayi hypothetical protein 0.0079 0.014 0.0411
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0133 0.0459
Schistosoma mansoni single-minded 0.0156 0.0356 0.0424
Echinococcus multilocularis G-protein coupled receptor, putative 0.0129 0.028 0.0333
Echinococcus multilocularis tumor protein p63 0.0332 0.0847 0.1009
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0098 0.0116
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0264 0.0657 0.0783
Leishmania major hypothetical protein, conserved 0.0072 0.0122 0.0116
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0001 0.0001
Plasmodium vivax amine transporter, putative 0.0055 0.0073 0.0213
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0129 0.028 0.0333
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0041 0.0033 0.0087
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0995 0.2699 0.7936
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0042 0.0036 0.0106
Brugia malayi Carboxylesterase family protein 0.006 0.0088 0.0257
Brugia malayi TAR-binding protein 0.0072 0.0121 0.0356
Trichomonas vaginalis glucosylceramidase, putative 0.0549 0.1454 0.5368
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0119 0.0408
Echinococcus multilocularis neuropeptides capa receptor 0.0129 0.028 0.0333
Brugia malayi Cytochrome P450 family protein 0.0066 0.0104 0.0306
Loa Loa (eye worm) hypothetical protein 0.006 0.0088 0.0259
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0264 0.0657 0.1932
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0096 0.0188 0.0183
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0018 0.002
Loa Loa (eye worm) hypothetical protein 0.007 0.0115 0.0337
Loa Loa (eye worm) hypothetical protein 0.0364 0.0937 0.2754
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0995 0.2699 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0096 0.0188 0.0224
Brugia malayi Doublecortin family protein 0.007 0.0115 0.0335
Onchocerca volvulus 0.0129 0.028 0.2093
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0096 0.0188 0.0183
Entamoeba histolytica thioredoxin reductase, putative 0.0264 0.0657 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0096 0.0188 0.0183
Plasmodium falciparum ABC transporter G family member 2 0.0031 0.0006 0.0015
Echinococcus granulosus sex peptide receptor 0.0129 0.028 0.0333
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0133 0.0459
Plasmodium falciparum transporter, putative 0.0055 0.0073 0.0213
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0029 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0129 0.028 0.0823
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0119 0.0408
Echinococcus granulosus rhodopsin orphan GPCR 0.0129 0.028 0.0333
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0119 0.0253 0.0742
Toxoplasma gondii LsmAD domain-containing protein 0.0079 0.014 0.0411
Schistosoma mansoni netrin receptor unc5 0.0033 0.0012 0.0014
Brugia malayi Uncoordinated protein 44 0.0033 0.0012 0.0033
Trichomonas vaginalis glucosylceramidase, putative 0.036 0.0926 0.3407
Leishmania major protein kinase, putative 0.0042 0.0037 0.0032
Schistosoma mansoni coup transcription factor 0.0029 0.0001 0.0001
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0055 0.0073 0.0213
Onchocerca volvulus Bile acid receptor homolog 0.0029 0.0001 0.0004
Leishmania major cytochrome p450-like protein 0.0048 0.0054 0.0048
Onchocerca volvulus 0.0159 0.0364 0.2725
Mycobacterium tuberculosis Probable reductase 0.0502 0.1322 0.3788
Schistosoma mansoni hypothetical protein 0.007 0.0115 0.0136
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0029 0.0001 0.0002
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0098 0.0116
Loa Loa (eye worm) hypothetical protein 0.0129 0.028 0.0823
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0995 0.2699 0.2695
Echinococcus granulosus tm gpcr rhodopsin 0.0129 0.028 0.0333
Plasmodium falciparum ataxin-2 like protein, putative 0.0079 0.014 0.0411
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0096 0.0188 0.0183
Schistosoma mansoni thyroid hormone receptor 0.0029 0.0001 0.0001
Trichomonas vaginalis apoptosis inducing factor, putative 0.0264 0.0657 0.2408
Echinococcus multilocularis neuropeptide receptor 0.0129 0.028 0.0333
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0502 0.1322 0.3788
Schistosoma mansoni histamine h1 receptor 0.0129 0.028 0.0333
Trichomonas vaginalis PIKK family atypical protein kinase 0.0096 0.0188 0.0664
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0264 0.0657 0.1933
Schistosoma mansoni sodium/chloride dependent transporter 0.0056 0.0077 0.0091
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0084 0.0246
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0048 0.0054 0.0048
Schistosoma mansoni ap endonuclease 0.006 0.0088 0.0104
Brugia malayi Carboxylesterase family protein 0.0357 0.0916 0.2693
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0098 0.0116
Schistosoma mansoni hypothetical protein 0.0129 0.028 0.0333
Loa Loa (eye worm) hypothetical protein 0.0055 0.0073 0.0214
Schistosoma mansoni opsin-like receptor 0.0129 0.028 0.0333
Brugia malayi cytochrome P450 0.0048 0.0054 0.0156
Treponema pallidum NADH oxidase 0.0995 0.2699 1
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0041 0.0033 0.0087
Brugia malayi hypothetical protein 0.012 0.0254 0.0744
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.0316 0.0311

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) > 8 mg kg-1 In vivo antibacterial activity of the compound against Staphylococcus aureus NCTC 10649 infected mouse by subcutaneous administration ChEMBL. 1573632
ED50 (functional) > 12 mg kg-1 In vivo antibacterial activity against Staphylococcus aureus NCTC 10649 infected mouse by oral administration ChEMBL. 1573632
MIC (functional) = 0.05 ug ml-1 In vitro minimum inhibitory concentration against Staphylococcus aureus ATCC 6538P using brain-heart infusion agar ChEMBL. 1573632
MIC (functional) = 0.05 ug ml-1 In vitro minimum inhibitory concentration against Staphylococcus aureus NCTC 10649 using brain-heart infusion agar ChEMBL. 1573632
MIC (functional) = 0.1 ug ml-1 In vitro minimum inhibitory concentration against Staphylococcus aureus A 5177 using brain-heart infusion agar ChEMBL. 1573632
MIC (functional) = 0.1 ug ml-1 In vitro minimum inhibitory concentration against Staphylococcus epidermidis 3159 using brain-heart infusion agar ChEMBL. 1573632
MIC (functional) = 0.2 ug ml-1 In vitro minimum inhibitory concentration against Staphylococcus aureus CMX 553 using brain-heart infusion agar ChEMBL. 1573632
MIC (functional) = 0.2 ug ml-1 In vitro minimum inhibitory concentration against Escherichia coli Juhl using brain-heart infusion agar ChEMBL. 1573632
MIC (functional) = 0.2 ug ml-1 In vitro minimum inhibitory concentration against Escherichia coli Juhl using brain-heart infusion agar ChEMBL. 1573632
MIC (functional) = 1.56 ug ml-1 In vitro minimum inhibitory concentration against Streptococcus agalactiae CMX 508 using brain-heart infusion agar ChEMBL. 1573632
MIC (functional) = 1.56 ug ml-1 In vitro minimum inhibitory concentration against Streptococcus pyogenes 930 using brain-heart infusion agar ChEMBL. 1573632
MIC (functional) = 3.1 ug ml-1 In vitro minimum inhibitory concentration against Enterococcus faecium ATCC 8043 using brain-heart infusion agar ChEMBL. 1573632
MIC (functional) = 3.1 ug ml-1 In vitro minimum inhibitory concentration against Klebsiella pneumoniae 8045 using brain-heart infusion agar ChEMBL. 1573632
MIC (functional) = 6.2 ug ml-1 In vitro minimum inhibitory concentration against Streptococcus bovis A5169 using brain-heart infusion agar ChEMBL. 1573632
MIC (functional) = 6.2 ug ml-1 In vitro minimum inhibitory concentration against Acinetobacter CMX 669 using brain-heart infusion agar ChEMBL. 1573632
MIC (functional) > 100 ug ml-1 In vitro minimum inhibitory concentration against Enterobacter aerogenes ATCC 13048 using brain-heart infusion agar ChEMBL. 1573632
MIC (functional) > 100 ug ml-1 Compound was evaluated in vitro for minimum inhibitory concentration against Pseudomonas aeruginosa A5007 using brain-heart infusion agar ChEMBL. 1573632
MIC (functional) > 100 ug ml-1 Compound was evaluated in vitro for minimum inhibitory concentration against Pseudomonas aeruginosa K799 / WT using brain-heart infusion agar ChEMBL. 1573632

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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