Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | orotate phosphoribosyltransferase | 0.0124 | 0.2251 | 0.2251 |
Loa Loa (eye worm) | hypothetical protein | 0.0321 | 1 | 1 |
Trypanosoma cruzi | orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative | 0.0124 | 0.2251 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | orotidine-5'-phosphate decarboxylase | 0.0069 | 0.0099 | 0.5 |
Toxoplasma gondii | orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase | 0.0124 | 0.2251 | 0.5 |
Schistosoma mansoni | orotidine 5'-phosphate decarboxylase | 0.0124 | 0.2251 | 0.2251 |
Leishmania major | orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative,OMPDCase-OPRTase, putative | 0.0124 | 0.2251 | 0.5 |
Echinococcus granulosus | uridine 5' monophosphate synthase | 0.0124 | 0.2251 | 0.3576 |
Plasmodium falciparum | orotidine 5'-phosphate decarboxylase | 0.0124 | 0.2251 | 0.5 |
Onchocerca volvulus | Phospholipase A2 homolog | 0.009 | 0.0924 | 1 |
Mycobacterium ulcerans | orotidine 5'-phosphate decarboxylase | 0.0124 | 0.2251 | 0.5 |
Brugia malayi | orotate phosphoribosyltransferase family protein | 0.0124 | 0.2251 | 0.2251 |
Trypanosoma brucei | orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative | 0.0124 | 0.2251 | 0.5 |
Brugia malayi | hypothetical protein | 0.0104 | 0.1472 | 0.1472 |
Onchocerca volvulus | Phospholipase A2 homolog | 0.009 | 0.0924 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0136 | 0.2743 | 0.4357 |
Brugia malayi | Phospholipase A2 family protein | 0.009 | 0.0924 | 0.0924 |
Trypanosoma cruzi | orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative | 0.0124 | 0.2251 | 0.5 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0227 | 0.6296 | 1 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0227 | 0.6296 | 1 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0227 | 0.6296 | 0.6296 |
Loa Loa (eye worm) | hypothetical protein | 0.0281 | 0.8458 | 0.8458 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0136 | 0.2743 | 0.4357 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0321 | 1 | 1 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0227 | 0.6296 | 0.6296 |
Trypanosoma cruzi | orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative | 0.0124 | 0.2251 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0136 | 0.2743 | 0.2743 |
Plasmodium vivax | orotidine 5'-phosphate decarboxylase, putative | 0.0124 | 0.2251 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0321 | 1 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0136 | 0.2743 | 0.4357 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0924 | 0.0924 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0924 | 0.0924 |
Echinococcus multilocularis | uridine 5' monophosphate synthase | 0.0124 | 0.2251 | 0.3576 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.2743 | 0.2743 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.2743 | 0.2743 |
Mycobacterium leprae | Probable orotidine 5'-phosphate decarboxylase PyrF (OMP decarboxylase) (OMPDCase) (OMPdecase) | 0.0124 | 0.2251 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Hypothermic effect (functional) | = | Evaluated for its ability to modify the core body temperature of mice; Moderate activity | ChEMBL. | 12061880 |
Hypothermic effect (functional) | = 0 | Evaluated for its ability to modify the core body temperature of mice; Moderate activity | ChEMBL. | 12061880 |
Pigment induction (functional) | = 0 | Evaluated for pigment induction capacity based on the P. destructiva halo color; Moderate activity | ChEMBL. | 12061880 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.